IL268125B2 - Pridopidine for the treatment of fragile x syndrome - Google Patents

Pridopidine for the treatment of fragile x syndrome

Info

Publication number
IL268125B2
IL268125B2 IL268125A IL26812519A IL268125B2 IL 268125 B2 IL268125 B2 IL 268125B2 IL 268125 A IL268125 A IL 268125A IL 26812519 A IL26812519 A IL 26812519A IL 268125 B2 IL268125 B2 IL 268125B2
Authority
IL
Israel
Prior art keywords
pridopidine
pharmaceutical composition
fxs
subject
amount
Prior art date
Application number
IL268125A
Other languages
English (en)
Hebrew (he)
Other versions
IL268125A (en
IL268125B (en
Inventor
Michael Hayden
Mahmoud Abdulhossein Pouladi
Original Assignee
Prilenia Neurotherapeutics Ltd
Nat Univ Singapore
Agency Science Tech & Res
Michael Hayden
Mahmoud Abdulhossein Pouladi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prilenia Neurotherapeutics Ltd, Nat Univ Singapore, Agency Science Tech & Res, Michael Hayden, Mahmoud Abdulhossein Pouladi filed Critical Prilenia Neurotherapeutics Ltd
Publication of IL268125A publication Critical patent/IL268125A/en
Publication of IL268125B publication Critical patent/IL268125B/en
Publication of IL268125B2 publication Critical patent/IL268125B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL268125A 2017-01-20 2018-01-18 Pridopidine for the treatment of fragile x syndrome IL268125B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762448595P 2017-01-20 2017-01-20
PCT/US2018/014169 WO2018136600A1 (en) 2017-01-20 2018-01-18 Use of pridopidine for the treatment of fragile x syndrome

Publications (3)

Publication Number Publication Date
IL268125A IL268125A (en) 2019-09-26
IL268125B IL268125B (en) 2022-12-01
IL268125B2 true IL268125B2 (en) 2023-04-01

Family

ID=62908348

Family Applications (1)

Application Number Title Priority Date Filing Date
IL268125A IL268125B2 (en) 2017-01-20 2018-01-18 Pridopidine for the treatment of fragile x syndrome

Country Status (13)

Country Link
US (2) US11234973B2 (https=)
EP (1) EP3570940B1 (https=)
JP (1) JP7114604B2 (https=)
CN (1) CN110505902B (https=)
AU (1) AU2018210145B2 (https=)
BR (1) BR112019015000A2 (https=)
CA (1) CA3050700C (https=)
DK (1) DK3570940T3 (https=)
ES (1) ES2972205T3 (https=)
HU (1) HUE068300T2 (https=)
IL (1) IL268125B2 (https=)
PL (1) PL3570940T3 (https=)
WO (1) WO2018136600A1 (https=)

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SG188298A1 (en) 2010-09-03 2013-04-30 Ivax Int Gmbh Deuterated analogs of pridopidine useful as dopaminergic stabilizers
US11090297B2 (en) 2013-06-21 2021-08-17 Prilenia Neurotherapeutics Ltd. Pridopidine for treating huntington's disease
WO2018039475A1 (en) 2016-08-24 2018-03-01 Teva Pharmaceuticals International Gmbh Use of pridopidine for treating dystonias
ES3025836T3 (en) 2016-08-24 2025-06-09 Prilenia Neurotherapeutics Ltd Use of pridopidine for treating functional decline
US12102627B2 (en) 2016-09-16 2024-10-01 Prilenia Neurotherapeutics Ltd. Use of pridopidine for treating rett syndrome
US12036213B2 (en) 2017-09-08 2024-07-16 Prilenia Neurotherapeutics Ltd. Pridopidine for treating drug induced dyskinesias
AU2018329628B2 (en) 2017-09-08 2021-04-22 Prilenia Neurotherapeutics Ltd. Pridopidine for treating drug induced dyskinesias
EP3920924A4 (en) 2019-02-04 2022-11-16 Prilenia Neurotherapeutics Ltd. LOW-DOSE PRIDOIDIN FOR THE TREATMENT OF PARKINSON'S DISEASE AND OTHER PARKINSONIC-RELATED DISEASES
KR102528677B1 (ko) * 2020-01-08 2023-05-04 주식회사 뉴로벤티 리수리드 화합물을 유효성분으로 포함하는 취약 x 증후군 또는 관련 발달 장애 치료용 조성물
CN116472043A (zh) * 2020-10-20 2023-07-21 普瑞尼亚神经治疗有限公司 普利多匹定和类似物用于治疗焦虑和抑郁的用途

Citations (2)

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WO2001046145A1 (en) * 1999-12-22 2001-06-28 A. Carlsson Research Ab New modulators of dopamine neurotransmission
WO2016138130A1 (en) * 2015-02-25 2016-09-01 Teva Pharmaceuticals International Gmbh Use of pridopidine to improve cognitive function and for treating alzheimer's disease

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SE0401465D0 (sv) 2004-06-08 2004-06-08 Carlsson A Research Ab New substituted piperdines as modulators of dopamine neurotransmission
CN101068782A (zh) 2004-10-13 2007-11-07 神经研究瑞典公司 合成4－(3－磺酰基苯基)－哌啶类的方法
CA2584831C (en) 2004-10-13 2013-09-17 Neurosearch Sweden Ab Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
EP1961742A1 (en) 2007-02-22 2008-08-27 Novartis AG compounds of formula (I) as serine protease inhibitors
SI2146961T1 (sl) 2007-04-12 2014-08-29 IVAX International GmbH N-oksidni in/ali di-N-oksidni derivati stabilizatorjev/modulatorjev dopaminskega receptorja, ki izkazujejo izboljšane profile kardiovaskularnih stranskih učinkov
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MX347209B (es) 2011-12-08 2017-04-19 Teva Pharmaceuticals Int Gmbh La sal de bromhidrato de pridopidina.
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EP2900226A4 (en) * 2012-09-27 2016-03-30 Teva Pharma COMBINATION OF RASAGILIN AND PRIDOPIDIN FOR TREATING NEURODEGENERATIVE DISORDERS, ESPECIALLY HUNTINGTON'S DISEASE
PE20160195A1 (es) 2013-06-21 2016-05-14 Teva Pharmaceuticals Int Gmbh Uso de pridopidina en dosis altas para el tratamiento de enfermedad de huntington
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TW201613859A (en) 2014-06-30 2016-04-16 Teva Pharma Analogs of PRIDOPIDINE, their preparation and use
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CA2993183A1 (en) 2015-07-22 2017-01-26 Teva Pharmaceuticals International Gmbh Pridopidine base formulations and their use
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AU2017326436A1 (en) 2016-09-15 2019-04-11 Prilenia Neurotherapeutics Ltd Use of pridopidine for the treatment of anxiety and depression
JP7436524B2 (ja) 2019-06-12 2024-02-21 プリレニア ニューロセラピューティクス リミテッド ハンチントン病及びその症状を治療するためのプリドピジン及びその類似体を含む組成物

Patent Citations (2)

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WO2001046145A1 (en) * 1999-12-22 2001-06-28 A. Carlsson Research Ab New modulators of dopamine neurotransmission
WO2016138130A1 (en) * 2015-02-25 2016-09-01 Teva Pharmaceuticals International Gmbh Use of pridopidine to improve cognitive function and for treating alzheimer's disease

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Also Published As

Publication number Publication date
US11234973B2 (en) 2022-02-01
US20220202798A1 (en) 2022-06-30
CA3050700C (en) 2023-10-03
AU2018210145A1 (en) 2019-08-29
CN110505902A (zh) 2019-11-26
DK3570940T3 (da) 2024-02-19
IL268125A (en) 2019-09-26
HUE068300T2 (hu) 2024-12-28
AU2018210145B2 (en) 2023-06-29
EP3570940A4 (en) 2020-10-28
BR112019015000A2 (pt) 2020-04-07
JP7114604B2 (ja) 2022-08-08
CN110505902B (zh) 2022-11-11
US12551474B2 (en) 2026-02-17
CA3050700A1 (en) 2018-07-26
IL268125B (en) 2022-12-01
ES2972205T3 (es) 2024-06-11
WO2018136600A1 (en) 2018-07-26
JP2020514313A (ja) 2020-05-21
PL3570940T3 (pl) 2024-06-17
US20190336488A1 (en) 2019-11-07
EP3570940A1 (en) 2019-11-27
EP3570940B1 (en) 2023-12-13

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