ES2975172T1 - Métodos para la purificación de proteínas usando ácido caprílico - Google Patents

Métodos para la purificación de proteínas usando ácido caprílico

Info

Publication number
ES2975172T1
ES2975172T1 ES22197320T ES22197320T ES2975172T1 ES 2975172 T1 ES2975172 T1 ES 2975172T1 ES 22197320 T ES22197320 T ES 22197320T ES 22197320 T ES22197320 T ES 22197320T ES 2975172 T1 ES2975172 T1 ES 2975172T1
Authority
ES
Spain
Prior art keywords
methods
protein purification
caprylic acid
caprylic
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES22197320T
Other languages
English (en)
Inventor
Ole Elvang Jensen
Per Kaersgaard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50679865&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2975172(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of ES2975172T1 publication Critical patent/ES2975172T1/es
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES22197320T 2014-04-30 2015-04-30 Métodos para la purificación de proteínas usando ácido caprílico Pending ES2975172T1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14166535 2014-04-30

Publications (1)

Publication Number Publication Date
ES2975172T1 true ES2975172T1 (es) 2024-07-03

Family

ID=50679865

Family Applications (2)

Application Number Title Priority Date Filing Date
ES15722478T Active ES2857582T3 (es) 2014-04-30 2015-04-30 Métodos para la purificación de proteínas mediante el uso de ácido caprílico
ES22197320T Pending ES2975172T1 (es) 2014-04-30 2015-04-30 Métodos para la purificación de proteínas usando ácido caprílico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES15722478T Active ES2857582T3 (es) 2014-04-30 2015-04-30 Métodos para la purificación de proteínas mediante el uso de ácido caprílico

Country Status (7)

Country Link
US (2) US20170044210A1 (es)
EP (3) EP4147761A1 (es)
JP (3) JP6700197B2 (es)
CN (1) CN106459142B (es)
DE (1) DE22197320T1 (es)
ES (2) ES2857582T3 (es)
WO (1) WO2015166072A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014186350A1 (en) * 2013-05-15 2014-11-20 Medimmune Limited Purification of recombinantly produced polypeptides
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
CN109311949B (zh) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 储存分离基质的方法
ES2874974T3 (es) 2016-05-11 2021-11-05 Cytiva Bioprocess R & D Ab Matriz de separación
US11753438B2 (en) 2016-05-11 2023-09-12 Cytiva Bioprocess R&D Ab Method of cleaning and/or sanitizing a separation matrix
AU2016231646B2 (en) * 2016-09-26 2021-04-08 Instituto Grifols, S.A. Method for the preparation of immunoglobulins
CN109134648A (zh) * 2018-09-14 2019-01-04 武汉伊莱瑞特生物科技股份有限公司 一种抗体纯化方法
CN112409477B (zh) * 2019-08-21 2022-11-08 广东菲鹏生物有限公司 IgM纯化方法
CN111991571B (zh) * 2020-08-12 2022-04-05 湖州师范学院 一种柱上低pH病毒灭活的方法
CN115873810B (zh) * 2022-12-26 2024-02-09 苏州良辰生物医药科技有限公司 一种鼠白血病病毒的纯化方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4534972A (en) 1983-03-29 1985-08-13 Miles Laboratories, Inc. Protein compositions substantially free from infectious agents
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4939176A (en) 1988-12-20 1990-07-03 Miles Inc. Viral inactivation process
JP2658358B2 (ja) * 1989-02-14 1997-09-30 松下電器産業株式会社 発光半導体装置
DE59009020D1 (de) 1990-03-22 1995-06-08 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verträglichen Immunglobulin-G-Präparates.
US5728553A (en) * 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
US5886154A (en) * 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
EP1584242B1 (en) 2001-06-01 2010-01-20 Upfront Chromatography A/S Fractionation of protein containing mixtures
EP1506810A1 (en) * 2003-08-11 2005-02-16 Boehringer Ingelheim Pharma GmbH & Co.KG Regeneration of hydrolysis sensitive adsorbent matrices
BRPI0507298A (pt) * 2004-01-30 2007-07-03 Suomen Punainen Risti Veripalv processo para a produção de imunoglobulina segura a vìrus
BRPI0508096B8 (pt) * 2004-02-27 2021-05-25 Octapharma Ag método de preparação de um preparado de anticorpo seguro purificado contra vírus e vírus inativado
UA85733C2 (ru) 2007-02-14 2009-02-25 Костянтин Васильевич Курищук Способ инактивации вирусов при получении церулоплазмина
US20100111853A1 (en) * 2008-10-20 2010-05-06 Abbott Laboratories, Inc. Antibodies that bind to il-12 and methods of purifying the same
CA2738499A1 (en) * 2008-10-20 2010-04-29 Abbott Laboratories Viral inactivation during purification of antibodies
FR2977893B1 (fr) * 2011-07-11 2015-02-20 Lab Francais Du Fractionnement Procede de preparation d'un concentre d'immunoglobulines polyvalentes
EP2578286A1 (en) 2011-10-04 2013-04-10 Merck Patent GmbH Method and apparatus for chromatographic purification
AU2013205138B2 (en) * 2012-08-09 2015-06-25 Grifols, S.A. Caprylate Viral Deactivation
TWI625335B (zh) 2013-03-15 2018-06-01 Glaxosmithkline Intellectual Property (No. 2) Limited 純化抗體的方法
WO2014186350A1 (en) 2013-05-15 2014-11-20 Medimmune Limited Purification of recombinantly produced polypeptides

Also Published As

Publication number Publication date
JP7414874B2 (ja) 2024-01-16
CN106459142A (zh) 2017-02-22
JP2017514826A (ja) 2017-06-08
JP7094322B2 (ja) 2022-07-01
CN106459142B (zh) 2021-07-13
EP4147761A1 (en) 2023-03-15
JP6700197B2 (ja) 2020-05-27
JP2022069571A (ja) 2022-05-11
ES2857582T3 (es) 2021-09-29
EP3842108A1 (en) 2021-06-30
DE22197320T1 (de) 2024-05-29
WO2015166072A1 (en) 2015-11-05
EP3137186B1 (en) 2021-01-27
EP3137186A1 (en) 2017-03-08
US20170044210A1 (en) 2017-02-16
US20220324906A1 (en) 2022-10-13
JP2020114879A (ja) 2020-07-30

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