IL40972A - Process for the preparation of(3-benzoylphenyl)alkanoic acids - Google Patents
Process for the preparation of(3-benzoylphenyl)alkanoic acidsInfo
- Publication number
- IL40972A IL40972A IL40972A IL4097272A IL40972A IL 40972 A IL40972 A IL 40972A IL 40972 A IL40972 A IL 40972A IL 4097272 A IL4097272 A IL 4097272A IL 40972 A IL40972 A IL 40972A
- Authority
- IL
- Israel
- Prior art keywords
- benzoylphenyl
- process according
- acid
- nitrile
- benzene
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 14
- 239000002253 acid Substances 0.000 title claims abstract 13
- 150000007513 acids Chemical class 0.000 title claims abstract 6
- 238000002360 preparation method Methods 0.000 title claims abstract 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims abstract 15
- 150000002825 nitriles Chemical class 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 238000005727 Friedel-Crafts reaction Methods 0.000 claims abstract 4
- 238000006243 chemical reaction Methods 0.000 claims abstract 2
- -1 3-chlorocarbonylphenyl Chemical group 0.000 claims 8
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- RGYOCHMZSLUCNP-UHFFFAOYSA-N 2-(3-benzoylphenyl)propanenitrile Chemical compound N#CC(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 RGYOCHMZSLUCNP-UHFFFAOYSA-N 0.000 claims 1
- XXQNFMGCPMJJSJ-UHFFFAOYSA-N 3-(1-cyanoethyl)benzoyl chloride Chemical compound N#CC(C)C1=CC=CC(C(Cl)=O)=C1 XXQNFMGCPMJJSJ-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 239000001117 sulphuric acid Substances 0.000 claims 1
- 235000011149 sulphuric acid Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000005171 halobenzenes Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7143565A FR2163875A5 (en) | 1971-12-03 | 1971-12-03 | 3-benzoylphenyl acetic and 2-(3-benzoyl phenyl) - propionic acids prepn - for use as anti-inflammatories |
| FR7236570A FR2202873A2 (en) | 1972-10-16 | 1972-10-16 | 3-benzoylphenyl acetic and 2-(3-benzoyl phenyl) - propionic acids prepn - for use as anti-inflammatories |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL40972A0 IL40972A0 (en) | 1973-01-30 |
| IL40972A true IL40972A (en) | 1976-03-31 |
Family
ID=26216758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL40972A IL40972A (en) | 1971-12-03 | 1972-11-30 | Process for the preparation of(3-benzoylphenyl)alkanoic acids |
Country Status (26)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS582934B2 (ja) * | 1974-07-29 | 1983-01-19 | ニツシンセイフン カブシキガイシヤ | ２−（置換アリ−ル）−プロピオン酸の製法 |
| DE2708142C3 (de) * | 1977-02-25 | 1981-10-29 | Rütgerswerke AG, 6000 Frankfurt | Verfahren zur Herstellung von substituierten Phenylacetonitrilen und neue Phenylacetonitrile |
| EP0025262B1 (en) | 1979-07-16 | 1983-10-05 | Sagami Chemical Research Center | Alpha-thio-alpha-aryl-substituted alkanonitriles, process for their preparation, process for preparing alpha-aryl-substituted alkanonitriles and the corresponding carboxylic acids therefrom and process for preparing intermediates |
| SE8400239D0 (sv) * | 1984-01-19 | 1984-01-19 | Pharmacia Ab | Nya arylettiksyraderivat |
| ES2058024B1 (es) * | 1992-11-10 | 1995-05-01 | Menarini Lab | Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. |
| ES2163986B1 (es) * | 1999-07-13 | 2003-02-16 | Menarini Lab | Acidos-alfa-arilpropionicos y arilaceticos como inhibidores de la ciclooxigenasa-ii. |
| CN111675631A (zh) * | 2020-06-24 | 2020-09-18 | 湖北仙盛科技股份有限公司 | 一种氰基酮洛芬合成工艺 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1546478A (fr) * | 1967-01-27 | 1968-11-22 | Rhone Poulenc Sa | Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation |
| GB1226344A (enrdf_load_stackoverflow) * | 1967-07-31 | 1971-03-24 |
-
1972
- 1972-11-22 OA OA54753A patent/OA04219A/xx unknown
- 1972-11-24 NL NL7215990A patent/NL7215990A/xx unknown
- 1972-11-30 JP JP47119468A patent/JPS528301B2/ja not_active Expired
- 1972-11-30 IL IL40972A patent/IL40972A/en unknown
- 1972-11-30 IE IE1660/72A patent/IE36936B1/xx unknown
- 1972-12-01 SU SU1859757A patent/SU457210A3/ru active
- 1972-12-01 CA CA158,010A patent/CA972765A/en not_active Expired
- 1972-12-01 CS CS8228A patent/CS170457B2/cs unknown
- 1972-12-01 NO NO4425/72A patent/NO139782C/no unknown
- 1972-12-01 PL PL1972159227A patent/PL77271B1/pl unknown
- 1972-12-01 CH CH1756172A patent/CH545761A/xx not_active IP Right Cessation
- 1972-12-01 FI FI3415/72A patent/FI55173C/fi active
- 1972-12-01 SE SE7215722A patent/SE397675B/xx unknown
- 1972-12-01 DD DD167245A patent/DD100239A5/xx unknown
- 1972-12-01 DE DE2258985A patent/DE2258985C2/de not_active Expired
- 1972-12-01 CY CY916A patent/CY916A/xx unknown
- 1972-12-01 DK DK602072AA patent/DK134814B/da not_active IP Right Cessation
- 1972-12-01 LU LU66586A patent/LU66586A1/xx unknown
- 1972-12-01 AT AT1022772A patent/AT321283B/de active
- 1972-12-01 GB GB5564072A patent/GB1360560A/en not_active Expired
- 1972-12-01 BE BE792218D patent/BE792218A/xx not_active IP Right Cessation
- 1972-12-01 YU YU2990/72A patent/YU36003B/xx unknown
- 1972-12-01 AR AR245440A patent/AR194864A1/es active
- 1972-12-01 HU HURO687A patent/HU166290B/hu unknown
- 1972-12-02 ES ES409237A patent/ES409237A1/es not_active Expired
-
1977
- 1977-12-01 HK HK601/77A patent/HK60177A/xx unknown
Also Published As
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