IL296844B2 - Compounds and methods for reducing TAU expression - Google Patents

Compounds and methods for reducing TAU expression

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Publication number
IL296844B2
IL296844B2 IL296844A IL29684422A IL296844B2 IL 296844 B2 IL296844 B2 IL 296844B2 IL 296844 A IL296844 A IL 296844A IL 29684422 A IL29684422 A IL 29684422A IL 296844 B2 IL296844 B2 IL 296844B2
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IL
Israel
Prior art keywords
oligonucleotide
tau
mrna
seq
disease
Prior art date
Application number
IL296844A
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English (en)
Hebrew (he)
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IL296844A (en
IL296844B1 (en
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Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL296844A publication Critical patent/IL296844A/en
Publication of IL296844B1 publication Critical patent/IL296844B1/en
Publication of IL296844B2 publication Critical patent/IL296844B2/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL296844A 2015-12-21 2016-12-19 Compounds and methods for reducing TAU expression IL296844B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562270165P 2015-12-21 2015-12-21
PCT/IB2016/057794 WO2017109679A1 (en) 2015-12-21 2016-12-19 Compositions and methods for decreasing tau expression

Publications (3)

Publication Number Publication Date
IL296844A IL296844A (en) 2022-11-01
IL296844B1 IL296844B1 (en) 2023-12-01
IL296844B2 true IL296844B2 (en) 2024-04-01

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ID=57758674

Family Applications (3)

Application Number Title Priority Date Filing Date
IL296844A IL296844B2 (en) 2015-12-21 2016-12-19 Compounds and methods for reducing TAU expression
IL305866A IL305866B2 (en) 2015-12-21 2016-12-19 Compositions and methods for decreasing tau expression
IL260124A IL260124A (en) 2015-12-21 2018-06-18 Compounds and methods for reducing tau expression

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL305866A IL305866B2 (en) 2015-12-21 2016-12-19 Compositions and methods for decreasing tau expression
IL260124A IL260124A (en) 2015-12-21 2018-06-18 Compounds and methods for reducing tau expression

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US (2) US11473083B2 (enExample)
EP (2) EP3394259B1 (enExample)
JP (4) JP7027328B2 (enExample)
KR (2) KR20250112919A (enExample)
CN (2) CN116218848A (enExample)
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FI (1) FI3394259T3 (enExample)
HR (1) HRP20240672T1 (enExample)
HU (1) HUE066548T2 (enExample)
IL (3) IL296844B2 (enExample)
JO (2) JOP20200228A1 (enExample)
LT (1) LT3394259T (enExample)
MA (2) MA71468A (enExample)
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TW (2) TWI787163B (enExample)
UY (1) UY37038A (enExample)
WO (1) WO2017109679A1 (enExample)
ZA (1) ZA201803661B (enExample)

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