DK2971037T3 - Temperaturændring til ekspression med højt udbytte af polypeptider i gær og andre transformerede celler - Google Patents
Temperaturændring til ekspression med højt udbytte af polypeptider i gær og andre transformerede cellerInfo
- Publication number
- DK2971037T3 DK2971037T3 DK14764393.6T DK14764393T DK2971037T3 DK 2971037 T3 DK2971037 T3 DK 2971037T3 DK 14764393 T DK14764393 T DK 14764393T DK 2971037 T3 DK2971037 T3 DK 2971037T3
- Authority
- DK
- Denmark
- Prior art keywords
- yester
- polypeptides
- expression
- modification
- temperature
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Analytical Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361790613P | 2013-03-15 | 2013-03-15 | |
| US201361791471P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/030453 WO2014145650A1 (en) | 2013-03-15 | 2014-03-17 | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2971037T3 true DK2971037T3 (da) | 2019-10-14 |
Family
ID=51538058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14764393.6T DK2971037T3 (da) | 2013-03-15 | 2014-03-17 | Temperaturændring til ekspression med højt udbytte af polypeptider i gær og andre transformerede celler |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10138294B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3597664B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6412552B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102202477B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN105121652B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014232813B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2905180C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2971037T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2749751T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL241176B (cg-RX-API-DMAC7.html) |
| MX (2) | MX366647B (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201506034TA (cg-RX-API-DMAC7.html) |
| TW (1) | TWI636136B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014145650A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201505483B (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10202630B2 (en) * | 2013-03-15 | 2019-02-12 | Alderbio Holdings Llc | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| CN111973740A (zh) | 2014-03-21 | 2020-11-24 | 泰华制药国际有限公司 | 针对降钙素基因相关肽的拮抗剂抗体及其使用方法 |
| US11518797B2 (en) | 2014-11-11 | 2022-12-06 | Clara Foods Co. | Methods and compositions for egg white protein production |
| JP2017045865A (ja) | 2015-08-26 | 2017-03-02 | ルネサスエレクトロニクス株式会社 | 半導体装置およびその製造方法 |
| CN106191181B (zh) | 2016-07-22 | 2019-12-13 | 江苏江山聚源生物技术有限公司 | 一种毕赤酵母表达重组蛋白的发酵工艺 |
| CN109952314A (zh) | 2016-09-23 | 2019-06-28 | 泰瓦制药国际有限公司 | 治疗难治性偏头痛 |
| KR102638074B1 (ko) | 2017-03-10 | 2024-02-20 | 볼트 쓰레즈, 인크. | 재조합 단백질을 고분비 수율로 생산하기 위한 조성물 및 방법 |
| JP7063486B2 (ja) | 2017-03-10 | 2022-05-09 | ボルト スレッズ インコーポレイテッド | 高分泌収量の組み換えタンパク質を産生するための組成物及び方法 |
| KR20250016476A (ko) * | 2018-03-16 | 2025-02-03 | 젠자임 코포레이션 | 생산용 생물 반응기에서의 세포 생존력을 개선하는 방법 |
| US10221403B1 (en) * | 2018-04-25 | 2019-03-05 | Life Rainbow Biotech Co., Ltd. | Method of preparing zearalenone hydrolase |
| CN108546637A (zh) * | 2018-05-23 | 2018-09-18 | 华东理工大学 | 重组毕赤酵母表达葡萄糖氧化酶发酵装置以及发酵培养方法 |
| EP3821022A1 (en) * | 2018-07-12 | 2021-05-19 | Amyris, Inc. | Methods for controlling fermentation feed rates |
| CA3146649A1 (en) | 2019-07-11 | 2021-01-14 | Clara Foods Co. | Protein compositions and consumable products thereof |
| US12096784B2 (en) | 2019-07-11 | 2024-09-24 | Clara Foods Co. | Protein compositions and consumable products thereof |
| US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
| WO2021092356A1 (en) * | 2019-11-08 | 2021-05-14 | Danisco Us Inc | Fungal strains comprising enhanced protein productivity phenotypes and methods thereof |
| US20230074785A1 (en) * | 2020-01-14 | 2023-03-09 | Basf Se | Method For Producing Recombinant Protein In Yeast Cells |
| US20250207158A1 (en) * | 2022-03-24 | 2025-06-26 | Versalis S.P.A. | Fermentation process for the production of lipids from oleaginous yeasts |
| WO2024073755A2 (en) * | 2022-09-29 | 2024-04-04 | Antheia, Inc. | Methods of improving production of morphinan alkaloids and derivatives |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855231A (en) | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
| US4818700A (en) | 1985-10-25 | 1989-04-04 | Phillips Petroleum Company | Pichia pastoris argininosuccinate lyase gene and uses thereof |
| US4812405A (en) | 1986-02-18 | 1989-03-14 | Phillips Petroleum Company | Double auxotrophic mutants of Pichia pastoris and methods for preparation |
| US4929555A (en) | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
| WO1994021293A1 (en) | 1993-03-19 | 1994-09-29 | Duke University | Method of treatment of tumors with an antibody binding to tenascin |
| ATE306930T1 (de) | 1994-08-12 | 2005-11-15 | Immunomedics Inc | Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper |
| US5955349A (en) | 1996-08-26 | 1999-09-21 | Zymogenetics, Inc. | Compositions and methods for producing heterologous polypeptides in Pichia methanolica |
| US5736383A (en) | 1996-08-26 | 1998-04-07 | Zymogenetics, Inc. | Preparation of Pichia methanolica auxotrophic mutants |
| US6730499B1 (en) | 1998-07-03 | 2004-05-04 | Research Corporation Technologies, Inc. | Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1 |
| US6258559B1 (en) | 1999-03-22 | 2001-07-10 | Zymogenetics, Inc. | Method for producing proteins in transformed Pichia |
| US6221630B1 (en) * | 1999-03-24 | 2001-04-24 | The Penn State Research Foundation | High copy number recombinant expression construct for regulated high-level production of polypeptides in yeast |
| NZ547279A (en) | 2003-10-22 | 2008-04-30 | Keck Graduate Inst | Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy |
| EP2021463B1 (en) | 2006-05-19 | 2016-11-23 | Alder Biopharmaceuticals, Inc. | Culture method for obtaining a clonal population of antigen-specific b cells |
| CN105001332B (zh) | 2007-05-21 | 2018-12-04 | 奥尔德生物控股有限责任公司 | 针对il-6的抗体及其用途 |
| EP2162469A4 (en) | 2007-05-21 | 2012-08-01 | Alderbio Holdings Llc | NEW METHODS OF HUMANIZING RABBIT ANTIBODIES AND HUMANIZED RABBIT ANTIBODIES |
| US20090269832A1 (en) * | 2007-11-05 | 2009-10-29 | Modular Genetics, Inc. | Growth of Microorganisms in Media Containing Crude Glycerol |
| US8501449B2 (en) * | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
| WO2011075686A2 (en) * | 2009-12-18 | 2011-06-23 | Ventria Bioscience | Methods & compositions comprising heat shock proteins |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| EP2744903B1 (en) * | 2011-08-19 | 2018-10-10 | AlderBio Holdings LLC | Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as a antibodies in transformed microbes such as pichia pastoris |
| US10150968B2 (en) | 2011-08-19 | 2018-12-11 | Alderbio Holdings Llc | Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| WO2014145521A2 (en) * | 2013-03-15 | 2014-09-18 | Alderbio Holdings Llc | Fermentation process for antibody production |
| US10202630B2 (en) * | 2013-03-15 | 2019-02-12 | Alderbio Holdings Llc | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
-
2014
- 2014-03-17 MX MX2015011968A patent/MX366647B/es active IP Right Grant
- 2014-03-17 EP EP19177519.6A patent/EP3597664B1/en active Active
- 2014-03-17 MX MX2019008417A patent/MX384491B/es unknown
- 2014-03-17 US US14/776,892 patent/US10138294B2/en active Active
- 2014-03-17 DK DK14764393.6T patent/DK2971037T3/da active
- 2014-03-17 JP JP2016503404A patent/JP6412552B2/ja active Active
- 2014-03-17 EP EP14764393.6A patent/EP2971037B1/en active Active
- 2014-03-17 CN CN201480014647.8A patent/CN105121652B/zh active Active
- 2014-03-17 KR KR1020157028401A patent/KR102202477B1/ko active Active
- 2014-03-17 SG SG11201506034TA patent/SG11201506034TA/en unknown
- 2014-03-17 WO PCT/US2014/030453 patent/WO2014145650A1/en not_active Ceased
- 2014-03-17 CA CA2905180A patent/CA2905180C/en active Active
- 2014-03-17 AU AU2014232813A patent/AU2014232813B2/en active Active
- 2014-03-17 TW TW103109931A patent/TWI636136B/zh active
- 2014-03-17 ES ES14764393T patent/ES2749751T3/es active Active
-
2015
- 2015-07-30 ZA ZA2015/05483A patent/ZA201505483B/en unknown
- 2015-09-03 IL IL241176A patent/IL241176B/en active IP Right Grant
-
2018
- 2018-10-24 US US16/169,130 patent/US11447540B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3597664B1 (en) | 2025-11-26 |
| EP2971037A4 (en) | 2016-07-20 |
| IL241176B (en) | 2020-05-31 |
| AU2014232813B2 (en) | 2017-12-07 |
| MX384491B (es) | 2025-03-14 |
| KR20150140678A (ko) | 2015-12-16 |
| CN105121652B (zh) | 2020-07-28 |
| TW201512401A (zh) | 2015-04-01 |
| EP2971037A1 (en) | 2016-01-20 |
| ES2749751T3 (es) | 2020-03-23 |
| KR102202477B1 (ko) | 2021-01-13 |
| NZ711400A (en) | 2021-05-28 |
| AU2014232813A1 (en) | 2015-09-03 |
| US20190119360A1 (en) | 2019-04-25 |
| ZA201505483B (en) | 2022-08-31 |
| CN105121652A (zh) | 2015-12-02 |
| SG11201506034TA (en) | 2015-09-29 |
| US10138294B2 (en) | 2018-11-27 |
| EP2971037B1 (en) | 2019-07-10 |
| US11447540B2 (en) | 2022-09-20 |
| TWI636136B (zh) | 2018-09-21 |
| EP3597664A2 (en) | 2020-01-22 |
| MX2015011968A (es) | 2017-01-06 |
| CA2905180C (en) | 2023-03-07 |
| JP6412552B2 (ja) | 2018-10-24 |
| MX366647B (es) | 2019-07-17 |
| CA2905180A1 (en) | 2014-09-18 |
| MX2019008417A (es) | 2019-09-13 |
| US20160039911A1 (en) | 2016-02-11 |
| IL241176A0 (en) | 2015-11-30 |
| EP3597664A3 (en) | 2020-03-11 |
| JP2016516412A (ja) | 2016-06-09 |
| WO2014145650A1 (en) | 2014-09-18 |
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