IL240753B - Methods for purifying antibodies - Google Patents

Methods for purifying antibodies

Info

Publication number
IL240753B
IL240753B IL240753A IL24075315A IL240753B IL 240753 B IL240753 B IL 240753B IL 240753 A IL240753 A IL 240753A IL 24075315 A IL24075315 A IL 24075315A IL 240753 B IL240753 B IL 240753B
Authority
IL
Israel
Prior art keywords
purification methods
antibody purification
antibody
methods
purification
Prior art date
Application number
IL240753A
Other languages
English (en)
Hebrew (he)
Other versions
IL240753A0 (en
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50391244&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL240753(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip No 2 Ltd, Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of IL240753A0 publication Critical patent/IL240753A0/en
Publication of IL240753B publication Critical patent/IL240753B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL240753A 2013-03-15 2015-08-23 Methods for purifying antibodies IL240753B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361787309P 2013-03-15 2013-03-15
PCT/IB2014/059755 WO2014141150A1 (en) 2013-03-15 2014-03-13 Methods for purifying antibodies

Publications (2)

Publication Number Publication Date
IL240753A0 IL240753A0 (en) 2015-10-29
IL240753B true IL240753B (en) 2021-01-31

Family

ID=50391244

Family Applications (1)

Application Number Title Priority Date Filing Date
IL240753A IL240753B (en) 2013-03-15 2015-08-23 Methods for purifying antibodies

Country Status (15)

Country Link
US (3) US10676503B2 (enExample)
EP (3) EP4371996A3 (enExample)
JP (2) JP6599773B2 (enExample)
KR (1) KR102114021B1 (enExample)
CN (1) CN105188872B (enExample)
AU (1) AU2014229280B2 (enExample)
BR (1) BR112015022321A2 (enExample)
CA (1) CA2902287A1 (enExample)
DK (2) DK3680000T3 (enExample)
ES (2) ES2765206T3 (enExample)
IL (1) IL240753B (enExample)
RU (1) RU2651483C2 (enExample)
SG (1) SG11201506494XA (enExample)
TW (1) TWI625335B (enExample)
WO (1) WO2014141150A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4371996A3 (en) 2013-03-15 2024-08-14 GlaxoSmithKline Intellectual Property Development Limited Methods for purifying antibodies
US10259842B2 (en) 2013-05-15 2019-04-16 Medimmune, Llc Purification of recombinantly produced polypeptides
ES2975172T1 (es) 2014-04-30 2024-07-03 Novo Nordisk As Métodos para la purificación de proteínas usando ácido caprílico
JP6663360B2 (ja) 2015-01-26 2020-03-11 株式会社カネカ 変異型免疫グロブリンκ鎖可変領域結合性ペプチド
JPWO2016121701A1 (ja) 2015-01-26 2017-11-09 株式会社カネカ 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス
WO2017195638A1 (ja) * 2016-05-09 2017-11-16 株式会社カネカ 抗体またはκ鎖可変領域含有抗体断片の精製方法
RU2759909C2 (ru) * 2016-09-07 2021-11-18 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Способы очистки антител
CN106939045B (zh) * 2017-05-01 2020-03-31 深圳市国创纳米抗体技术有限公司 一种单克隆抗体细胞培养液澄清的方法
CN108085358A (zh) * 2018-02-08 2018-05-29 保定冀中药业有限公司 一种犬细小病毒单克隆抗体IgG2b-Fab片段的制备方法
TW202000891A (zh) 2018-03-07 2020-01-01 英商葛蘭素史克智慧財產發展有限公司 純化抗體之方法
TW202003555A (zh) * 2018-03-07 2020-01-16 英商葛蘭素史克智慧財產發展有限公司 用於純化重組多肽之方法
CN116234619B (zh) * 2020-08-18 2026-07-21 赛多利斯比亚分离有限责任公司 宿主细胞dna的金属亲和提取
CN114133446A (zh) * 2021-12-31 2022-03-04 方坦思(上海)生物医药有限公司 单克隆抗体的纯化方法
CN116179582A (zh) * 2022-09-27 2023-05-30 南京医事达生物科技有限公司 一种通用型基因重组蛋白质a亲和纯化填料制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005082937A2 (en) * 2004-02-27 2005-09-09 Octapharma Ag A method of providing a purified, virus safe antibody preparation
WO2007109163A2 (en) * 2006-03-16 2007-09-27 Amgen Inc Wash buffer and method of using

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106673A (en) 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US6955917B2 (en) 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
ATE515950T1 (de) * 2001-06-01 2011-07-15 Upfront Chromatography As Fraktionierung von proteinhaltigen mischungen
AU2002319544B2 (en) 2001-08-10 2008-07-10 Aberdeen University Antigen binding domains from fish
WO2003102208A2 (en) 2002-05-31 2003-12-11 Indian Council Of Agricultural Research Rapid detection of bt-cry toxins
US20050272917A1 (en) * 2004-05-14 2005-12-08 Hematech, Llc Methods for immunoglobulin purification
TW200821026A (en) 2006-09-08 2008-05-16 Wyeth Corp Arginine wash in protein purification using affinity chromatography
WO2008085988A1 (en) * 2007-01-05 2008-07-17 Amgen Inc. Methods of purifying proteins
EP2691411B1 (en) 2011-03-29 2020-02-26 GlaxoSmithKline LLC Buffer system for protein purification
EP4371996A3 (en) 2013-03-15 2024-08-14 GlaxoSmithKline Intellectual Property Development Limited Methods for purifying antibodies
US10259842B2 (en) * 2013-05-15 2019-04-16 Medimmune, Llc Purification of recombinantly produced polypeptides
SG11201601823TA (en) 2013-09-13 2016-04-28 Genentech Inc Methods and compositions comprising purified recombinant polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005082937A2 (en) * 2004-02-27 2005-09-09 Octapharma Ag A method of providing a purified, virus safe antibody preparation
WO2007109163A2 (en) * 2006-03-16 2007-09-27 Amgen Inc Wash buffer and method of using

Also Published As

Publication number Publication date
EP3680000A1 (en) 2020-07-15
ES2765206T3 (es) 2020-06-08
DK2969098T3 (da) 2020-01-27
EP2969098B1 (en) 2019-10-30
AU2014229280A1 (en) 2015-10-01
TW201522365A (zh) 2015-06-16
AU2014229280B2 (en) 2017-01-05
US20250353878A1 (en) 2025-11-20
JP2016519052A (ja) 2016-06-30
EP4371996A3 (en) 2024-08-14
JP2020019795A (ja) 2020-02-06
BR112015022321A2 (pt) 2017-07-18
WO2014141150A1 (en) 2014-09-18
US10676503B2 (en) 2020-06-09
KR20150131235A (ko) 2015-11-24
JP6599773B2 (ja) 2019-10-30
US12358945B2 (en) 2025-07-15
ES2978309T3 (es) 2024-09-10
US20160024146A1 (en) 2016-01-28
RU2015136860A (ru) 2017-04-28
KR102114021B1 (ko) 2020-05-22
CN105188872A (zh) 2015-12-23
TWI625335B (zh) 2018-06-01
CN105188872B (zh) 2019-01-15
JP7002511B2 (ja) 2022-02-21
EP3680000B1 (en) 2024-03-13
CA2902287A1 (en) 2014-09-18
EP4371996A2 (en) 2024-05-22
DK3680000T3 (da) 2024-04-02
SG11201506494XA (en) 2015-09-29
RU2651483C2 (ru) 2018-04-19
EP2969098A1 (en) 2016-01-20
IL240753A0 (en) 2015-10-29
US20200277330A1 (en) 2020-09-03

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