IL182756A - A compound of inverted micelles for the delivery of metal cations, containing diglycerides and phytosterols and a method for its preparation - Google Patents
A compound of inverted micelles for the delivery of metal cations, containing diglycerides and phytosterols and a method for its preparationInfo
- Publication number
- IL182756A IL182756A IL182756A IL18275607A IL182756A IL 182756 A IL182756 A IL 182756A IL 182756 A IL182756 A IL 182756A IL 18275607 A IL18275607 A IL 18275607A IL 182756 A IL182756 A IL 182756A
- Authority
- IL
- Israel
- Prior art keywords
- metal
- reverse micelles
- water
- reverse
- activity
- Prior art date
Links
- 239000000693 micelle Substances 0.000 title claims abstract description 93
- 229910052751 metal Inorganic materials 0.000 title claims abstract description 85
- 239000002184 metal Substances 0.000 title claims abstract description 85
- 230000002441 reversible effect Effects 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 title claims abstract description 48
- 239000000203 mixture Substances 0.000 title claims description 62
- 150000001768 cations Chemical class 0.000 title claims description 30
- 238000002360 preparation method Methods 0.000 title abstract description 25
- 229930182558 Sterol Natural products 0.000 claims abstract description 25
- 150000003432 sterols Chemical class 0.000 claims abstract description 25
- 235000003702 sterols Nutrition 0.000 claims abstract description 25
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 45
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 claims description 40
- 229950005143 sitosterol Drugs 0.000 claims description 36
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 claims description 35
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 claims description 35
- 229910052712 strontium Inorganic materials 0.000 claims description 26
- 229910052720 vanadium Inorganic materials 0.000 claims description 25
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 24
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims description 23
- 239000008213 purified water Substances 0.000 claims description 16
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- 238000000527 sonication Methods 0.000 claims description 15
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 14
- 239000000194 fatty acid Substances 0.000 claims description 14
- 229930195729 fatty acid Natural products 0.000 claims description 14
- 150000004665 fatty acids Chemical class 0.000 claims description 14
- 229910052744 lithium Inorganic materials 0.000 claims description 11
- 238000007254 oxidation reaction Methods 0.000 claims description 11
- 230000003647 oxidation Effects 0.000 claims description 10
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 6
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- 229910052711 selenium Inorganic materials 0.000 claims description 5
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
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- PWTCCMJTPHCGMS-KHPPLWFESA-N (2-acetyloxy-3-hydroxypropyl) (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(CO)OC(C)=O PWTCCMJTPHCGMS-KHPPLWFESA-N 0.000 claims description 3
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- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 3
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- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 claims description 2
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-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Mycology (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
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- Transplantation (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04025987A EP1652512A1 (en) | 2004-11-02 | 2004-11-02 | Reverse micelle composition for delivery of metal cations comprising a diglyceride and a phytosterol and method of preparation |
| PCT/IB2005/003605 WO2006048773A1 (en) | 2004-11-02 | 2005-11-02 | Reverse micelle composition for delivery of metal cations comprising a diglyceride and a phytosterol and method of preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL182756A0 IL182756A0 (en) | 2007-07-24 |
| IL182756A true IL182756A (en) | 2011-02-28 |
Family
ID=34927200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL182756A IL182756A (en) | 2004-11-02 | 2007-04-23 | A compound of inverted micelles for the delivery of metal cations, containing diglycerides and phytosterols and a method for its preparation |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9173838B2 (ja) |
| EP (2) | EP1652512A1 (ja) |
| JP (1) | JP4975631B2 (ja) |
| CN (1) | CN101102751B (ja) |
| AT (1) | ATE483454T1 (ja) |
| AU (1) | AU2005300253B2 (ja) |
| CA (1) | CA2584684C (ja) |
| DE (1) | DE602005024036D1 (ja) |
| DK (1) | DK1807048T3 (ja) |
| EA (1) | EA012210B1 (ja) |
| ES (1) | ES2353804T3 (ja) |
| HK (1) | HK1108368A1 (ja) |
| IL (1) | IL182756A (ja) |
| PL (1) | PL1807048T3 (ja) |
| PT (1) | PT1807048E (ja) |
| WO (1) | WO2006048773A1 (ja) |
| ZA (1) | ZA200704286B (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1652513A1 (en) * | 2004-11-02 | 2006-05-03 | Denderah Pharm Sa | Reverse micelles based on sterols and acylglycerols and therapeutic uses thereof |
| WO2011117333A2 (en) | 2010-03-24 | 2011-09-29 | Medesis Pharma | Reverse micelle system comprising metal ions and use thereof |
| BRPI1000970A2 (pt) * | 2010-04-07 | 2011-11-29 | Fundacao Arnaldo Vieira De Carvalho | composição farmacêutica para o tratamento da doença de alzheimer, processo para sua obtenção e uso |
| WO2012007387A1 (en) * | 2010-07-13 | 2012-01-19 | Medesis Pharma | Low- dose lithium for the treatment of neurodegenerative disorders |
| CN116459214A (zh) | 2015-07-09 | 2023-07-21 | 麦迪西斯医药公司 | 在生物相容性反胶束系统内原位制备氰基桥接的金属纳米粒子的方法 |
| JP7399162B2 (ja) * | 2018-07-06 | 2023-12-15 | メディシス・ファルマ | 放射線曝露に起因する傷害の治療及び予防 |
| WO2024184369A1 (en) * | 2023-03-06 | 2024-09-12 | Medesis Pharma | Formulation for the buccal administration of a biocompatible reverse micelle system |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5252333A (en) * | 1987-04-27 | 1993-10-12 | Scotia Holdings Plc | Lithium salt-containing pharmaceutical compositions |
| FR2658816A1 (fr) * | 1990-02-27 | 1991-08-30 | Adir | Nouveaux sels de metaux alcalinoterreux d'oxa-polyacides leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2729957B1 (fr) | 1995-01-31 | 1997-12-05 | Maurel Sante | Complexes organometalliques a base de sitosterols et d'acylglycerols et compositions pharmaceutiques et produits dietetiques en contenant. |
| FR2750606B1 (fr) * | 1996-07-03 | 1999-01-29 | Maurel Sante | Complexes organometalliques a base de sitosterols et de diglycerides et compositions pharmaceutiques en contenant |
| JPH119988A (ja) * | 1997-06-26 | 1999-01-19 | Advanced Sukin Res Kenkyusho:Kk | 油中水型マイクロエマルション |
| JPH1129464A (ja) * | 1997-07-07 | 1999-02-02 | Advanced Sukin Res Kenkyusho:Kk | コレステロールを添加する油中水型マイクロエマルション |
| AU4031500A (en) * | 1999-03-26 | 2000-10-16 | Akesis Pharmaceuticals, Inc. | Edible solids for treatment of glucose metabolism disorders |
| US6623765B1 (en) * | 2000-08-01 | 2003-09-23 | University Of Florida, Research Foundation, Incorporated | Microemulsion and micelle systems for solubilizing drugs |
| US6365176B1 (en) * | 2000-08-08 | 2002-04-02 | Functional Foods, Inc. | Nutritional supplement for patients with type 2 diabetes mellitus for lipodystrophy |
| PL201177B1 (pl) * | 2001-01-25 | 2009-03-31 | Unilever Nv | Jadalna mikroemulsja woda w oleju, sposób jej wytwarzania oraz jej zastosowanie |
| US20030113366A1 (en) * | 2001-12-14 | 2003-06-19 | Macgregor Alexander | Reverse-micellar delivery system for controlled transportation and enhanced absorption of agents |
| EP1452175A1 (en) * | 2003-02-28 | 2004-09-01 | Medesis Pharma S.A. | Manganese based organometallic complexes, pharmaceutical compositions and dietetic products |
| CN1457773A (zh) * | 2003-06-02 | 2003-11-26 | 乐益 | 治疗糖尿病的双胍钒络合物颗粒剂和/或胶囊剂及其用途 |
| EP1652513A1 (en) * | 2004-11-02 | 2006-05-03 | Denderah Pharm Sa | Reverse micelles based on sterols and acylglycerols and therapeutic uses thereof |
-
2004
- 2004-11-02 EP EP04025987A patent/EP1652512A1/en not_active Withdrawn
-
2005
- 2005-11-02 EA EA200700994A patent/EA012210B1/ru not_active IP Right Cessation
- 2005-11-02 JP JP2007539653A patent/JP4975631B2/ja not_active Expired - Fee Related
- 2005-11-02 AT AT05804076T patent/ATE483454T1/de active
- 2005-11-02 DK DK05804076.7T patent/DK1807048T3/da active
- 2005-11-02 DE DE602005024036T patent/DE602005024036D1/de active Active
- 2005-11-02 PT PT05804076T patent/PT1807048E/pt unknown
- 2005-11-02 WO PCT/IB2005/003605 patent/WO2006048773A1/en active Application Filing
- 2005-11-02 US US11/718,511 patent/US9173838B2/en not_active Expired - Fee Related
- 2005-11-02 EP EP05804076A patent/EP1807048B1/en not_active Not-in-force
- 2005-11-02 PL PL05804076T patent/PL1807048T3/pl unknown
- 2005-11-02 AU AU2005300253A patent/AU2005300253B2/en not_active Ceased
- 2005-11-02 CN CN200580037670XA patent/CN101102751B/zh active Active
- 2005-11-02 CA CA2584684A patent/CA2584684C/en not_active Expired - Fee Related
- 2005-11-02 ES ES05804076T patent/ES2353804T3/es active Active
-
2007
- 2007-04-23 IL IL182756A patent/IL182756A/en active IP Right Grant
- 2007-05-25 ZA ZA200704286A patent/ZA200704286B/xx unknown
- 2007-12-13 HK HK07113627.7A patent/HK1108368A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1108368A1 (en) | 2008-05-09 |
| CA2584684A1 (en) | 2006-05-11 |
| CN101102751A (zh) | 2008-01-09 |
| CA2584684C (en) | 2013-07-02 |
| PL1807048T3 (pl) | 2011-03-31 |
| ES2353804T3 (es) | 2011-03-07 |
| ZA200704286B (en) | 2008-09-25 |
| JP2008519026A (ja) | 2008-06-05 |
| IL182756A0 (en) | 2007-07-24 |
| DE602005024036D1 (de) | 2010-11-18 |
| EA012210B1 (ru) | 2009-08-28 |
| DK1807048T3 (da) | 2011-01-10 |
| WO2006048773A1 (en) | 2006-05-11 |
| EP1807048B1 (en) | 2010-10-06 |
| US20090087477A1 (en) | 2009-04-02 |
| EA200700994A1 (ru) | 2007-10-26 |
| CN101102751B (zh) | 2011-08-24 |
| ATE483454T1 (de) | 2010-10-15 |
| AU2005300253B2 (en) | 2010-09-09 |
| JP4975631B2 (ja) | 2012-07-11 |
| EP1652512A1 (en) | 2006-05-03 |
| EP1807048A1 (en) | 2007-07-18 |
| PT1807048E (pt) | 2010-11-29 |
| US9173838B2 (en) | 2015-11-03 |
| AU2005300253A1 (en) | 2006-05-11 |
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