IL245009B - A bracelet consisting of drug, protein and polymer - Google Patents
A bracelet consisting of drug, protein and polymerInfo
- Publication number
- IL245009B IL245009B IL245009A IL24500916A IL245009B IL 245009 B IL245009 B IL 245009B IL 245009 A IL245009 A IL 245009A IL 24500916 A IL24500916 A IL 24500916A IL 245009 B IL245009 B IL 245009B
- Authority
- IL
- Israel
- Prior art keywords
- kda
- integer
- drug
- polymer
- conjugate
- Prior art date
Links
- 239000000580 polymer-drug conjugate Substances 0.000 title description 114
- 239000003814 drug Substances 0.000 claims description 283
- 229940079593 drug Drugs 0.000 claims description 242
- 229920000642 polymer Polymers 0.000 claims description 220
- 230000008685 targeting Effects 0.000 claims description 54
- 239000003446 ligand Substances 0.000 claims description 45
- 206010028980 Neoplasm Diseases 0.000 claims description 44
- 229940124597 therapeutic agent Drugs 0.000 claims description 37
- 239000000427 antigen Substances 0.000 claims description 34
- 102000036639 antigens Human genes 0.000 claims description 32
- 239000012634 fragment Substances 0.000 claims description 32
- 108091007433 antigens Proteins 0.000 claims description 31
- 108010044540 auristatin Proteins 0.000 claims description 31
- XHXOHGJMQNOIIO-LMPBRMKVSA-N (2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-n-[(3r,4s,5s)-1-[(2s)-2-[(1r,2r)-3-[[(2s)-1-(3-hydroxypropylamino)-1-oxo-3-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-n,3-dimethylbu Chemical compound CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(=O)NCCCO)CC1=CC=CC=C1 XHXOHGJMQNOIIO-LMPBRMKVSA-N 0.000 claims description 30
- 229910052760 oxygen Inorganic materials 0.000 claims description 30
- 229940126585 therapeutic drug Drugs 0.000 claims description 29
- 230000000903 blocking effect Effects 0.000 claims description 28
- 239000000178 monomer Substances 0.000 claims description 27
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- 201000011510 cancer Diseases 0.000 claims description 18
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
- 229960005501 duocarmycin Drugs 0.000 claims description 18
- 229930184221 duocarmycin Natural products 0.000 claims description 18
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 17
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical compound C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical group OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 claims description 13
- 229930195731 calicheamicin Natural products 0.000 claims description 13
- LGNCNVVZCUVPOT-FUVGGWJZSA-N (2s)-2-[[(2r,3r)-3-[(2s)-1-[(3r,4s,5s)-4-[[(2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-methoxy-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 LGNCNVVZCUVPOT-FUVGGWJZSA-N 0.000 claims description 12
- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims description 12
- 108010093470 monomethyl auristatin E Proteins 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 12
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 claims description 11
- MFRNYXJJRJQHNW-DEMKXPNLSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[(2s)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-DEMKXPNLSA-N 0.000 claims description 10
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 claims description 10
- 108010059074 monomethylauristatin F Proteins 0.000 claims description 10
- 229910052717 sulfur Inorganic materials 0.000 claims description 10
- 238000002560 therapeutic procedure Methods 0.000 claims description 10
- 229940034982 antineoplastic agent Drugs 0.000 claims description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- 206010060862 Prostate cancer Diseases 0.000 claims description 8
- 230000000118 anti-neoplastic effect Effects 0.000 claims description 8
- 229930188854 dolastatin Natural products 0.000 claims description 8
- 125000004434 sulfur atom Chemical group 0.000 claims description 8
- 206010009944 Colon cancer Diseases 0.000 claims description 7
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 7
- AMRJKAQTDDKMCE-UHFFFAOYSA-N dolastatin Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 claims description 7
- 239000003937 drug carrier Substances 0.000 claims description 7
- 206010006187 Breast cancer Diseases 0.000 claims description 6
- 208000026310 Breast neoplasm Diseases 0.000 claims description 6
- 229960005532 CC-1065 Drugs 0.000 claims description 6
- 208000003445 Mouth Neoplasms Diseases 0.000 claims description 6
- 206010033128 Ovarian cancer Diseases 0.000 claims description 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 6
- 229950004955 adozelesin Drugs 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 206010017758 gastric cancer Diseases 0.000 claims description 6
- 210000004185 liver Anatomy 0.000 claims description 6
- 201000011549 stomach cancer Diseases 0.000 claims description 6
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 claims description 5
- FONKWHRXTPJODV-DNQXCXABSA-N 1,3-bis[2-[(8s)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3h-pyrrolo[3,2-e]indole-6-carbonyl]-1h-indol-5-yl]urea Chemical compound C1([C@H](CCl)CN2C(=O)C=3NC4=CC=C(C=C4C=3)NC(=O)NC=3C=C4C=C(NC4=CC=3)C(=O)N3C4=CC(O)=C5NC=C(C5=C4[C@H](CCl)C3)C)=C2C=C(O)C2=C1C(C)=CN2 FONKWHRXTPJODV-DNQXCXABSA-N 0.000 claims description 5
- 206010003571 Astrocytoma Diseases 0.000 claims description 5
- 206010005003 Bladder cancer Diseases 0.000 claims description 5
- AZVARJHZBXHUSO-UHFFFAOYSA-N Duocarmycin A Natural products COC1=C(OC)C(OC)=C2NC(C(=O)N3CC4CC44C5=C(C(C=C43)=O)NC(C5=O)(C)C(=O)OC)=CC2=C1 AZVARJHZBXHUSO-UHFFFAOYSA-N 0.000 claims description 5
- FIZSMXNFUBCGCU-UHFFFAOYSA-N Duocarmycin C1 Natural products COC(=O)C1(C)NC2=C(C3CC(Cl)CN(C(=O)c4cc5cc(OC)c(OC)c(OC)c5[nH]4)C3=CC2=O)C1=O FIZSMXNFUBCGCU-UHFFFAOYSA-N 0.000 claims description 5
- WKODMLPZIYVYIR-UHFFFAOYSA-N Duocarmycin C2 Natural products COC(=O)C1(C)NC2=C(C3C(CCl)CN(C(=O)c4cc5cc(OC)c(OC)c(OC)c5[nH]4)C3=CC2=O)C1=O WKODMLPZIYVYIR-UHFFFAOYSA-N 0.000 claims description 5
- VQNATVDKACXKTF-UHFFFAOYSA-N Duocarmycin SA Natural products COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C(C64CC6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-UHFFFAOYSA-N 0.000 claims description 5
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 206010025323 Lymphomas Diseases 0.000 claims description 5
- 206010027406 Mesothelioma Diseases 0.000 claims description 5
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- 206010038389 Renal cancer Diseases 0.000 claims description 5
- 206010039491 Sarcoma Diseases 0.000 claims description 5
- 206010043515 Throat cancer Diseases 0.000 claims description 5
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 5
- BYRVKDUQDLJUBX-JJCDCTGGSA-N adozelesin Chemical compound C1=CC=C2OC(C(=O)NC=3C=C4C=C(NC4=CC=3)C(=O)N3C[C@H]4C[C@]44C5=C(C(C=C43)=O)NC=C5C)=CC2=C1 BYRVKDUQDLJUBX-JJCDCTGGSA-N 0.000 claims description 5
- 229950006844 bizelesin Drugs 0.000 claims description 5
- BBZDXMBRAFTCAA-AREMUKBSSA-N carzelesin Chemical compound C1=2NC=C(C)C=2C([C@H](CCl)CN2C(=O)C=3NC4=CC=C(C=C4C=3)NC(=O)C3=CC4=CC=C(C=C4O3)N(CC)CC)=C2C=C1OC(=O)NC1=CC=CC=C1 BBZDXMBRAFTCAA-AREMUKBSSA-N 0.000 claims description 5
- 229950007509 carzelesin Drugs 0.000 claims description 5
- 208000029742 colonic neoplasm Diseases 0.000 claims description 5
- 229960005519 duocarmycin A Drugs 0.000 claims description 5
- 229960005513 duocarmycin B1 Drugs 0.000 claims description 5
- NIADGRRCOZRRQF-UHFFFAOYSA-N duocarmycin B1 Natural products COC(=O)C1(C)NC2=C(C3CC(Br)CN(C(=O)c4cc5cc(OC)c(OC)c(OC)c5[nH]4)C3=CC2=O)C1=O NIADGRRCOZRRQF-UHFFFAOYSA-N 0.000 claims description 5
- 229960005514 duocarmycin B2 Drugs 0.000 claims description 5
- UQPQXFUURNIVNJ-UHFFFAOYSA-N duocarmycin B2 Natural products COC1=C(OC)C(OC)=C2NC(C(=O)N3CC(CBr)C=4C5=C(C(=CC=43)O)NC(C5=O)(C)C(=O)OC)=CC2=C1 UQPQXFUURNIVNJ-UHFFFAOYSA-N 0.000 claims description 5
- 229960005512 duocarmycin C1 Drugs 0.000 claims description 5
- 229960005511 duocarmycin C2 Drugs 0.000 claims description 5
- 229960005518 duocarmycin D Drugs 0.000 claims description 5
- OXYZQOYSQSPFMI-UHFFFAOYSA-N duocarmycin D Natural products COC1=C(OC)C(OC)=C2NC(C(=O)N3C=C(CO)C=4C5=C(C(=CC=43)O)NC(C5=O)(C)C(=O)OC)=CC2=C1 OXYZQOYSQSPFMI-UHFFFAOYSA-N 0.000 claims description 5
- 229960005510 duocarmycin SA Drugs 0.000 claims description 5
- 201000010982 kidney cancer Diseases 0.000 claims description 5
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- 208000020816 lung neoplasm Diseases 0.000 claims description 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 5
- AZVARJHZBXHUSO-DZQVEHCYSA-N methyl (1R,4R,12S)-4-methyl-3,7-dioxo-10-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-5,10-diazatetracyclo[7.4.0.01,12.02,6]trideca-2(6),8-diene-4-carboxylate Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C[C@H]4C[C@]44C5=C(C(C=C43)=O)N[C@@](C5=O)(C)C(=O)OC)=CC2=C1 AZVARJHZBXHUSO-DZQVEHCYSA-N 0.000 claims description 5
- ILRQRCTVPANBBE-GWQKEKGPSA-N methyl (2R,8S)-8-chloro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,7,8,9-tetrahydropyrrolo[3,2-f]quinoline-2-carboxylate Chemical compound COC(=O)[C@]1(C)Nc2c(C1=O)c1C[C@H](Cl)CN(C(=O)c3cc4cc(OC)c(OC)c(OC)c4[nH]3)c1cc2O ILRQRCTVPANBBE-GWQKEKGPSA-N 0.000 claims description 5
- OXYZQOYSQSPFMI-AREMUKBSSA-N methyl (2r)-4-hydroxy-8-(hydroxymethyl)-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1h-indole-2-carbonyl)-3h-pyrrolo[3,2-e]indole-2-carboxylate Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C=C(CO)C=4C5=C(C(=CC=43)O)N[C@@](C5=O)(C)C(=O)OC)=CC2=C1 OXYZQOYSQSPFMI-AREMUKBSSA-N 0.000 claims description 5
- UQPQXFUURNIVNJ-MZHQLVBMSA-N methyl (2r,8s)-8-(bromomethyl)-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1h-indole-2-carbonyl)-7,8-dihydro-3h-pyrrolo[3,2-e]indole-2-carboxylate Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C[C@@H](CBr)C=4C5=C(C(=CC=43)O)N[C@@](C5=O)(C)C(=O)OC)=CC2=C1 UQPQXFUURNIVNJ-MZHQLVBMSA-N 0.000 claims description 5
- BOGFADYROAVVTF-MZHQLVBMSA-N methyl (2r,8s)-8-(chloromethyl)-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1h-indole-2-carbonyl)-7,8-dihydro-3h-pyrrolo[3,2-e]indole-2-carboxylate Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C[C@@H](CCl)C=4C5=C(C(=CC=43)O)N[C@@](C5=O)(C)C(=O)OC)=CC2=C1 BOGFADYROAVVTF-MZHQLVBMSA-N 0.000 claims description 5
- SUWUAMDOMCWKCL-GWQKEKGPSA-N methyl (2r,8s)-8-bromo-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1h-indole-2-carbonyl)-3,7,8,9-tetrahydropyrrolo[3,2-f]quinoline-2-carboxylate Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C[C@@H](Br)CC=4C5=C(C(=CC=43)O)N[C@@](C5=O)(C)C(=O)OC)=CC2=C1 SUWUAMDOMCWKCL-GWQKEKGPSA-N 0.000 claims description 5
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- BOGFADYROAVVTF-UHFFFAOYSA-N pyrindamycin A Natural products COC1=C(OC)C(OC)=C2NC(C(=O)N3CC(CCl)C=4C5=C(C(=CC=43)O)NC(C5=O)(C)C(=O)OC)=CC2=C1 BOGFADYROAVVTF-UHFFFAOYSA-N 0.000 claims description 5
- ILRQRCTVPANBBE-UHFFFAOYSA-N pyrindamycin B Natural products COC1=C(OC)C(OC)=C2NC(C(=O)N3CC(Cl)CC=4C5=C(C(=CC=43)O)NC(C5=O)(C)C(=O)OC)=CC2=C1 ILRQRCTVPANBBE-UHFFFAOYSA-N 0.000 claims description 5
- UOWVMDUEMSNCAV-WYENRQIDSA-N rachelmycin Chemical compound C1([C@]23C[C@@H]2CN1C(=O)C=1NC=2C(OC)=C(O)C4=C(C=2C=1)CCN4C(=O)C1=CC=2C=4CCN(C=4C(O)=C(C=2N1)OC)C(N)=O)=CC(=O)C1=C3C(C)=CN1 UOWVMDUEMSNCAV-WYENRQIDSA-N 0.000 claims description 5
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- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims description 4
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Classifications
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
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- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP6420331B2 (ja) | 2013-10-11 | 2018-11-07 | メルサナ セラピューティクス,インコーポレイティド | タンパク質−高分子−薬剤コンジュゲート |
EP3054992B1 (en) * | 2013-10-11 | 2019-08-14 | Asana BioSciences, LLC | Protein-polymer-drug conjugates |
WO2015155345A1 (en) * | 2014-04-11 | 2015-10-15 | Medimmune Limited | Antibodies and antibody-drug conjugates |
US9808528B2 (en) | 2014-06-18 | 2017-11-07 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates and methods of using same |
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GB201516067D0 (en) | 2015-09-10 | 2015-10-28 | Imp Innovations Ltd | Defined monomer sequence polymers |
CN110606890B (zh) * | 2015-12-24 | 2021-11-26 | 凯惠科技发展(上海)有限公司 | 一种tpbg抗体及其制备方法、其偶联物和应用 |
BR112018067379A2 (pt) | 2016-03-02 | 2019-01-15 | Eisai R&D Man Co Ltd | conjugado anticorpo-droga, composição, método para tratamento de um paciente que tem ou corre o risco de ter um câncer, para produzir o conjugado anticorpo-droga ou a composição, para determinar se um paciente será responsivo a um tratamento com o conjugado anticorpo-droga ou a composição, e, uso de um conjugado anticorpo-droga ou de uma composição. |
EP4302782A3 (en) | 2016-03-15 | 2024-03-27 | Mersana Therapeutics, Inc. | Napi2b-targeted antibody-drug conjugates and methods of use thereof |
CN109563215B (zh) | 2016-06-03 | 2021-11-19 | 诺灵生物医药科技(北京)有限公司 | 聚合物连接子及其用途 |
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BR112020005390A2 (pt) | 2017-09-20 | 2020-09-29 | Mersana Therapeutics, Inc. | composições e métodos para prever a resposta à terapia direcionada ao napi2b |
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KR20210049122A (ko) | 2018-08-17 | 2021-05-04 | 메르사나 테라퓨틱스, 인코포레이티드 | NaPi2b 표적화 폴리머 항체-약물 접합체 및 이것의 사용 방법 |
BR112021008293A2 (pt) * | 2018-11-09 | 2021-08-03 | Byondis B.V. | composição, método, e, método para liberar/aprovar um lote de conjugado de anticorpo-fármaco |
CN111362990B (zh) * | 2018-12-26 | 2021-08-17 | 联宁(苏州)生物制药有限公司 | 一种抗肿瘤药物lnd1026-034及其合成方法 |
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