KR20110134386A - 단일 세포의 세포독성을 평가하기 위한 조성물 및 방법 - Google Patents

단일 세포의 세포독성을 평가하기 위한 조성물 및 방법 Download PDF

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KR20110134386A
KR20110134386A KR1020117018895A KR20117018895A KR20110134386A KR 20110134386 A KR20110134386 A KR 20110134386A KR 1020117018895 A KR1020117018895 A KR 1020117018895A KR 20117018895 A KR20117018895 A KR 20117018895A KR 20110134386 A KR20110134386 A KR 20110134386A
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cells
cell
hiv
effector
antibody
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Korean (ko)
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존 크리스토퍼 러브
나빈 바라다라잔
보리스 율크
브루스 워커
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메사추세츠 인스티튜트 오브 테크놀로지
더 제너럴 하스피털 코포레이션 두잉 비즈니스 애즈 매사츄세츠 제너럴 하스피털
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Publication of KR20110134386A publication Critical patent/KR20110134386A/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
KR1020117018895A 2009-01-21 2009-07-13 단일 세포의 세포독성을 평가하기 위한 조성물 및 방법 Ceased KR20110134386A (ko)

Applications Claiming Priority (2)

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US14610609P 2009-01-21 2009-01-21
US61/146,106 2009-01-21

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KR20110134386A true KR20110134386A (ko) 2011-12-14

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US (1) US9244071B2 (enExample)
EP (1) EP2389446B1 (enExample)
JP (2) JP2012515548A (enExample)
KR (1) KR20110134386A (enExample)
CN (2) CN102388145A (enExample)
AU (1) AU2009338127B2 (enExample)
CA (1) CA2689681C (enExample)
IL (1) IL213938A0 (enExample)
RU (1) RU2532228C2 (enExample)
SG (2) SG172889A1 (enExample)
WO (1) WO2010085275A1 (enExample)

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EP2370814B1 (en) 2008-12-04 2015-04-29 Massachusetts Institute of Technology Method for diagnosing allergic reactions
US9404924B2 (en) 2008-12-04 2016-08-02 Massachusetts Institute Of Technology Method of performing one-step, single cell RT-PCR
AU2009338127B2 (en) 2009-01-21 2015-11-26 Massachusetts Institute Of Technology Compositions and methods for assessing cytotoxicity of single cells
EP2646798B1 (en) 2010-12-03 2017-06-28 Cellply S.R.L. Microanalysis of cellular function
EP2646830B1 (en) * 2010-12-03 2016-04-13 Cellply S.R.L. Rapid screening of monoclonal antibodies
CA2856868C (en) * 2011-12-13 2020-07-07 Single Cell Technology, Inc. Method of screening a plurality of single secreting cells for functional activity
US20150191772A1 (en) 2012-06-29 2015-07-09 Danmarks Tekniske Universitet Method of charging a test carrier and a test carrier
CN104884605B (zh) * 2012-08-24 2018-05-18 耶鲁大学 用于高通量多重检测的系统、装置和方法
EP3039162B1 (en) * 2013-08-26 2019-01-02 President and Fellows of Harvard College Determination of immune cells and other cells
US9877486B2 (en) 2014-01-31 2018-01-30 AgBiome, Inc. Methods of growing plants using modified biological control agents
US10508280B2 (en) 2014-01-31 2019-12-17 AgBiome, Inc. Modified biological control agents and their uses
EP3227684B1 (en) 2014-12-03 2019-10-02 Isoplexis Corporation Analysis and screening of cell secretion profiles
US10488321B2 (en) 2015-03-19 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip
CN107667178A (zh) 2015-03-26 2018-02-06 休斯敦大学系统 细胞的整合功能和分子概况
WO2017124101A2 (en) 2016-01-15 2017-07-20 The Broad Institute Inc. Semi-permeable arrays for analyzing biological systems and methods of using same
WO2017165791A1 (en) 2016-03-25 2017-09-28 President And Fellows Of Harvard College Microfluidic determination of immune and other cells
WO2017169267A1 (ja) * 2016-03-30 2017-10-05 ソニー株式会社 細胞観察装置、免疫細胞の活性度の評価方法及び免疫細胞の品質管理方法
SG11201811104TA (en) 2016-06-14 2019-01-30 Cellply S R L Screening kit and method
CN106086171A (zh) * 2016-06-15 2016-11-09 广州中大南沙科技创新产业园有限公司 一种抑制肿瘤细胞增殖的药物筛选方法
EP3472351B1 (de) 2016-06-15 2020-10-28 Ludwig-Maximilians-Universität München Einzelmolekülnachweis bzw. -quantifizierung durch dna-nanotechnologie
EP3510398A1 (en) 2016-09-12 2019-07-17 Isoplexis Corporation System and methods for multiplexed analysis of cellular and other immunotherapeutics
EP3532600A4 (en) * 2016-10-19 2020-09-16 General Automation LAB Technologies Inc. HIGH RESOLUTION SYSTEMS, KITS, DEVICES AND METHODS FOR SCREENING MICRO-ORGANISMS AND OTHER HIGH-PERFORMANCE MICROBIOLOGICAL APPLICATIONS
US11493508B2 (en) 2016-11-11 2022-11-08 IsoPlexis Corporation Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells
US11085912B2 (en) * 2016-12-14 2021-08-10 University Of Cincinnati Methods of diagnosing Clostridium difficile infection or recurrence in a subject
SE543211C2 (en) 2017-06-29 2020-10-27 Mabtech Production Ab Method and system for analyzing Fluorospot assays
CA3084439A1 (en) 2017-12-07 2019-06-13 Massachusetts Institute Of Technology Single cell analyses
CN108728356B (zh) * 2018-05-23 2022-02-22 北京科技大学 用于不同三维细胞团配对的装置及共培养方法
CN113614532A (zh) * 2019-01-16 2021-11-05 烟台澳斯邦生物工程有限公司 沉积用于显微镜检查的生物样品的自动液体处理系统和方法
KR102800844B1 (ko) 2019-02-18 2025-04-29 가부시키가이샤 에누비 켄코우겡큐쇼 세포의 선발 방법, 핵산의 제조 방법, 재조합 세포의 제조 방법, 목적 물질의 제조 방법, 의약 조성물의 제조 방법, 및 시약
US12064768B2 (en) 2020-02-21 2024-08-20 Northeastern University Single cell isolation and processing system with reversible well shape
US20240182849A1 (en) 2022-11-07 2024-06-06 Shennon Biotechnologies Inc. Microfluidic Devices for High Throughput Screening of Cell-Cell Interactions

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EP2370814B1 (en) 2008-12-04 2015-04-29 Massachusetts Institute of Technology Method for diagnosing allergic reactions
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US20120149592A1 (en) 2012-06-14
JP2012515548A (ja) 2012-07-12
AU2009338127A1 (en) 2011-07-28
WO2010085275A1 (en) 2010-07-29
SG10201401643PA (en) 2014-08-28
AU2009338127B2 (en) 2015-11-26
EP2389446A4 (en) 2012-10-03
SG172889A1 (en) 2011-08-29
CA2689681C (en) 2017-08-29
RU2532228C2 (ru) 2014-10-27
RU2011134898A (ru) 2013-02-27
JP2015144617A (ja) 2015-08-13
IL213938A0 (en) 2011-07-31
JP6017620B2 (ja) 2016-11-02
CN104745669A (zh) 2015-07-01
CN102388145A (zh) 2012-03-21
EP2389446B1 (en) 2017-07-05
EP2389446A1 (en) 2011-11-30
US9244071B2 (en) 2016-01-26
CA2689681A1 (en) 2010-07-21

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