ES8403900A1 - Procedimiento para la fabricacion de derivados de indolicina. - Google Patents

Procedimiento para la fabricacion de derivados de indolicina.

Info

Publication number
ES8403900A1
ES8403900A1 ES523389A ES523389A ES8403900A1 ES 8403900 A1 ES8403900 A1 ES 8403900A1 ES 523389 A ES523389 A ES 523389A ES 523389 A ES523389 A ES 523389A ES 8403900 A1 ES8403900 A1 ES 8403900A1
Authority
ES
Spain
Prior art keywords
derivatives
compositions containing
preparation
pharmaceutical compositions
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523389A
Other languages
English (en)
Other versions
ES523389A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8403900A1 publication Critical patent/ES8403900A1/es
Publication of ES523389A0 publication Critical patent/ES523389A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Telephonic Communication Services (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE INDOLICINA Y DE SUS SALES DE ADICION NO TOXICAS, DE FORMULA (I), EN LA QUE R ES ALQUILO C1-4; R1 ES ALQUILO C1-6; R2 PUEDE SER VARIOS RADICALES; Y N VALE 1 O 2.CONSISTE EN LA REACCION DE CONDENSACION DE UN BROMOALCOXI BENZOIL INDOLICINA, DE FORMULA (II), CON UNA AMINA PRIMARIA DE FORMULA H2NR1, EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN MEDIO INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 75JC.ESTOS COMPUESTOS TIENEN APLICACIONESFARMACOLOGICAS PARA EL TRATAMIENTO DE LA ANGINA DE PECHO, HIPERTENSION, ARRITMIA E INSUFICIENCIA CIRCULATORIA CEREBRAL, Y COMO ANTICANCEROSOS.
ES523389A 1982-06-17 1983-06-17 Procedimiento para la fabricacion de derivados de indolicina. Granted ES523389A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8210598A FR2528845A1 (fr) 1982-06-17 1982-06-17 Nouveaux derives d'indolizine, leur procede de preparation ainsi que les compositions therapeutiques les contenant

Publications (2)

Publication Number Publication Date
ES8403900A1 true ES8403900A1 (es) 1984-04-01
ES523389A0 ES523389A0 (es) 1984-04-01

Family

ID=9275110

Family Applications (1)

Application Number Title Priority Date Filing Date
ES523389A Granted ES523389A0 (es) 1982-06-17 1983-06-17 Procedimiento para la fabricacion de derivados de indolicina.

Country Status (25)

Country Link
US (1) US4499095A (es)
EP (1) EP0097636B1 (es)
JP (1) JPS5980682A (es)
KR (1) KR870001065B1 (es)
AT (1) ATE15042T1 (es)
AU (1) AU553758B2 (es)
BE (1) BE897059A (es)
CA (1) CA1195979A (es)
CS (1) CS240963B2 (es)
DD (1) DD210046A5 (es)
DE (1) DE3360609D1 (es)
DK (1) DK158000C (es)
ES (1) ES523389A0 (es)
FI (1) FI74000C (es)
FR (1) FR2528845A1 (es)
GR (1) GR78285B (es)
HU (1) HU189298B (es)
IE (1) IE55429B1 (es)
IL (1) IL68778A (es)
NO (1) NO159723C (es)
NZ (1) NZ204608A (es)
PT (1) PT76876B (es)
SU (1) SU1194272A3 (es)
YU (1) YU43313B (es)
ZA (1) ZA833875B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215988A (en) * 1986-02-14 1993-06-01 Sanofi Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same
FR2642756B1 (fr) * 1989-02-07 1994-03-04 Sanofi Derives cycloaminoalkoxyphenyle, leur procede de preparation ainsi que les compositions pharmaceutiques ou veterinaires en contenant
FR2642755B1 (es) * 1989-02-07 1993-11-05 Sanofi
DE69224850T2 (de) * 1991-08-09 1998-09-24 Nycomed Innovation Ab Verwendung von dauerhafte frei radikalen zur bilderzeugung mittels magnetischer resonanz
FR2838123B1 (fr) * 2002-04-04 2005-06-10 Sanofi Synthelabo Nouveaux derives d'indolozine-1,2,3 substituee, inhibiteurs selectifs du b-fgf
FR2859997B1 (fr) * 2003-09-18 2006-02-03 Sanofi Synthelabo Nouveaux derives d'indolizine 1,2,3,6,7,8 substituee, inhibiteurs des fgfs, leur procede de preparation et les compositions pharmaceutiques les contenant.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI61030C (fi) * 1976-02-19 1982-05-10 Sanofi Sa Foerfarande foer framstaellning av terapeutiskt verkande 2-substituerade-1- eller 3-benzoyl-indolizinderivat
US4378362A (en) * 1979-12-06 1983-03-29 S.A. Labaz N.V. Indolizine derivatives and process for preparing the same
FR2495616A1 (fr) * 1980-12-09 1982-06-11 Labaz Nv Nouveaux derives d'indolizine, leur procede de preparation ainsi que leurs applications en therapeutique

Also Published As

Publication number Publication date
NO159723C (no) 1989-02-01
AU1542483A (en) 1984-12-20
YU133183A (en) 1986-02-28
AU553758B2 (en) 1986-07-24
BE897059A (fr) 1983-12-16
DE3360609D1 (en) 1985-09-26
EP0097636A1 (fr) 1984-01-04
YU43313B (en) 1989-06-30
IE55429B1 (en) 1990-09-12
ATE15042T1 (de) 1985-09-15
FR2528845B1 (es) 1984-11-23
DK276183A (da) 1983-12-18
FI832209A0 (fi) 1983-06-16
DK276183D0 (da) 1983-06-15
EP0097636B1 (fr) 1985-08-21
IE831408L (en) 1983-12-17
CS440183A2 (en) 1985-06-13
FI74000B (fi) 1987-08-31
FR2528845A1 (fr) 1983-12-23
DK158000B (da) 1990-03-12
IL68778A0 (en) 1983-09-30
SU1194272A3 (ru) 1985-11-23
FI832209L (fi) 1983-12-18
ZA833875B (en) 1984-02-29
JPS5980682A (ja) 1984-05-10
CS240963B2 (en) 1986-03-13
HU189298B (en) 1986-06-30
JPH0372072B2 (es) 1991-11-15
GR78285B (es) 1984-09-26
DK158000C (da) 1990-08-20
ES523389A0 (es) 1984-04-01
PT76876A (en) 1983-07-01
DD210046A5 (de) 1984-05-30
US4499095A (en) 1985-02-12
CA1195979A (en) 1985-10-29
KR840005140A (ko) 1984-11-03
PT76876B (en) 1986-01-27
IL68778A (en) 1986-10-31
FI74000C (fi) 1987-12-10
NZ204608A (en) 1985-09-13
KR870001065B1 (ko) 1987-05-27
NO159723B (no) 1988-10-24
NO832176L (no) 1983-12-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103