IL241176B - Temperature change for high-utilization expression of polypeptides in yeast and other transformed cells - Google Patents
Temperature change for high-utilization expression of polypeptides in yeast and other transformed cellsInfo
- Publication number
- IL241176B IL241176B IL241176A IL24117615A IL241176B IL 241176 B IL241176 B IL 241176B IL 241176 A IL241176 A IL 241176A IL 24117615 A IL24117615 A IL 24117615A IL 241176 B IL241176 B IL 241176B
- Authority
- IL
- Israel
- Prior art keywords
- polypeptides
- yeast
- high yield
- transformed cells
- temperature shift
- Prior art date
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Analytical Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361790613P | 2013-03-15 | 2013-03-15 | |
| US201361791471P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/030453 WO2014145650A1 (en) | 2013-03-15 | 2014-03-17 | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL241176A0 IL241176A0 (en) | 2015-11-30 |
| IL241176B true IL241176B (en) | 2020-05-31 |
Family
ID=51538058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL241176A IL241176B (en) | 2013-03-15 | 2015-09-03 | Temperature change for high-utilization expression of polypeptides in yeast and other transformed cells |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10138294B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3597664B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6412552B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102202477B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN105121652B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014232813B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2905180C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2971037T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2749751T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL241176B (cg-RX-API-DMAC7.html) |
| MX (2) | MX366647B (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201506034TA (cg-RX-API-DMAC7.html) |
| TW (1) | TWI636136B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014145650A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201505483B (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10202630B2 (en) * | 2013-03-15 | 2019-02-12 | Alderbio Holdings Llc | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| CN111973740A (zh) | 2014-03-21 | 2020-11-24 | 泰华制药国际有限公司 | 针对降钙素基因相关肽的拮抗剂抗体及其使用方法 |
| US11518797B2 (en) | 2014-11-11 | 2022-12-06 | Clara Foods Co. | Methods and compositions for egg white protein production |
| JP2017045865A (ja) | 2015-08-26 | 2017-03-02 | ルネサスエレクトロニクス株式会社 | 半導体装置およびその製造方法 |
| CN106191181B (zh) | 2016-07-22 | 2019-12-13 | 江苏江山聚源生物技术有限公司 | 一种毕赤酵母表达重组蛋白的发酵工艺 |
| CN109952314A (zh) | 2016-09-23 | 2019-06-28 | 泰瓦制药国际有限公司 | 治疗难治性偏头痛 |
| KR102638074B1 (ko) | 2017-03-10 | 2024-02-20 | 볼트 쓰레즈, 인크. | 재조합 단백질을 고분비 수율로 생산하기 위한 조성물 및 방법 |
| JP7063486B2 (ja) | 2017-03-10 | 2022-05-09 | ボルト スレッズ インコーポレイテッド | 高分泌収量の組み換えタンパク質を産生するための組成物及び方法 |
| KR20250016476A (ko) * | 2018-03-16 | 2025-02-03 | 젠자임 코포레이션 | 생산용 생물 반응기에서의 세포 생존력을 개선하는 방법 |
| US10221403B1 (en) * | 2018-04-25 | 2019-03-05 | Life Rainbow Biotech Co., Ltd. | Method of preparing zearalenone hydrolase |
| CN108546637A (zh) * | 2018-05-23 | 2018-09-18 | 华东理工大学 | 重组毕赤酵母表达葡萄糖氧化酶发酵装置以及发酵培养方法 |
| EP3821022A1 (en) * | 2018-07-12 | 2021-05-19 | Amyris, Inc. | Methods for controlling fermentation feed rates |
| CA3146649A1 (en) | 2019-07-11 | 2021-01-14 | Clara Foods Co. | Protein compositions and consumable products thereof |
| US12096784B2 (en) | 2019-07-11 | 2024-09-24 | Clara Foods Co. | Protein compositions and consumable products thereof |
| US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
| WO2021092356A1 (en) * | 2019-11-08 | 2021-05-14 | Danisco Us Inc | Fungal strains comprising enhanced protein productivity phenotypes and methods thereof |
| US20230074785A1 (en) * | 2020-01-14 | 2023-03-09 | Basf Se | Method For Producing Recombinant Protein In Yeast Cells |
| US20250207158A1 (en) * | 2022-03-24 | 2025-06-26 | Versalis S.P.A. | Fermentation process for the production of lipids from oleaginous yeasts |
| WO2024073755A2 (en) * | 2022-09-29 | 2024-04-04 | Antheia, Inc. | Methods of improving production of morphinan alkaloids and derivatives |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855231A (en) | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
| US4818700A (en) | 1985-10-25 | 1989-04-04 | Phillips Petroleum Company | Pichia pastoris argininosuccinate lyase gene and uses thereof |
| US4812405A (en) | 1986-02-18 | 1989-03-14 | Phillips Petroleum Company | Double auxotrophic mutants of Pichia pastoris and methods for preparation |
| US4929555A (en) | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
| WO1994021293A1 (en) | 1993-03-19 | 1994-09-29 | Duke University | Method of treatment of tumors with an antibody binding to tenascin |
| ATE306930T1 (de) | 1994-08-12 | 2005-11-15 | Immunomedics Inc | Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper |
| US5955349A (en) | 1996-08-26 | 1999-09-21 | Zymogenetics, Inc. | Compositions and methods for producing heterologous polypeptides in Pichia methanolica |
| US5736383A (en) | 1996-08-26 | 1998-04-07 | Zymogenetics, Inc. | Preparation of Pichia methanolica auxotrophic mutants |
| US6730499B1 (en) | 1998-07-03 | 2004-05-04 | Research Corporation Technologies, Inc. | Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1 |
| US6258559B1 (en) | 1999-03-22 | 2001-07-10 | Zymogenetics, Inc. | Method for producing proteins in transformed Pichia |
| US6221630B1 (en) * | 1999-03-24 | 2001-04-24 | The Penn State Research Foundation | High copy number recombinant expression construct for regulated high-level production of polypeptides in yeast |
| NZ547279A (en) | 2003-10-22 | 2008-04-30 | Keck Graduate Inst | Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy |
| EP2021463B1 (en) | 2006-05-19 | 2016-11-23 | Alder Biopharmaceuticals, Inc. | Culture method for obtaining a clonal population of antigen-specific b cells |
| CN105001332B (zh) | 2007-05-21 | 2018-12-04 | 奥尔德生物控股有限责任公司 | 针对il-6的抗体及其用途 |
| EP2162469A4 (en) | 2007-05-21 | 2012-08-01 | Alderbio Holdings Llc | NEW METHODS OF HUMANIZING RABBIT ANTIBODIES AND HUMANIZED RABBIT ANTIBODIES |
| US20090269832A1 (en) * | 2007-11-05 | 2009-10-29 | Modular Genetics, Inc. | Growth of Microorganisms in Media Containing Crude Glycerol |
| US8501449B2 (en) * | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
| WO2011075686A2 (en) * | 2009-12-18 | 2011-06-23 | Ventria Bioscience | Methods & compositions comprising heat shock proteins |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| EP2744903B1 (en) * | 2011-08-19 | 2018-10-10 | AlderBio Holdings LLC | Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as a antibodies in transformed microbes such as pichia pastoris |
| US10150968B2 (en) | 2011-08-19 | 2018-12-11 | Alderbio Holdings Llc | Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| WO2014145521A2 (en) * | 2013-03-15 | 2014-09-18 | Alderbio Holdings Llc | Fermentation process for antibody production |
| US10202630B2 (en) * | 2013-03-15 | 2019-02-12 | Alderbio Holdings Llc | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
-
2014
- 2014-03-17 MX MX2015011968A patent/MX366647B/es active IP Right Grant
- 2014-03-17 EP EP19177519.6A patent/EP3597664B1/en active Active
- 2014-03-17 MX MX2019008417A patent/MX384491B/es unknown
- 2014-03-17 US US14/776,892 patent/US10138294B2/en active Active
- 2014-03-17 DK DK14764393.6T patent/DK2971037T3/da active
- 2014-03-17 JP JP2016503404A patent/JP6412552B2/ja active Active
- 2014-03-17 EP EP14764393.6A patent/EP2971037B1/en active Active
- 2014-03-17 CN CN201480014647.8A patent/CN105121652B/zh active Active
- 2014-03-17 KR KR1020157028401A patent/KR102202477B1/ko active Active
- 2014-03-17 SG SG11201506034TA patent/SG11201506034TA/en unknown
- 2014-03-17 WO PCT/US2014/030453 patent/WO2014145650A1/en not_active Ceased
- 2014-03-17 CA CA2905180A patent/CA2905180C/en active Active
- 2014-03-17 AU AU2014232813A patent/AU2014232813B2/en active Active
- 2014-03-17 TW TW103109931A patent/TWI636136B/zh active
- 2014-03-17 ES ES14764393T patent/ES2749751T3/es active Active
-
2015
- 2015-07-30 ZA ZA2015/05483A patent/ZA201505483B/en unknown
- 2015-09-03 IL IL241176A patent/IL241176B/en active IP Right Grant
-
2018
- 2018-10-24 US US16/169,130 patent/US11447540B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3597664B1 (en) | 2025-11-26 |
| EP2971037A4 (en) | 2016-07-20 |
| AU2014232813B2 (en) | 2017-12-07 |
| MX384491B (es) | 2025-03-14 |
| KR20150140678A (ko) | 2015-12-16 |
| CN105121652B (zh) | 2020-07-28 |
| TW201512401A (zh) | 2015-04-01 |
| EP2971037A1 (en) | 2016-01-20 |
| ES2749751T3 (es) | 2020-03-23 |
| KR102202477B1 (ko) | 2021-01-13 |
| NZ711400A (en) | 2021-05-28 |
| AU2014232813A1 (en) | 2015-09-03 |
| US20190119360A1 (en) | 2019-04-25 |
| ZA201505483B (en) | 2022-08-31 |
| CN105121652A (zh) | 2015-12-02 |
| SG11201506034TA (en) | 2015-09-29 |
| US10138294B2 (en) | 2018-11-27 |
| DK2971037T3 (da) | 2019-10-14 |
| EP2971037B1 (en) | 2019-07-10 |
| US11447540B2 (en) | 2022-09-20 |
| TWI636136B (zh) | 2018-09-21 |
| EP3597664A2 (en) | 2020-01-22 |
| MX2015011968A (es) | 2017-01-06 |
| CA2905180C (en) | 2023-03-07 |
| JP6412552B2 (ja) | 2018-10-24 |
| MX366647B (es) | 2019-07-17 |
| CA2905180A1 (en) | 2014-09-18 |
| MX2019008417A (es) | 2019-09-13 |
| US20160039911A1 (en) | 2016-02-11 |
| IL241176A0 (en) | 2015-11-30 |
| EP3597664A3 (en) | 2020-03-11 |
| JP2016516412A (ja) | 2016-06-09 |
| WO2014145650A1 (en) | 2014-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL241176A0 (en) | Temperature change for high-utilization expression of polypeptides in yeast and other transformed cells | |
| IL273504A (en) | Compositions for cell culture with antioxidants and methods for polypeptide production | |
| SG11201604584QA (en) | In vitro production of foregut stem cells | |
| SG11201507510PA (en) | Isolation of non-embryonic stem cells and uses thereof | |
| IL241572B (en) | Preparations and methods for stem cell proliferation and culture | |
| EP2971040A4 (en) | CELL CULTURE METHODS | |
| EP2971014A4 (en) | CELL CULTURE METHODS | |
| EP2998969A4 (en) | Composition for forming solar cell electrode and electrode manufactured therefrom | |
| IL247798B (en) | Expansion of mature stem cells in vitro | |
| IL269252A (en) | Expression constructs and methods for expressing polypeptides in eukaryotic cells | |
| IL246276B (en) | Stem cells derived from mammalian muscles | |
| EP3075469A4 (en) | Fuel cell and method of manufacturing same | |
| GB201314769D0 (en) | A fuel cell and its method of manufacture | |
| EP2964746A4 (en) | FERMENTATION MONITORING DEVICE FOR FUEL CELL | |
| KR101882068B1 (ko) | 연료 전지의 작동 | |
| GB201315992D0 (en) | Fuel cells and method of manufacture | |
| EP2970883B8 (en) | Enhanced placental stem cells and uses thereof | |
| GB2523045B (en) | Fuel cells and method of operation | |
| IL226728A0 (en) | Metal-air fuel tea that works at high heat | |
| GB201307377D0 (en) | Devices and methods for culture of cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |