IL192081A0 - Novel, cyclic substituted furopyrimidine derivatives and use thereof for treating cardiovascular diseases - Google Patents
Novel, cyclic substituted furopyrimidine derivatives and use thereof for treating cardiovascular diseasesInfo
- Publication number
- IL192081A0 IL192081A0 IL192081A IL19208108A IL192081A0 IL 192081 A0 IL192081 A0 IL 192081A0 IL 192081 A IL192081 A IL 192081A IL 19208108 A IL19208108 A IL 19208108A IL 192081 A0 IL192081 A0 IL 192081A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- alkoxy
- mono
- ocf
- cycloalkyl
- Prior art date
Links
- JUQAECQBUNODQP-UHFFFAOYSA-N furo[3,2-d]pyrimidine Chemical class C1=NC=C2OC=CC2=N1 JUQAECQBUNODQP-UHFFFAOYSA-N 0.000 title abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 102000009079 Epoprostenol Receptors Human genes 0.000 abstract 2
- 108091006335 Prostaglandin I receptors Proteins 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- -1 1H-tetrazol-5-yl Chemical group 0.000 abstract 1
- CBIWCJGTVQGGIQ-UHFFFAOYSA-N 2-[3-[[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino]phenoxy]acetic acid Chemical compound C1=CC(OC)=CC=C1C1=C(C=2C=CC=CC=2)OC2=NC=NC(NC=3C=C(OCC(O)=O)C=CC=3)=C12 CBIWCJGTVQGGIQ-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000003257 anti-anginal effect Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 230000001966 cerebroprotective effect Effects 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000002439 hemostatic effect Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000001525 receptor binding assay Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005061171A DE102005061171A1 (de) | 2005-12-21 | 2005-12-21 | Neue, cyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung |
| PCT/EP2006/011825 WO2007079861A1 (de) | 2005-12-21 | 2006-12-08 | Neue, zyklisch substituierte furopyrimidin-derivate und ihre verwendung zur behandlung von kardiovaskulären erkrankungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL192081A0 true IL192081A0 (en) | 2008-12-29 |
Family
ID=37758644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL192081A IL192081A0 (en) | 2005-12-21 | 2008-06-12 | Novel, cyclic substituted furopyrimidine derivatives and use thereof for treating cardiovascular diseases |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8324222B2 (OSRAM) |
| EP (1) | EP1966218B1 (OSRAM) |
| JP (1) | JP2009523711A (OSRAM) |
| KR (1) | KR20080081325A (OSRAM) |
| CN (1) | CN101384602A (OSRAM) |
| AT (1) | ATE473982T1 (OSRAM) |
| AU (1) | AU2006334855A1 (OSRAM) |
| BR (1) | BRPI0620647A2 (OSRAM) |
| CA (1) | CA2633698A1 (OSRAM) |
| DE (2) | DE102005061171A1 (OSRAM) |
| ES (1) | ES2347593T3 (OSRAM) |
| IL (1) | IL192081A0 (OSRAM) |
| RU (1) | RU2008129364A (OSRAM) |
| WO (1) | WO2007079861A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007019690A1 (de) * | 2007-04-26 | 2008-10-30 | Bayer Healthcare Ag | Verwendung von cyclisch substituierten Furopyrimidin-Derivaten zur Behandlung der pulmonalen arteriellen Hypertonie |
| DE102007027800A1 (de) * | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
| DE102007051762A1 (de) | 2007-10-30 | 2009-05-07 | Bayer Healthcare Ag | Substituierte Pyrrolotriazine und ihre Verwendung |
| DE102007054786A1 (de) * | 2007-11-16 | 2009-05-20 | Bayer Healthcare Ag | Trisubstituierte Furopyrimidine und ihre Verwendung |
| EP2315739B1 (en) | 2008-08-25 | 2014-11-12 | DuPont Electronic Polymers L.P. | New propanoates and processes for preparing the same |
| WO2022119823A1 (en) * | 2020-12-04 | 2022-06-09 | The Johns Hopkins University | Compounds and their use for treating neuropathic pain |
| CN115462369B (zh) * | 2022-09-29 | 2023-09-22 | 安徽省立医院(中国科学技术大学附属第一医院) | 一种玻璃化冷冻外泌体保存方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577420A (en) * | 1968-01-05 | 1971-05-04 | Pfizer | Certain 4-aminofuro(2,3-d)pyrimidines |
| WO2000005234A1 (en) | 1998-07-22 | 2000-02-03 | Suntory Limited | NF-λB INHIBITORS CONTAINING INDAN DERIVATIVES AS THE ACTIVE INGREDIENT |
| WO2000075145A1 (en) | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| CA2350992C (en) | 1999-09-17 | 2009-06-23 | Suntory Limited | Preventive or therapeutic agents for myocarditis, dilated cardiomyopathy and heart failure comprising nf-kb inhibitors as active ingredients |
| JP4155827B2 (ja) | 2001-05-14 | 2008-09-24 | ノバルティス アクチエンゲゼルシャフト | オキサゾロ−およびフロピリミジンならびに腫瘍に対する医薬としてのその使用 |
| DE10141212A1 (de) | 2001-08-22 | 2003-03-06 | Bayer Ag | Neue 4-Aminofuropyrimidine und ihre Verwendung |
| JP2005508904A (ja) | 2001-09-11 | 2005-04-07 | スミスクライン ビーチャム コーポレーション | 血管新生阻害剤としてのフロ−及びチエノピリミジン誘導体 |
| DE10148883A1 (de) * | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | Pyrimidinderivate |
| US20030225098A1 (en) * | 2002-03-21 | 2003-12-04 | Hirst Gavin C. | Kinase inhibitors |
| KR20050091462A (ko) | 2004-03-12 | 2005-09-15 | 한국과학기술연구원 | 푸로피리미딘 화합물 및 이를 포함하는 ｄｄｒ2 티로신키나아제 활성 저해제 |
| EP1758909A1 (en) | 2004-06-10 | 2007-03-07 | Xention Limited | Furanopyrimidine compounds effective as potassium channel inhibitors |
| AU2005260077A1 (en) * | 2004-06-29 | 2006-01-12 | Amgen Inc. | Furanopyrimidines |
-
2005
- 2005-12-21 DE DE102005061171A patent/DE102005061171A1/de not_active Withdrawn
-
2006
- 2006-12-08 JP JP2008546192A patent/JP2009523711A/ja active Pending
- 2006-12-08 CA CA002633698A patent/CA2633698A1/en not_active Abandoned
- 2006-12-08 AU AU2006334855A patent/AU2006334855A1/en not_active Abandoned
- 2006-12-08 AT AT06840964T patent/ATE473982T1/de active
- 2006-12-08 WO PCT/EP2006/011825 patent/WO2007079861A1/de not_active Ceased
- 2006-12-08 DE DE502006007450T patent/DE502006007450D1/de active Active
- 2006-12-08 RU RU2008129364/04A patent/RU2008129364A/ru not_active Application Discontinuation
- 2006-12-08 BR BRPI0620647-6A patent/BRPI0620647A2/pt not_active IP Right Cessation
- 2006-12-08 KR KR1020087017645A patent/KR20080081325A/ko not_active Withdrawn
- 2006-12-08 US US12/086,784 patent/US8324222B2/en not_active Expired - Fee Related
- 2006-12-08 EP EP06840964A patent/EP1966218B1/de not_active Not-in-force
- 2006-12-08 ES ES06840964T patent/ES2347593T3/es active Active
- 2006-12-08 CN CNA200680053205XA patent/CN101384602A/zh active Pending
-
2008
- 2008-06-12 IL IL192081A patent/IL192081A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006334855A1 (en) | 2007-07-19 |
| ATE473982T1 (de) | 2010-07-15 |
| US20110124665A1 (en) | 2011-05-26 |
| ES2347593T3 (es) | 2010-11-02 |
| EP1966218A1 (de) | 2008-09-10 |
| DE102005061171A1 (de) | 2007-07-05 |
| CN101384602A (zh) | 2009-03-11 |
| WO2007079861A1 (de) | 2007-07-19 |
| DE502006007450D1 (de) | 2010-08-26 |
| CA2633698A1 (en) | 2007-07-19 |
| EP1966218B1 (de) | 2010-07-14 |
| BRPI0620647A2 (pt) | 2011-11-16 |
| JP2009523711A (ja) | 2009-06-25 |
| US8324222B2 (en) | 2012-12-04 |
| RU2008129364A (ru) | 2010-01-27 |
| KR20080081325A (ko) | 2008-09-09 |
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