JP7407511B2 - ＩＬ－２Ｒβ選択的作動薬と長時間作用型ＩＬ－１５作動薬との併用 - Google Patents

ＩＬ－２Ｒβ選択的作動薬と長時間作用型ＩＬ－１５作動薬との併用 Download PDF

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JP7407511B2
JP7407511B2 JP2018517898A JP2018517898A JP7407511B2 JP 7407511 B2 JP7407511 B2 JP 7407511B2 JP 2018517898 A JP2018517898 A JP 2018517898A JP 2018517898 A JP2018517898 A JP 2018517898A JP 7407511 B2 JP7407511 B2 JP 7407511B2
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デボラ エイチ． チャリッチ，
ピーター カーク，
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ネクター セラピューティクス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2018517898A 2015-10-08 2016-10-07 ＩＬ－２Ｒβ選択的作動薬と長時間作用型ＩＬ－１５作動薬との併用 Active JP7407511B2 (ja)

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US201562239207P 2015-10-08 2015-10-08
US62/239,207 2015-10-08
PCT/US2016/056088 WO2017062832A1 (en) 2015-10-08 2016-10-07 Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist

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JP2021016606A Withdrawn JP2021066748A (ja) 2015-10-08 2021-02-04 ＩＬ−２Ｒβ選択的作動薬と長時間作用型ＩＬ−１５作動薬との併用
JP2023085387A Withdrawn JP2023099731A (ja) 2015-10-08 2023-05-24 ＩＬ－２Ｒβ選択的作動薬と長時間作用型ＩＬ－１５作動薬との併用

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JP2023085387A Withdrawn JP2023099731A (ja) 2015-10-08 2023-05-24 ＩＬ－２Ｒβ選択的作動薬と長時間作用型ＩＬ－１５作動薬との併用

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US (1) US12233104B2 (https=)
EP (1) EP3359182B1 (https=)
JP (3) JP7407511B2 (https=)
KR (1) KR102861230B1 (https=)
CN (1) CN108135978A (https=)
AU (1) AU2016335860B2 (https=)
IL (1) IL258456B (https=)
MA (1) MA47290A (https=)
MX (1) MX2018004296A (https=)
WO (1) WO2017062832A1 (https=)

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US12036283B2 (en) * 2017-05-15 2024-07-16 Nektar Therapeutics Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods
WO2020247388A2 (en) 2019-06-03 2020-12-10 Medikine, Inc. Il-2alpha receptor subunit binding compounds
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
US20250222027A1 (en) 2022-04-01 2025-07-10 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies

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Ｓｈｉｂａｔａ Ｈ ｅｔ ａｌ．，Ｏｐｔｉｍｉｚａｔｉｏｎ ｏｆ ｐｒｏｔｅｉｎ ｔｈｅｒａｐｉｅｓ ｂｙ ｐｏｌｙｍｅｒ－ｃｏｎｊｕｇａｔｉｏｎ ａｓ ａｎ ｅｆｆｅｃｔｉｖｅ ＤＤＳ，Ｍｏｌｅｃｕｌｅｓ，２００５年，Ｖｏｌ．１０， Ｎｏ．１，ｐ．１６２－１８０，ｄｏｉ：１０．３３９０／１００１０１６２
Ｗｅｉ Ｃ ｅｔ ａｌ．，Ｔｈｅ ＣＩＫ ｃｅｌｌｓ ｓｔｉｍｕｌａｔｅｄ ｗｉｔｈ ｃｏｍｂｉｎａｔｉｏｎ ｏｆ ＩＬ－２ ａｎｄ ＩＬ－１５ ｐｒｏｖｉｄｅ ａｎ ｉｍｐｒｏｖｅｄ ｃｙｔｏｔｏｘｉｃ ｃａｐａｃｉｔｙ ａｇａｉｎｓｔ ｈｕｍａｎ ｌｕｎｇ ａｄｅｎｏｃａｒｃｉｎｏｍａ，Ｔｕｍｏｒ Ｂｉｏｌｏｇｙ，２０１４年，Ｖｏｌ．３５， Ｎｏ．３，ｐ．１９９７－２００７，ｄｏｉ：１０．１００７／ｓ１３２７７－０１３－１２６５－２２．

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WO2017062832A1 (en) 2017-04-13
US20180296645A1 (en) 2018-10-18
KR102861230B1 (ko) 2025-09-17
IL258456A (en) 2018-06-28
AU2016335860A1 (en) 2018-04-12
EP3359182B1 (en) 2023-04-19
JP2018530568A (ja) 2018-10-18
CN108135978A (zh) 2018-06-08
HK1253347A1 (en) 2019-06-14
MA47290A (fr) 2019-11-27
JP2021066748A (ja) 2021-04-30
MX2018004296A (es) 2018-08-01
US12233104B2 (en) 2025-02-25
CA3000211A1 (en) 2017-04-13
IL258456B (en) 2021-07-29
EP3359182A1 (en) 2018-08-15
AU2016335860B2 (en) 2023-08-10
KR20180063184A (ko) 2018-06-11
JP2023099731A (ja) 2023-07-13

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