ES8106708A1 - Un procedimiento para preparar 7-alcoxicarbonil-6,8-dime- til-4-hidroximetil-1-ftalazona - Google Patents

Un procedimiento para preparar 7-alcoxicarbonil-6,8-dime- til-4-hidroximetil-1-ftalazona

Info

Publication number
ES8106708A1
ES8106708A1 ES493798A ES493798A ES8106708A1 ES 8106708 A1 ES8106708 A1 ES 8106708A1 ES 493798 A ES493798 A ES 493798A ES 493798 A ES493798 A ES 493798A ES 8106708 A1 ES8106708 A1 ES 8106708A1
Authority
ES
Spain
Prior art keywords
alpha
phthalazone
dimethyl
alkoxycarbonyl
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493798A
Other languages
English (en)
Other versions
ES493798A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9676379A external-priority patent/JPS5636464A/ja
Priority claimed from JP9676479A external-priority patent/JPS5636465A/ja
Priority claimed from JP16087379A external-priority patent/JPS5683478A/ja
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Publication of ES8106708A1 publication Critical patent/ES8106708A1/es
Publication of ES493798A0 publication Critical patent/ES493798A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 7-ALCOXICARBONIL-6,8-DIMETIL-4-HIDROXIMETIL-1-FTALAZONAS DE FORMULA (I), EN LA QUE R1 ES UN ALCOHILO INFERIOR. CONSISTE EN LA REACCION DE UN ANHIDRIDO 3,5-DIMETIL-4-ALCOXICARBONIL-FTALICO DE FORMULA (II), EN LA QUE R1 ES EL MISMO QUE EN LA FORMULA (I), CON UN COMPUESTO DE FORMULA (III), EN LA QUE R2 ES -CN O -COOES, SIENDO ES UN RESIDUO DE ESTER, SEGUIDA POR LA REACCION CON HIDRACINA, HIDROLISIS, HALOGENACION, DE NUEVO HIDROLISIS DEL DERIVADO HALOGENADO OBTENIDO Y, POR ULTIMO, DESCARBOXILACION, BIEN POR VIA DIRECTA O DESPUES DE TRANSFORMAR EL ACIDO EN UNA SAL. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS CONTRA LA HEMORRAGIA CEREBRAL, LA ARTEROSCLEROSIS Y LA APOPLEJIA CEREBRAL. *FORMULA* U
ES493798A 1979-07-31 1980-07-29 Un procedimiento para preparar 7-alcoxicarbonil-6,8-dime- til-4-hidroximetil-1-ftalazona Granted ES493798A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9676379A JPS5636464A (en) 1979-07-31 1979-07-31 Phthalazone-4-halogenoacetic acid derivative, its preparation and production of 4-hydroxymethylphthalazone derivative
JP9676479A JPS5636465A (en) 1979-07-31 1979-07-31 Phthalazone-4-hydroxyacetic acid derivative, its preparation and production of 4-hydroxymethylphthalazone derivative
JP16087379A JPS5683478A (en) 1979-12-13 1979-12-13 4-halogenomethyl-1-phthalazone derivative, its preparation and preparation of 4-hydroxymethylphthalazone derivative

Publications (2)

Publication Number Publication Date
ES8106708A1 true ES8106708A1 (es) 1981-08-01
ES493798A0 ES493798A0 (es) 1981-08-01

Family

ID=27308205

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493798A Granted ES493798A0 (es) 1979-07-31 1980-07-29 Un procedimiento para preparar 7-alcoxicarbonil-6,8-dime- til-4-hidroximetil-1-ftalazona

Country Status (13)

Country Link
US (1) US4350813A (es)
AR (1) AR227158A1 (es)
AU (1) AU531727B2 (es)
CA (1) CA1143733A (es)
CH (1) CH645360A5 (es)
DE (1) DE3028369A1 (es)
DK (1) DK328280A (es)
ES (1) ES493798A0 (es)
FR (3) FR2462429A1 (es)
GB (1) GB2055825B (es)
HU (1) HU185378B (es)
IT (1) IT1147016B (es)
NL (1) NL8004231A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464532A (en) * 1979-07-31 1984-08-07 Nippon Kayaku Kabushiki Kaisha Intermediates of 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazone
JPS58140077A (ja) * 1982-02-13 1983-08-19 Nippon Kayaku Co Ltd ４−ヒドロキシメチル−１−フタラゾン誘導体の製造法およびその中間体
US4539579A (en) * 1982-11-05 1985-09-03 The Hilton-Davis Chemical Co. Compounds, processes and marking systems
US4665181A (en) * 1984-05-17 1987-05-12 Pennwalt Corporation Anti-inflammatory phthalazinones
US4900844A (en) * 1987-06-09 1990-02-13 Pfizer Inc. Intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains
US4904782A (en) * 1988-02-29 1990-02-27 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel intermediate
US5254663A (en) * 1992-04-28 1993-10-19 Hay Allan S Polymers derived from phenolphthaleins
US5237062A (en) * 1992-04-28 1993-08-17 Hay Allan S Polymers derived from phenolphthaleins
US8800215B2 (en) 2011-08-22 2014-08-12 Performance Contracting, Inc. Self-contained portable container habitat for use in radiological environments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture

Also Published As

Publication number Publication date
US4350813A (en) 1982-09-21
DK328280A (da) 1981-02-01
GB2055825B (en) 1984-07-04
FR2462429A1 (fr) 1981-02-13
DE3028369A1 (de) 1981-02-19
IT8049362A0 (it) 1980-07-28
AR227158A1 (es) 1982-09-30
GB2055825A (en) 1981-03-11
AU531727B2 (en) 1983-09-01
HU185378B (en) 1985-01-28
CA1143733A (en) 1983-03-29
ES493798A0 (es) 1981-08-01
CH645360A5 (de) 1984-09-28
IT1147016B (it) 1986-11-19
AU6069180A (en) 1981-02-05
NL8004231A (nl) 1981-02-03
FR2510109A1 (fr) 1983-01-28
FR2510110A1 (es) 1983-01-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301