IL244694B - Microcyclization reactions and useful intermediates in the synthesis of helichondrin b analogs - Google Patents

Microcyclization reactions and useful intermediates in the synthesis of helichondrin b analogs

Info

Publication number
IL244694B
IL244694B IL244694A IL24469416A IL244694B IL 244694 B IL244694 B IL 244694B IL 244694 A IL244694 A IL 244694A IL 24469416 A IL24469416 A IL 24469416A IL 244694 B IL244694 B IL 244694B
Authority
IL
Israel
Prior art keywords
halichondrin
analogs
synthesis
intermediates useful
macrocyclization reactions
Prior art date
Application number
IL244694A
Other languages
English (en)
Hebrew (he)
Other versions
IL244694A0 (en
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of IL244694A0 publication Critical patent/IL244694A0/en
Publication of IL244694B publication Critical patent/IL244694B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL244694A 2013-11-04 2016-03-21 Microcyclization reactions and useful intermediates in the synthesis of helichondrin b analogs IL244694B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361899697P 2013-11-04 2013-11-04
PCT/US2014/063960 WO2015066729A1 (en) 2013-11-04 2014-11-04 Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b

Publications (2)

Publication Number Publication Date
IL244694A0 IL244694A0 (en) 2016-04-21
IL244694B true IL244694B (en) 2019-07-31

Family

ID=53005318

Family Applications (4)

Application Number Title Priority Date Filing Date
IL244694A IL244694B (en) 2013-11-04 2016-03-21 Microcyclization reactions and useful intermediates in the synthesis of helichondrin b analogs
IL267936A IL267936B (en) 2013-11-04 2019-07-09 Microcyclization reactions and useful intermediates in the synthesis of helichondrin b analogs
IL275240A IL275240B (en) 2013-11-04 2020-06-09 Microcyclization reactions and useful intermediates in the synthesis of helichondrin b analogs
IL288468A IL288468B2 (en) 2013-11-04 2021-11-28 Microcyclization reactions and useful intermediates in the synthesis of helichondrin b analogs

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL267936A IL267936B (en) 2013-11-04 2019-07-09 Microcyclization reactions and useful intermediates in the synthesis of helichondrin b analogs
IL275240A IL275240B (en) 2013-11-04 2020-06-09 Microcyclization reactions and useful intermediates in the synthesis of helichondrin b analogs
IL288468A IL288468B2 (en) 2013-11-04 2021-11-28 Microcyclization reactions and useful intermediates in the synthesis of helichondrin b analogs

Country Status (12)

Country Link
US (5) US9783549B2 (https=)
EP (2) EP3689881B1 (https=)
JP (3) JP6625533B2 (https=)
CN (3) CN105683198B (https=)
BR (1) BR112016009452B1 (https=)
CA (1) CA2929084C (https=)
ES (1) ES2787603T3 (https=)
HU (1) HUE049387T2 (https=)
IL (4) IL244694B (https=)
RU (1) RU2710545C2 (https=)
SG (1) SG11201603490TA (https=)
WO (1) WO2015066729A1 (https=)

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CN105801599A (zh) 2008-04-04 2016-07-27 卫材R&D管理有限公司 软海绵素b类似物
WO2011094339A1 (en) 2010-01-26 2011-08-04 Eisai R&D Management Co., Ltd. Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
EP3689881B1 (en) 2013-11-04 2022-01-12 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b
MX384292B (es) 2013-12-06 2025-03-14 Eisai R&D Man Co Ltd Metodos utiles en la sintesis de analogos de halicondrina b.
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
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CN111566113B (zh) 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途
US11419856B2 (en) 2017-11-20 2022-08-23 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
CN109970822B (zh) * 2017-12-27 2023-03-28 上海科胜药物研发有限公司 一种合成埃格列净中间体的制备方法
SG11202005548WA (en) 2018-01-03 2020-07-29 Eisai R&D Man Co Ltd Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
EP3608323B1 (en) * 2018-03-02 2021-11-03 Beijing Tienyi Lufu Pharmatech Co. Ltd. Pyran fused ring compound, preparation method therefor and use thereof
WO2019211877A1 (en) * 2018-05-03 2019-11-07 Cipla Limited Process for the preparation of macrocyclic ketone analogs of halichondrin b
JP2021532102A (ja) * 2018-07-20 2021-11-25 ドクター レディズ ラボラトリーズ リミテッド エリブリンおよびその中間体の調製のための精製プロセス
US11447499B2 (en) * 2019-06-14 2022-09-20 Rk Pharma Inc. Process for the preparation of eribulin mesylate intermediate
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KR102743950B1 (ko) * 2015-05-07 2024-12-18 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편
EP3413887B1 (en) 2016-02-12 2021-04-07 Eisai R&D Management Co., Ltd. Intermediates in the synthesis of eribulin and related methods of synthesis
US11136335B2 (en) 2016-06-30 2021-10-05 Eisai R&D Management Co., Ltd. Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
US20180009825A1 (en) * 2016-07-06 2018-01-11 Apicore Us Llc Methods of making eribulin mesylate
WO2018217894A1 (en) 2017-05-24 2018-11-29 Eisai R&D Management Co., Ltd. Fluorine-labelled halichondrin derivatives and related methods of synthesis
SG11202005548WA (en) 2018-01-03 2020-07-29 Eisai R&D Man Co Ltd Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof

Also Published As

Publication number Publication date
RU2016121648A (ru) 2017-12-08
HUE049387T2 (hu) 2020-09-28
US10611773B2 (en) 2020-04-07
IL288468B (en) 2022-10-01
US20190144463A1 (en) 2019-05-16
US20160264594A1 (en) 2016-09-15
EP3066102A4 (en) 2017-04-26
IL288468B2 (en) 2023-02-01
ES2787603T3 (es) 2020-10-16
JP2020023521A (ja) 2020-02-13
JP6625533B2 (ja) 2019-12-25
CN109942560B (zh) 2022-06-17
SG11201603490TA (en) 2016-05-30
IL275240A (en) 2020-07-30
EP3689881B1 (en) 2022-01-12
US9783549B2 (en) 2017-10-10
WO2015066729A1 (en) 2015-05-07
US20180002342A1 (en) 2018-01-04
RU2016121648A3 (https=) 2018-08-06
JP6909840B2 (ja) 2021-07-28
BR112016009452B1 (pt) 2022-06-07
CN109942560A (zh) 2019-06-28
EP3689881A1 (en) 2020-08-05
IL267936B (en) 2020-06-30
CN105683198A (zh) 2016-06-15
EP3066102B1 (en) 2020-02-26
CA2929084C (en) 2022-01-11
US10934307B2 (en) 2021-03-02
EP3066102A1 (en) 2016-09-14
JP2020059728A (ja) 2020-04-16
IL244694A0 (en) 2016-04-21
JP2016536316A (ja) 2016-11-24
IL288468A (en) 2022-01-01
CA2929084A1 (en) 2015-05-07
CN114716453A (zh) 2022-07-08
IL275240B (en) 2022-01-01
RU2710545C2 (ru) 2019-12-27
US20200223864A1 (en) 2020-07-16
BR112016009452A8 (pt) 2020-03-24
US11643418B2 (en) 2023-05-09
JP6889232B2 (ja) 2021-06-18
IL267936A (en) 2019-09-26
US20210188867A1 (en) 2021-06-24
CN105683198B (zh) 2019-03-12
US10221189B2 (en) 2019-03-05

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