IL48667A - 4a-aryl-1,3-diketo-trans-decahydroisoquinolines and 4a-aryl-1,3-diketo-1,2,3,4,4a,5,6,7-octahydroisoquinolines and their preparation - Google Patents
4a-aryl-1,3-diketo-trans-decahydroisoquinolines and 4a-aryl-1,3-diketo-1,2,3,4,4a,5,6,7-octahydroisoquinolines and their preparationInfo
- Publication number
- IL48667A IL48667A IL48667A IL4866773A IL48667A IL 48667 A IL48667 A IL 48667A IL 48667 A IL48667 A IL 48667A IL 4866773 A IL4866773 A IL 4866773A IL 48667 A IL48667 A IL 48667A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- hydrogen
- diketo
- formula
- methoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (1)
1. 8. . The compound of claim 2 wherein R is CH "* is , and Ar" is m-methoxyphenyl ; N-methyl-4a-(m H meth6xyphenyl)-l,3-diketo-l ,2,3 ,4,4a,5,6,7-octahydroiso quinoline. 9. Compounds according to Claim 1 of the general formul lb wherein R is hydrogen, c]~c6 alkyl, benzyl, phenethyl, or cycloalkylmethyl of the formula -CH2CH< (CH2)n in which n is an integer in the range 2-5» Ar is ch Claim 9 (continued) 7 R is hydrogen or methoxy and R is methoxy . ■ 10- A"compound according to claim 9 which is dextrorotatory. 11. , A compound according to claim 9 which is laevorotatory. 12. . The compound of claim 9 wherein R^" is hydrogen, R5 is , H Ar1 is C6H5; ½-phenyl-l , 3-diketo-trahs-de ydrolsoquinollne . The compound of claim 9 whe R1 is CH-, is CAlc; N-me hyl-i 14. A process for producing a compound of formula la in Claim 2, which comprises heating a compound of the. general formula wherein R is hydrogen or methoxy , and . 8 R is methoxy, with at · least an.-1 equimolar amount of* an^anhydrous alkanol 6 R OH- in the presence of at least an equimolar amount of anhydrous HCl under inert, anhydrous conditions at a temperature in the range of 50-120°C to produce a compound of the formula ■ ; P] wherein R5 and Ar1 are as defined above and, if desired, heating this compound with sodium hydride and a halide R½r or R^I to form the corresponding N-substituted derivative of the formula wherein R = R except- or the meaning hydrogen. 15. The process of claim 14 wherein the reactants are 2-cyano-3-phenyl-3-carbethxymethylcyclohexene and ethyl alcohol. lis. A process for preparing a compound of the general formula lb in Claim 9, which comprises contacting a compound of the general formula la in Claim 2 with hydrogen in the presence of a maucing catalyst. HEirar
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27380672A | 1972-07-20 | 1972-07-20 | |
| US36584373A | 1973-06-01 | 1973-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL48667A true IL48667A (en) | 1976-11-30 |
Family
ID=26956443
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42790A IL42790A (en) | 1972-07-20 | 1973-07-19 | 4a-aryl-trans-decahydroisoquinolines their preparation and pharmaceutical compositions containing them |
| IL48667A IL48667A (en) | 1972-07-20 | 1973-07-19 | 4a-aryl-1,3-diketo-trans-decahydroisoquinolines and 4a-aryl-1,3-diketo-1,2,3,4,4a,5,6,7-octahydroisoquinolines and their preparation |
| IL48667A IL48667A0 (en) | 1972-07-20 | 1975-12-15 | 4alpha-aryl-1,3-diketo-trans-decahydroisoquinolines and 4alpha-aryl-1,3-diketo-1,2,3,4,4alpha,5,6,7-octahydroisoquinolines and their preparation |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42790A IL42790A (en) | 1972-07-20 | 1973-07-19 | 4a-aryl-trans-decahydroisoquinolines their preparation and pharmaceutical compositions containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL48667A IL48667A0 (en) | 1972-07-20 | 1975-12-15 | 4alpha-aryl-1,3-diketo-trans-decahydroisoquinolines and 4alpha-aryl-1,3-diketo-1,2,3,4,4alpha,5,6,7-octahydroisoquinolines and their preparation |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS4985075A (en) |
| AR (1) | AR208650A1 (en) |
| CA (1) | CA1024149A (en) |
| DE (2) | DE2351599A1 (en) |
| ES (1) | ES417127A1 (en) |
| FR (1) | FR2193600B1 (en) |
| GB (2) | GB1436377A (en) |
| HU (1) | HU167738B (en) |
| IE (1) | IE37929B1 (en) |
| IL (3) | IL42790A (en) |
| LU (1) | LU68066A1 (en) |
| NL (1) | NL7310078A (en) |
| SE (1) | SE7602150L (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7509337L (en) * | 1974-09-23 | 1976-03-24 | Du Pont | PAINING ASSOCIATIONS |
| BG30927A3 (en) * | 1977-12-27 | 1981-09-15 | Eli Lilly And Company | Method for obtaining of trans- 4- alpha- phenyl- octahydro- 1h- 2- pyridine |
| KR950002885B1 (en) * | 1990-06-05 | 1995-03-28 | 토레이가부시키가이샤 | Indole derivatives |
| CA2112744A1 (en) * | 1991-07-05 | 1993-01-21 | Vittorrio Vecchietti | Hydroisoquinoline derivatives |
| IT1307327B1 (en) * | 1995-09-12 | 2001-10-30 | Smithkline Beecham Spa | REPLACED HYDROISOKINOLINIC DERIVATIVES |
-
1973
- 1973-07-18 DE DE19732351599 patent/DE2351599A1/en active Pending
- 1973-07-18 CA CA176,763A patent/CA1024149A/en not_active Expired
- 1973-07-18 DE DE19732336559 patent/DE2336559A1/en active Pending
- 1973-07-19 FR FR7326508A patent/FR2193600B1/fr not_active Expired
- 1973-07-19 IL IL42790A patent/IL42790A/en unknown
- 1973-07-19 IE IE1229/73A patent/IE37929B1/en unknown
- 1973-07-19 HU HUDU206A patent/HU167738B/hu unknown
- 1973-07-19 GB GB3938775A patent/GB1436377A/en not_active Expired
- 1973-07-19 NL NL7310078A patent/NL7310078A/xx not_active Application Discontinuation
- 1973-07-19 AR AR249168A patent/AR208650A1/en active
- 1973-07-19 GB GB3443873A patent/GB1436376A/en not_active Expired
- 1973-07-19 IL IL48667A patent/IL48667A/en unknown
- 1973-07-20 ES ES417127A patent/ES417127A1/en not_active Expired
- 1973-07-20 LU LU68066A patent/LU68066A1/xx unknown
- 1973-07-20 JP JP48082484A patent/JPS4985075A/ja active Pending
-
1975
- 1975-12-15 IL IL48667A patent/IL48667A0/en unknown
-
1976
- 1976-02-23 SE SE7602150A patent/SE7602150L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1436377A (en) | 1976-05-19 |
| ES417127A1 (en) | 1976-04-01 |
| IE37929B1 (en) | 1977-11-09 |
| CA1024149A (en) | 1978-01-10 |
| AU5820773A (en) | 1975-01-23 |
| IL48667A0 (en) | 1976-02-29 |
| FR2193600A1 (en) | 1974-02-22 |
| NL7310078A (en) | 1974-01-22 |
| DE2351599A1 (en) | 1974-01-31 |
| LU68066A1 (en) | 1973-09-26 |
| IL42790A0 (en) | 1973-10-25 |
| IL42790A (en) | 1976-11-30 |
| HU167738B (en) | 1975-12-25 |
| DE2336559A1 (en) | 1974-01-31 |
| FR2193600B1 (en) | 1976-10-22 |
| IE37929L (en) | 1974-01-20 |
| AR208650A1 (en) | 1977-02-28 |
| GB1436376A (en) | 1976-05-19 |
| JPS4985075A (en) | 1974-08-15 |
| SE7602150L (en) | 1976-02-23 |
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