IL282006B2 - Treatment of bone tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide - Google Patents

Treatment of bone tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide

Info

Publication number
IL282006B2
IL282006B2 IL282006A IL28200621A IL282006B2 IL 282006 B2 IL282006 B2 IL 282006B2 IL 282006 A IL282006 A IL 282006A IL 28200621 A IL28200621 A IL 28200621A IL 282006 B2 IL282006 B2 IL 282006B2
Authority
IL
Israel
Prior art keywords
dosage form
oral dosage
hours
composition
cav3
Prior art date
Application number
IL282006A
Other languages
English (en)
Hebrew (he)
Other versions
IL282006A (en
IL282006B1 (en
Original Assignee
Cavion Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cavion Inc filed Critical Cavion Inc
Publication of IL282006A publication Critical patent/IL282006A/en
Publication of IL282006B1 publication Critical patent/IL282006B1/en
Publication of IL282006B2 publication Critical patent/IL282006B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL282006A 2018-10-03 2019-10-03 Treatment of bone tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide IL282006B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862740755P 2018-10-03 2018-10-03
US201862780049P 2018-12-14 2018-12-14
PCT/US2019/054498 WO2020072773A1 (en) 2018-10-03 2019-10-03 Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide

Publications (3)

Publication Number Publication Date
IL282006A IL282006A (en) 2021-05-31
IL282006B1 IL282006B1 (en) 2023-04-01
IL282006B2 true IL282006B2 (en) 2023-08-01

Family

ID=70055875

Family Applications (2)

Application Number Title Priority Date Filing Date
IL282006A IL282006B2 (en) 2018-10-03 2019-10-03 Treatment of bone tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
IL300798A IL300798B2 (en) 2018-10-03 2019-10-03 Treatment of skeletal tremor with (r)–2-(4–isopropylphenyl)–n-(1-(5-(2,2,2–trifluoroethoxy)pyridin-2-yl)ethyl)acetamide

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL300798A IL300798B2 (en) 2018-10-03 2019-10-03 Treatment of skeletal tremor with (r)–2-(4–isopropylphenyl)–n-(1-(5-(2,2,2–trifluoroethoxy)pyridin-2-yl)ethyl)acetamide

Country Status (12)

Country Link
US (3) US12383539B2 (enExample)
EP (1) EP3860571A4 (enExample)
JP (2) JP7480131B2 (enExample)
KR (1) KR20210087459A (enExample)
CN (1) CN113164393A (enExample)
AU (2) AU2019355021B2 (enExample)
BR (1) BR112021006398A2 (enExample)
CA (1) CA3115235A1 (enExample)
IL (2) IL282006B2 (enExample)
MX (2) MX2021003706A (enExample)
TW (1) TWI879741B (enExample)
WO (1) WO2020072773A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2936400T3 (es) 2015-10-22 2023-03-16 Cavion Inc Métodos para tratar el síndrome Angelman
SG10202111885PA (en) 2017-04-26 2021-12-30 Cavion Inc Methods for improving memory and cognition and for treating memory and cognitive disorders
AU2019355021B2 (en) 2018-10-03 2024-09-12 Cavion, Inc. Treating essential tremor using (R)-2-(4-Isopropylphenyl)-N-(1-(5-(2,2,2-Trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
CN114340670A (zh) 2019-07-11 2022-04-12 普拉克西斯精密药物股份有限公司 T-型钙通道调节剂的制剂及其使用方法
TWI870475B (zh) * 2019-10-02 2025-01-21 美商卡凡恩公司 用於治療神經毒性之方法及材料
AU2021263804A1 (en) * 2020-04-29 2023-01-19 Praxis Precision Medicines, Inc. Methods of use of T-type calcium channel modulators
AU2022281023A1 (en) * 2021-05-24 2023-11-30 Cavion, Inc. Method of treating essential tremor
IL322960A (en) * 2023-03-02 2025-10-01 Praxis Prec Medicines Inc High-strength single-unit dosage formulations and methods of using them
AU2024229800A1 (en) * 2023-03-02 2025-09-11 Praxis Precision Medicines, Inc. Methods of treating essential tremor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100151022A9 (en) * 2002-10-25 2010-06-17 Vincent Lenaerts Controlled-release compositions

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100389752C (zh) * 1978-04-21 2008-05-28 莱博法姆公司 控释组合物
CA1319144C (en) 1986-11-14 1993-06-15 Quirico Branca Tetrahydronaphthalene derivatives
WO1993004047A1 (en) 1991-08-16 1993-03-04 Merck & Co., Inc. Quinazoline derivatives as inhibitors of hiv reverse transcriptase
CA2246229C (en) 1996-02-14 2011-08-23 Isis Pharmaceuticals Inc. Sugar-modified gapped oligonucleotides
WO2001062740A1 (en) 2000-02-25 2001-08-30 South Alabama Medical Science Foundation Mibefradil analogues and their use
US7112319B2 (en) 2001-04-06 2006-09-26 The Research Foundation Of The City University Of New York Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using microelectrodes with microvoltammetry
JP4491240B2 (ja) 2002-01-17 2010-06-30 ザ ユニバーシティ オブ ブリティッシュ コロンビア Ｉｇｆｂｐ−２およびｉｇｆｂｐ−５を阻害する二重特異性アンチセンスオリゴヌクレオチド、並びにこれらの使用方法
US7347101B2 (en) 2002-07-01 2008-03-25 University Of Manitoba Measuring strain in a structure using a sensor having an electromagnetic resonator
US20060003985A1 (en) 2002-10-17 2006-01-05 Renger John J Enhancement of sleep with t-type calcium channel antagonists
CN1791399A (zh) 2003-03-21 2006-06-21 戴诺根医药品公司 用α2δ亚基钙通道调节剂和平滑肌调节剂一起治疗下泌尿道病症的方法
WO2005007124A2 (en) 2003-07-23 2005-01-27 Bristol-Myers Squibb Company Substituted dihydropyrimidine inhibitors of calcium channel function
US7166603B2 (en) 2003-07-23 2007-01-23 Bristol-Myers Squibb Co. Dihydropyrimidone inhibitors of calcium channel function
KR100610731B1 (ko) 2004-02-24 2006-08-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
US7504431B2 (en) 2004-04-16 2009-03-17 Bristol-Myers Squibb Company Sulfonyl amide inhibitors of calcium channel function
CA2576186A1 (en) 2004-08-20 2006-03-02 University Of Virginia Patent Foundation T type calcium channel blockers and the treatment of diseases
JP4927735B2 (ja) 2004-08-20 2012-05-09 ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン Ｔ型カルシウムチャネル阻害剤
BRPI0608343A2 (pt) 2005-03-09 2016-10-04 Merck & Co Inc composto, composição farmacêutica, e, métodos para tratamento ou controle de uma doença ou condição, para intensificação da qualidade do sono, para aumento de sono rem e do sono de onda lenta, para diminuição da fragmentação de padrões do sono, para intensificação de cognição, para aumento da retenção de memória, e, para tratamento, controle, melhora ou redução do risco de esquizofrenia em um paciente mamífero em necessidade destes
EP1896414A4 (en) 2005-06-23 2009-09-09 Merck & Co Inc ANTAGONISTS OF T-FLUORO-PIPERIDINE T-CALCIUM CANAL
CN101212974A (zh) 2005-06-29 2008-07-02 默克公司 4-氟-哌啶t-型钙通道拮抗剂
EP1906215A4 (en) 2005-07-14 2012-04-18 Teijin Chemicals Ltd FOAM SHEET AND LIQUID CRYSTAL DISPLAY
KR100654328B1 (ko) 2005-08-26 2006-12-08 한국과학기술연구원 피페라지닐알킬피라졸계 ｔ-타입 칼슘 채널 억제 화합물 및이의 제조방법
AU2006327173A1 (en) 2005-12-22 2007-06-28 Icagen, Inc. Calcium channel antagonists
CA2648569C (en) * 2006-04-12 2012-02-07 Merck & Co., Inc. Pyridyl amide t-type calcium channel antagonists
KR100743255B1 (ko) 2006-05-04 2007-07-27 한국과학기술연구원 Ｔ-형 칼슘 채널에 활성을 지닌 신규1,3-다이옥소아이소인돌 유도체
KR100749843B1 (ko) 2006-07-13 2007-08-21 한국과학기술연구원 Ｔ-타입 칼슘 채널에 억제 활성을 지닌 신규2,4-디옥소-퀴나졸린 유도체 및 이의 제조방법
KR100969686B1 (ko) 2006-08-07 2010-07-14 한국과학기술연구원 신규한 티아졸계 화합물 및 이를 함유하는 ｔ-형 칼슘 채널저해제
MX2009002920A (es) 2006-09-15 2009-04-01 Schering Corp Tratamiento del dolor, diabetes y trastornos del metabolismo de los lipidos.
WO2008033447A1 (en) 2006-09-15 2008-03-20 Schering Corporation Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism
CN101541795A (zh) 2006-09-15 2009-09-23 先灵公司 用于治疗疼痛、糖尿病和脂类代谢紊乱的螺-稠合氮杂环丁烷衍生物
WO2008033465A1 (en) 2006-09-15 2008-03-20 Schering Corporation Azetidinone derivatives and methods of use thereof
US7884080B2 (en) 2006-09-15 2011-02-08 Schering Plough Corporation Azetidinone derivatives and methods of use thereof
WO2008050200A1 (en) 2006-10-24 2008-05-02 Pfizer Products Inc. Oxadiazole compounds as calcium channel antagonists
WO2008112715A2 (en) 2007-03-12 2008-09-18 Vm Discovery Inc. Novel agents of calcium ion channel modulators
US20080227823A1 (en) 2007-03-12 2008-09-18 Hassan Pajouhesh Amide derivatives as calcium channel blockers
WO2008117148A1 (en) 2007-03-23 2008-10-02 Pfizer Products Inc. Substituted oxadiazole analogs as calcium channel antagonists
WO2008138126A1 (en) 2007-05-09 2008-11-20 Neuromed Pharmaceuticals Ltd. Bicyclic pyrimidine derivatives as calcium channel blockers
KR100863239B1 (ko) 2007-05-23 2008-10-15 한국과학기술연구원 신규한 2-이미노-1,3-티아졸린계 화합물 및 이를 함유하는ｔ-형 칼슘 채널 저해제
CA2692783A1 (en) 2007-07-10 2009-01-15 Merck Sharp & Dohme Corp. Quinazolinone t-type calcium channel antagonists
KR101079459B1 (ko) 2007-09-14 2011-11-03 이화여자대학교 산학협력단 신규한 화합물, 이의 제조방법 및 이를 포함하는 통증억제용 조성물
JP2011500808A (ja) 2007-10-24 2011-01-06 メルク・シャープ・エンド・ドーム・コーポレイション 複素環アミドｔ型カルシウムチャネルアンタゴニスト
RU2010120671A (ru) 2007-10-24 2011-11-27 Мерк Шарп Энд Домэ Корп. (Us) Гетероциклические фениламидные антагонисты кальциевых каналов т-типа
CA2703471A1 (en) 2007-10-24 2009-04-30 Merck Sharp & Dohme Corp. Pyrazinyl amide t-type calcium channel antagonists
WO2009056934A1 (en) 2007-10-31 2009-05-07 Pfizer Products Inc. 1,4-dihydronaphthyridine derivatives
KR100917037B1 (ko) 2007-11-01 2009-09-10 한국과학기술연구원 피라졸릴카르복스아미도알킬피페라진 유도체 및 이의제조방법
CA2722706A1 (en) 2008-04-28 2009-11-05 Zalicus Pharmaceuticals Ltd. Di-t-butylphenyl piperazines as calcium channel blockers
EP2285374B1 (en) 2008-04-29 2019-09-18 Pharnext Combination compositions for treating alzheimer disease and related disorders with zonisamide and acamprosate
US20090298834A1 (en) 2008-06-02 2009-12-03 Hassan Pajouhesh 4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
KR101014887B1 (ko) 2008-06-26 2011-02-15 한국과학기술연구원 칼슘이온 채널 조절제로서 유효한 이미다졸릴알킬카르보닐유도체 및 그의 제조방법
KR20100005476A (ko) 2008-07-07 2010-01-15 한국과학기술연구원 Ｔ-형 칼슘 채널에 활성을 지닌 신규 아이소인돌리논유도체 및 이의 제조방법
US20100137403A1 (en) 2008-07-10 2010-06-03 Scott Malstrom Method for enhancing cognition or inhibiting cognitive decline
KR101052620B1 (ko) 2008-08-28 2011-07-29 한국과학기술연구원 신규 페닐아세테이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 ｔ-형 칼슘 이온 채널의 활성에 의해 유발되는 질환의 예방 또는 치료용 조성물
KR101052065B1 (ko) 2008-10-15 2011-07-27 한국과학기술연구원 칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체와 이의 제조방법
TW201028421A (en) 2009-01-15 2010-08-01 Abbott Lab Novel benzenesulfonamides as calcium channel blockers
KR20120030112A (ko) 2009-06-05 2012-03-27 타우 쎄라퓨틱스 엘엘씨 암 또는 전암성 질환을 치료하기 위한 인터레이스 방법
EP2476308A2 (en) 2009-08-12 2012-07-18 Carlos Alberto Barcelo Rojas Bioelectronic system
WO2011093393A1 (ja) 2010-01-29 2011-08-04 国立大学法人岡山大学 Dravet症候群の発症可能性の判定方法およびその利用
US8575361B2 (en) 2010-03-02 2013-11-05 Concert Pharmaceuticals Inc. Tetrahydronaphthalene derivatives
US20140004186A1 (en) 2010-09-08 2014-01-02 Pronova Biopharma Norge As Compositions comprising a fatty acid oil mixture comprising epa and dha in free acid form, a surfactant, and a statin
WO2012094612A1 (en) 2011-01-07 2012-07-12 Zenyaku Kogyo Kabushikikaisha Method of treating essential tremor
BR112014028041A2 (pt) 2012-05-08 2017-06-27 Zafgen Inc tratamento de obesidade hipotalâmica com inibidores de metap2
HK1216548A1 (zh) 2013-01-10 2016-11-18 Tau Therapeutics Llc 用於治療癌症的t-型鈣通道抑制劑
US10292989B2 (en) 2014-03-28 2019-05-21 University Of Virginia Patent Foundation General anesthetics that are not neurotoxic
CN107920987A (zh) 2015-05-26 2018-04-17 艾萨·欧蒂迪 控制延缓释放普瑞巴林
KR101679262B1 (ko) 2015-06-08 2016-11-24 한국과학기술연구원 4-이소프로필크로만-3-올 화합물
GB2539472A (en) 2015-06-17 2016-12-21 Gw Res Ltd Use of cannabinoids in the treatment of epilepsy
US9351968B1 (en) 2015-09-09 2016-05-31 Ovid Therapeutics Inc Methods of treating developmental disorders using pipradrol
US9634019B1 (en) * 2015-10-01 2017-04-25 Silicon Storage Technology, Inc. Non-volatile split gate memory cells with integrated high K metal gate, and method of making same
ES2936400T3 (es) 2015-10-22 2023-03-16 Cavion Inc Métodos para tratar el síndrome Angelman
JP6902033B2 (ja) 2015-12-30 2021-07-14 アダマス ファーマシューティカルズ， インコーポレイテッド 発作−関連障害の処置のための方法および組成物
SG10202111885PA (en) 2017-04-26 2021-12-30 Cavion Inc Methods for improving memory and cognition and for treating memory and cognitive disorders
IL270137B2 (en) 2017-04-26 2024-04-01 Cavion Inc A T-type calcium channel antagonist for the treatment of Derbet's syndrome
GB2571978A (en) 2018-03-15 2019-09-18 Andre Fisahn Uses, compositions and methods
AU2019355021B2 (en) 2018-10-03 2024-09-12 Cavion, Inc. Treating essential tremor using (R)-2-(4-Isopropylphenyl)-N-(1-(5-(2,2,2-Trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
CN114340670A (zh) * 2019-07-11 2022-04-12 普拉克西斯精密药物股份有限公司 T-型钙通道调节剂的制剂及其使用方法
TWI870475B (zh) 2019-10-02 2025-01-21 美商卡凡恩公司 用於治療神經毒性之方法及材料

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100151022A9 (en) * 2002-10-25 2010-06-17 Vincent Lenaerts Controlled-release compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SPIRIDON PAPAPETROPOULOS ET AL,, A PHASE 2 EFFICACY STUDY OF AN ORAL, POTENT AND SELECTIVE T-TYPE CALCIUM (CAV3) MODULATOR INESSENTIAL TREMOR PATIENTS (T-CALM): DESIGN AND DOSE SELECTION RATIONALE (P6.060), 9 April 2018 (2018-04-09) *

Also Published As

Publication number Publication date
JP2022504182A (ja) 2022-01-13
AU2019355021A1 (en) 2021-05-06
IL282006A (en) 2021-05-31
WO2020072773A1 (en) 2020-04-09
JP7480131B2 (ja) 2024-05-09
WO2020072773A9 (en) 2020-07-16
AU2024278171A1 (en) 2025-01-02
IL300798B2 (en) 2025-09-01
AU2019355021B2 (en) 2024-09-12
TWI879741B (zh) 2025-04-11
US20250312323A1 (en) 2025-10-09
EP3860571A1 (en) 2021-08-11
MX2021003706A (es) 2021-11-04
JP2024102139A (ja) 2024-07-30
IL282006B1 (en) 2023-04-01
IL300798A (en) 2023-04-01
KR20210087459A (ko) 2021-07-12
TW202027728A (zh) 2020-08-01
US11311522B1 (en) 2022-04-26
US12383539B2 (en) 2025-08-12
CN113164393A (zh) 2021-07-23
US20220016095A1 (en) 2022-01-20
CA3115235A1 (en) 2020-04-09
IL300798B1 (en) 2025-05-01
EP3860571A4 (en) 2022-06-29
MX2025002145A (es) 2025-04-02
BR112021006398A2 (pt) 2021-07-06

Similar Documents

Publication Publication Date Title
US11311522B1 (en) Treating essential tremor using (R)-2-(4-Isopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
Onrust et al. Perospirone
US20230165847A1 (en) Methods of use of t-type calcium channel modulators
US12503485B2 (en) Human aminosterol ENT-03 compounds, related compositions comprising the same, and methods of using the same
EP2958573B1 (en) Pharmaceutical formulations of nitrite and uses thereof
US20240277732A1 (en) Compositions and methods for treating brain-gut disorders
US20190298740A1 (en) Methods and compositions for treating hallucinations and conditions related to the same
Ermer et al. An open-label investigation of the pharmacokinetic profiles of lisdexamfetamine dimesylate and venlafaxine extended-release, administered alone and in combination, in healthy adults
US20200129528A1 (en) Methods for treating blood pressure conditions using aminosterol compositions
US20250295646A1 (en) Methods of use of t-type calcium channel modulators
US20200038420A1 (en) Aminosterol compositions and methods of using the same for treating depression
RU2780318C1 (ru) Лечение эссенциального тремора с помощью (r)-2-(4-изопропилфенил)-n-(1-(5-(2,2,2-трифторэтокси)пиридин-2-ил)этил)ацетамида
HK40057141A (en) Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
US20250387382A1 (en) Methods of treating essential tremor
WO2024182677A1 (en) Methods of treating essential tremor
WO2024145719A1 (en) Improved pharmacokinetics of tryptamine prodrugs
HK1157591A (en) Compositions and methods for extended therapy with aminopyridines