IL271964B2 - Macrocyclic compounds and their uses - Google Patents

Macrocyclic compounds and their uses

Info

Publication number
IL271964B2
IL271964B2 IL271964A IL27196420A IL271964B2 IL 271964 B2 IL271964 B2 IL 271964B2 IL 271964 A IL271964 A IL 271964A IL 27196420 A IL27196420 A IL 27196420A IL 271964 B2 IL271964 B2 IL 271964B2
Authority
IL
Israel
Prior art keywords
alkyl
compound
pharmaceutically acceptable
acceptable salt
cancer
Prior art date
Application number
IL271964A
Other languages
English (en)
Hebrew (he)
Other versions
IL271964B1 (en
IL271964A (en
Original Assignee
Turning Point Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65039935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL271964(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Turning Point Therapeutics Inc filed Critical Turning Point Therapeutics Inc
Publication of IL271964A publication Critical patent/IL271964A/en
Publication of IL271964B1 publication Critical patent/IL271964B1/en
Publication of IL271964B2 publication Critical patent/IL271964B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL271964A 2017-07-28 2018-07-26 Macrocyclic compounds and their uses IL271964B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762538193P 2017-07-28 2017-07-28
US201862700990P 2018-07-20 2018-07-20
PCT/US2018/043817 WO2019023417A1 (en) 2017-07-28 2018-07-26 MACROCYCLIC COMPOUNDS AND USES THEREOF

Publications (3)

Publication Number Publication Date
IL271964A IL271964A (en) 2020-02-27
IL271964B1 IL271964B1 (en) 2024-08-01
IL271964B2 true IL271964B2 (en) 2024-12-01

Family

ID=65039935

Family Applications (1)

Application Number Title Priority Date Filing Date
IL271964A IL271964B2 (en) 2017-07-28 2018-07-26 Macrocyclic compounds and their uses

Country Status (29)

Country Link
US (4) US11286264B2 (OSRAM)
EP (1) EP3658148B1 (OSRAM)
JP (2) JP7224334B2 (OSRAM)
KR (1) KR102645316B1 (OSRAM)
CN (1) CN111182903A (OSRAM)
AU (1) AU2018306328B2 (OSRAM)
BR (1) BR112020001695A2 (OSRAM)
CA (1) CA3069232A1 (OSRAM)
CL (1) CL2020000169A1 (OSRAM)
CO (1) CO2020000633A2 (OSRAM)
DK (1) DK3658148T3 (OSRAM)
ES (1) ES2986593T3 (OSRAM)
FI (1) FI3658148T3 (OSRAM)
HR (1) HRP20241197T1 (OSRAM)
IL (1) IL271964B2 (OSRAM)
LT (1) LT3658148T (OSRAM)
MY (1) MY201925A (OSRAM)
PE (1) PE20200700A1 (OSRAM)
PH (1) PH12020500033A1 (OSRAM)
PL (1) PL3658148T3 (OSRAM)
PT (1) PT3658148T (OSRAM)
RS (1) RS65884B1 (OSRAM)
SA (1) SA520411108B1 (OSRAM)
SG (1) SG11202000356VA (OSRAM)
SI (1) SI3658148T1 (OSRAM)
SM (1) SMT202400343T1 (OSRAM)
TW (1) TWI818917B (OSRAM)
UA (1) UA126158C2 (OSRAM)
WO (1) WO2019023417A1 (OSRAM)

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BR112019001607A2 (pt) 2016-07-28 2019-04-30 Tp Therapeutics, Inc. inibidores macrocíclicos de quinases
TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
ES2986593T3 (es) * 2017-07-28 2024-11-12 Turning Point Therapeutics Inc Compuestos macrocíclicos y usos de los mismos
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WO2020233645A1 (zh) 2019-05-21 2020-11-26 浙江海正药业股份有限公司 大环类衍生物、及其制备方法和用途
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CN116635076A (zh) * 2020-12-17 2023-08-22 荣山医药股份有限公司 大环化合物及其用途
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US20240132517A1 (en) * 2021-02-10 2024-04-25 Goharmony Therapeutics (Shenzhen) Co., Ltd. Macrocyclic compound, pharmaceutical composition, and use thereof
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CN116063326B (zh) * 2021-11-02 2025-08-05 赛诺哈勃药业（成都）有限公司 作为蛋白激酶调节剂的含氨基大环化合物
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US12168640B2 (en) 2021-11-16 2024-12-17 ProDeg, LLC USP9X inhibitors
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Also Published As

Publication number Publication date
JP7554300B2 (ja) 2024-09-19
MY201925A (en) 2024-03-23
SI3658148T1 (sl) 2024-10-30
PH12020500033A1 (en) 2020-09-28
JP2020528907A (ja) 2020-10-01
JP2023065403A (ja) 2023-05-12
US20200157119A1 (en) 2020-05-21
UA126158C2 (uk) 2022-08-25
PE20200700A1 (es) 2020-06-23
AU2018306328B2 (en) 2023-03-09
CL2020000169A1 (es) 2020-08-14
FI3658148T3 (fi) 2024-09-20
KR20200034998A (ko) 2020-04-01
EP3658148B1 (en) 2024-07-10
BR112020001695A2 (pt) 2020-07-21
KR102645316B1 (ko) 2024-03-07
AU2018306328A1 (en) 2020-01-16
LT3658148T (lt) 2024-09-10
RS65884B1 (sr) 2024-09-30
JP7224334B2 (ja) 2023-02-17
WO2019023417A1 (en) 2019-01-31
CN111182903A (zh) 2020-05-19
DK3658148T3 (da) 2024-10-07
IL271964B1 (en) 2024-08-01
US20240391935A1 (en) 2024-11-28
TW201920198A (zh) 2019-06-01
US11981684B2 (en) 2024-05-14
CA3069232A1 (en) 2019-01-31
PL3658148T3 (pl) 2024-10-07
US20210214373A1 (en) 2021-07-15
US11155563B2 (en) 2021-10-26
EP3658148A1 (en) 2020-06-03
ES2986593T3 (es) 2024-11-12
IL271964A (en) 2020-02-27
US11286264B2 (en) 2022-03-29
PT3658148T (pt) 2024-08-26
HRP20241197T1 (hr) 2024-11-22
SG11202000356VA (en) 2020-02-27
SA520411108B1 (ar) 2024-03-03
SMT202400343T1 (it) 2024-11-15
CO2020000633A2 (es) 2020-01-31
TWI818917B (zh) 2023-10-21
US20220324879A1 (en) 2022-10-13
EP3658148A4 (en) 2021-04-28

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