IL242289B - Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells - Google Patents

Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells

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Publication number
IL242289B
IL242289B IL242289A IL24228915A IL242289B IL 242289 B IL242289 B IL 242289B IL 242289 A IL242289 A IL 242289A IL 24228915 A IL24228915 A IL 24228915A IL 242289 B IL242289 B IL 242289B
Authority
IL
Israel
Prior art keywords
cells
pluripotent
interneuronal
cerebral cortex
direct differentiation
Prior art date
Application number
IL242289A
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English (en)
Hebrew (he)
Original Assignee
Memorial Sloan Kettering Cancer Center
Univ Cornell
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Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center, Univ Cornell filed Critical Memorial Sloan Kettering Cancer Center
Publication of IL242289B publication Critical patent/IL242289B/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
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  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
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IL242289A 2013-04-26 2015-10-26 Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells IL242289B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361816624P 2013-04-26 2013-04-26
PCT/US2014/035760 WO2014176606A1 (en) 2013-04-26 2014-04-28 Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells

Publications (1)

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IL242289B true IL242289B (en) 2021-09-30

Family

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Family Applications (2)

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IL242289A IL242289B (en) 2013-04-26 2015-10-26 Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
IL285922A IL285922A (en) 2013-04-26 2021-08-29 Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells

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IL285922A IL285922A (en) 2013-04-26 2021-08-29 Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells

Country Status (7)

Country Link
US (2) US11649431B2 (https=)
EP (2) EP3498824A1 (https=)
JP (3) JP6756610B2 (https=)
AU (2) AU2014256876B2 (https=)
CA (1) CA2910394A1 (https=)
IL (2) IL242289B (https=)
WO (1) WO2014176606A1 (https=)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010096496A2 (en) 2009-02-17 2010-08-26 Memorial Sloan-Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
EP3693455A1 (en) 2011-11-04 2020-08-12 Memorial Sloan-Kettering Cancer Center Midbrain dopamine (da) neurons for engraftment
EP3498824A1 (en) * 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
WO2014201133A1 (en) * 2013-06-11 2014-12-18 President And Fellows Of Harvard College Compositions and methods for improving induced neuron generation
WO2015069736A1 (en) 2013-11-08 2015-05-14 The Mclean Hospital Corporation METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS
US10626368B2 (en) 2015-04-14 2020-04-21 Kyoto University Method for inducing cerebral cortex neurons
AU2016270793B2 (en) 2015-06-01 2022-06-09 Memorial Sloan-Kettering Cancer Center Methods of in vitro differentiation of midbrain dopamine (MDA) neurons
US10669528B2 (en) 2015-06-25 2020-06-02 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
JP7023840B2 (ja) * 2015-10-07 2022-02-22 メモリアル スローン ケタリング キャンサー センター 神経筋接合活性のモジュレーターを同定するｉｎ ｖｉｔｒｏの方法
US20180369287A1 (en) * 2015-10-08 2018-12-27 Neurona Therapeutics Inc. Neural precursor cell populations and uses thereof
US20190018000A1 (en) 2016-01-12 2019-01-17 Cedars-Sinai Medical Center A method of non destructive monitoring of biological processes in microfluidic tissue culture systems
EP3448985A4 (en) * 2016-01-27 2019-08-21 Memorial Sloan-Kettering Cancer Center DIFFERENTIATION OF CORTIC NEURONS FROM HUMAN PLURIPOTENTIAL STEM CELLS
EP3411470A4 (en) 2016-02-01 2019-10-09 Emulate, Inc. SYSTEMS AND METHOD FOR BREEDING DARM CELLS IN MICROFLUIDIC DEVICES
KR20180105236A (ko) 2016-02-05 2018-09-27 메모리얼 슬로안-케터링 캔서 센터 줄기 세포-유래 외배엽 계통 전구체의 분화 방법
EP4049665B1 (en) 2016-03-15 2025-03-12 The Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
US11913022B2 (en) 2017-01-25 2024-02-27 Cedars-Sinai Medical Center In vitro induction of mammary-like differentiation from human pluripotent stem cells
US11767513B2 (en) 2017-03-14 2023-09-26 Cedars-Sinai Medical Center Neuromuscular junction
WO2018176001A2 (en) 2017-03-24 2018-09-27 Cedars-Sinai Medical Center Methods and compositions for production of fallopian tube epithelium
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
EP3395942A1 (en) * 2017-04-25 2018-10-31 IMBA-Institut für Molekulare Biotechnologie GmbH Bi- or multi-differentiated organoid
US10889800B2 (en) 2017-05-25 2021-01-12 New York Stem Cell Foundation, Inc. Method and composition for generating basal forebrain cholinergic neurons (BFCNS)
CA3071454A1 (en) 2017-07-28 2019-01-31 Memorial Sloan-Kettering Cancer Center Establishing topographic organization in three-dimensional tissue culture
EP3715450A4 (en) * 2017-11-24 2021-08-25 Sumitomo Chemical Company, Limited METHOD OF PREPARING CELL MASS, INCLUDING HYPOPHYSICAL TISSUE, AND CELL MASS THEREOF
EP3715452A4 (en) * 2017-11-24 2021-08-18 Sumitomo Chemical Company, Limited METHOD OF MANUFACTURING A CELL MASS WITH NEURAL CELLS / TISSUE AND NON-NEURAL EPITHELIAL TISSUE AND CELL MASS FROM THEM
GB2611641B (en) * 2018-03-14 2023-06-28 Emulate Inc Innervated intestine on-chip
EP4700387A2 (en) 2018-03-23 2026-02-25 Cedars-Sinai Medical Center Methods of use of islet cells
WO2019195798A1 (en) 2018-04-06 2019-10-10 Cedars-Sinai Medical Center Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip
WO2019195800A1 (en) 2018-04-06 2019-10-10 Cedars-Sinai Medical Center Novel differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells
EP3787613B1 (en) 2018-04-30 2026-03-11 Cedars-Sinai Medical Center Pkc activation for use in treating early onset sporadic parkinson's disease
US20210340502A1 (en) * 2018-09-28 2021-11-04 The Mclean Hospital Corporation Generation of Post-Mitotic Migratory Cortical Interneurons
US12343359B2 (en) 2019-05-23 2025-07-01 Dignity Health Inhibitory interneuron treatment methods, uses and compositions for diabetes
JP7364208B2 (ja) * 2019-06-21 2023-10-18 独立行政法人国立病院機構 前脳型の神経前駆細胞の製造方法、分化用培地、及び、前脳型の神経前駆細胞
WO2021004864A1 (en) * 2019-07-05 2021-01-14 Novo Nordisk A/S Generation of neural stem cell lines derived from human pluripotent stem cells
JP7810357B2 (ja) 2019-07-25 2026-02-03 ザ スクリプス リサーチ インスティテュート ドーパミン作動性ニューロン及び前駆細胞を特定する方法
CN110484505B (zh) * 2019-08-21 2022-03-11 安徽中盛溯源生物科技有限公司 一种运动神经元及其制备方法和应用
JP7728747B2 (ja) 2019-08-23 2025-08-25 サナ バイオテクノロジー，インコーポレイテッド Ｃｄ２４発現細胞およびそれらの用途
CN114729323B (zh) * 2019-11-22 2024-09-17 诺和诺德股份有限公司 旋转聚集的神经微球及其应用
KR20220158046A (ko) 2020-03-25 2022-11-29 사나 바이오테크놀로지, 인크. 신경계 장애 및 병태의 치료를 위한 면역저하성 신경 세포
CN115768875A (zh) * 2020-04-02 2023-03-07 纪念斯隆-凯特琳癌症中心 产生中脑多巴胺神经元的方法、中脑神经元及其用途
WO2021216623A1 (en) 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
US20250263752A1 (en) 2020-04-21 2025-08-21 Aspen Neuroscience, Inc. Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
WO2021232234A1 (zh) * 2020-05-19 2021-11-25 武汉睿健医药科技有限公司 一种感觉神经元细胞的无血清诱导方法
CN111514149B (zh) * 2020-06-16 2021-02-23 中国人民解放军空军军医大学 Xav939在制备治疗孤独症谱系障碍的药物中的应用
WO2022036150A1 (en) 2020-08-13 2022-02-17 Sana Biotechnology, Inc. Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions
CN114736864B (zh) 2020-12-23 2024-01-26 武汉睿健医药科技有限公司 一种神经干细胞诱导分化培养基及诱导分化方法
CA3204035A1 (en) * 2021-01-07 2022-07-14 Lorenz Studer Methods of generating cortical excitatory neurons
WO2022221765A1 (en) 2021-04-16 2022-10-20 Brainxell, Inc. Methods of making, expanding and purifying midbrain dopaminergic progenitor cells
US20240226164A1 (en) 2021-05-27 2024-07-11 Sana Biotechnology, Inc. Hypoimmunogenic cells comprising engineered hla-e or hla-g
WO2022266097A1 (en) * 2021-06-15 2022-12-22 Chan Zuckerberg Biohub, Inc. Methods for generating parvalbumin-positive interneurons
KR20240046319A (ko) 2021-07-14 2024-04-08 사나 바이오테크놀로지, 인크. 저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현
MX2024000713A (es) * 2021-07-16 2024-03-25 Sana Biotechnology Inc Vectores policistrónicos para terapias a base de células.
WO2023004366A1 (en) 2021-07-21 2023-01-26 Aspen Neuroscience, Inc. Transposon-based modulation of gba1 and related compositions and uses thereof
WO2023004370A1 (en) 2021-07-21 2023-01-26 Aspen Neuroscience, Inc. Aav-based modulation of gba1 and related compositions and uses thereof
AU2022327174A1 (en) 2021-08-11 2024-02-15 Sana Biotechnology, Inc. Inducible systems for altering gene expression in hypoimmunogenic cells
JP2024535677A (ja) 2021-08-11 2024-10-02 サナ バイオテクノロジー，インコーポレイテッド 即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞
EP4384598A1 (en) 2021-08-11 2024-06-19 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
US20240358761A1 (en) 2021-08-11 2024-10-31 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
WO2023104792A1 (en) 2021-12-07 2023-06-15 Vib Vzw Enhancers of neuronal maturation
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
WO2023201361A1 (en) 2022-04-15 2023-10-19 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells
KR20230162885A (ko) * 2022-05-20 2023-11-29 코아스템켐온 주식회사 삼차원 시상하부 오가노이드로부터 유래된 신경줄기세포를 포함하는 노인성 질환 예방 및 치료용 약학 조성물 및 그의 용도
CN118064356A (zh) * 2022-11-22 2024-05-24 浙江霍德生物工程有限公司 前脑神经前体细胞在治疗与前脑神经细胞的死亡和/或功能不全相关的疾病中的应用
WO2025054202A1 (en) 2023-09-05 2025-03-13 Sana Biotechnology, Inc. Method of screening a sample comprising a transgene with a unique barcode
WO2025091318A1 (en) * 2023-11-01 2025-05-08 Nuwacell Biotechnologies Co., Ltd. Improved production of induced midbrain dopaminergic progenitor cells from pluripotent stem cells
WO2025151838A1 (en) 2024-01-12 2025-07-17 Sana Biotechnology, Inc. Safety switches to control in vitro and in vivo proliferation of cell therapy products
WO2026008612A1 (en) 2024-07-02 2026-01-08 Fondazione Human Technopole Method for hindbrain neuron generation

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623922B2 (en) 1988-08-04 1992-05-28 Amrad Operations Pty. Limited In vitro propagation of embryonic stem cells
US5650148A (en) 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
US5082670A (en) 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US5340740A (en) 1992-05-15 1994-08-23 North Carolina State University Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process
US5589376A (en) 1992-07-27 1996-12-31 California Institute Of Technology Mammalian neural crest stem cells
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US6787356B1 (en) 1998-07-24 2004-09-07 The United States Of America As Represented By The Department Of Health And Human Services Cell expansion system for use in neural transplantation
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US6610540B1 (en) 1998-11-18 2003-08-26 California Institute Of Technology Low oxygen culturing of central nervous system progenitor cells
US6087168A (en) 1999-01-20 2000-07-11 Cedars Sinai Medical Center Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
US7041507B1 (en) 1999-01-20 2006-05-09 Cedars-Sinai Medical Center Transdiffentiation of transfected epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
US20050042749A1 (en) 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
US7005252B1 (en) 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
WO2001068815A1 (en) 2000-03-14 2001-09-20 Es Cell International Pte Ltd Embryonic stem cells and neural progenitor cells derived therefrom
US7011828B2 (en) 2000-03-14 2006-03-14 Es Cell International Pte. Ltd. Implanting neural progenitor cells derived for human embryonic stem cells
WO2001088104A2 (en) 2000-05-17 2001-11-22 Geron Corporation Neural progenitor cell populations
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
EP2298867A3 (en) 2000-06-20 2013-01-16 ES Cell International Pte Ltd. Method of controlling differentiation of embryonic stem (ES) cells by culturing ES cells in the presence of bmp-2 pathway antagonists
DE10037759A1 (de) 2000-08-03 2002-07-04 Gruenenthal Gmbh Screeningverfahren
WO2002026941A2 (en) 2000-09-29 2002-04-04 Kooy Derek V D Primitive neural stem cells and method for differentiation of stem cells to neural cells
JP3660601B2 (ja) 2001-03-30 2005-06-15 独立行政法人科学技術振興機構 胚性幹細胞からの神経幹細胞、運動ニューロン及びｇａｂａ作動性ニューロンの製造法
WO2002086073A2 (en) 2001-04-20 2002-10-31 Memorial Sloan-Kettering Cancer Center Generation of differentiated tissue from nuclear transfer embryonic stem cells and methods of use
US20030211605A1 (en) 2001-05-01 2003-11-13 Lee Sang-Hun Derivation of midbrain dopaminergic neurons from embryonic stem cells
US6887706B2 (en) 2001-10-03 2005-05-03 Wisconsin Alumni Research Foundation Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells
US20040224302A1 (en) 2002-07-16 2004-11-11 Thomas Jessel Systems and methods for screening for modulators of neural differentiation
CA2492442A1 (en) 2002-07-31 2004-02-05 Stem Cell Therapeutics Inc. Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (pacap)
US7732203B2 (en) 2002-08-17 2010-06-08 Ajoll University Industry Cooperation Foundation Method for transdifferentiating mesenchymal stem cells into neuronal cells
WO2004029203A2 (en) 2002-09-25 2004-04-08 Bresagen, Inc. Compositions and methods for enrichment of neural stem cells using ceramide analogs
US20040214324A1 (en) 2002-12-09 2004-10-28 Ole Isacson Dopaminergic neurons differentiated from embryonic cells for treating neurodegenerative diseases
US7252995B2 (en) 2002-12-13 2007-08-07 Yu-Show Fu Method of generating neurons from stem cells and medium for culturing stem cells
WO2006019366A1 (en) 2003-03-28 2006-02-23 Wisconsin Alumni Research Foundation Physiochemical culture conditions for embryonic stem cells
CA2522712A1 (en) 2003-04-18 2004-10-28 Kyowa Hakko Kogyo Co., Ltd. Nerve regenerating drug
US7332336B2 (en) 2003-08-19 2008-02-19 Effector Cell Institute, Inc. Methods for inducing differentiation of pluripotent cells
CA2929754A1 (en) 2004-04-12 2005-10-27 Sanbio Inc. Cells exhibiting neuronal progenitor cell characteristics
AU2005282414C1 (en) 2004-09-08 2011-04-07 Wisconsin Alumni Research Foundation Culturing human embryonic stem cells
US7590589B2 (en) 2004-09-10 2009-09-15 Hoffberg Steven M Game theoretic prioritization scheme for mobile ad hoc networks permitting hierarchal deference
EP1814979B1 (en) 2004-11-17 2015-04-08 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions
EP1992360A4 (en) 2006-02-01 2010-02-17 Univ Tokyo COMMON USE OF A TGF BETA SIGNAL HEMMER AND AN ANTITUMORAL AGENT
JP5680850B2 (ja) 2006-03-30 2015-03-04 ザ・ユニバーシティ・コート・オブ・ザ・ユニバーシティ・オブ・エディンバラＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｃｏｕｒｔ ｏｆ ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｅｄｉｎｂｕｒｇｈ キナーゼインヒビターを含む培養培地およびその使用
PL2044056T3 (pl) 2006-07-14 2013-01-31 Novartis Ag Pochodne pirymidyny jako inhibitory ALK-5
WO2008018190A1 (en) 2006-08-09 2008-02-14 Biomaster, Inc. Fat-derived neural crest cells
JP2008099662A (ja) 2006-09-22 2008-05-01 Institute Of Physical & Chemical Research 幹細胞の培養方法
GB0622394D0 (en) 2006-11-09 2006-12-20 Univ Cambridge Tech Differentiation of pluripotent cells
AU2007322033B2 (en) 2006-11-20 2013-07-11 President And Fellows Of Harvard College Methods, compositions, and kits for treating pain and pruritis
WO2008089351A1 (en) 2007-01-17 2008-07-24 Wisconsin Alumni Research Foundation Improved culture of stem cells
CA2676044C (en) 2007-01-30 2019-10-22 University Of Georgia Research Foundation, Inc. Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc)
EP2028268A1 (en) 2007-08-20 2009-02-25 Université Libre De Bruxelles Generation of neuronal cells from pluripotent stem cells
CA2954431C (en) * 2007-11-27 2021-08-24 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic cells
KR20130030309A (ko) 2008-02-06 2013-03-26 가부시키가이샤 구라레 세포 배양 방법 및 스크리닝 방법
CN101550406B (zh) 2008-04-03 2016-02-10 北京大学 制备多潜能干细胞的方法,试剂盒及用途
JP5435388B2 (ja) 2008-04-25 2014-03-05 国立大学法人 千葉大学 インスリン様増殖因子結合タンパク質を含有するＷｎｔシグナル伝達阻害剤
JP2011521958A (ja) 2008-05-27 2011-07-28 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム Ｗｎｔタンパク質シグナル伝達阻害剤
JPWO2009148170A1 (ja) * 2008-06-06 2011-11-04 独立行政法人理化学研究所 幹細胞の培養方法
WO2009155301A2 (en) 2008-06-17 2009-12-23 The Mclean Hospital Corporation Multipotent neural cells
ES2633935T3 (es) 2008-12-05 2017-09-26 Inserm - Institut National De La Santé Et De La Recherche Médicale Método y medio para la diferenciación neural de células pluripotentes
WO2010096496A2 (en) 2009-02-17 2010-08-26 Memorial Sloan-Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
US9487751B2 (en) * 2009-06-02 2016-11-08 Cornell University Method to isolate, identify, and use embryonic stem cells directed to forebrain interneuron fate
WO2010144696A1 (en) * 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
WO2011019092A1 (en) 2009-08-12 2011-02-17 Kyoto University Method for inducing differentiation of pluripotent stem cells into neural precursor cells
WO2011056971A2 (en) 2009-11-04 2011-05-12 Cellular Dynamics International, Inc. Episomal reprogramming with chemicals
KR101168053B1 (ko) 2009-11-06 2012-07-24 연세대학교 산학협력단 효율적이고 보편적인 전분화능 줄기세포의 신경세포 분화 유도방법
US9097727B2 (en) 2010-03-03 2015-08-04 Kyoto University Method for diagnosing a protein misfolding disease using nerve cells derived from iPS cells
CN102191221B (zh) 2010-03-17 2014-11-19 中国人民解放军第二军医大学东方肝胆外科医院 一种能无限自我更新的神经干细胞、其制备方法及其用途
WO2011130675A2 (en) 2010-04-16 2011-10-20 The Mclean Hospital Corporation Dopaminergic neurons differentiated from pluripotent stem cells and uses of thereof
DK3578988T3 (da) 2010-05-25 2025-02-24 Memorial Sloan Kettering Cancer Center Fremgangsmåde til nociceptordifferentiering af humane embryonale stamceller og anvendelse heraf
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
JP5936134B2 (ja) 2010-06-15 2016-06-15 国立大学法人京都大学 ヒト人工多能性幹細胞の選択方法
US8895302B2 (en) 2010-08-12 2014-11-25 Wisconsin Alumni Research Foundation Directed differentiation of primate pluripotent stem cells into functional basal forebrain cholinergic neurons (BFCNs) and medium spiny gabaergic projection neurons
US8883502B2 (en) 2010-09-09 2014-11-11 The Regents Of The University Of California Expandable cell source of neuronal stem cell populations and methods for obtaining and using them
DK2980209T3 (en) 2011-05-20 2018-04-23 Mclean Hospital Corp NEURONAL PROGENITOR CELLS AND APPLICATIONS
KR101331034B1 (ko) 2011-06-09 2013-11-19 연세대학교 산학협력단 미분화 줄기세포로부터 중뇌특이적 도파민 신경세포의 제조 방법
JP6090937B2 (ja) * 2011-07-27 2017-03-08 国立大学法人京都大学 新規ドーパミン産生神経前駆細胞マーカー
US20150086481A1 (en) 2011-07-28 2015-03-26 Memorial Sloan-Kettering Cancer Center Diagnosis and treatment of parkinson's disease
EP3693455A1 (en) 2011-11-04 2020-08-12 Memorial Sloan-Kettering Cancer Center Midbrain dopamine (da) neurons for engraftment
US10472607B2 (en) 2011-12-14 2019-11-12 National Chung Hsing University Culture medium and method for inducing differentiation of pluripotent stem cells into neuroepithelial cells
EP2614829A1 (en) 2012-01-11 2013-07-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons
CN102604894B (zh) 2012-02-29 2014-07-30 中国科学院广州生物医药与健康研究院 用于制备神经干细胞的培养基及其用途
WO2013163228A1 (en) 2012-04-24 2013-10-31 International Stem Cell Corporation Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells
SG11201505152PA (en) 2012-12-28 2015-08-28 Univ Kyoto Method for inducing astrocytes
WO2014127289A1 (en) 2013-02-15 2014-08-21 International Stem Cell Corporation Use of neural cells derived from human pluripotent stem cells for the treatment of neurodegenerative diseases
US20140248696A1 (en) 2013-03-01 2014-09-04 Wisconsin Alumni Research Foundation Methods of maintaining, expanding, and diffrentiating neuronal subtype specific progenitors
CA2899507A1 (en) * 2013-03-14 2014-09-25 The Regents Of The University Of California In vitro production of medial ganglionic eminence precursor cells
CA2909695A1 (en) 2013-04-16 2014-10-23 Memorial Sloan-Kettering Cancer Center Age-modified cells and methods for making age-modified cells
EP3498824A1 (en) * 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
AU2014316100B2 (en) 2013-09-05 2020-11-05 Eisai R&D Management Co., Ltd. New method for inducing dopamine-producing neural precursor cells
EP3047017B1 (en) 2013-10-09 2025-09-10 The Regents of the University of California Methods of mammalian retinal stem cell production and applications
AU2014352773B2 (en) 2013-11-21 2021-04-29 Memorial Sloan-Kettering Cancer Center Specification of functional cranial placode derivatives from human pluripotent stem cells
ES2939807T3 (es) 2014-03-21 2023-04-27 Fujifilm Cellular Dynamics Inc Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización
CN105121633B (zh) 2014-03-25 2018-05-01 云南中科灵长类生物医学重点实验室 一种建立神经上皮干细胞的培养基、方法及其应用
TWI810142B (zh) 2014-10-24 2023-08-01 日商住友製藥股份有限公司 神經組織的製造方法
JP6998772B2 (ja) 2015-04-09 2022-02-04 ビオラミナ アーベー 神経変性疾患の処置における使用のための幹細胞由来のドパミン作用性細胞を生成するための方法および組成物

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