IL213938A0 - Compositions and methods for assessing cytotoxicity of single cells - Google Patents
Compositions and methods for assessing cytotoxicity of single cellsInfo
- Publication number
- IL213938A0 IL213938A0 IL213938A IL21393811A IL213938A0 IL 213938 A0 IL213938 A0 IL 213938A0 IL 213938 A IL213938 A IL 213938A IL 21393811 A IL21393811 A IL 21393811A IL 213938 A0 IL213938 A0 IL 213938A0
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- methods
- single cells
- assessing cytotoxicity
- cytotoxicity
- Prior art date
Links
- 230000003013 cytotoxicity Effects 0.000 title 1
- 231100000135 cytotoxicity Toxicity 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
- G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- G01N2333/16—HIV-1, HIV-2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14610609P | 2009-01-21 | 2009-01-21 | |
| PCT/US2009/050411 WO2010085275A1 (en) | 2009-01-21 | 2009-07-13 | Compositions and methods for assessing cytotoxicity of single cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL213938A0 true IL213938A0 (en) | 2011-07-31 |
Family
ID=42356144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL213938A IL213938A0 (en) | 2009-01-21 | 2011-07-05 | Compositions and methods for assessing cytotoxicity of single cells |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9244071B2 (enExample) |
| EP (1) | EP2389446B1 (enExample) |
| JP (2) | JP2012515548A (enExample) |
| KR (1) | KR20110134386A (enExample) |
| CN (2) | CN102388145A (enExample) |
| AU (1) | AU2009338127B2 (enExample) |
| CA (1) | CA2689681C (enExample) |
| IL (1) | IL213938A0 (enExample) |
| RU (1) | RU2532228C2 (enExample) |
| SG (2) | SG172889A1 (enExample) |
| WO (1) | WO2010085275A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9404924B2 (en) | 2008-12-04 | 2016-08-02 | Massachusetts Institute Of Technology | Method of performing one-step, single cell RT-PCR |
| DK2370814T3 (da) | 2008-12-04 | 2015-07-20 | Massachusetts Inst Technology | Fremgangsmåde til diagnosticering af allergiske reaktioner |
| CN102388145A (zh) | 2009-01-21 | 2012-03-21 | 麻省理工学院 | 用于对单个细胞所具有的细胞毒性进行评价的组合物以及方法 |
| WO2012072823A1 (en) * | 2010-12-03 | 2012-06-07 | Mindseeds Laboratories Srl | Rapid screening of monoclonal antibodies |
| US9891157B2 (en) | 2010-12-03 | 2018-02-13 | Cellply S.R.L. | Microanalysis of cellular function |
| WO2013090404A2 (en) * | 2011-12-13 | 2013-06-20 | Single Cell Technology, Inc. | Method of screening a plurality of single secreting cells for functional activity |
| US20150191772A1 (en) | 2012-06-29 | 2015-07-09 | Danmarks Tekniske Universitet | Method of charging a test carrier and a test carrier |
| CN104884605B (zh) * | 2012-08-24 | 2018-05-18 | 耶鲁大学 | 用于高通量多重检测的系统、装置和方法 |
| WO2015031190A1 (en) * | 2013-08-26 | 2015-03-05 | President And Fellows Of Harvard College | Determination of immune cells and other cells |
| US10508280B2 (en) | 2014-01-31 | 2019-12-17 | AgBiome, Inc. | Modified biological control agents and their uses |
| US9877486B2 (en) | 2014-01-31 | 2018-01-30 | AgBiome, Inc. | Methods of growing plants using modified biological control agents |
| EP3227684B1 (en) | 2014-12-03 | 2019-10-02 | Isoplexis Corporation | Analysis and screening of cell secretion profiles |
| WO2016149639A1 (en) | 2015-03-19 | 2016-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip |
| US10746736B2 (en) | 2015-03-26 | 2020-08-18 | University Of Houston System | Integrated functional and molecular profiling of cells |
| US12071663B2 (en) | 2016-01-15 | 2024-08-27 | Massachusetts Institute Of Technology | Semi-permeable arrays for analyzing biological systems and methods of using same |
| US12345708B2 (en) | 2016-03-25 | 2025-07-01 | President And Fellows Of Harvard College | Microfluidic determination of immune and other cells |
| WO2017169267A1 (ja) * | 2016-03-30 | 2017-10-05 | ソニー株式会社 | 細胞観察装置、免疫細胞の活性度の評価方法及び免疫細胞の品質管理方法 |
| WO2017216739A1 (en) | 2016-06-14 | 2017-12-21 | Cellply S.R.L. | Screening kit and method |
| WO2017216270A1 (de) | 2016-06-15 | 2017-12-21 | Grabmayr Heinrich | Einzelmolekülnachweis bzw. -quantifizierung durch dna-nanotechnologie |
| CN106086171A (zh) * | 2016-06-15 | 2016-11-09 | 广州中大南沙科技创新产业园有限公司 | 一种抑制肿瘤细胞增殖的药物筛选方法 |
| US20200166518A1 (en) | 2016-09-12 | 2020-05-28 | IsoPlexis Corporation | System and methods for multiplexed analysis of cellular and other immunotherapeutics |
| EP3532600A4 (en) * | 2016-10-19 | 2020-09-16 | General Automation LAB Technologies Inc. | HIGH RESOLUTION SYSTEMS, KITS, DEVICES AND METHODS FOR SCREENING MICRO-ORGANISMS AND OTHER HIGH-PERFORMANCE MICROBIOLOGICAL APPLICATIONS |
| US11493508B2 (en) * | 2016-11-11 | 2022-11-08 | IsoPlexis Corporation | Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells |
| US11085912B2 (en) * | 2016-12-14 | 2021-08-10 | University Of Cincinnati | Methods of diagnosing Clostridium difficile infection or recurrence in a subject |
| SE543211C2 (en) * | 2017-06-29 | 2020-10-27 | Mabtech Production Ab | Method and system for analyzing Fluorospot assays |
| WO2019113457A1 (en) | 2017-12-07 | 2019-06-13 | Massachusetts Institute Of Technology | Single cell analyses |
| CN108728356B (zh) * | 2018-05-23 | 2022-02-22 | 北京科技大学 | 用于不同三维细胞团配对的装置及共培养方法 |
| CN113614532A (zh) * | 2019-01-16 | 2021-11-05 | 烟台澳斯邦生物工程有限公司 | 沉积用于显微镜检查的生物样品的自动液体处理系统和方法 |
| CA3130051A1 (en) * | 2019-02-18 | 2020-08-27 | Nb Health Laboratory Co., Ltd. | Method for selecting cells, method for producing nucleic acid, method for producing recombinant cells, method for producing target substance, method for producing pharmaceutical composition, and reagent |
| US12064768B2 (en) | 2020-02-21 | 2024-08-20 | Northeastern University | Single cell isolation and processing system with reversible well shape |
| CN115176158A (zh) | 2020-02-27 | 2022-10-11 | 伊索普莱克西斯公司 | 用于多路分析的系统、装置及方法 |
| WO2024102720A2 (en) | 2022-11-07 | 2024-05-16 | Shennon Biotechnologies Inc. | Microfluidic devices for high throughput screening of cell-cell interactions |
| WO2026042829A1 (ja) * | 2024-08-21 | 2026-02-26 | ジェノコンシェルジュ京都株式会社 | Ｋｉｒ遺伝子のｐｃｒ増幅法およびロングリードシークエンサーを用いた増幅産物のシークエンス法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68507A (en) | 1982-05-10 | 1986-01-31 | Univ Bar Ilan | System and methods for cell selection |
| SU1650094A1 (ru) * | 1987-12-29 | 1991-05-23 | Научно-исследовательский институт проктологии | Способ диагностики прот женности активного воспалени в толстой кишке при неспецифическом звенном колите |
| US6410252B1 (en) | 1995-12-22 | 2002-06-25 | Case Western Reserve University | Methods for measuring T cell cytokines |
| US6210910B1 (en) | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
| EP1175439A4 (en) * | 1999-04-09 | 2002-10-09 | Human Genome Sciences Inc | 49 HUMANE SECRETIED PROTEINS |
| AU5591200A (en) * | 1999-06-11 | 2001-01-02 | Human Genome Sciences, Inc. | 49 human secreted proteins |
| US7332286B2 (en) * | 2001-02-02 | 2008-02-19 | University Of Pennsylvania | Peptide or protein microassay method and apparatus |
| US20020141906A1 (en) | 2001-03-30 | 2002-10-03 | American Type Culture Collection | Microtiter plate sealing cover with well identifiers |
| US7776553B2 (en) | 2005-09-16 | 2010-08-17 | Presidents And Fellows Of Harvard College | Screening assays and methods |
| CN102112624A (zh) | 2008-05-30 | 2011-06-29 | 麻省理工学院 | 用于对细胞进行空间分割以及筛选的组合物以及方法 |
| DK2370814T3 (da) | 2008-12-04 | 2015-07-20 | Massachusetts Inst Technology | Fremgangsmåde til diagnosticering af allergiske reaktioner |
| US9404924B2 (en) | 2008-12-04 | 2016-08-02 | Massachusetts Institute Of Technology | Method of performing one-step, single cell RT-PCR |
| CN102388145A (zh) | 2009-01-21 | 2012-03-21 | 麻省理工学院 | 用于对单个细胞所具有的细胞毒性进行评价的组合物以及方法 |
| US8569046B2 (en) | 2009-02-20 | 2013-10-29 | Massachusetts Institute Of Technology | Microarray with microchannels |
-
2009
- 2009-07-13 CN CN2009801551526A patent/CN102388145A/zh active Pending
- 2009-07-13 US US13/145,300 patent/US9244071B2/en active Active
- 2009-07-13 EP EP09839012.3A patent/EP2389446B1/en not_active Not-in-force
- 2009-07-13 CN CN201510140107.0A patent/CN104745669A/zh active Pending
- 2009-07-13 WO PCT/US2009/050411 patent/WO2010085275A1/en not_active Ceased
- 2009-07-13 JP JP2011547913A patent/JP2012515548A/ja not_active Withdrawn
- 2009-07-13 CA CA2689681A patent/CA2689681C/en not_active Expired - Fee Related
- 2009-07-13 SG SG2011049459A patent/SG172889A1/en unknown
- 2009-07-13 KR KR1020117018895A patent/KR20110134386A/ko not_active Ceased
- 2009-07-13 SG SG10201401643PA patent/SG10201401643PA/en unknown
- 2009-07-13 AU AU2009338127A patent/AU2009338127B2/en not_active Ceased
- 2009-07-13 RU RU2011134898/10A patent/RU2532228C2/ru not_active IP Right Cessation
-
2011
- 2011-07-05 IL IL213938A patent/IL213938A0/en unknown
-
2015
- 2015-05-05 JP JP2015094509A patent/JP6017620B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2389446B1 (en) | 2017-07-05 |
| RU2532228C2 (ru) | 2014-10-27 |
| CN102388145A (zh) | 2012-03-21 |
| CN104745669A (zh) | 2015-07-01 |
| SG172889A1 (en) | 2011-08-29 |
| SG10201401643PA (en) | 2014-08-28 |
| CA2689681A1 (en) | 2010-07-21 |
| US20120149592A1 (en) | 2012-06-14 |
| JP2015144617A (ja) | 2015-08-13 |
| US9244071B2 (en) | 2016-01-26 |
| AU2009338127B2 (en) | 2015-11-26 |
| KR20110134386A (ko) | 2011-12-14 |
| AU2009338127A1 (en) | 2011-07-28 |
| JP6017620B2 (ja) | 2016-11-02 |
| CA2689681C (en) | 2017-08-29 |
| WO2010085275A1 (en) | 2010-07-29 |
| JP2012515548A (ja) | 2012-07-12 |
| EP2389446A4 (en) | 2012-10-03 |
| EP2389446A1 (en) | 2011-11-30 |
| RU2011134898A (ru) | 2013-02-27 |
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