IL177280A - Monohydrate crystal of 2-aminothiazole-5-aromatic carboxamide, process for its preparation, its pharmaceutical composition and its use in the preparation of medicine - Google Patents

Monohydrate crystal of 2-aminothiazole-5-aromatic carboxamide, process for its preparation, its pharmaceutical composition and its use in the preparation of medicine

Info

Publication number
IL177280A
IL177280A IL177280A IL17728006A IL177280A IL 177280 A IL177280 A IL 177280A IL 177280 A IL177280 A IL 177280A IL 17728006 A IL17728006 A IL 17728006A IL 177280 A IL177280 A IL 177280A
Authority
IL
Israel
Prior art keywords
same
aminothiazole
medicament
preparation
pharmaceutical composition
Prior art date
Application number
IL177280A
Other languages
English (en)
Hebrew (he)
Other versions
IL177280A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34864498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL177280(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL177280A0 publication Critical patent/IL177280A0/en
Publication of IL177280A publication Critical patent/IL177280A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL177280A 2004-02-06 2006-08-03 Monohydrate crystal of 2-aminothiazole-5-aromatic carboxamide, process for its preparation, its pharmaceutical composition and its use in the preparation of medicine IL177280A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54249004P 2004-02-06 2004-02-06
US62493704P 2004-11-04 2004-11-04
PCT/US2005/003728 WO2005077945A2 (en) 2004-02-06 2005-02-04 Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors

Publications (2)

Publication Number Publication Date
IL177280A0 IL177280A0 (en) 2006-12-10
IL177280A true IL177280A (en) 2013-09-30

Family

ID=34864498

Family Applications (1)

Application Number Title Priority Date Filing Date
IL177280A IL177280A (en) 2004-02-06 2006-08-03 Monohydrate crystal of 2-aminothiazole-5-aromatic carboxamide, process for its preparation, its pharmaceutical composition and its use in the preparation of medicine

Country Status (27)

Country Link
EP (1) EP1711481B2 (pt)
JP (2) JP5148115B2 (pt)
KR (2) KR101310427B1 (pt)
AR (1) AR047533A1 (pt)
AT (1) ATE453630T1 (pt)
AU (1) AU2005212405B2 (pt)
BR (1) BRPI0507476B8 (pt)
CA (1) CA2555291C (pt)
CY (1) CY1109907T1 (pt)
DE (1) DE602005018601D1 (pt)
DK (1) DK1711481T4 (pt)
ES (1) ES2337272T5 (pt)
GE (1) GEP20094804B (pt)
HK (1) HK1091835A1 (pt)
HR (1) HRP20100166T4 (pt)
IL (1) IL177280A (pt)
IN (1) IN2014DN06567A (pt)
NO (1) NO338049B1 (pt)
NZ (1) NZ548613A (pt)
PE (1) PE20050691A1 (pt)
PL (1) PL1711481T5 (pt)
PT (1) PT1711481E (pt)
RU (1) RU2382039C2 (pt)
SI (1) SI1711481T2 (pt)
TW (1) TWI338004B (pt)
WO (1) WO2005077945A2 (pt)
ZA (1) ZA200606242B (pt)

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PT1618092E (pt) 2003-05-01 2010-11-22 Bristol Myers Squibb Co Compostos de pirazol-amida substituídos com arilo úteis enquanto inibidores de cinase
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US7652146B2 (en) 2004-02-06 2010-01-26 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors
TW200600513A (en) 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
US20060251723A1 (en) 2005-05-05 2006-11-09 Gao Julia Z Formulations of a SRC/ABL inhibitor
ATE466003T1 (de) 2005-08-05 2010-05-15 Bristol Myers Squibb Co Herstellung von 2-aminothiazol-5- carbonsäurederivaten
US20070105867A1 (en) * 2005-09-21 2007-05-10 Bristol-Myers Squibb Company Oral administration of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-1,3-thiazole-5-carboxamide and salts thereof
US20070219370A1 (en) * 2006-03-15 2007-09-20 Bristol-Myers Squibb Company Process for preparing n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino] -5-thiazolecarboxamide and related metabolites thereof
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CN103319476B (zh) * 2013-06-13 2015-12-02 济南德爱医药技术有限公司 一种激酶抑制剂
WO2015011120A2 (en) * 2013-07-25 2015-01-29 Basf Se Salts of dasatinib in crystalline form
JP6370377B2 (ja) 2013-07-25 2018-08-08 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 非晶質形態のダサチニブの塩
CN104341410A (zh) * 2013-08-09 2015-02-11 上海科胜药物研发有限公司 一种达沙替尼新晶型及其制备方法
CN103483289B (zh) * 2013-09-06 2016-01-27 浙江科源化工有限公司 一种2-氨基-n-(2-氯-6-甲基苯基)噻唑-5-甲酰胺的合成方法
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CN105503854A (zh) * 2015-12-31 2016-04-20 哈药集团技术中心 一种达沙替尼无水合物的新晶型物及其制备方法
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CN105830582B (zh) * 2016-04-15 2018-05-01 成都大学 一种白及种子的快速回土培育方法
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CN109369638B (zh) * 2018-11-21 2020-07-07 山东罗欣药业集团股份有限公司 一种达沙替尼的制备工艺
CN109503568B (zh) * 2018-12-29 2020-08-07 山东罗欣药业集团股份有限公司 一种达沙替尼的制备方法
CN112409349A (zh) * 2019-08-20 2021-02-26 湖南华纳大药厂股份有限公司 激酶抑制剂及其制备、药物组合物和用途
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Also Published As

Publication number Publication date
ES2337272T3 (es) 2010-04-22
SI1711481T2 (sl) 2013-10-30
EP1711481B1 (en) 2009-12-30
IL177280A0 (en) 2006-12-10
BRPI0507476B1 (pt) 2020-12-08
ZA200606242B (en) 2008-01-08
KR101310427B1 (ko) 2013-09-24
NO20063780L (no) 2006-10-27
PE20050691A1 (es) 2005-09-25
EP1711481A2 (en) 2006-10-18
AR047533A1 (es) 2006-01-25
PL1711481T5 (pl) 2013-10-31
HRP20100166T4 (en) 2013-09-30
GEP20094804B (en) 2009-10-26
NZ548613A (en) 2010-05-28
CY1109907T1 (el) 2014-09-10
SI1711481T1 (sl) 2010-03-31
TWI338004B (en) 2011-03-01
ATE453630T1 (de) 2010-01-15
CA2555291A1 (en) 2005-08-25
RU2006131591A (ru) 2008-03-20
EP1711481B2 (en) 2013-05-22
HRP20100166T1 (hr) 2010-05-31
TW200530205A (en) 2005-09-16
IN2014DN06567A (pt) 2015-07-10
KR20120097424A (ko) 2012-09-03
PL1711481T3 (pl) 2010-05-31
PT1711481E (pt) 2010-02-25
NO338049B1 (no) 2016-07-25
AU2005212405A1 (en) 2005-08-25
ES2337272T5 (es) 2013-09-30
DK1711481T3 (da) 2010-04-19
JP2007521340A (ja) 2007-08-02
KR20060124692A (ko) 2006-12-05
DK1711481T4 (da) 2013-08-26
WO2005077945A2 (en) 2005-08-25
AU2005212405B2 (en) 2010-08-12
HK1091835A1 (en) 2007-01-26
WO2005077945A3 (en) 2006-05-18
JP5148115B2 (ja) 2013-02-20
BRPI0507476A (pt) 2007-07-17
RU2382039C2 (ru) 2010-02-20
JP2012188446A (ja) 2012-10-04
BRPI0507476B8 (pt) 2021-05-25
DE602005018601D1 (de) 2010-02-11
CA2555291C (en) 2017-01-17

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