IL225060A - Chanelrodopsin 2 mutant - Google Patents
Chanelrodopsin 2 mutantInfo
- Publication number
- IL225060A IL225060A IL225060A IL22506013A IL225060A IL 225060 A IL225060 A IL 225060A IL 225060 A IL225060 A IL 225060A IL 22506013 A IL22506013 A IL 22506013A IL 225060 A IL225060 A IL 225060A
- Authority
- IL
- Israel
- Prior art keywords
- cell
- light
- cys
- ion channel
- seq
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38079310P | 2010-09-08 | 2010-09-08 | |
| EP10175832 | 2010-09-08 | ||
| PCT/EP2011/065510 WO2012032103A1 (en) | 2010-09-08 | 2011-09-08 | Mutant channelrhodopsin 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL225060A true IL225060A (en) | 2016-10-31 |
Family
ID=42979822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL225060A IL225060A (en) | 2010-09-08 | 2013-03-05 | Chanelrodopsin 2 mutant |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8748578B2 (https=) |
| EP (1) | EP2614079B1 (https=) |
| JP (1) | JP5933556B2 (https=) |
| KR (1) | KR101945962B1 (https=) |
| CN (1) | CN103261219B (https=) |
| AU (1) | AU2011298745B2 (https=) |
| BR (1) | BR112013005634A2 (https=) |
| CA (1) | CA2810757C (https=) |
| DK (1) | DK2614079T3 (https=) |
| ES (1) | ES2545992T3 (https=) |
| HR (1) | HRP20150846T1 (https=) |
| HU (1) | HUE025952T2 (https=) |
| IL (1) | IL225060A (https=) |
| MX (1) | MX347453B (https=) |
| PL (1) | PL2614079T3 (https=) |
| PT (1) | PT2614079E (https=) |
| RU (1) | RU2595384C2 (https=) |
| SG (1) | SG188409A1 (https=) |
| SI (1) | SI2614079T1 (https=) |
| WO (1) | WO2012032103A1 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1919497B1 (en) | 2005-07-22 | 2020-02-12 | The Board of Trustees of the Leland Stanford Junior University | Light-activated cation channel and uses thereof |
| US9238150B2 (en) | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
| US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
| US10052497B2 (en) | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| CN101484005A (zh) | 2006-05-04 | 2009-07-15 | 韦恩州立大学 | 通过向体内递送视紫红质核酸恢复视觉响应 |
| WO2008086470A1 (en) | 2007-01-10 | 2008-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| US8401609B2 (en) | 2007-02-14 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System, method and applications involving identification of biological circuits such as neurological characteristics |
| WO2008106694A2 (en) | 2007-03-01 | 2008-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Systems, methods and compositions for optical stimulation of target cells |
| US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
| US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
| JP5801188B2 (ja) | 2008-04-23 | 2015-10-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 標的細胞を光刺激するためのシステム、方法、および組成物 |
| MY152003A (en) | 2008-05-29 | 2014-08-15 | Univ Leland Stanford Junior | Cell line, system and method for optical control of secondary messengers |
| CA2728238C (en) | 2008-06-17 | 2019-03-12 | M. Bret Schneider | Methods, systems and devices for optical stimulation of target cells using an optical transmission element |
| MY162929A (en) | 2008-06-17 | 2017-07-31 | Univ Leland Stanford Junior | Apparatus and methods for controlling cellular development |
| US9101759B2 (en) | 2008-07-08 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
| NZ602416A (en) | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
| EP2547762B1 (en) | 2010-03-17 | 2018-04-25 | The Board of Trustees of the Leland Stanford Junior University | Light-sensitive ion-passing molecules |
| WO2011140279A1 (en) | 2010-05-04 | 2011-11-10 | Wayne State University | Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells |
| CA2816972C (en) | 2010-11-05 | 2019-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Control and characterization of memory function |
| EP2635111B1 (en) * | 2010-11-05 | 2018-05-23 | The Board of Trustees of the Leland Stanford Junior University | Stabilized step function opsin proteins and methods of using the same |
| WO2012061679A2 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
| CA2816968C (en) | 2010-11-05 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Optically-controlled cns dysfunction |
| WO2012061688A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of reward-related behaviors |
| US9522288B2 (en) | 2010-11-05 | 2016-12-20 | The Board Of Trustees Of The Leland Stanford Junior University | Upconversion of light for use in optogenetic methods |
| US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
| ES2724803T3 (es) | 2011-12-16 | 2019-09-16 | Univ Leland Stanford Junior | Polipéptidos opsinas y métodos de utilización de los mismos |
| CN104363961B (zh) | 2012-02-21 | 2017-10-03 | 斯坦福大学托管董事会 | 用于治疗盆底神经源性病症的组合物和方法 |
| CA2866405A1 (en) | 2012-03-05 | 2013-09-12 | Wayne State University | Identification of channelopsin-2 (chop2) mutations and methods of use |
| US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
| JP6594854B2 (ja) | 2013-03-15 | 2019-10-23 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 行動状態の光遺伝学的制御方法 |
| JP6549559B2 (ja) | 2013-04-29 | 2019-07-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 標的細胞における活動電位の光遺伝学的調節のための装置、システム及び方法 |
| JP6621747B2 (ja) | 2013-08-14 | 2019-12-18 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 疼痛を制御するための組成物及び方法 |
| JP6118239B2 (ja) | 2013-11-29 | 2017-04-19 | 雅敏 堀 | 害虫の防除方法及び防除装置 |
| EP3102290A1 (en) * | 2014-02-07 | 2016-12-14 | Massachusetts Institute Of Technology | Blue light-activated ion channel molecules and uses thereof |
| WO2015142984A1 (en) | 2014-03-18 | 2015-09-24 | Washington University | Methods and compositions for red-shifted chromophore substitution for optogenetic applications |
| WO2015161308A1 (en) * | 2014-04-18 | 2015-10-22 | Massachusetts Institute Of Technology | Mutant channelrhodopsins with altered ion selectivity |
| WO2016209654A1 (en) | 2015-06-22 | 2016-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
| CN109476720A (zh) * | 2016-06-03 | 2019-03-15 | 马克斯-普朗克科学促进协会 | 通道视紫红质的突变型光诱导离子通道 |
| CN109790209B (zh) * | 2016-06-03 | 2022-10-04 | 马克斯-普朗克科学促进协会 | Chrimson的突变型光诱导离子通道 |
| EP3504227A1 (en) | 2016-08-29 | 2019-07-03 | Wayne State University | Identification of mutations in channelopsin variants having improved light sensitivity and methods of use thereof |
| JP6779546B2 (ja) * | 2016-11-06 | 2020-11-04 | ナノスコープ テクノロジーズ エルエルシーＮａｎｏｓｃｏｐｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ | 視力回復のための多特性オプシンによる光遺伝学的調節及びその別の用途 |
| US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
| US20200115419A1 (en) * | 2017-04-12 | 2020-04-16 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | New optogenetic tool |
| CN110483645B (zh) * | 2018-05-14 | 2023-05-12 | 郑州大学第一附属医院 | 线粒体定位质子泵型视紫红质、其突变蛋白及其应用 |
| WO2020021568A1 (en) * | 2018-07-26 | 2020-01-30 | Council Of Scientific And Industrial Research | Screening kit for detection of grades of cervical cancer and process for the preparation thereof |
| JPWO2020054868A1 (ja) * | 2018-09-14 | 2021-08-30 | 国立大学法人 名古屋工業大学 | 光応答性タンパク質及びその利用 |
| EP4119666A4 (en) * | 2020-03-13 | 2024-04-03 | Nagoya Institute Of Technology | Light-responsive protein for color recognition and use thereof |
| WO2022176754A1 (ja) * | 2021-02-18 | 2022-08-25 | 国立大学法人名古屋工業大学 | 青色光もしくは藍色光応答性タンパク質及びその利用 |
| EP4223768B1 (en) | 2022-02-04 | 2026-05-06 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Novel mutant bacteriorhodopsin-like-channelrhodopsin ion channel |
| WO2024092248A1 (en) * | 2022-10-28 | 2024-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced light gated potassium selective channelrhodopsin |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2112501A1 (de) | 1998-02-05 | 2009-10-28 | Novartis Ag | Verfahren und Vorrichtung zur Lumineszenzmessung |
| DE10216005A1 (de) * | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
| CN101484005A (zh) * | 2006-05-04 | 2009-07-15 | 韦恩州立大学 | 通过向体内递送视紫红质核酸恢复视觉响应 |
| DE102008020152B4 (de) * | 2008-04-22 | 2012-04-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
| NZ602416A (en) * | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
-
2011
- 2011-09-08 KR KR1020137008660A patent/KR101945962B1/ko active Active
- 2011-09-08 CA CA2810757A patent/CA2810757C/en active Active
- 2011-09-08 DK DK11760432.2T patent/DK2614079T3/en active
- 2011-09-08 AU AU2011298745A patent/AU2011298745B2/en active Active
- 2011-09-08 MX MX2013002591A patent/MX347453B/es active IP Right Grant
- 2011-09-08 HR HRP20150846TT patent/HRP20150846T1/hr unknown
- 2011-09-08 CN CN201180052156.9A patent/CN103261219B/zh active Active
- 2011-09-08 WO PCT/EP2011/065510 patent/WO2012032103A1/en not_active Ceased
- 2011-09-08 EP EP11760432.2A patent/EP2614079B1/en active Active
- 2011-09-08 BR BR112013005634A patent/BR112013005634A2/pt not_active Application Discontinuation
- 2011-09-08 HU HUE11760432A patent/HUE025952T2/en unknown
- 2011-09-08 PT PT117604322T patent/PT2614079E/pt unknown
- 2011-09-08 PL PL11760432T patent/PL2614079T3/pl unknown
- 2011-09-08 ES ES11760432.2T patent/ES2545992T3/es active Active
- 2011-09-08 US US13/821,353 patent/US8748578B2/en active Active
- 2011-09-08 SI SI201130552T patent/SI2614079T1/sl unknown
- 2011-09-08 SG SG2013016332A patent/SG188409A1/en unknown
- 2011-09-08 RU RU2013115454/10A patent/RU2595384C2/ru active
- 2011-09-08 JP JP2013527595A patent/JP5933556B2/ja active Active
-
2013
- 2013-03-05 IL IL225060A patent/IL225060A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011298745A1 (en) | 2013-03-21 |
| PL2614079T3 (pl) | 2016-01-29 |
| CA2810757C (en) | 2020-06-09 |
| SG188409A1 (en) | 2013-04-30 |
| WO2012032103A1 (en) | 2012-03-15 |
| HRP20150846T1 (hr) | 2015-09-11 |
| HUE025952T2 (en) | 2016-04-28 |
| EP2614079B1 (en) | 2015-07-15 |
| CN103261219A (zh) | 2013-08-21 |
| AU2011298745B2 (en) | 2015-05-07 |
| DK2614079T3 (en) | 2015-08-10 |
| RU2595384C2 (ru) | 2016-08-27 |
| RU2013115454A (ru) | 2014-10-20 |
| PT2614079E (pt) | 2015-10-06 |
| MX2013002591A (es) | 2013-07-22 |
| JP5933556B2 (ja) | 2016-06-15 |
| BR112013005634A2 (pt) | 2017-06-27 |
| US20130281379A1 (en) | 2013-10-24 |
| JP2013544494A (ja) | 2013-12-19 |
| CA2810757A1 (en) | 2012-03-15 |
| KR20130108335A (ko) | 2013-10-02 |
| CN103261219B (zh) | 2017-05-17 |
| KR101945962B1 (ko) | 2019-02-08 |
| US8748578B2 (en) | 2014-06-10 |
| SI2614079T1 (sl) | 2015-10-30 |
| MX347453B (es) | 2017-04-27 |
| EP2614079A1 (en) | 2013-07-17 |
| ES2545992T3 (es) | 2015-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2011298745B2 (en) | Mutant channelrhodopsin 2 | |
| Kleinlogel et al. | Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh | |
| US7144733B2 (en) | Bio-synthetic photostimulators and methods of use | |
| US20070128662A1 (en) | Photoreactive regulator of protein function and methods of use thereof | |
| US20170174730A1 (en) | Blue light-activated ion channel molecules and uses thereof | |
| US20120214188A1 (en) | Light-activated ion channel molecules and uses thereof | |
| US20240002444A1 (en) | New optogenetic tool | |
| US20190218256A1 (en) | Mutant light-inducible ion channel of channelrhodopsin | |
| US11384132B2 (en) | Mutant light-inducible ion channel of chrimson | |
| Kleinlogel et al. | Ultra light-sensitive and fast neuronal activation with the Ca permeable Channelrhodopsin CatCh | |
| EP4223768B1 (en) | Novel mutant bacteriorhodopsin-like-channelrhodopsin ion channel | |
| Meijer | Genetically encoded optical control of protein function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |