IL203797A - Benzimidazole and Indole History of Oxadiazole and Oxazole Preserved as 1dgat Inhibitors - Google Patents

Benzimidazole and Indole History of Oxadiazole and Oxazole Preserved as 1dgat Inhibitors

Info

Publication number
IL203797A
IL203797A IL203797A IL20379710A IL203797A IL 203797 A IL203797 A IL 203797A IL 203797 A IL203797 A IL 203797A IL 20379710 A IL20379710 A IL 20379710A IL 203797 A IL203797 A IL 203797A
Authority
IL
Israel
Prior art keywords
oxadiazole
oxazole
indole
derivatives
substituted benzimidazole
Prior art date
Application number
IL203797A
Other languages
English (en)
Hebrew (he)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL203797A publication Critical patent/IL203797A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL203797A 2007-09-28 2010-02-08 Benzimidazole and Indole History of Oxadiazole and Oxazole Preserved as 1dgat Inhibitors IL203797A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97606407P 2007-09-28 2007-09-28
PCT/EP2008/062900 WO2009040410A1 (en) 2007-09-28 2008-09-26 Oxadiazole- and oxazole-substituted benzimidazole- and indole-derivatives as dgat1 inhibitors

Publications (1)

Publication Number Publication Date
IL203797A true IL203797A (en) 2014-01-30

Family

ID=39971086

Family Applications (1)

Application Number Title Priority Date Filing Date
IL203797A IL203797A (en) 2007-09-28 2010-02-08 Benzimidazole and Indole History of Oxadiazole and Oxazole Preserved as 1dgat Inhibitors

Country Status (27)

Country Link
US (2) US7879850B2 (cg-RX-API-DMAC7.html)
EP (1) EP2205595B1 (cg-RX-API-DMAC7.html)
JP (1) JP5675359B2 (cg-RX-API-DMAC7.html)
KR (1) KR101616133B1 (cg-RX-API-DMAC7.html)
CN (1) CN101932576B (cg-RX-API-DMAC7.html)
AR (1) AR066169A1 (cg-RX-API-DMAC7.html)
AU (1) AU2008303541B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0817272A2 (cg-RX-API-DMAC7.html)
CA (1) CA2701053C (cg-RX-API-DMAC7.html)
CL (1) CL2008002871A1 (cg-RX-API-DMAC7.html)
CO (1) CO6251263A2 (cg-RX-API-DMAC7.html)
CR (1) CR11261A (cg-RX-API-DMAC7.html)
CU (1) CU20100049A7 (cg-RX-API-DMAC7.html)
EA (1) EA019347B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP10010051A (cg-RX-API-DMAC7.html)
ES (1) ES2525703T3 (cg-RX-API-DMAC7.html)
IL (1) IL203797A (cg-RX-API-DMAC7.html)
MA (1) MA31707B1 (cg-RX-API-DMAC7.html)
MX (1) MX2010003264A (cg-RX-API-DMAC7.html)
MY (1) MY151551A (cg-RX-API-DMAC7.html)
NZ (1) NZ583285A (cg-RX-API-DMAC7.html)
PE (1) PE20090774A1 (cg-RX-API-DMAC7.html)
TN (1) TN2010000096A1 (cg-RX-API-DMAC7.html)
TW (1) TWI429642B (cg-RX-API-DMAC7.html)
UA (1) UA99305C2 (cg-RX-API-DMAC7.html)
WO (1) WO2009040410A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201000829B (cg-RX-API-DMAC7.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2588162A1 (en) 2004-12-14 2006-06-22 Astrazeneca Ab Oxadiazole derivatives as dgat inhibitors
US7749997B2 (en) 2005-12-22 2010-07-06 Astrazeneca Ab Pyrimido [4,5-B] -Oxazines for use as DGAT inhibitors
AU2007266796B2 (en) 2006-05-30 2011-02-10 Astrazeneca Ab Substituted 5-phenylamino-1,3,4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase
AR066169A1 (es) * 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
WO2009112445A1 (en) * 2008-03-10 2009-09-17 Novartis Ag Method of increasing cellular phosphatidyl choline by dgat1 inhibition
US8637507B2 (en) 2009-03-18 2014-01-28 Merck Sharp & Dohme Corp. Bicyclic compounds as inhibitors of diacylglycerol acyltransferase
US8748426B2 (en) 2009-12-31 2014-06-10 Piramal Enterprises Limited Inhibitors of diacylglycerol acyl transferase
EP2552441B1 (en) * 2010-03-30 2016-05-04 Novartis AG Uses of dgat1 inhibitors
WO2012044567A2 (en) * 2010-09-30 2012-04-05 Merck Sharp & Dohme Corp. Imidazole derivatives
WO2012064569A1 (en) * 2010-11-08 2012-05-18 Merck Sharp & Dohme Corp. Imidazole derivatives
RU2609200C2 (ru) 2011-07-08 2017-01-30 Новартис Аг Способ лечения атеросклероза у субъектов с высоким уровнем триглицеридов
WO2013074387A1 (en) * 2011-11-14 2013-05-23 Merck Sharp & Dohme Corp. Imidazole derivatives
WO2013169648A1 (en) 2012-05-07 2013-11-14 Novartis Ag Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug
EP2903985A1 (en) 2012-10-03 2015-08-12 Advinus Therapeutics Limited Spirocyclic compounds, compositions and medicinal applications thereof
HRP20190099T1 (hr) * 2012-11-23 2019-04-19 Glaxosmithkline Llc Novi spojevi kao inhibitori diacilglicerin aciltransferaze
WO2014081996A1 (en) * 2012-11-23 2014-05-30 Glaxosmithkline Llc Novel compounds as diacylglycerol acyltransferase inhibitors
US9796729B2 (en) 2012-11-23 2017-10-24 Glaxosmithkline Llc Compounds as diacylglycerol acyltransferase inhibitors
CN103087045B (zh) * 2013-01-11 2015-08-12 上海交通大学 一种苯并咪唑类杂环化合物、药物组合物及其用途
CN104672144A (zh) * 2015-02-13 2015-06-03 佛山市赛维斯医药科技有限公司 一种环丙基酰肼和硝基苯类gpr119激动剂、制备方法及其用途
CN104610152A (zh) * 2015-02-13 2015-05-13 佛山市赛维斯医药科技有限公司 一类环丙基酰肼类gpr119激动剂、制备方法及其用途
MY205335A (en) 2018-03-16 2024-10-16 Anji Pharmaceuticals Inc Compositions and methods for treating severe constipation
WO2020110008A1 (en) 2018-11-27 2020-06-04 Novartis Ag Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
JP7657151B2 (ja) 2018-11-27 2025-04-04 ノバルティス アーゲー 代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン／ケキシン９型（ｐｃｓｋ９）阻害剤としての環状ペプチド
WO2023084449A1 (en) 2021-11-12 2023-05-19 Novartis Ag Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder
CN117466863A (zh) * 2022-07-20 2024-01-30 盛睿泽华医药科技（苏州）有限公司 含芳香族取代基的苯并咪唑化合物及其制备方法和用途

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69635135T2 (de) 1995-12-28 2006-07-06 Fujisawa Pharmaceutical Co., Ltd. Benzimidazolderivate
WO2002072549A1 (en) 2001-03-12 2002-09-19 Millennium Pharmaceuticals, Inc. Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
CA2451980C (en) 2001-08-13 2012-12-11 Janssen Pharmaceutica N.V. 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune disorders
WO2004047755A2 (en) 2002-11-22 2004-06-10 Japan Tobacco Inc. Fused bicyclic nitrogen-containing heterocycles
BR0316948A (pt) * 2002-12-11 2005-10-18 Lilly Co Eli Composto, formulação farmacêutica, e, uso de um composto
JP4560035B2 (ja) 2003-01-27 2010-10-13 メルク・シャープ・エンド・ドーム・コーポレイション 置換ピラゾール、このような化合物を含有する組成物及び使用方法
AR044152A1 (es) * 2003-05-09 2005-08-24 Bayer Corp Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad
JP3878625B2 (ja) 2003-06-20 2007-02-07 松下電器産業株式会社 振幅調整回路、モータ駆動制御装置、振幅調整方法、及びモータ駆動制御方法
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
EP1653969A4 (en) * 2003-08-07 2006-12-20 Japan Tobacco Inc PYRROLO 1,2-B PYRIDAZINE DERIVATIVES
WO2005035526A1 (en) 2003-10-09 2005-04-21 Argenta Discovery Ltd. Bicyclic compounds and their therapeutic use
WO2005080371A1 (en) 2004-02-12 2005-09-01 Merck & Co., Inc. Amino heterocyclic modulators of chemokine receptor activity
JPWO2005108370A1 (ja) * 2004-04-16 2008-03-21 味の素株式会社 ベンゼン化合物
WO2005121132A1 (ja) 2004-06-11 2005-12-22 Shionogi & Co., Ltd. 抗ｈｃｖ作用を有する縮合ヘテロ環化合物
EP1764360A4 (en) 2004-07-02 2010-08-11 Sankyo Co UREA DERIVATIVE
CN101087769A (zh) 2004-10-15 2007-12-12 拜尔药品公司 用于治疗肥胖的联苯－4－基－羰基氨基酸衍生物的制备及用途
EP1807396B1 (en) 2004-10-29 2013-06-26 Merck Sharp & Dohme Corp. 2-aminopyridine compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
CA2588162A1 (en) 2004-12-14 2006-06-22 Astrazeneca Ab Oxadiazole derivatives as dgat inhibitors
EP1845081A4 (en) 2005-02-01 2009-03-25 Takeda Pharmaceutical amide
KR20080000652A (ko) 2005-04-19 2008-01-02 바이엘 파마슈티칼스 코포레이션 아릴 알킬산 유도체 및 그의 용도
CA2607121A1 (en) 2005-05-10 2006-11-16 Christophe Michoud Diacylglycerol acyltransferase inhibitors
JP2008543747A (ja) * 2005-06-11 2008-12-04 アストラゼネカ アクチボラグ Ｄｇａｔ阻害剤としてのオキサジアゾール誘導体
EP1912634A4 (en) 2005-07-29 2010-06-09 Bayer Healthcare Llc PREPARATION AND USE OF BIPHENYL AMINOACIDAL DERIVATIVES TO TREAT OBESITY
WO2007022269A2 (en) 2005-08-15 2007-02-22 Irm Llc Compounds and compositions as tpo mimetics
CA2669736C (en) 2005-11-03 2017-02-21 Chembridge Research Laboratories, Inc. Heterocyclic compounds as tyrosine kinase modulators
AU2006316560B2 (en) * 2005-11-28 2011-06-16 Madrigal Pharmaceuticals, Inc. Inhibitors of diacyglycerol acyltransferase (DGAT)
US7749997B2 (en) 2005-12-22 2010-07-06 Astrazeneca Ab Pyrimido [4,5-B] -Oxazines for use as DGAT inhibitors
WO2007137103A2 (en) 2006-05-19 2007-11-29 Abbott Laboratories Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme
US20080064717A1 (en) 2006-05-19 2008-03-13 Rajesh Iyengar Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme
AU2007266796B2 (en) 2006-05-30 2011-02-10 Astrazeneca Ab Substituted 5-phenylamino-1,3,4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase
NZ572585A (en) 2006-05-30 2011-02-25 Astrazeneca Ab 1,3,4-Oxadiazole derivatives as DGAT1 inhibitors
CN101460469A (zh) 2006-06-06 2009-06-17 阿斯利康(瑞典)有限公司 化合物
MX2008015725A (es) 2006-06-08 2009-02-13 Astrazeneca Ab Benzimidazolas y su uso para el tratamiento de diabetes.
GB0611506D0 (en) 2006-06-10 2006-07-19 Astrazeneca Ab Chemical compounds
GB0611507D0 (en) 2006-06-10 2006-07-19 Astrazeneca Ab Chemical compounds
GB0611552D0 (en) 2006-06-12 2006-07-19 Astrazeneca Ab Chemical compounds
US20120065196A1 (en) 2006-07-21 2012-03-15 Shuji Kitamura Amide compounds
EP2044055A4 (en) 2006-07-21 2011-03-23 Takeda Pharmaceutical amide compounds
CA2669884A1 (en) 2006-11-15 2008-05-22 High Point Pharmaceuticals, Llc Novel 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes
CN101636155A (zh) 2006-11-29 2010-01-27 艾博特公司 二酰甘油o-酰基转移酶1型酶的抑制剂
WO2008099221A1 (en) 2007-02-15 2008-08-21 Prosidion Limited Amide and urea derivatives for the treatment of metabolic diseases
GB0707662D0 (en) 2007-04-20 2007-05-30 Astrazeneca Ab Chemical compounds
JP5383661B2 (ja) 2007-04-30 2014-01-08 アッヴィ・インコーポレイテッド ジアシルグリセロールｏ−アシル転移酵素１型酵素の阻害剤
JP2010526781A (ja) 2007-04-30 2010-08-05 アボット・ラボラトリーズ ジアシルグリセロールｏ−アシル転移酵素１型酵素の阻害剤
US8115011B2 (en) * 2007-05-22 2012-02-14 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8058299B2 (en) * 2007-05-22 2011-11-15 Via Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
AU2008253118B2 (en) 2007-05-22 2013-11-21 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8153644B2 (en) * 2007-05-22 2012-04-10 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
CA2687918C (en) 2007-06-08 2016-11-08 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
CN101678019B (zh) 2007-06-08 2016-03-30 詹森药业有限公司 哌啶/哌嗪衍生物
AU2008258549B2 (en) 2007-06-08 2013-11-14 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
WO2009011285A1 (ja) 2007-07-13 2009-01-22 Taisho Pharmaceutical Co., Ltd. ヘテロアリールベンゼン化合物
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
US20110092547A1 (en) 2007-08-17 2011-04-21 Alan Martin Birch Chemical compounds 979
US20090076275A1 (en) * 2007-09-19 2009-03-19 David Robert Bolin Diacylglycerol acyltransferase inhibitors
AR066169A1 (es) 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
WO2009071483A1 (en) 2007-12-07 2009-06-11 Via Pharmaceuticals, Inc. 1- (indaz0l-5-yl) -ureas as diacylglycerol acyltransferase inhibitors
EP2234978B1 (en) 2007-12-20 2015-02-25 AstraZeneca AB Carbamoyl compounds as dgat1 inhibitors 190
BRPI0913986A2 (pt) 2008-03-26 2015-10-20 Daiichi Sankyo Co Ltd composto, composição farmacêutica, e, uso de um composto
UY31863A (es) 2008-06-05 2010-01-05 Janssen Pharmaceutica Nv Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
AR072559A1 (es) 2008-07-15 2010-09-08 Novartis Ag Amidas sustituidas, composicion farmaceutica que las comprende y su uso en el tratamiento de enfermedades mediadas por dgat1.

Also Published As

Publication number Publication date
AU2008303541B2 (en) 2012-06-07
CN101932576B (zh) 2014-09-10
ES2525703T3 (es) 2014-12-29
CU20100049A7 (es) 2011-09-21
CR11261A (es) 2010-04-26
US20090186891A1 (en) 2009-07-23
US8217065B2 (en) 2012-07-10
CU23901B1 (cg-RX-API-DMAC7.html) 2013-06-28
MA31707B1 (fr) 2010-09-01
JP2011501735A (ja) 2011-01-13
CA2701053A1 (en) 2009-04-02
US7879850B2 (en) 2011-02-01
TW200914449A (en) 2009-04-01
AU2008303541A1 (en) 2009-04-02
ZA201000829B (en) 2010-12-29
MY151551A (en) 2014-06-13
CL2008002871A1 (es) 2009-05-15
KR20100071048A (ko) 2010-06-28
PE20090774A1 (es) 2009-07-17
JP5675359B2 (ja) 2015-02-25
EA201000428A1 (ru) 2010-10-29
EA019347B1 (ru) 2014-03-31
CA2701053C (en) 2016-08-23
UA99305C2 (ru) 2012-08-10
TN2010000096A1 (en) 2011-09-26
CO6251263A2 (es) 2011-02-21
WO2009040410A1 (en) 2009-04-02
US20110077277A1 (en) 2011-03-31
MX2010003264A (es) 2010-04-01
CN101932576A (zh) 2010-12-29
NZ583285A (en) 2012-05-25
TWI429642B (zh) 2014-03-11
EP2205595A1 (en) 2010-07-14
KR101616133B1 (ko) 2016-04-27
EP2205595B1 (en) 2014-09-10
AR066169A1 (es) 2009-07-29
ECSP10010051A (es) 2010-04-30
BRPI0817272A2 (pt) 2015-06-16

Similar Documents

Publication Publication Date Title
ZA201000829B (en) Oxadiazole- and oxazole-substituted benzamidazole-and indole-derivatives as dgat1 inhibitors
HUS1700018I1 (hu) Proteoszóma inhibitorok
IL211693A0 (en) Imidazopyridazinecarbonitriles useful as kinase inhibitors
PT2402319T (pt) Inibidores de dgat
IL209729A0 (en) Novel phenylpyrazinones as kinase inhibitors
IL210292A0 (en) Heteroaryl derivatives as dgat1 inhibitors
ZA201004942B (en) Ptrrolopyrazine kinase inhibitors
IL211018A0 (en) Novel inhibitors
IL201367A0 (en) 2 - morpholin - 4 - yl - pyrimidines as pi3k inhibitors
ZA201008878B (en) Naphthyridiniones as aurora kinase inhibitors
ZA201102837B (en) Phosphodiestarase inhibitors
GB0714941D0 (en) Inhibitors
HK1142316A (en) Oxadiazole- and oxazole-substituted benzimidazole- and indole-derivatives as dgat1 inhibitors
GB0713152D0 (en) Phosphodlesterase inhibitors
GB0707632D0 (en) Novel inhibitors
GB0704589D0 (en) Novel inhibitors
GB0707495D0 (en) Novel inhibitors
GB0707499D0 (en) Novel inhibitors
GB0707498D0 (en) Novel inhibitors
GB0707493D0 (en) Novel inhibitors
GB0707497D0 (en) Novel inhibitors
GB0707488D0 (en) Novel inhibitors
GB201019387D0 (en) Inhibitors
GB0816125D0 (en) Novel inhibitors
GB0720364D0 (en) Inhibitor

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees