IL228231A - Stable Preparation Containing (5-Fluoro-2-Methyl-3-Quinoline-2-Ylmethyl-Indole-1-Il) Amorphous Acetic Acid and Polymer for Use in Medicine and Process for Preparation - Google Patents

Stable Preparation Containing (5-Fluoro-2-Methyl-3-Quinoline-2-Ylmethyl-Indole-1-Il) Amorphous Acetic Acid and Polymer for Use in Medicine and Process for Preparation

Info

Publication number
IL228231A
IL228231A IL228231A IL22823113A IL228231A IL 228231 A IL228231 A IL 228231A IL 228231 A IL228231 A IL 228231A IL 22823113 A IL22823113 A IL 22823113A IL 228231 A IL228231 A IL 228231A
Authority
IL
Israel
Prior art keywords
compound
lot
solvent
spray
solution
Prior art date
Application number
IL228231A
Other languages
English (en)
Hebrew (he)
Inventor
Betancourt Aimesther
Lemieux Marc
Thibert Roch
Original Assignee
Atopix Therapeutics Ltd
Betancourt Aimesther
Lemieux Marc
Thibert Roch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atopix Therapeutics Ltd, Betancourt Aimesther, Lemieux Marc, Thibert Roch filed Critical Atopix Therapeutics Ltd
Publication of IL228231A publication Critical patent/IL228231A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL228231A 2011-03-07 2013-09-01 Stable Preparation Containing (5-Fluoro-2-Methyl-3-Quinoline-2-Ylmethyl-Indole-1-Il) Amorphous Acetic Acid and Polymer for Use in Medicine and Process for Preparation IL228231A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1103837.9A GB201103837D0 (en) 2011-03-07 2011-03-07 Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
PCT/EP2012/052504 WO2012119841A1 (en) 2011-03-07 2012-02-14 Amorphous (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid

Publications (1)

Publication Number Publication Date
IL228231A true IL228231A (en) 2016-08-31

Family

ID=43923311

Family Applications (1)

Application Number Title Priority Date Filing Date
IL228231A IL228231A (en) 2011-03-07 2013-09-01 Stable Preparation Containing (5-Fluoro-2-Methyl-3-Quinoline-2-Ylmethyl-Indole-1-Il) Amorphous Acetic Acid and Polymer for Use in Medicine and Process for Preparation

Country Status (18)

Country Link
US (2) US8703956B2 (pt)
EP (2) EP2697215B1 (pt)
JP (1) JP5932848B2 (pt)
KR (1) KR101907712B1 (pt)
CN (1) CN103502236B (pt)
AU (1) AU2012224809B2 (pt)
BR (1) BR112013022779B1 (pt)
CA (1) CA2829801C (pt)
ES (1) ES2659938T3 (pt)
GB (1) GB201103837D0 (pt)
IL (1) IL228231A (pt)
MX (1) MX346907B (pt)
RU (1) RU2616000C2 (pt)
TR (1) TR201802206T4 (pt)
TW (1) TWI538676B (pt)
UA (1) UA113620C2 (pt)
WO (1) WO2012119841A1 (pt)
ZA (1) ZA201306560B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201103837D0 (en) * 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
GB201121557D0 (en) 2011-12-15 2012-01-25 Oxagen Ltd Process
CN102988297A (zh) * 2012-12-21 2013-03-27 无锡泓兴生物医药科技有限公司 罗氟司特固体分散体及含有其的药物组合物
EP3021836B1 (en) * 2013-07-19 2020-10-07 Siga Technologies Inc. Amorphous tecovirimat preparation
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
US10246508B2 (en) * 2014-03-04 2019-04-02 Chemomab Ltd. Anti eotaxin-2 antibodies that recognize additional CCR3-binding chemokines
CN103830194A (zh) * 2014-03-11 2014-06-04 熊妲妮 茚达特罗固体分散体及含有其的药物组合物
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
JP6618736B2 (ja) * 2015-09-01 2019-12-11 沢井製薬株式会社 ミラベグロン含有錠剤、ミラベグロン含有製剤の製造方法及びミラベグロン含有造粒物の製造方法
CN106176618A (zh) * 2016-09-18 2016-12-07 佛山市弘泰药物研发有限公司 一种罗氟司特固体分散体制剂及其制备方法
CA3059939A1 (en) 2017-04-21 2018-10-25 Kyn Therapeutics Indole ahr inhibitors and uses thereof
CN107693494B (zh) * 2017-08-31 2021-02-09 山东达因海洋生物制药股份有限公司 一种孟鲁司特钠颗粒组合物及其制备方法
IL293326A (en) 2019-11-26 2022-07-01 Ikena Oncology Inc Polymorphic Carbazole History and Uses
CN115279347A (zh) * 2019-11-26 2022-11-01 医肯纳肿瘤学公司 Ahr抑制剂和其用途
CN114432250B (zh) * 2022-02-22 2022-10-04 深圳市泰力生物医药有限公司 一种非晶态夫西地酸的稳定方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1121557A (en) 1965-08-14 1968-07-31 Barsyke Ltd An attachment for a tractor
US6040426A (en) 1996-06-05 2000-03-21 Bml, Inc. Human Th2 specific protein
US6884593B1 (en) 1999-08-23 2005-04-26 Bml, Inc. Method of identifying properties of substance with respect to human prostaglandin D2 receptors
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
JP4783278B2 (ja) 2003-02-03 2011-09-28 ノバルティス アーゲー 医薬製剤
CA2542716A1 (en) 2003-10-14 2005-05-06 Oxagen Limited Compounds having crth2 antagonist activity
GB0324763D0 (en) 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
KR101086254B1 (ko) * 2004-11-04 2011-11-24 에스케이케미칼주식회사 생체이용률이 개선된 프란루카스트 고체분산체 조성물 및그 고체분산체의 제조방법
GB0504150D0 (en) * 2005-03-01 2005-04-06 Oxagen Ltd Microcrystalline material
GB0505048D0 (en) 2005-03-11 2005-04-20 Oxagen Ltd Compounds with PGD antagonist activity
GB0605743D0 (en) 2006-03-22 2006-05-03 Oxagen Ltd Salts with CRTH2 antagonist activity
RU2458918C2 (ru) 2006-07-22 2012-08-20 Оксаген Лимитед Соединения, обладающие антагонистической активностью по отношению к crth2
EP2155166A2 (en) * 2007-05-11 2010-02-24 F. Hoffmann-Roche AG Pharmaceutical compositions for poorly soluble drugs
US20110124683A1 (en) 2007-11-13 2011-05-26 Oxagen Limited Use of CRTH2 Antagonist Compounds
GB0722203D0 (en) 2007-11-13 2007-12-19 Oxagen Ltd Use of CRTH2 antagonist compounds
GB0722216D0 (en) 2007-11-13 2007-12-27 Oxagen Ltd Use of crth2 antagonist compounds
MX2010007833A (es) 2008-01-18 2010-08-11 Oxagen Ltd Compuestos que tienen actividad antagonista de crth2.
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
WO2009093029A1 (en) 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
US20100022613A1 (en) 2008-01-22 2010-01-28 Oxagen Limited Compounds Having CRTH2 Antagonist Activity
WO2009131696A1 (en) * 2008-04-23 2009-10-29 Vertex Pharmaceuticals Incorporated Treatment of hepatitis c virus infections with telaprevir (vx-950) in patients non-responsive to treatment with pegylated interfer0n-alpha-2a/2b and ribavirin
RS55157B2 (sr) * 2008-10-07 2023-10-31 Kudos Pharm Ltd Farmaceutska formulacija 514
US20130052190A1 (en) 2011-02-22 2013-02-28 Oxagen Limited CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions
GB201103837D0 (en) * 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
GB201121557D0 (en) 2011-12-15 2012-01-25 Oxagen Ltd Process
WO2013088109A1 (en) 2011-12-16 2013-06-20 Oxagen Limited Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis

Also Published As

Publication number Publication date
MX2013010245A (es) 2013-12-16
GB201103837D0 (en) 2011-04-20
RU2013140619A (ru) 2015-04-20
AU2012224809A1 (en) 2013-09-19
CA2829801C (en) 2019-07-02
BR112013022779A2 (pt) 2016-12-06
TWI538676B (zh) 2016-06-21
NZ614852A (en) 2015-04-24
CN103502236A (zh) 2014-01-08
WO2012119841A1 (en) 2012-09-13
JP2014507449A (ja) 2014-03-27
US8703956B2 (en) 2014-04-22
EP2697215B1 (en) 2017-11-22
EP3345897A1 (en) 2018-07-11
ZA201306560B (en) 2015-03-25
AU2012224809B2 (en) 2016-11-17
EP2697215A1 (en) 2014-02-19
CA2829801A1 (en) 2012-09-13
TW201309295A (zh) 2013-03-01
CN103502236B (zh) 2016-08-17
RU2616000C2 (ru) 2017-04-12
UA113620C2 (xx) 2017-02-27
BR112013022779B1 (pt) 2021-11-09
KR20140022816A (ko) 2014-02-25
US20120282223A1 (en) 2012-11-08
US8980918B2 (en) 2015-03-17
US20140255340A1 (en) 2014-09-11
TR201802206T4 (tr) 2018-03-21
MX346907B (es) 2017-04-05
ES2659938T3 (es) 2018-03-20
JP5932848B2 (ja) 2016-06-08
KR101907712B1 (ko) 2018-10-12

Similar Documents

Publication Publication Date Title
AU2012224809B2 (en) Amorphous (5-Fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid
ES2284871T3 (es) Composiciones farmaceuticas que contienen una dispersion solida de farmaco poco soluble y un polimero potenciador de la solubilidad.
WO2009063215A2 (en) Use of crth2 antagonist compounds
EP2219645A2 (en) Use of crth2 antagonist compounds
CZ20033456A3 (en) Pharmaceutical compositions comprising adsorbates of amorphous drug
US20110124683A1 (en) Use of CRTH2 Antagonist Compounds
TWI380829B (zh) 具有改良的生物可利用率之普侖斯特（ｐｒａｎｌｕｋａｓｔ）固態分散物組成物及製備該固態分散物之方法
EP3137452B1 (en) Polymorphic form of [5-fluoro-3-({2-[(4-fluorobenzene) sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]-acetic acid
RU2702343C2 (ru) Полиморфная форма [5-фтор-3-({ 2-[(4-фторбензол) сульфонил]пиридин-3-ил} метил)-2-метилиндол-1-ил]-уксусной кислоты
JP6345762B2 (ja) ピペラキンマイクロカプセル及びそれらを含有する組成物
NZ614852B2 (en) Amorphous (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid
WO2015166278A1 (en) Polymorphic form of [5-fluoro-3-({2-[(4-fluorobenzene) sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]-acetic acid

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed