IL230126A - Propionic acid derivatives converted to heteroarylamino in position 3 and their use as pharmaceuticals - Google Patents
Propionic acid derivatives converted to heteroarylamino in position 3 and their use as pharmaceuticalsInfo
- Publication number
- IL230126A IL230126A IL230126A IL23012613A IL230126A IL 230126 A IL230126 A IL 230126A IL 230126 A IL230126 A IL 230126A IL 23012613 A IL23012613 A IL 23012613A IL 230126 A IL230126 A IL 230126A
- Authority
- IL
- Israel
- Prior art keywords
- heteroaroylamino
- pharmaceuticals
- propionic acid
- acid derivatives
- derivatives
- Prior art date
Links
Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Diabetes (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11305971 | 2011-07-26 | ||
PCT/EP2012/064628 WO2013014204A2 (en) | 2011-07-26 | 2012-07-25 | 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals |
Publications (2)
Publication Number | Publication Date |
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IL230126A0 IL230126A0 (en) | 2014-03-06 |
IL230126A true IL230126A (en) | 2017-02-28 |
Family
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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IL230126A IL230126A (en) | 2011-07-26 | 2013-12-23 | Propionic acid derivatives converted to heteroarylamino in position 3 and their use as pharmaceuticals |
IL250370A IL250370A0 (en) | 2011-07-26 | 2017-01-31 | Propionic acid derivatives substituted with heteroaroylamino in position 3 and their use as pharmaceuticals |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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IL250370A IL250370A0 (en) | 2011-07-26 | 2017-01-31 | Propionic acid derivatives substituted with heteroaroylamino in position 3 and their use as pharmaceuticals |
Country Status (22)
Country | Link |
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US (2) | US9353068B2 (zh) |
EP (2) | EP3037417B1 (zh) |
JP (2) | JP6021910B2 (zh) |
KR (1) | KR20140049019A (zh) |
CN (2) | CN105646362B (zh) |
AU (2) | AU2012288842A1 (zh) |
BR (1) | BR112014001518A2 (zh) |
CA (1) | CA2841905A1 (zh) |
CY (1) | CY1117397T1 (zh) |
DK (1) | DK2736888T3 (zh) |
ES (1) | ES2560381T3 (zh) |
HK (2) | HK1192559A1 (zh) |
HR (1) | HRP20160047T1 (zh) |
HU (1) | HUE028418T2 (zh) |
IL (2) | IL230126A (zh) |
MX (1) | MX337173B (zh) |
MY (1) | MY169319A (zh) |
PL (1) | PL2736888T3 (zh) |
PT (1) | PT2736888E (zh) |
RU (1) | RU2014107000A (zh) |
SI (1) | SI2736888T1 (zh) |
WO (1) | WO2013014204A2 (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2841905A1 (en) | 2011-07-26 | 2013-01-31 | Sanofi | 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals |
BR112014001587A2 (pt) * | 2011-07-26 | 2017-02-14 | Sanofi Sa | derivados de ácido 3-(tiazol-4-carbonil)- ou 3-(tiazol-2-carbonil) amino-propiônico substituídos e seu uso como produtos farmacêuticos |
UA117913C2 (uk) | 2012-05-31 | 2018-10-25 | Фінекс Фармас'Ютікалс Аг | КАРБОКСАМІД- АБО СУЛЬФОНАМІДЗАМІЩЕНІ ТІАЗОЛИ ТА СПОРІДНЕНІ ПОХІДНІ ЯК МОДУЛЯТОРИ ОРФАНОВОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ |
JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
WO2014053533A1 (en) | 2012-10-05 | 2014-04-10 | Sanofi | Use of substituted 3-heteroaroylamino-propionic acid derivatives as pharmaceuticals for prevention/treatment of atrial fibrillation |
JP6359634B2 (ja) | 2013-03-28 | 2018-07-18 | サノフイ | ビアリール−プロピオン酸誘導体および医薬品としてのその使用 |
TW201522318A (zh) | 2013-03-28 | 2015-06-16 | Sanofi Sa | 聯芳基丙酸及其作為醫藥品之用途 |
US10377718B2 (en) * | 2014-06-06 | 2019-08-13 | Research Triangle Institute | Apelin receptor (APJ) agonists and uses thereof |
EP3386976A1 (en) | 2015-12-09 | 2018-10-17 | Research Triangle Institute, International | Improved apelin receptor (apj) agonists and uses thereof |
AU2017343638B2 (en) * | 2016-10-12 | 2021-12-09 | Research Triangle Institute | Heterocyclic apelin receptor (APJ) agonists and uses thereof |
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US6080767A (en) * | 1996-01-02 | 2000-06-27 | Aventis Pharmaceuticals Products Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
PE32799A1 (es) * | 1996-12-25 | 1999-04-09 | Agrogene Ltd | Nuevo derivado del acido aminobutirico para la proteccion de enfermedades fungosas |
JP4555468B2 (ja) * | 1997-10-31 | 2010-09-29 | アベンテイス・フアルマ・リミテツド | 置換アニリド |
US6468977B1 (en) * | 1998-03-02 | 2002-10-22 | Apotex Inc. | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes |
TR200100631T2 (tr) * | 1998-08-20 | 2002-08-21 | Agouron Pharmaceuticals,Inc. | Peptit-olmayan GnRH maddeleri |
DE19858191A1 (de) * | 1998-12-17 | 2000-06-21 | Aventis Cropscience Gmbh | 4-Haloalkyl-3-heterocyclylpyridine und 4-Haloalkyl-5-heterocyclyl-pyrimidine und ihre Verwendung als Repellentien |
US6462076B2 (en) | 2000-06-14 | 2002-10-08 | Hoffmann-La Roche Inc. | Beta-amino acid nitrile derivatives as cathepsin K inhibitors |
JP2002326980A (ja) * | 2001-04-27 | 2002-11-15 | Nippon Nohyaku Co Ltd | ジアミド誘導体及び農園芸用薬剤並びにその使用方法 |
WO2003048123A1 (en) * | 2001-12-04 | 2003-06-12 | F. Hoffmann-La Roche Ag | Substituted 2-amino-cycloalkanecarboxamides and their use as cysteine protease inhibitors |
US20040072802A1 (en) | 2002-10-09 | 2004-04-15 | Jingwu Duan | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
MXPA05006200A (es) | 2002-12-23 | 2005-08-19 | Aventis Pharma Gmbh | Derivados de pirazol como inhibidores del factor xa. |
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EP1493740A1 (fr) * | 2003-07-03 | 2005-01-05 | Warner-Lambert Company LLC | Dérivés de 5-fluoro-thiophene, leur procédé de preparation, les compositions pharmaceutiques les contenant et leur utilisation comme inhibiteurs de métalloprotéinases |
EP1493739A1 (fr) * | 2003-07-03 | 2005-01-05 | Warner-Lambert Company LLC | Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
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JP2005145839A (ja) | 2003-11-12 | 2005-06-09 | Japan Science & Technology Agency | 新規なカテプシンa阻害剤 |
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CA2841905A1 (en) | 2011-07-26 | 2013-01-31 | Sanofi | 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals |
-
2012
- 2012-07-25 CA CA2841905A patent/CA2841905A1/en not_active Abandoned
- 2012-07-25 EP EP15190731.8A patent/EP3037417B1/en not_active Not-in-force
- 2012-07-25 SI SI201230439T patent/SI2736888T1/sl unknown
- 2012-07-25 KR KR1020147004756A patent/KR20140049019A/ko not_active Application Discontinuation
- 2012-07-25 CN CN201511021647.3A patent/CN105646362B/zh not_active Expired - Fee Related
- 2012-07-25 BR BR112014001518A patent/BR112014001518A2/pt not_active IP Right Cessation
- 2012-07-25 WO PCT/EP2012/064628 patent/WO2013014204A2/en active Application Filing
- 2012-07-25 PL PL12738473T patent/PL2736888T3/pl unknown
- 2012-07-25 PT PT127384733T patent/PT2736888E/pt unknown
- 2012-07-25 HU HUE12738473A patent/HUE028418T2/en unknown
- 2012-07-25 ES ES12738473.3T patent/ES2560381T3/es active Active
- 2012-07-25 JP JP2014522086A patent/JP6021910B2/ja not_active Expired - Fee Related
- 2012-07-25 EP EP12738473.3A patent/EP2736888B1/en not_active Not-in-force
- 2012-07-25 CN CN201280046863.1A patent/CN103827097B/zh not_active Expired - Fee Related
- 2012-07-25 DK DK12738473.3T patent/DK2736888T3/da active
- 2012-07-25 MX MX2014000598A patent/MX337173B/es active IP Right Grant
- 2012-07-25 RU RU2014107000/04A patent/RU2014107000A/ru not_active Application Discontinuation
- 2012-07-25 MY MYPI2013004643A patent/MY169319A/en unknown
- 2012-07-25 AU AU2012288842A patent/AU2012288842A1/en not_active Abandoned
- 2012-07-26 US US13/559,401 patent/US9353068B2/en not_active Expired - Fee Related
-
2013
- 2013-12-23 IL IL230126A patent/IL230126A/en not_active IP Right Cessation
-
2014
- 2014-06-19 HK HK14105865.5A patent/HK1192559A1/zh not_active IP Right Cessation
-
2016
- 2016-01-15 HR HRP20160047TT patent/HRP20160047T1/hr unknown
- 2016-02-03 CY CY20161100093T patent/CY1117397T1/el unknown
- 2016-04-27 US US15/140,350 patent/US9751858B2/en not_active Expired - Fee Related
- 2016-09-30 JP JP2016192793A patent/JP6360534B2/ja not_active Expired - Fee Related
- 2016-12-06 HK HK16113874A patent/HK1225714A1/zh unknown
-
2017
- 2017-01-31 IL IL250370A patent/IL250370A0/en unknown
- 2017-06-02 AU AU2017203739A patent/AU2017203739A1/en not_active Abandoned
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