IL258456B - A combination of a selective 2-il beta receptor agonist and a long-acting 15-il agonist - Google Patents
A combination of a selective 2-il beta receptor agonist and a long-acting 15-il agonistInfo
- Publication number
- IL258456B IL258456B IL258456A IL25845618A IL258456B IL 258456 B IL258456 B IL 258456B IL 258456 A IL258456 A IL 258456A IL 25845618 A IL25845618 A IL 25845618A IL 258456 B IL258456 B IL 258456B
- Authority
- IL
- Israel
- Prior art keywords
- agonist
- beta
- acting
- combination
- long
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 2
- 102000008193 Interleukin-2 Receptor beta Subunit Human genes 0.000 title 1
- 108010060632 Interleukin-2 Receptor beta Subunit Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239207P | 2015-10-08 | 2015-10-08 | |
| PCT/US2016/056088 WO2017062832A1 (en) | 2015-10-08 | 2016-10-07 | Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL258456A IL258456A (en) | 2018-06-28 |
| IL258456B true IL258456B (en) | 2021-07-29 |
Family
ID=57249859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL258456A IL258456B (en) | 2015-10-08 | 2018-03-29 | A combination of a selective 2-il beta receptor agonist and a long-acting 15-il agonist |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12233104B2 (https=) |
| EP (1) | EP3359182B1 (https=) |
| JP (3) | JP7407511B2 (https=) |
| KR (1) | KR102861230B1 (https=) |
| CN (1) | CN108135978A (https=) |
| AU (1) | AU2016335860B2 (https=) |
| IL (1) | IL258456B (https=) |
| MA (1) | MA47290A (https=) |
| MX (1) | MX2018004296A (https=) |
| WO (1) | WO2017062832A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL270634B2 (en) * | 2017-05-15 | 2025-06-01 | Nektar Therapeutics | Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods |
| US11248025B2 (en) | 2019-06-03 | 2022-02-15 | Medikine, Inc. | IL-2alpha receptor subunit binding compounds |
| EP4463135A2 (en) | 2022-01-10 | 2024-11-20 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
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| US5078997A (en) | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
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| AU2009209565B2 (en) | 2008-02-01 | 2013-09-19 | Ascendis Pharma As | Prodrug comprising a self-cleavable linker |
| KR20090103209A (ko) | 2008-03-27 | 2009-10-01 | (주)한국비엠아이 | 사람 인터루킨-2 동종체 |
| WO2009135031A1 (en) * | 2008-04-30 | 2009-11-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Substituted il-15 |
| JP2011520447A (ja) | 2008-05-16 | 2011-07-21 | ネクター セラピューティックス | コリンエステラーゼ部分とポリマーとのコンジュゲート |
| WO2010014258A2 (en) | 2008-08-01 | 2010-02-04 | Nektar Therapeutics Al, Corporation | Conjugates having a releasable linkage |
| WO2010033240A2 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
| PL2431741T3 (pl) | 2008-10-21 | 2014-01-31 | Baxalta Inc | Sposoby określania ilości aktywnych składników w prolekach, będących koniugatami PEG-białko, za pomocą reagentów uwalniających PEG (depegylacja in vitro) |
| TR201908836T4 (tr) | 2010-07-30 | 2019-07-22 | Baxalta GmbH | Oksim bağına yönelik nükleofilik katalizörler. |
| WO2012065086A1 (en) | 2010-11-12 | 2012-05-18 | Nektar Therapeutics | Conjugates of an il-2 moiety and a polymer |
| WO2013020079A2 (en) * | 2011-08-04 | 2013-02-07 | Nektar Therapeutics | Conjugates of an il-11 moiety and a polymer |
| US20150017120A1 (en) | 2013-06-13 | 2015-01-15 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-pk il-2 and adoptive cell therapy |
| KR102410090B1 (ko) | 2014-02-21 | 2022-06-16 | 넥타르 테라퓨틱스 (인디아) 프라이빗 리미티드 | 항-ｃｔｌａ－４ 항체 또는 항-ｐｄ－１ 항체와 조합한 ｉｌ－２ｒ베타-선택적 효현제 |
| MA39711A (fr) | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
-
2016
- 2016-10-07 WO PCT/US2016/056088 patent/WO2017062832A1/en not_active Ceased
- 2016-10-07 JP JP2018517898A patent/JP7407511B2/ja active Active
- 2016-10-07 EP EP16791713.7A patent/EP3359182B1/en active Active
- 2016-10-07 US US15/765,207 patent/US12233104B2/en active Active
- 2016-10-07 MA MA047290A patent/MA47290A/fr unknown
- 2016-10-07 AU AU2016335860A patent/AU2016335860B2/en active Active
- 2016-10-07 KR KR1020187011922A patent/KR102861230B1/ko active Active
- 2016-10-07 MX MX2018004296A patent/MX2018004296A/es unknown
- 2016-10-07 CN CN201680058497.XA patent/CN108135978A/zh active Pending
-
2018
- 2018-03-29 IL IL258456A patent/IL258456B/en unknown
-
2021
- 2021-02-04 JP JP2021016606A patent/JP2021066748A/ja not_active Withdrawn
-
2023
- 2023-05-24 JP JP2023085387A patent/JP2023099731A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MA47290A (fr) | 2019-11-27 |
| KR20180063184A (ko) | 2018-06-11 |
| AU2016335860A1 (en) | 2018-04-12 |
| WO2017062832A1 (en) | 2017-04-13 |
| IL258456A (en) | 2018-06-28 |
| US20180296645A1 (en) | 2018-10-18 |
| JP7407511B2 (ja) | 2024-01-04 |
| HK1253347A1 (en) | 2019-06-14 |
| CA3000211A1 (en) | 2017-04-13 |
| MX2018004296A (es) | 2018-08-01 |
| JP2018530568A (ja) | 2018-10-18 |
| EP3359182B1 (en) | 2023-04-19 |
| CN108135978A (zh) | 2018-06-08 |
| US12233104B2 (en) | 2025-02-25 |
| AU2016335860B2 (en) | 2023-08-10 |
| JP2023099731A (ja) | 2023-07-13 |
| JP2021066748A (ja) | 2021-04-30 |
| KR102861230B1 (ko) | 2025-09-17 |
| EP3359182A1 (en) | 2018-08-15 |
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