IL305912A - Improved serum albumin binding agents - Google Patents
Improved serum albumin binding agentsInfo
- Publication number
- IL305912A IL305912A IL305912A IL30591223A IL305912A IL 305912 A IL305912 A IL 305912A IL 305912 A IL305912 A IL 305912A IL 30591223 A IL30591223 A IL 30591223A IL 305912 A IL305912 A IL 305912A
- Authority
- IL
- Israel
- Prior art keywords
- amino acid
- acid sequence
- seq
- compound
- polypeptide
- Prior art date
Links
- 102000007562 Serum Albumin Human genes 0.000 title claims 3
- 108010071390 Serum Albumin Proteins 0.000 title claims 3
- 239000011230 binding agent Substances 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 30
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 210000004899 c-terminal region Anatomy 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 6
- 150000005829 chemical entities Chemical class 0.000 claims 6
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762446992P | 2017-01-17 | 2017-01-17 | |
PCT/EP2018/051082 WO2018134234A1 (en) | 2017-01-17 | 2018-01-17 | Improved serum albumin binders |
Publications (1)
Publication Number | Publication Date |
---|---|
IL305912A true IL305912A (en) | 2023-11-01 |
Family
ID=61163666
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL305912A IL305912A (en) | 2017-01-17 | 2018-01-17 | Improved serum albumin binding agents |
IL267897A IL267897A (en) | 2017-01-17 | 2019-07-07 | Improved serum albumin binding agents |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL267897A IL267897A (en) | 2017-01-17 | 2019-07-07 | Improved serum albumin binding agents |
Country Status (12)
Country | Link |
---|---|
US (1) | US11897944B2 (ko) |
EP (1) | EP3571224A1 (ko) |
JP (2) | JP7300385B2 (ko) |
KR (2) | KR20230165374A (ko) |
CN (2) | CN110461870B (ko) |
AU (1) | AU2018209150A1 (ko) |
BR (1) | BR112019014600A2 (ko) |
CA (1) | CA3050574A1 (ko) |
IL (2) | IL305912A (ko) |
MX (1) | MX2019008536A (ko) |
SG (2) | SG11201906341XA (ko) |
WO (1) | WO2018134234A1 (ko) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170121399A1 (en) | 2014-05-16 | 2017-05-04 | Ablynx N.V. | Improved immunoglobulin variable domains |
CN110049997B (zh) * | 2016-12-07 | 2023-09-22 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合免疫球蛋白单可变结构域 |
CN110461870B (zh) * | 2017-01-17 | 2023-09-29 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合物 |
CN117285623A (zh) * | 2017-01-17 | 2023-12-26 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合物 |
CN114980923A (zh) | 2019-12-06 | 2022-08-30 | 艾伯霖克斯公司 | 包含靶向TNFα和OX40L的免疫球蛋白单可变结构域的多肽 |
KR20220122652A (ko) | 2019-12-06 | 2022-09-02 | 아블린쓰 엔.브이. | TNFα 및 IL-23을 표적화하는 면역글로불린 단일 가변 도메인을 포함하는 폴리펩티드 |
CA3163910A1 (en) | 2019-12-09 | 2021-06-17 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-13 and tslp |
EP4126971A1 (en) | 2020-03-30 | 2023-02-08 | Ablynx N.V. | Method for the production and purification of multivalent immunoglobulin single variable domains |
EP4217390A1 (en) | 2020-09-25 | 2023-08-02 | Ablynx N.V. | Polypeptides comprising immunoglobulin single variable domains targeting il-13 and ox40l |
WO2022089435A1 (en) * | 2020-10-27 | 2022-05-05 | Beijing Ql Biopharmaceutical Co., Ltd. | Fusion proteins of gdf15 and use thereof |
IL303740A (en) | 2020-12-18 | 2023-08-01 | Sanofi Sa | Polypeptides that recruit T cells based on reactivity to alpha/beta receptors |
WO2022129572A1 (en) | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha |
KR20230123495A (ko) | 2020-12-18 | 2023-08-23 | 아블린쓰 엔.브이. | 글리피칸-3 및 t세포 수용체를 표적으로 하는 면역글로불린단일 가변 도메인을 포함하는 폴리펩티드 |
WO2023111266A1 (en) | 2021-12-17 | 2023-06-22 | Ablynx Nv | POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TCRαβ, CD33 AND CD123 |
WO2023230488A1 (en) * | 2022-05-23 | 2023-11-30 | Cereius, Inc. | Her2-binding agents and uses thereof |
TW202415678A (zh) | 2022-06-14 | 2024-04-16 | 比利時商艾伯霖克斯公司 | 靶向t細胞受體的免疫球蛋白單可變結構域 |
US20240132624A1 (en) | 2022-07-27 | 2024-04-25 | Ablynx N.V. | Polypeptides binding to a specific epitope of the neonatal fc receptor |
WO2024133935A1 (en) | 2022-12-23 | 2024-06-27 | Ablynx Nv | Protein-based conjugation carriers |
WO2024151515A2 (en) | 2023-01-09 | 2024-07-18 | Odyssey Therapeutics, Inc. | Anti-tnfr2 antigen-binding proteins and uses thereof |
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EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
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US20170121399A1 (en) | 2014-05-16 | 2017-05-04 | Ablynx N.V. | Improved immunoglobulin variable domains |
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EP3611192A3 (en) | 2015-05-13 | 2020-03-25 | Ablynx N.V. | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
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CN110049997B (zh) * | 2016-12-07 | 2023-09-22 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合免疫球蛋白单可变结构域 |
CN110461870B (zh) * | 2017-01-17 | 2023-09-29 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合物 |
CN117285623A (zh) | 2017-01-17 | 2023-12-26 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合物 |
-
2018
- 2018-01-17 CN CN201880015687.2A patent/CN110461870B/zh active Active
- 2018-01-17 KR KR1020237040677A patent/KR20230165374A/ko active Application Filing
- 2018-01-17 CN CN202311114345.5A patent/CN117327175A/zh active Pending
- 2018-01-17 SG SG11201906341XA patent/SG11201906341XA/en unknown
- 2018-01-17 WO PCT/EP2018/051082 patent/WO2018134234A1/en unknown
- 2018-01-17 SG SG10202108973SA patent/SG10202108973SA/en unknown
- 2018-01-17 KR KR1020197024114A patent/KR102653724B1/ko active IP Right Grant
- 2018-01-17 IL IL305912A patent/IL305912A/en unknown
- 2018-01-17 MX MX2019008536A patent/MX2019008536A/es unknown
- 2018-01-17 US US16/477,927 patent/US11897944B2/en active Active
- 2018-01-17 AU AU2018209150A patent/AU2018209150A1/en active Pending
- 2018-01-17 BR BR112019014600-8A patent/BR112019014600A2/pt unknown
- 2018-01-17 JP JP2019538383A patent/JP7300385B2/ja active Active
- 2018-01-17 EP EP18703213.1A patent/EP3571224A1/en active Pending
- 2018-01-17 CA CA3050574A patent/CA3050574A1/en active Pending
-
2019
- 2019-07-07 IL IL267897A patent/IL267897A/en unknown
-
2022
- 2022-10-20 JP JP2022168448A patent/JP2023002700A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IL267897A (en) | 2019-09-26 |
CA3050574A1 (en) | 2018-07-26 |
MX2019008536A (es) | 2019-09-10 |
KR20230165374A (ko) | 2023-12-05 |
CN110461870B (zh) | 2023-09-29 |
BR112019014600A2 (pt) | 2020-02-18 |
JP2023002700A (ja) | 2023-01-10 |
CN117327175A (zh) | 2024-01-02 |
SG11201906341XA (en) | 2019-08-27 |
RU2019125949A (ru) | 2021-02-19 |
JP7300385B2 (ja) | 2023-06-29 |
JP2020506898A (ja) | 2020-03-05 |
KR20190104609A (ko) | 2019-09-10 |
US20190367598A1 (en) | 2019-12-05 |
SG10202108973SA (en) | 2021-09-29 |
KR102653724B1 (ko) | 2024-04-02 |
AU2018209150A1 (en) | 2019-07-25 |
US11897944B2 (en) | 2024-02-13 |
CN110461870A (zh) | 2019-11-15 |
WO2018134234A1 (en) | 2018-07-26 |
EP3571224A1 (en) | 2019-11-27 |
RU2019125949A3 (ko) | 2021-03-09 |
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