AU2014232813B2 - Temperature shift for high yield expression of polypeptides in yeast and other transformed cells - Google Patents

Temperature shift for high yield expression of polypeptides in yeast and other transformed cells Download PDF

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Publication number
AU2014232813B2
AU2014232813B2 AU2014232813A AU2014232813A AU2014232813B2 AU 2014232813 B2 AU2014232813 B2 AU 2014232813B2 AU 2014232813 A AU2014232813 A AU 2014232813A AU 2014232813 A AU2014232813 A AU 2014232813A AU 2014232813 B2 AU2014232813 B2 AU 2014232813B2
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temperature
antibody
pichia
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previous
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AU2014232813A1 (en
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Franz Hartner
Gary LESNICKI
Patricia Dianne Mcneill
Mark Young
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H Lundbeck AS
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H Lundbeck AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Analytical Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2014232813A 2013-03-15 2014-03-17 Temperature shift for high yield expression of polypeptides in yeast and other transformed cells Active AU2014232813B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361790613P 2013-03-15 2013-03-15
US201361791471P 2013-03-15 2013-03-15
US61/791,471 2013-03-15
US61/790,613 2013-03-15
PCT/US2014/030453 WO2014145650A1 (en) 2013-03-15 2014-03-17 Temperature shift for high yield expression of polypeptides in yeast and other transformed cells

Publications (2)

Publication Number Publication Date
AU2014232813A1 AU2014232813A1 (en) 2015-09-03
AU2014232813B2 true AU2014232813B2 (en) 2017-12-07

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AU2014232813A Active AU2014232813B2 (en) 2013-03-15 2014-03-17 Temperature shift for high yield expression of polypeptides in yeast and other transformed cells

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US (2) US10138294B2 (cg-RX-API-DMAC7.html)
EP (2) EP3597664B1 (cg-RX-API-DMAC7.html)
JP (1) JP6412552B2 (cg-RX-API-DMAC7.html)
KR (1) KR102202477B1 (cg-RX-API-DMAC7.html)
CN (1) CN105121652B (cg-RX-API-DMAC7.html)
AU (1) AU2014232813B2 (cg-RX-API-DMAC7.html)
CA (1) CA2905180C (cg-RX-API-DMAC7.html)
DK (1) DK2971037T3 (cg-RX-API-DMAC7.html)
ES (1) ES2749751T3 (cg-RX-API-DMAC7.html)
IL (1) IL241176B (cg-RX-API-DMAC7.html)
MX (2) MX366647B (cg-RX-API-DMAC7.html)
SG (1) SG11201506034TA (cg-RX-API-DMAC7.html)
TW (1) TWI636136B (cg-RX-API-DMAC7.html)
WO (1) WO2014145650A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201505483B (cg-RX-API-DMAC7.html)

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US10202630B2 (en) * 2013-03-15 2019-02-12 Alderbio Holdings Llc Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
CN111973740A (zh) 2014-03-21 2020-11-24 泰华制药国际有限公司 针对降钙素基因相关肽的拮抗剂抗体及其使用方法
US11518797B2 (en) 2014-11-11 2022-12-06 Clara Foods Co. Methods and compositions for egg white protein production
JP2017045865A (ja) 2015-08-26 2017-03-02 ルネサスエレクトロニクス株式会社 半導体装置およびその製造方法
CN106191181B (zh) 2016-07-22 2019-12-13 江苏江山聚源生物技术有限公司 一种毕赤酵母表达重组蛋白的发酵工艺
CN109952314A (zh) 2016-09-23 2019-06-28 泰瓦制药国际有限公司 治疗难治性偏头痛
KR102638074B1 (ko) 2017-03-10 2024-02-20 볼트 쓰레즈, 인크. 재조합 단백질을 고분비 수율로 생산하기 위한 조성물 및 방법
JP7063486B2 (ja) 2017-03-10 2022-05-09 ボルト スレッズ インコーポレイテッド 高分泌収量の組み換えタンパク質を産生するための組成物及び方法
KR20250016476A (ko) * 2018-03-16 2025-02-03 젠자임 코포레이션 생산용 생물 반응기에서의 세포 생존력을 개선하는 방법
US10221403B1 (en) * 2018-04-25 2019-03-05 Life Rainbow Biotech Co., Ltd. Method of preparing zearalenone hydrolase
CN108546637A (zh) * 2018-05-23 2018-09-18 华东理工大学 重组毕赤酵母表达葡萄糖氧化酶发酵装置以及发酵培养方法
EP3821022A1 (en) * 2018-07-12 2021-05-19 Amyris, Inc. Methods for controlling fermentation feed rates
CA3146649A1 (en) 2019-07-11 2021-01-14 Clara Foods Co. Protein compositions and consumable products thereof
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
WO2021092356A1 (en) * 2019-11-08 2021-05-14 Danisco Us Inc Fungal strains comprising enhanced protein productivity phenotypes and methods thereof
US20230074785A1 (en) * 2020-01-14 2023-03-09 Basf Se Method For Producing Recombinant Protein In Yeast Cells
US20250207158A1 (en) * 2022-03-24 2025-06-26 Versalis S.P.A. Fermentation process for the production of lipids from oleaginous yeasts
WO2024073755A2 (en) * 2022-09-29 2024-04-04 Antheia, Inc. Methods of improving production of morphinan alkaloids and derivatives

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US20090162343A1 (en) * 2007-12-04 2009-06-25 Franano F Nicholas Recombinant elastase proteins and methods of manufacturing and use thereof

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Publication number Publication date
EP3597664B1 (en) 2025-11-26
EP2971037A4 (en) 2016-07-20
IL241176B (en) 2020-05-31
MX384491B (es) 2025-03-14
KR20150140678A (ko) 2015-12-16
CN105121652B (zh) 2020-07-28
TW201512401A (zh) 2015-04-01
EP2971037A1 (en) 2016-01-20
ES2749751T3 (es) 2020-03-23
KR102202477B1 (ko) 2021-01-13
NZ711400A (en) 2021-05-28
AU2014232813A1 (en) 2015-09-03
US20190119360A1 (en) 2019-04-25
ZA201505483B (en) 2022-08-31
CN105121652A (zh) 2015-12-02
SG11201506034TA (en) 2015-09-29
US10138294B2 (en) 2018-11-27
DK2971037T3 (da) 2019-10-14
EP2971037B1 (en) 2019-07-10
US11447540B2 (en) 2022-09-20
TWI636136B (zh) 2018-09-21
EP3597664A2 (en) 2020-01-22
MX2015011968A (es) 2017-01-06
CA2905180C (en) 2023-03-07
JP6412552B2 (ja) 2018-10-24
MX366647B (es) 2019-07-17
CA2905180A1 (en) 2014-09-18
MX2019008417A (es) 2019-09-13
US20160039911A1 (en) 2016-02-11
IL241176A0 (en) 2015-11-30
EP3597664A3 (en) 2020-03-11
JP2016516412A (ja) 2016-06-09
WO2014145650A1 (en) 2014-09-18

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Owner name: LUNDBECK SEATTLE BIOPHARMACEUTICALS, INC

Free format text: FORMER NAME(S): ALDER BIOPHARMACEUTICALS, INC.

PC Assignment registered

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Free format text: FORMER OWNER(S): LUNDBECK SEATTLE BIOPHARMACEUTICALS, INC