IL166444A0 - Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry - Google Patents

Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry

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Publication number
IL166444A0
IL166444A0 IL16644405A IL16644405A IL166444A0 IL 166444 A0 IL166444 A0 IL 166444A0 IL 16644405 A IL16644405 A IL 16644405A IL 16644405 A IL16644405 A IL 16644405A IL 166444 A0 IL166444 A0 IL 166444A0
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IL
Israel
Prior art keywords
organeome
proteome
mass spectrometry
flux rates
scale measurement
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Application number
IL16644405A
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English (en)
Original Assignee
Univ California
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Publication date
Application filed by Univ California filed Critical Univ California
Publication of IL166444A0 publication Critical patent/IL166444A0/xx

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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0002General or multifunctional contrast agents, e.g. chelated agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/15Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Primary Health Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Business, Economics & Management (AREA)
  • Tourism & Hospitality (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Economics (AREA)
  • Human Resources & Organizations (AREA)
IL16644405A 2002-07-30 2005-01-23 Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry IL166444A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39995002P 2002-07-30 2002-07-30
PCT/US2003/023340 WO2004011426A2 (fr) 2002-07-30 2003-07-25 Procede de mesure automatique a grande echelle des taux de flux moleculaire proteomique ou organeomique par spectrometrie de masse

Publications (1)

Publication Number Publication Date
IL166444A0 true IL166444A0 (en) 2006-01-15

Family

ID=31188647

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16644405A IL166444A0 (en) 2002-07-30 2005-01-23 Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry

Country Status (7)

Country Link
US (5) US20060094057A1 (fr)
EP (1) EP1546364A4 (fr)
JP (1) JP4804753B2 (fr)
AU (1) AU2003256819B2 (fr)
CA (1) CA2494715C (fr)
IL (1) IL166444A0 (fr)
WO (1) WO2004011426A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910403A (en) * 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
JP2005515452A (ja) * 2001-10-24 2005-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アイソトープで標識された水を用いるヒトおよび実験系におけるタンパク質合成速度の測定
WO2003068919A2 (fr) 2002-02-12 2003-08-21 The Regents Of The University Of California Mesure de vitesses de biosynthese et de degradation de molecules biologiques inaccessibles ou peu accessibles a un echantillonnage direct, de maniere non invasive, par incorporation d'etiquettes dans des derives metaboliques et des produits cataboliques
WO2004011426A2 (fr) * 2002-07-30 2004-02-05 The Regents Of The University Of California Procede de mesure automatique a grande echelle des taux de flux moleculaire proteomique ou organeomique par spectrometrie de masse
AU2003268416A1 (en) * 2002-09-04 2004-03-29 The Regents Of The University Of California Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism
ATE415486T1 (de) 2002-09-13 2008-12-15 Univ California Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
JP4611025B2 (ja) 2002-11-04 2011-01-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験
US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) * 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
CA2553223A1 (fr) * 2004-01-15 2005-08-04 Cedars-Sinai Medical Center Systeme et procede pour la proteomique d'expression basee sur la modification de rapport isotopique
US8510054B2 (en) 2004-02-05 2013-08-13 Ajinomoto Co., Inc. Intracellular metabolic flux analysis method using substrate labeled with isotope
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2005087943A1 (fr) * 2004-03-11 2005-09-22 The Regents Of The University Of California Caracterisation temporelle ou spatiale d'evenements de biosynthese dans des organismes vivants par etablissement d'empreintes isotopiques dans des conditions de gradients isotopiques imposees
WO2005094327A2 (fr) * 2004-03-29 2005-10-13 The Regents Of The University Of California Isolation de cellules epitheliales ou de leurs contenus biochimiques a partir de feces apres marquage isotopique in vivo
JP4118918B2 (ja) * 2005-02-28 2008-07-16 シャープ株式会社 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
TW200711660A (en) 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
KR20070092939A (ko) * 2007-08-27 2007-09-14 최원철 동위원소의 측정에 의한 암진단 방법
WO2013036885A1 (fr) 2011-09-08 2013-03-14 The Regents Of The University Of California Mesure de flux métabolique, imagerie et microscopie
CA2858368A1 (fr) 2011-12-07 2013-06-13 Glaxosmithkline Llc Procedes de determination de la masse musculaire squelettique totale du corps
US20130338932A1 (en) * 2012-06-13 2013-12-19 Agilent Technologies, Inc. Computational method for mapping peptides to proteins using sequencing data
US9500657B2 (en) 2012-10-25 2016-11-22 Run Them Sweet Llc Formulations containing labels for medical diagnostics
US9366678B2 (en) * 2012-10-25 2016-06-14 Wisconsin Alumni Research Foundation Neutron encoded mass tags for analyte quantification
WO2014066628A2 (fr) * 2012-10-25 2014-05-01 Run Them Sweet, LLC Procédés et systèmes pour estimer les besoins nutritionnels de patients humains et d'autres patients et pour prendre en charge de tels besoins nutritionnels
US9134319B2 (en) * 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
EP3268746B1 (fr) 2015-03-12 2024-07-17 Mars, Incorporated Spectrométrie de masse à ultra-haute résolution et ses procédés d'utilisation
US9697994B1 (en) 2015-04-09 2017-07-04 Ricarez Biosciences, LLC Use of stable label compounds with accelerator mass spectrometry
US20160363580A1 (en) * 2015-06-11 2016-12-15 The Texas A&M University System Methods of Metabolic Kinetic Phenotyping and Uses Thereof
WO2017040498A1 (fr) * 2015-08-31 2017-03-09 Yale University Techniques de spectométrie de masse destinées à une analyse d'isotopomère, et systèmes et procédés associés
EP3347713A4 (fr) * 2015-09-08 2019-03-27 Kinemed, Inc. Mesure de taux de flux moléculaires de protéines par quantification d'abondances d'isotopologues dans des fragments d'ions iminium à l'aide d'une spectrométrie de masse haute résolution
WO2017044500A1 (fr) * 2015-09-08 2017-03-16 Hellerstein Marc K Mesure des débits moléculaires par quantification des abondances des isotopologues par spectrométrie de masse haute résolution
US10607723B2 (en) 2016-07-05 2020-03-31 University Of Kentucky Research Foundation Method and system for identification of metabolites using mass spectra
EP3529724B1 (fr) 2016-10-20 2024-07-03 Vito NV Détermination de la masse monoisotopique de macromolécules par spectrométrie de masse
CN110196288A (zh) * 2018-02-26 2019-09-03 中国科学院上海生命科学研究院 一种动态代谢流量分析技术的建立与应用

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065552A (en) * 1975-05-05 1977-12-27 Giovanni Giacomo Costa Method of detecting malignant neoplasms
US4332784A (en) 1979-02-06 1982-06-01 The Radiochemical Centre Limited Dual isotope assays
SU968036A1 (ru) 1980-03-10 1982-10-23 Научно-исследовательский институт медицинской радиологии АМН СССР Способ получени меченого белка
US5317098A (en) * 1986-03-17 1994-05-31 Hiroaki Shizuya Non-radioisotope tagging of fragments
EP0248924B1 (fr) * 1986-06-09 1989-11-23 Bruker Analytische Messtechnik GmbH Méthode pour déterminer le cycle métabolique de matériaux organiques dans les tissus vivants et spectromètre à résonance magnétique nucléaire pour la mise en oeuvre de cette méthode
US4940658A (en) * 1986-11-20 1990-07-10 University Patents, Inc. Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency
AU1966188A (en) * 1987-08-07 1989-03-09 Mallinckrodt, Inc. Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
US5042488A (en) * 1987-09-29 1991-08-27 The Washington University Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ
US6004781A (en) * 1988-01-22 1999-12-21 The General Hospital Corporation Nucleic acid encoding Ig-CD4 fusion proteins
JPH04504049A (ja) 1989-03-20 1992-07-23 アンティキャンサー インコーポレイテッド インビトロにおける組織の生存能力及び増殖能力を測定する、自生状態法及びシステム
GB2229718B (en) * 1989-03-22 1993-01-06 Inst Molekularnoi Genetik Method for preparing hydrogen-isotape labelled biologically active organic compounds
US5217903A (en) * 1990-05-15 1993-06-08 Trustees Of Boston University Measuring connective tissue breakdown products in body fluids
CA2027714C (fr) * 1990-07-13 2003-01-28 Kenneth W. Turtletaub Methode de mesure pour les systemes biologiques
US5209919A (en) * 1990-07-13 1993-05-11 Regents Of The University Of California Method of measurement in biological systems
US5597548A (en) * 1990-07-18 1997-01-28 Board Of Regents, The University Of Texas System 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling
HU208084B (en) 1991-10-31 1993-08-30 Hyd Kutato Fejlesztoe Kft Process for producing compositions suitable for curing tumorous diseases
US5394236A (en) * 1992-02-03 1995-02-28 Rutgers, The State University Methods and apparatus for isotopic analysis
WO1993020800A1 (fr) 1992-04-08 1993-10-28 Paavo Kai Johannes Kinnunen Composition a usage therapeutique ou diagnostique, et mode de preparation et d'utilisation
US5338686A (en) * 1992-04-29 1994-08-16 Hellerstein Marc K Method for measuring in vivo synthesis of biopolymers
JP2960832B2 (ja) * 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト エストラジオールの投与システム
US5366885A (en) 1992-06-09 1994-11-22 Barranco Iii Sam C Method and kit for testing tumors for drug sensitivity
US5432058A (en) 1992-09-30 1995-07-11 Lange, Iii; Louis G. Method for measuring human cholesterol absorption using metabolically stable isotopes
US5506147A (en) * 1993-04-15 1996-04-09 Kolhouse; J. Fred Non-invasive evaluation of maldigestion and malaborption
ES2072847T3 (es) * 1993-05-17 1998-03-01 Amersham Int Plc Dispositivos y metodos para la medida de procesos bioquimicos celulares.
US5439803A (en) 1993-08-13 1995-08-08 The Regents Of The University Of Michigan Isotope and assay for glycolysis and the pentose phosphate pathway
CA2176005A1 (fr) 1993-11-08 1995-05-18 Trevor G. Redgrave Compositions de diagnostic marquees et leurs procedes d'utilisation
AU6631296A (en) * 1995-08-08 1997-03-05 Otsuka Pharmaceutical Co., Ltd. Diagnostic and diagnosis method for central nervous abnormality and phenylketonuria
US5922554A (en) 1995-10-30 1999-07-13 The Regents Of The University Of California Inhibition of cellular uptake of cholesterol
ES2186844T3 (es) * 1996-08-27 2003-05-16 Tokyo Gas Co Ltd Agentes de diagnostico para la diabetes.
CN1217007C (zh) * 1997-02-14 2005-08-31 乔治华盛顿大学 测量dna合成率的分析方法
IL131798A (en) * 1997-03-14 2004-02-19 George Washington University S Device for continuous isotope ratio monitoring following fluorine based chemical reactions
US5910403A (en) 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
US5961470A (en) 1997-07-09 1999-10-05 Wagner; David A. Breath test for assessing hepatic function
US6329208B1 (en) * 1997-07-16 2001-12-11 Board Of Regents, The University Of Texas System Methods for determining gluconeogenesis, anapleurosis and pyruvate recycling
CA2249173C (fr) * 1997-10-06 2008-12-16 Tokyo Gas Co., Ltd. Agent diagnostique pour l'exploration fonctionnelle du foie
US5924995A (en) * 1997-11-10 1999-07-20 Meretek Diagnostics Non-invasive method for the functional assessment of infants and children with an inherited metabolic disorder
WO1999056790A2 (fr) 1998-05-06 1999-11-11 Isotechnika, Inc. Test respiratoire au glucose 13c pour le diagnostic de signes de diabete et la surveillance de la glycemie
US6461870B2 (en) 1998-05-06 2002-10-08 Isotechnika Inc. 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
US6284219B1 (en) * 1998-06-30 2001-09-04 Phenome Sciences Inc. In vivo determination of metabolic function for use in therapy management
US6625547B1 (en) * 1998-08-05 2003-09-23 Washington State University Research Foundation Relative rates of cytochrome p450 metabolism
ATE253126T1 (de) * 1998-08-25 2003-11-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
DE19839491A1 (de) * 1998-08-29 2000-03-02 Hermann Heumann Verfahren zur Markierung von Biopolymeren mit Isotopen
US6653076B1 (en) 1998-08-31 2003-11-25 The Regents Of The University Of Washington Stable isotope metabolic labeling for analysis of biopolymers
US6693186B2 (en) * 1998-09-01 2004-02-17 Antex Biologics Inc Neisseria meningitidis polypeptide, nucleic acid sequence and uses thereof
US6887712B1 (en) * 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US20030119069A1 (en) * 1999-04-20 2003-06-26 Target Discovery, Inc. Labeling of protein samples
CA2370749A1 (fr) * 1999-04-20 2000-10-26 Target Discovery, Inc. Procedes de cartographie peptidique de polypeptides, etablissement de profils et systeme de base de donnees bioinformatique
US6764817B1 (en) 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
US6391649B1 (en) * 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
US7057168B2 (en) * 1999-07-21 2006-06-06 Sionex Corporation Systems for differential ion mobility analysis
US6653090B1 (en) 1999-11-05 2003-11-25 University Of Alberta Methods for measuring the metabolism of and screening for drugs in isolated hearts
JP2001211782A (ja) * 2000-02-02 2001-08-07 Masa Yamamoto tob遺伝子欠損ノックアウト非ヒト哺乳動物
EP1274996A4 (fr) * 2000-04-13 2006-02-01 Thermo Finnigan Llc Analyse proteomique par spectrometrie de masse parallele
WO2001080715A2 (fr) 2000-04-21 2001-11-01 The Trustees Of Columbia University In The City Of New York Procedes d'identification de composes utiles dans la prevention d'evenements vasculaires aigus chez un sujet
EP1311858B1 (fr) * 2000-05-05 2006-11-02 Purdue Research Foundation Peptides a signature a affinite selective permettant l'identification et la quantification de proteines
WO2001087352A1 (fr) * 2000-05-18 2001-11-22 Metabolic Solutions, Inc. Dosage de dilution d'isotopes inverse et dosage d'intolerance au lactose
US6680203B2 (en) * 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
US7048907B2 (en) * 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
GB0106923D0 (en) 2001-03-20 2001-05-09 Univ Dundee Liver function test
US7256047B2 (en) 2001-05-01 2007-08-14 Board Of Regents, The University Of Texas System Measurement of gluconeogenesis and intermediary metabolism using stable isotopes
JP2004536600A (ja) 2001-06-26 2004-12-09 ニュー ヨーク ステイト オフィス オブ メンタル ヘルス 細胞に基づいた高スループットスクリーニング法
JP2003079270A (ja) 2001-09-10 2003-03-18 Japan Science & Technology Corp ミエリン発達障害モデル非ヒト動物
US6835927B2 (en) * 2001-10-15 2004-12-28 Surromed, Inc. Mass spectrometric quantification of chemical mixture components
JP2005515452A (ja) 2001-10-24 2005-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アイソトープで標識された水を用いるヒトおよび実験系におけるタンパク質合成速度の測定
EP1456667B2 (fr) * 2001-12-08 2010-01-20 Micromass UK Limited Procede de spectrometrie de masse
US7635841B2 (en) * 2001-12-12 2009-12-22 Micromass Uk Limited Method of mass spectrometry
WO2003068919A2 (fr) 2002-02-12 2003-08-21 The Regents Of The University Of California Mesure de vitesses de biosynthese et de degradation de molecules biologiques inaccessibles ou peu accessibles a un echantillonnage direct, de maniere non invasive, par incorporation d'etiquettes dans des derives metaboliques et des produits cataboliques
US20030180710A1 (en) 2002-03-22 2003-09-25 Lee Wai-Nang Paul Method of enhancing the efficiency of a pharmaceutical business
US20050281745A1 (en) * 2002-03-22 2005-12-22 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development
US20060100903A1 (en) * 2002-03-22 2006-05-11 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Method of enhancing the efficiency of a pharmaceutical business
US20030180800A1 (en) 2002-03-22 2003-09-25 Lee Wai-Nang Paul Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development
US20030224420A1 (en) 2002-04-05 2003-12-04 Hellerstein Marc K. Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
US20030211036A1 (en) * 2002-05-07 2003-11-13 Hadassa Degani Method and apparatus for monitoring and quantitatively evaluating tumor perfusion
AU2003253702A1 (en) 2002-06-26 2004-01-19 The Regents Of The University Of California Methods and kits for determining energy expenditure in living organisms by metabolic water production
US7510880B2 (en) * 2002-06-26 2009-03-31 Gross Richard W Multidimensional mass spectrometry of serum and cellular lipids directly from biologic extracts
WO2004011426A2 (fr) * 2002-07-30 2004-02-05 The Regents Of The University Of California Procede de mesure automatique a grande echelle des taux de flux moleculaire proteomique ou organeomique par spectrometrie de masse
WO2004016156A2 (fr) 2002-08-16 2004-02-26 The Regents Of The University Of California Test de tolerance au glucose a recyclage hepatique dynamique
AU2003268416A1 (en) 2002-09-04 2004-03-29 The Regents Of The University Of California Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism
ATE415486T1 (de) 2002-09-13 2008-12-15 Univ California Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese
SG152923A1 (en) 2002-09-16 2009-06-29 Univ California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
US20070248540A1 (en) 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
US7084396B2 (en) * 2002-10-29 2006-08-01 Target Discovery, Inc. Method for increasing ionization efficiency in mass spectroscopy
JP4611025B2 (ja) * 2002-11-04 2011-01-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験
US20040121305A1 (en) * 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
US6906320B2 (en) * 2003-04-02 2005-06-14 Merck & Co., Inc. Mass spectrometry data analysis techniques
US20050014181A1 (en) * 2003-06-18 2005-01-20 Galis Zorina S. Methods and compositions for the assessment of polymer assembly
EP1644856A2 (fr) * 2003-06-30 2006-04-12 Ajinomoto Co., Inc. Methode d'analyse de flux metabolique intracellulaire au moyen d'un substrat marque par un isotope
WO2005009597A2 (fr) 2003-07-03 2005-02-03 The Regents Of The University Of California Methodes de comparaison des debits relatifs de deux ou de plusieurs molecules biologiques in vivo a l'aide d'un seul protocole
US7262020B2 (en) 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
US8510054B2 (en) * 2004-02-05 2013-08-13 Ajinomoto Co., Inc. Intracellular metabolic flux analysis method using substrate labeled with isotope
US20050180949A1 (en) 2004-02-13 2005-08-18 Nuvelo, Inc. hC1Q/TNF7 and uses thereof
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2005087943A1 (fr) 2004-03-11 2005-09-22 The Regents Of The University Of California Caracterisation temporelle ou spatiale d'evenements de biosynthese dans des organismes vivants par etablissement d'empreintes isotopiques dans des conditions de gradients isotopiques imposees
WO2005094327A2 (fr) 2004-03-29 2005-10-13 The Regents Of The University Of California Isolation de cellules epitheliales ou de leurs contenus biochimiques a partir de feces apres marquage isotopique in vivo
US20050255509A1 (en) 2004-03-30 2005-11-17 Kinemed, Inc. In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes
JP4654592B2 (ja) * 2004-04-02 2011-03-23 味の素株式会社 代謝フラックスの決定方法
CA2588260A1 (fr) 2004-10-29 2006-05-11 Target Discovery, Inc. Analyse de glycanes utilisant le glucose deutere
WO2006081521A2 (fr) 2005-01-26 2006-08-03 The Regents Of The University Of Colorado Methodes pour diagnostic et intervention de troubles hepatiques
WO2006107814A2 (fr) 2005-04-06 2006-10-12 Washington University In St. Louis Methodes de mesure in vivo du metabolisme de biomolecules derivees du systeme nerveux
US20060251576A1 (en) 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
TW200711660A (en) 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development

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US8969287B2 (en) 2015-03-03
US20150233938A1 (en) 2015-08-20
JP4804753B2 (ja) 2011-11-02
JP2005534906A (ja) 2005-11-17
EP1546364A4 (fr) 2006-09-06
CA2494715C (fr) 2014-07-08
AU2003256819A1 (en) 2004-02-16
US20100172834A1 (en) 2010-07-08
US20120190560A1 (en) 2012-07-26
CA2494715A1 (fr) 2004-02-05
US8129335B2 (en) 2012-03-06
US20060094057A1 (en) 2006-05-04
US20140005074A1 (en) 2014-01-02
AU2003256819B2 (en) 2009-11-12
WO2004011426A2 (fr) 2004-02-05
US8481478B2 (en) 2013-07-09
WO2004011426A3 (fr) 2004-10-07
EP1546364A2 (fr) 2005-06-29

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