IL222930B - Chlorotoxin variants, conjugates and methods for their use - Google Patents
Chlorotoxin variants, conjugates and methods for their useInfo
- Publication number
- IL222930B IL222930B IL222930A IL22293012A IL222930B IL 222930 B IL222930 B IL 222930B IL 222930 A IL222930 A IL 222930A IL 22293012 A IL22293012 A IL 22293012A IL 222930 B IL222930 B IL 222930B
- Authority
- IL
- Israel
- Prior art keywords
- conjugates
- methods
- chlorotoxin variants
- chlorotoxin
- variants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
-
- G01N33/575—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33355610P | 2010-05-11 | 2010-05-11 | |
| PCT/US2011/023797 WO2011142858A2 (en) | 2010-05-11 | 2011-02-04 | Chlorotoxin variants, conjugates, and methods for their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL222930A0 IL222930A0 (en) | 2012-12-31 |
| IL222930B true IL222930B (en) | 2019-01-31 |
Family
ID=44914898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL222930A IL222930B (en) | 2010-05-11 | 2012-11-08 | Chlorotoxin variants, conjugates and methods for their use |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9944683B2 (enExample) |
| EP (2) | EP3165533B1 (enExample) |
| JP (2) | JP2013532126A (enExample) |
| KR (1) | KR101972173B1 (enExample) |
| CN (2) | CN106957356B (enExample) |
| AU (1) | AU2011253424B2 (enExample) |
| CA (1) | CA2799169C (enExample) |
| ES (2) | ES2811065T3 (enExample) |
| IL (1) | IL222930B (enExample) |
| WO (1) | WO2011142858A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2360519T3 (es) | 2005-04-22 | 2011-06-06 | University Of Washington | Conjugado de cianina-clorotoxina y procedimiento para la visualización intraquirúrgica del cáncer. |
| CA2749108C (en) | 2008-01-18 | 2017-06-27 | Visen Medical, Inc. | Intramolecularly-quenched fluorescent imaging agents |
| BRPI0912683A2 (pt) | 2008-05-15 | 2016-01-26 | Transmolecular Inc | tratamento de tumores metastáticos |
| WO2011097533A1 (en) * | 2010-02-04 | 2011-08-11 | Transmolecular, Inc. | Chlorotoxin polypeptides and conjugates and uses thereof |
| ES2811065T3 (es) | 2010-05-11 | 2021-03-10 | Hutchinson Fred Cancer Res | Variantes de clorotoxina, conjugados y métodos para su utilización |
| CN102688496B (zh) * | 2012-01-15 | 2013-12-11 | 河南科技大学 | 一种ctx介导的靶向纳米载体及纳米载药体系 |
| SG11201504602VA (en) | 2012-12-10 | 2015-07-30 | Hutchinson Fred Cancer Res | Lipocalin fusion partners |
| US9784730B2 (en) | 2013-03-21 | 2017-10-10 | University Of Washington Through Its Center For Commercialization | Nanoparticle for targeting brain tumors and delivery of O6-benzylguanine |
| AU2014323563B9 (en) * | 2013-09-17 | 2019-10-24 | Blaze Bioscience, Inc. | Chlorotoxin conjugates and methods of use thereof |
| US11559580B1 (en) * | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| JP6741599B2 (ja) | 2014-06-02 | 2020-08-19 | リ−コール，インコーポレイティド | フタロシアニンプローブ及びその使用 |
| US20180371033A1 (en) * | 2015-06-26 | 2018-12-27 | Fred Hutchinson Cancer Research Center | Therapeutic peptides and methods of use thereof |
| CN108135970B (zh) | 2015-09-09 | 2023-09-01 | 弗莱德哈钦森癌症中心 | 软骨归巢肽 |
| MA44386A (fr) * | 2015-10-07 | 2019-01-23 | Genentech Inc | Systèmes et méthodes de prédiction de demi-vie vitréenne de conjugués d'agent thérapeutique et de polymère |
| US20190161523A1 (en) | 2016-04-12 | 2019-05-30 | Blaze Bioscience, Inc. | Methods of treatment using chlorotoxin conjugates |
| WO2017181149A1 (en) | 2016-04-15 | 2017-10-19 | Blaze Bioscience, Inc. | Methods of treating breast cancer |
| US11878000B2 (en) * | 2016-10-21 | 2024-01-23 | Da Zen Theranostics, Inc. | Compounds and methods to sensitize cancer cells to tyrosine kinase inhibitors |
| WO2018086603A1 (zh) * | 2016-11-10 | 2018-05-17 | 北京普罗吉生物科技发展有限公司 | 聚乙二醇化血管内皮抑制素类似物及其应用 |
| IL266892B2 (en) | 2016-12-02 | 2025-10-01 | Univ Southern California | Artificial immune receptors and methods of using them |
| JP7191025B2 (ja) | 2017-01-18 | 2022-12-16 | フレッド ハッチンソン キャンサー センター | Ｔｅａｄ相互作用を妨害するためのペプチド組成物およびその使用方法 |
| AU2018236465A1 (en) | 2017-03-16 | 2019-08-22 | Blaze Bioscience, Inc. | Cartilage-homing peptide conjugates and methods of use thereof |
| CA3064436A1 (en) | 2017-06-15 | 2018-12-20 | Blaze Bioscience, Inc. | Renal-homing peptide conjugates and methods of use thereof |
| CN111542345B (zh) | 2017-09-15 | 2025-02-25 | 卫材公司 | 氯毒素剂及其用途 |
| WO2019126240A1 (en) | 2017-12-19 | 2019-06-27 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
| AU2020407558A1 (en) * | 2019-12-19 | 2022-03-17 | Blaze Bioscience, Inc. | Methods of treating vascular lesions and malformations |
| AU2021412432B2 (en) | 2020-12-30 | 2024-11-14 | Vrg Miniprotein Zrt. | Chlorotoxin derivatives and use thereof |
Family Cites Families (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444744A (en) | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
| DE3407582A1 (de) | 1984-03-01 | 1985-09-05 | Dornier System Gmbh, 7990 Friedrichshafen | Schaltungsanordnung fuer einen regelkreis |
| EP0282581A4 (en) | 1986-09-19 | 1988-11-02 | Scripps Clinic Res | Monoclonal paratopic molecule directed to human ganglioside gd2. |
| US5591829A (en) | 1987-05-29 | 1997-01-07 | Matsushita; Shuzo | Antibodies modified with toxic substance |
| US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| US5051364A (en) | 1989-02-16 | 1991-09-24 | The Salk Institute For Biological Studies | Anti-lipocortin-I and anti-lipocortin-II monoclonal antibodies |
| DE3909799A1 (de) | 1989-03-24 | 1990-09-27 | Behringwerke Ag | Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung |
| CA2066428C (en) | 1989-09-08 | 2000-11-28 | Bert Vogelstein | Structural alterations of the egf receptor gene in human gliomas |
| US5223253A (en) | 1989-09-28 | 1993-06-29 | American Home Products Corporation | Bovine vaccine compositions and method for preventing trichomonas infections using same |
| GB2250993B (en) | 1990-11-21 | 1995-02-15 | Inst Nat Sante Rech Med | Stromelysin-3 and its application in the diagnosis and treatment of malignant breast cancer |
| US5750376A (en) | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| ES2225819T3 (es) | 1991-09-20 | 2005-03-16 | Amgen Inc. | Factor neurotrofico de origen glial. |
| US5314992A (en) | 1991-11-25 | 1994-05-24 | Trustees Of Dartmouth College | Lipocortin-1 receptor protein and its uses |
| AU4373993A (en) | 1992-05-14 | 1993-12-13 | Ohio State University Research Foundation, The | Treatment of vascular leakage syndrome and collagenase induced disease by administration of matrix metalloproteinase inhibitors |
| IL108328A (en) | 1993-01-14 | 2010-05-31 | Cancer Res Campaign Tech | Pharmaceutical compositions containing temozolomide and atase inhibitor for potentiation of temozolomide toxicity to human tumor cells |
| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5688773A (en) | 1994-08-17 | 1997-11-18 | The General Hospital Corporation | Method of selectively destroying neoplastic cells |
| US5985822A (en) | 1994-12-09 | 1999-11-16 | The Scripps Research Institute | Inhibition of glial cell proliferation with N-CAM homophilic peptides |
| US5756340A (en) | 1995-05-08 | 1998-05-26 | The Regents Of The University Of California | Insect control with multiple toxins |
| JP3809502B2 (ja) | 1995-05-30 | 2006-08-16 | 二郎 有川 | ハンタウィルス抗原蛋白質およびモノクローナル抗体 |
| JPH0971599A (ja) | 1995-09-06 | 1997-03-18 | Nippon Seibutsu Kagaku Kenkyusho | 鶏貧血ウイルス（ｃａｖ）感染鶏血清と高い反応性を示すポリペプチド及びこのポリペプチドに対する抗体、鶏貧血ウイルス感染の診断法及びワクチン |
| US5905027A (en) | 1995-12-27 | 1999-05-18 | Uab Research Foundation | Method of diagnosing and treating gliomas |
| US6667156B2 (en) | 1995-12-27 | 2003-12-23 | Uab Research Foundation | Diagnosis and treatment of neuroectodermal tumors |
| US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| CN1284083A (zh) | 1997-12-05 | 2001-02-14 | 伊东恭悟 | 肿瘤抗原肽衍生物 |
| GB9809776D0 (en) | 1998-05-07 | 1998-07-08 | Nycomed Imaging As | Method |
| ATE279411T1 (de) * | 1998-08-12 | 2004-10-15 | Daiichi Pure Chemicals Co Ltd | Fluorszierende marker |
| US6703381B1 (en) | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
| US6214986B1 (en) | 1998-10-07 | 2001-04-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of bcl-x expression |
| SE9901387D0 (sv) | 1999-04-19 | 1999-04-19 | Astra Ab | New pharmaceutical foromaulations |
| US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| EP1216060A2 (de) | 1999-09-14 | 2002-06-26 | Biomedical Apherese Systeme GmbH | Magnetische nanoteilchen mit biochemischer wirksamkeit und verfahren zu ihrer herstellung sowie ihre verwendung |
| US6514481B1 (en) | 1999-11-22 | 2003-02-04 | The Research Foundation Of State University Of New York | Magnetic nanoparticles for selective therapy |
| DE10020376A1 (de) | 2000-04-26 | 2001-11-08 | Inst Zelltechnologie E V | Dynamische Marker |
| US7229960B2 (en) * | 2000-11-03 | 2007-06-12 | University Of Vermont And State Agricultural College | Methods and compositions for inhibiting GRB7 |
| US20020077921A1 (en) | 2000-12-15 | 2002-06-20 | Paul-David Morrison | Method and apparatus for an interactive catalog |
| US20040180846A1 (en) | 2001-03-01 | 2004-09-16 | Ruo-Pan Huang | Connexin enhances chemotherapy-induced apoptiosis in human cancer cells inhibiting tumor cell proliferation |
| WO2003008583A2 (en) | 2001-03-02 | 2003-01-30 | Sagres Discovery | Novel compositions and methods for cancer |
| US20030021810A1 (en) | 2001-06-26 | 2003-01-30 | Sontheimer Harald W. | Chlorotoxin inhibition of cell invasion, cancer metastasis, angiogenesis and tissue remodeling |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| US6972326B2 (en) | 2001-12-03 | 2005-12-06 | Molecular Probes, Inc. | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes |
| WO2003066663A2 (en) | 2002-02-04 | 2003-08-14 | Auburn University | Peptides for recognition and targeting of glial cell tumors |
| US20030232013A1 (en) | 2002-02-22 | 2003-12-18 | Gary Sieckman | Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides |
| EP1539207A4 (en) | 2002-05-31 | 2008-01-02 | Transmolecular Inc | TREATMENT OF CELL PROLIFERATION DISORDERS USING CHLOROTOXIN |
| US20060088899A1 (en) | 2002-05-31 | 2006-04-27 | Alvarez Vernon L | Combination chemotherapy with chlorotoxin |
| US7560160B2 (en) | 2002-11-25 | 2009-07-14 | Materials Modification, Inc. | Multifunctional particulate material, fluid, and composition |
| US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
| WO2005005601A2 (en) | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| DE10328251A1 (de) | 2003-06-24 | 2005-01-13 | Toximed Gmbh | Pharmazeutischer Wirkstoff |
| US20070275902A1 (en) | 2003-11-26 | 2007-11-29 | Transmolecular, Inc. | Treatment of Phosphatidylinositol Phospholipid Disorders |
| US20080153746A1 (en) * | 2004-04-06 | 2008-06-26 | Transmolecular, Inc. | Diagnosis and Treatment of Myeloid and Lymphoid Cell Cancers |
| CA2561494A1 (en) | 2004-04-06 | 2005-10-27 | Transmolecular, Inc. | Diagnosis and treatment of myeloid and lymphoid cell cancers |
| WO2005107793A2 (en) | 2004-05-06 | 2005-11-17 | The Trustees Of Columbia University | Ngal for reduction and amelioration of ischemic and nephrotoxic injuries |
| WO2006091231A2 (en) | 2004-07-21 | 2006-08-31 | Ambrx, Inc. | Biosynthetic polypeptides utilizing non-naturally encoded amino acids |
| GB0422901D0 (en) | 2004-10-14 | 2004-11-17 | Ares Trading Sa | Lipocalin protein |
| KR100681763B1 (ko) | 2005-02-28 | 2007-02-15 | 재단법인 목암생명공학연구소 | 인간 리포칼린 2를 유효성분으로 포함하는 암 전이 억제용약학적 조성물, 이를 이용한 암 전이 억제 방법 |
| GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| US7462446B2 (en) | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
| US20070037232A1 (en) | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
| EP1871911A2 (en) | 2005-04-07 | 2008-01-02 | Chiron Corporation | Cancer-related genes (prlr) |
| US20060286089A1 (en) | 2005-04-08 | 2006-12-21 | Xcyte Therapies, Inc. | Compositions and methods for the treatment of burns and sepsis |
| ES2360519T3 (es) | 2005-04-22 | 2011-06-06 | University Of Washington | Conjugado de cianina-clorotoxina y procedimiento para la visualización intraquirúrgica del cáncer. |
| US7833979B2 (en) * | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| AU2005335491B2 (en) | 2005-08-18 | 2010-11-25 | Ambrx, Inc. | Compositions of tRNA and uses thereof |
| EP2147927A3 (en) | 2006-03-31 | 2010-09-01 | Transmolecular, Inc. | Use of 131i-tm-601 for the diagnosis and treatment of gliomas |
| EP2029157A4 (en) | 2006-05-19 | 2009-11-18 | Georgia Tech Res Inst | ABC TRANSPORTERLIGAND |
| CN100564517C (zh) | 2006-09-21 | 2009-12-02 | 武汉大学 | 一种蝎抗神经胶质瘤肽及其制备方法和应用 |
| CN101003788A (zh) | 2006-09-21 | 2007-07-25 | 武汉大学 | 一种蝎抗肿瘤转移肽及其制备方法和应用 |
| PE20081140A1 (es) * | 2006-10-25 | 2008-09-22 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
| CN101970678B (zh) | 2007-06-21 | 2014-08-20 | 慕尼黑科技大学 | 具有增加的体内和/或体外稳定性的生物学活性蛋白 |
| US20090004105A1 (en) * | 2007-06-27 | 2009-01-01 | Zhen Cheng | Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin |
| WO2009021136A1 (en) | 2007-08-07 | 2009-02-12 | Transmolecular, Inc. | Chlorotoxins as drug carriers |
| WO2009029760A1 (en) | 2007-08-31 | 2009-03-05 | Iosemantics, Llc | Quality assurance tools for use with source code and a semantic model |
| CN101918041A (zh) | 2007-10-12 | 2010-12-15 | 超分子有限公司 | 用于肿瘤诊断和治疗的氯毒素剂的系统性给药 |
| US7904868B2 (en) | 2007-10-17 | 2011-03-08 | International Business Machines Corporation | Structures including means for lateral current carrying capability improvement in semiconductor devices |
| US20090124022A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Antibodies that bind to mammalian ngal and uses thereof |
| US20090176274A1 (en) | 2007-10-19 | 2009-07-09 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
| WO2009052400A1 (en) | 2007-10-19 | 2009-04-23 | Abbott Laboratories | Antibodies that bind to mammalian ngal and uses thereof |
| US20090123970A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
| US20090269777A1 (en) | 2007-10-19 | 2009-10-29 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
| US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
| US20090123946A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
| EP2215481B2 (en) | 2007-11-15 | 2017-01-18 | Bioporto Diagnostics A/S | Diagnostic use of individual molecular forms of a biomarker |
| CA2749108C (en) * | 2008-01-18 | 2017-06-27 | Visen Medical, Inc. | Intramolecularly-quenched fluorescent imaging agents |
| WO2009108762A2 (en) | 2008-02-26 | 2009-09-03 | The Penn State Research Foundation | Methods and compositions for treatment of retinoid-responsive conditions |
| US8093060B2 (en) * | 2008-02-28 | 2012-01-10 | Canon Kabushiki Kaisha | Multisite phosphorylated peptide (protein) recognizing compound and detection method, imaging method, alzheimer's disease diagnosing method and reagent kit using the same |
| CA2715034C (en) * | 2008-03-14 | 2016-12-06 | Visen Medical, Inc. | Integrin targeting agents and in-vivo and in-vitro imaging methods using the same |
| AU2008352925A1 (en) | 2008-03-20 | 2009-09-24 | Transmolecular, Inc. | Inhibition of angiogenesis |
| GB0807831D0 (en) * | 2008-04-29 | 2008-06-04 | Cambridge Entpr Ltd | Agents for imaging cell death |
| CN101270158B (zh) | 2008-04-30 | 2010-12-22 | 武汉大学 | 一种靶向抗神经胶质瘤蛋白及制备方法和用途 |
| BRPI0912683A2 (pt) | 2008-05-15 | 2016-01-26 | Transmolecular Inc | tratamento de tumores metastáticos |
| JP2009300110A (ja) * | 2008-06-10 | 2009-12-24 | Olympus Corp | 移植細胞の光学的検出方法又はイメージング方法 |
| EP2313430B1 (en) | 2008-06-24 | 2018-05-02 | Technische Universität München | Muteins of hngal and related proteins with affinity for a given target |
| AR073582A1 (es) * | 2008-09-12 | 2010-11-17 | Nitto Denko Corp | Agentes de produccion de imagenes de enfermedades fibroticas.conjugado. metodo |
| US20100098637A1 (en) * | 2008-09-23 | 2010-04-22 | The Regents Of The University Of Michigan | Dye-loaded nanoparticle |
| CN101381405B (zh) | 2008-09-24 | 2011-07-27 | 武汉摩尔生物科技有限公司 | 基因工程肿瘤靶向kct-w1多肽及制备方法和用途 |
| JP2010085108A (ja) * | 2008-09-29 | 2010-04-15 | Nano Factory:Kk | 生体光イメージング用プローブ |
| US20100105150A1 (en) | 2008-10-24 | 2010-04-29 | Abbott Laboratories | Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal |
| CN106519588B (zh) | 2009-11-09 | 2019-08-20 | 华盛顿大学商业化中心 | 官能化发色聚合物点及其生物共轭体 |
| CN101921769B (zh) | 2010-01-11 | 2012-07-25 | 山西大学 | 一种重组腺病毒及其制备方法和应用 |
| WO2011094671A2 (en) | 2010-01-29 | 2011-08-04 | The Uab Research Foundation | N-terminally conjugated polypeptides for targeted therapy and diagnosis |
| WO2011097533A1 (en) | 2010-02-04 | 2011-08-11 | Transmolecular, Inc. | Chlorotoxin polypeptides and conjugates and uses thereof |
| CN101824084A (zh) | 2010-04-08 | 2010-09-08 | 山西大学 | 靶向性抗胶质瘤蛋白质及其应用 |
| ES2811065T3 (es) | 2010-05-11 | 2021-03-10 | Hutchinson Fred Cancer Res | Variantes de clorotoxina, conjugados y métodos para su utilización |
| AU2011290751B2 (en) | 2010-08-16 | 2015-08-13 | Pieris Ag | Binding proteins for Hepcidin |
| SG11201504602VA (en) | 2012-12-10 | 2015-07-30 | Hutchinson Fred Cancer Res | Lipocalin fusion partners |
| WO2017181149A1 (en) * | 2016-04-15 | 2017-10-19 | Blaze Bioscience, Inc. | Methods of treating breast cancer |
| EP3442555A4 (en) * | 2016-04-15 | 2020-04-01 | Blaze Bioscience, Inc. | METHOD FOR TREATING BREAST CANCER |
-
2011
- 2011-02-04 ES ES16189999T patent/ES2811065T3/es active Active
- 2011-02-04 CN CN201710180111.9A patent/CN106957356B/zh active Active
- 2011-02-04 JP JP2013510087A patent/JP2013532126A/ja active Pending
- 2011-02-04 CA CA2799169A patent/CA2799169C/en active Active
- 2011-02-04 KR KR1020127032307A patent/KR101972173B1/ko active Active
- 2011-02-04 AU AU2011253424A patent/AU2011253424B2/en active Active
- 2011-02-04 ES ES11780950.9T patent/ES2601182T3/es active Active
- 2011-02-04 WO PCT/US2011/023797 patent/WO2011142858A2/en not_active Ceased
- 2011-02-04 CN CN201180031651.1A patent/CN103097403B/zh active Active
- 2011-02-04 EP EP16189999.2A patent/EP3165533B1/en active Active
- 2011-02-04 EP EP11780950.9A patent/EP2569330B1/en active Active
-
2012
- 2012-11-08 IL IL222930A patent/IL222930B/en active IP Right Grant
- 2012-11-09 US US13/673,779 patent/US9944683B2/en active Active
-
2017
- 2017-02-10 JP JP2017023098A patent/JP6553105B2/ja active Active
-
2018
- 2018-03-02 US US15/911,017 patent/US10822381B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10822381B2 (en) | 2020-11-03 |
| CA2799169C (en) | 2019-07-23 |
| KR20130113938A (ko) | 2013-10-16 |
| US9944683B2 (en) | 2018-04-17 |
| ES2811065T3 (es) | 2021-03-10 |
| EP2569330A4 (en) | 2013-11-13 |
| CN103097403A (zh) | 2013-05-08 |
| AU2011253424A1 (en) | 2012-12-20 |
| WO2011142858A9 (en) | 2012-03-22 |
| CN106957356B (zh) | 2021-05-25 |
| WO2011142858A3 (en) | 2012-01-05 |
| JP2013532126A (ja) | 2013-08-15 |
| EP3165533B1 (en) | 2020-04-08 |
| ES2601182T3 (es) | 2017-02-14 |
| US20180194818A1 (en) | 2018-07-12 |
| JP6553105B2 (ja) | 2019-07-31 |
| CA2799169A1 (en) | 2011-11-17 |
| IL222930A0 (en) | 2012-12-31 |
| EP2569330A2 (en) | 2013-03-20 |
| CN106957356A (zh) | 2017-07-18 |
| KR101972173B1 (ko) | 2019-04-24 |
| EP2569330B1 (en) | 2016-09-28 |
| WO2011142858A2 (en) | 2011-11-17 |
| EP3165533A1 (en) | 2017-05-10 |
| CN103097403B (zh) | 2017-04-19 |
| AU2011253424B2 (en) | 2016-02-04 |
| US20130195760A1 (en) | 2013-08-01 |
| JP2017137316A (ja) | 2017-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL222930B (en) | Chlorotoxin variants, conjugates and methods for their use | |
| IL243932A0 (en) | Certain chemical entities, compositions and methods | |
| BR112014009050A2 (pt) | pirrolbenzodiazepinas e conjugados destas | |
| BR112013010725A2 (pt) | método, e, composição | |
| BR112013007499A2 (pt) | piridazinonas - métodos de criação e usos | |
| BRPI1009455A2 (pt) | anticorpos anti-c40 e usos dos mesmos | |
| DK3103478T3 (da) | Stabiliserede fibronektin-domænesammensætninger, fremgangsmåder og anvendelser | |
| ME03766B (me) | Određeni amino-pirimidini, njihove kompozicije, i metode njihove upotrebe | |
| BR112012017441A2 (pt) | compostos e métodos | |
| BR112013013584A2 (pt) | endoscópio, e, método | |
| IL226307A0 (en) | Compounds and methods for treating pain | |
| HRP20150926T4 (hr) | Pripravci u krutom stanju | |
| ME03479B (me) | Metodi konjugacije | |
| PL2648726T3 (pl) | Policykliczny antagonista lpa1 i jego zastosowania | |
| DK2624866T3 (da) | Tumorspecifikke antistoffer og anvendelser deraf | |
| PT3686183T (pt) | Fenilacetato de l-ornitina e métodos de preparação do mesmo | |
| HRP20160737T1 (hr) | Anti-her3-protutijela i njihove uporabe | |
| EP2531206A4 (en) | CHLOROTOXINPOLYPEPTIDES AND CONJUGATES AND USES THEREOF | |
| BR112012027159A2 (pt) | estrutura e método | |
| IL226427A0 (en) | Anti ccr4 antibodies and uses thereof | |
| BR112012019626A2 (pt) | estrutura de plantio e métodos. | |
| FI20096339L (fi) | Liima-aine, menetelmä sen valmistamiseksi sekä sen käyttö | |
| EP2647648A4 (en) | hydroxyalkylcellulose | |
| IT1398438B1 (it) | Dispositivo di premacinazione e relativo procedimento | |
| HRP20170691T1 (hr) | Polimerni konjugati djelatnih tvari, njihov postupak dobivanja i njihovi polimerni intermedijeri |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |