ES2072847T3 - Dispositivos y metodos para la medida de procesos bioquimicos celulares. - Google Patents
Dispositivos y metodos para la medida de procesos bioquimicos celulares.Info
- Publication number
- ES2072847T3 ES2072847T3 ES94915227T ES94915227T ES2072847T3 ES 2072847 T3 ES2072847 T3 ES 2072847T3 ES 94915227 T ES94915227 T ES 94915227T ES 94915227 T ES94915227 T ES 94915227T ES 2072847 T3 ES2072847 T3 ES 2072847T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- methods
- devices
- biochemical processes
- measuring cellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/12—Well or multiwell plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/20—Material Coatings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/22—Transparent or translucent parts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
APARATO Y METODO PARA ESTUDIAR PROCESOS CELULARES QUE COMPRENDE UN RECIPIENTE QUE TIENE UNA BASE INCLUYENDO UNA CAPA QUE COMPRENDE UNA SUSTANCIA CENTELLEANTE Y QUE ESTA ADAPTADA PARA UNION Y/O CRECIMIENTO DE LAS CELULAS. LOS PROCESOS CELULARES SON EXAMINADOS POR CENTELLEO EN LAS PROXIMIDADES DE LA MUESTRA DE ENSAYO USANDO UN REACTIVO ETIQUETADO CON UN RADIOISOTOPO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93303806 | 1993-05-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2072847T1 ES2072847T1 (es) | 1995-08-01 |
ES2072847T3 true ES2072847T3 (es) | 1998-03-01 |
Family
ID=8214414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94915227T Expired - Lifetime ES2072847T3 (es) | 1993-05-17 | 1994-05-16 | Dispositivos y metodos para la medida de procesos bioquimicos celulares. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5665562A (es) |
EP (1) | EP0650396B1 (es) |
JP (1) | JP3152933B2 (es) |
AT (1) | ATE162216T1 (es) |
CA (1) | CA2139409C (es) |
DE (2) | DE69407923T2 (es) |
DK (1) | DK0650396T3 (es) |
ES (1) | ES2072847T3 (es) |
FI (1) | FI110488B (es) |
WO (1) | WO1994026413A1 (es) |
Families Citing this family (74)
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---|---|---|---|---|
JPH0716635B2 (ja) * | 1993-01-27 | 1995-03-01 | 旭サナック株式会社 | 建築用塗材吹付機 |
JP3152933B2 (ja) * | 1993-05-17 | 2001-04-03 | アマーシャム・インターナショナル・ピーエルシー | 細胞生化学プロセスを測定するための装置および方法 |
JP3315269B2 (ja) * | 1994-10-07 | 2002-08-19 | アロカ株式会社 | 放射性試料測定用プレート |
US5792426A (en) * | 1994-10-11 | 1998-08-11 | Schweizerische Eidgenossenschaft Vertreten Durch Das Ac-Laboratorium Spiez Der Gruppe Rustung | Multi-well titerplate for instrumental analysis |
CN1181720A (zh) * | 1995-04-25 | 1998-05-13 | 伊萝莉公司 | 可远程编程的存储器材料及其应用 |
US5961923A (en) * | 1995-04-25 | 1999-10-05 | Irori | Matrices with memories and uses thereof |
US5925562A (en) * | 1995-04-25 | 1999-07-20 | Irori | Remotely programmable matrices with memories |
JP3118528B2 (ja) | 1996-01-26 | 2000-12-18 | 東邦レーヨン株式会社 | ステアリングホイールおよびその製造方法 |
US5739001A (en) * | 1996-10-29 | 1998-04-14 | E. I. Du Pont De Nemours And Company | Solid phase cell-based assay |
GB2319836B (en) * | 1996-11-25 | 2001-04-04 | Porvair Plc | Microplates |
DE69831522T2 (de) | 1997-03-03 | 2006-06-14 | Amersham Biosciences Uk Ltd | In-situ Zellextraktion und Assay-Verfahren |
DE19712484C2 (de) * | 1997-03-25 | 1999-07-08 | Greiner Gmbh | Microplatte mit transparentem Boden und Verfahren zu deren Herstellung |
ATE224770T1 (de) | 1997-05-02 | 2002-10-15 | Gen Probe Inc | Reaktion behälter apparat |
US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
JP3719932B2 (ja) * | 1997-08-18 | 2005-11-24 | アメルシャム・パブリック・リミテッド・カンパニー | シンチレーションプロキシミティー試験 |
US6077669A (en) * | 1997-11-04 | 2000-06-20 | Becton Dickinson And Company | Kit and method for fluorescence based detection assay |
CA2306879C (en) | 1997-11-14 | 2007-10-16 | Gen-Probe Incorporated | Assay work station |
US6066446A (en) * | 1997-12-19 | 2000-05-23 | Nen Life Science Products, Inc. | Assay member and method for its manufacture |
US6977141B2 (en) | 1998-02-10 | 2005-12-20 | Vicuron Pharmaceuticals Inc. | Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes |
US6388788B1 (en) | 1998-03-16 | 2002-05-14 | Praelux, Inc. | Method and apparatus for screening chemical compounds |
US20030036855A1 (en) * | 1998-03-16 | 2003-02-20 | Praelux Incorporated, A Corporation Of New Jersey | Method and apparatus for screening chemical compounds |
US6463647B1 (en) * | 1998-03-18 | 2002-10-15 | Corning Incorporated | Method of making an extruded high density assay plate |
DE59903746D1 (de) * | 1998-03-27 | 2003-01-23 | Aventis Pharma Gmbh | Miniaturisierte mikrotiterplatte für hochdurchsatz-screening |
GB9808836D0 (en) * | 1998-04-27 | 1998-06-24 | Amersham Pharm Biotech Uk Ltd | Microfabricated apparatus for cell based assays |
EP1076719A1 (en) | 1998-05-15 | 2001-02-21 | AstraZeneca AB | A scintillation proximity assay for the detection of peptidoglycan synthesis |
DE19822827A1 (de) * | 1998-05-20 | 2001-01-18 | Forschungszentrum Juelich Gmbh | Verfahren zur Durchführung einer Messung der Interaktion von Chemikalien mit Zellen |
US6057092A (en) * | 1998-08-31 | 2000-05-02 | Trellis Bioinformatics, Inc. | Cellular transport detection method |
GB2342350A (en) * | 1998-10-05 | 2000-04-12 | Univ Nottingham Trent | Solid supports containing oxazole scintillants |
WO2001067103A1 (en) * | 2000-03-06 | 2001-09-13 | Bioseek, Inc. | Function homology screening |
DE60143703D1 (de) * | 2000-04-19 | 2011-02-03 | Corning Inc | Mehrfachlochplatte und ihr herstellungsverfahren |
US7347977B2 (en) * | 2000-06-08 | 2008-03-25 | Eppendorf Ag | Microtitration plate |
JP4282251B2 (ja) | 2000-08-02 | 2009-06-17 | 富士フイルム株式会社 | 生化学解析用ユニットおよびそれを用いた生化学解析方法 |
GB0027516D0 (en) * | 2000-11-10 | 2000-12-27 | Amersham Pharm Biotech Uk Ltd | Support and method for cell based assays |
EP1343973B2 (en) * | 2000-11-16 | 2020-09-16 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
EP1346230B1 (fr) * | 2000-12-26 | 2006-04-12 | Cerenis | Procede de criblage base sur les partenaires de liaison de tsap6 |
DE10108892B4 (de) * | 2001-02-23 | 2005-08-18 | Graffinity Pharmaceuticals Ag | Synthesevorrichtung und Verfahren zu deren Herstellung |
US20030064508A1 (en) * | 2001-09-20 | 2003-04-03 | 3-Dimensional Pharmaceuticals, Inc. | Conductive microtiter plate |
IL161498A0 (en) | 2001-10-24 | 2004-09-27 | Univ California | Measurement of protein synthesis rates in humans and experimental system by use of isotopically labeled water |
WO2003068919A2 (en) * | 2002-02-12 | 2003-08-21 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
US20030183958A1 (en) * | 2002-03-28 | 2003-10-02 | Becton, Dickinson And Company | Multi-well plate fabrication |
US20030224420A1 (en) * | 2002-04-05 | 2003-12-04 | Hellerstein Marc K. | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
WO2003089139A1 (en) * | 2002-04-15 | 2003-10-30 | Cool Options, Inc. | Thermally-conductive biological assay trays |
ATE418619T1 (de) * | 2002-06-14 | 2009-01-15 | Pierce Biotechnology Inc | Homogenes assay zum nachweis von enzymaktivität |
DE60329500D1 (de) * | 2002-07-12 | 2009-11-12 | Morehouse School Of Medicine | Verfahren zur identifikation von salzempfindlichen personen |
US20060094057A1 (en) * | 2002-07-30 | 2006-05-04 | Maro K. Hellerstein | Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
WO2004021863A2 (en) * | 2002-09-04 | 2004-03-18 | The Regents Of The University Of California | Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism |
CA2498378C (en) * | 2002-09-13 | 2013-12-17 | The Regents Of The University Of California | Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis |
US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
US7504233B2 (en) * | 2002-11-04 | 2009-03-17 | The Regents Of The University Of California | Methods for determining the metabolism of sugars and fats in an individual |
US20050202406A1 (en) | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
EP1723252A4 (en) * | 2004-03-11 | 2009-07-29 | Univ California | TIMELY AND SPATIAL CHARACTERIZATION OF BIOSYNTHETIC EVENTS IN LIVING ORGANISMS THROUGH ISOTOPEN FINGERPRINTING UNDER CONDITIONS OF IMPROPER ISOTOPE GRADIENTS |
US20050238577A1 (en) * | 2004-03-29 | 2005-10-27 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) * | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
DK1750155T3 (da) * | 2005-08-01 | 2013-01-07 | Ibidi Gmbh | Fremgangsmåde til fremstilling af et prøvekammer |
DE602006009220D1 (de) * | 2005-12-09 | 2009-10-29 | Hoffmann La Roche | Scintillation Proximity Assay |
US20130122580A1 (en) * | 2010-01-08 | 2013-05-16 | Sumitomo Bakelite Co., Ltd. | Culture vessel for forming aggregated cell mass |
US20140242600A1 (en) * | 2011-06-08 | 2014-08-28 | The Board Of Trustees Of The Leland Stanford Junior University | Imaging the heterogeneous uptake of radiolabeled molecules in single living cells |
WO2013036885A1 (en) | 2011-09-08 | 2013-03-14 | The Regents Of The University Of California | Metabolic flux measurement, imaging and microscopy |
EP2788772B1 (en) | 2011-12-07 | 2018-02-14 | GlaxoSmithKline LLC | Methods for determining total body skeletal muscle mass |
US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
US9790465B2 (en) * | 2013-04-30 | 2017-10-17 | Corning Incorporated | Spheroid cell culture well article and methods thereof |
BR112016018978B1 (pt) * | 2014-02-18 | 2024-03-12 | Takeda Pharmaceutical Company Limited | Método para medir atividade enzimática lisossomal |
SG11201703500XA (en) | 2014-10-29 | 2017-05-30 | Corning Inc | Perfusion bioreactor platform |
EP3212759A1 (en) | 2014-10-29 | 2017-09-06 | Corning Incorporated | Cell culture insert |
MX2019010115A (es) | 2017-02-27 | 2019-11-21 | Westrock Mwv Llc | Carton de barrera sellable termicamente. |
WO2019014610A1 (en) | 2017-07-14 | 2019-01-17 | Corning Incorporated | CELL CULTURE CONTAINER FOR 3D CULTURE AND METHODS OF CULTURING 3D CELLS |
JP7245222B2 (ja) | 2017-07-14 | 2023-03-23 | コーニング インコーポレイテッド | 手動又は自動で培地を交換するための3d細胞培養容器 |
JP7197557B2 (ja) | 2017-07-14 | 2022-12-27 | コーニング インコーポレイテッド | 多孔性支持体を有する細胞培養槽 |
US11857970B2 (en) | 2017-07-14 | 2024-01-02 | Corning Incorporated | Cell culture vessel |
PL3649229T3 (pl) | 2018-07-13 | 2021-12-06 | Corning Incorporated | Naczynia do hodowli komórkowych ze stabilizującymi urządzeniami |
US11912968B2 (en) | 2018-07-13 | 2024-02-27 | Corning Incorporated | Microcavity dishes with sidewall including liquid medium delivery surface |
US11661574B2 (en) | 2018-07-13 | 2023-05-30 | Corning Incorporated | Fluidic devices including microplates with interconnected wells |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000252A (en) * | 1974-01-04 | 1976-12-28 | Kenneth Kosak | Immunoscintillation cell |
US4382074A (en) * | 1978-03-27 | 1983-05-03 | Hiram Hart | Scintillation proximity assay |
ES8501998A1 (es) * | 1982-10-12 | 1984-12-16 | Dynatech Lab | Un recipiente que tiene al menos una cavidad o pocillo para contener al menos una muestra de ensayo durante una medicion fluometrica. |
US4588698A (en) * | 1982-10-19 | 1986-05-13 | University Patents, Inc. | Encapsulated scintillators for measuring the concentration of tritiated solutes |
US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
SE8803602D0 (sv) * | 1988-10-11 | 1988-10-11 | Wallac Oy | A sample plate with a plurality of sample wells or vials intended for radiolabeled binding assays |
JPH04335154A (ja) * | 1991-05-09 | 1992-11-24 | S R L:Kk | 薬物スクリ−ニング方法 |
DK0576090T3 (da) * | 1992-06-22 | 2001-11-12 | Packard Instr Bv | Klæbende plastscintillator |
JP3152933B2 (ja) * | 1993-05-17 | 2001-04-03 | アマーシャム・インターナショナル・ピーエルシー | 細胞生化学プロセスを測定するための装置および方法 |
-
1994
- 1994-05-16 JP JP52517394A patent/JP3152933B2/ja not_active Expired - Fee Related
- 1994-05-16 AT AT94915227T patent/ATE162216T1/de not_active IP Right Cessation
- 1994-05-16 ES ES94915227T patent/ES2072847T3/es not_active Expired - Lifetime
- 1994-05-16 CA CA002139409A patent/CA2139409C/en not_active Expired - Lifetime
- 1994-05-16 US US08/373,316 patent/US5665562A/en not_active Expired - Lifetime
- 1994-05-16 DE DE69407923T patent/DE69407923T2/de not_active Expired - Lifetime
- 1994-05-16 EP EP94915227A patent/EP0650396B1/en not_active Expired - Lifetime
- 1994-05-16 DK DK94915227T patent/DK0650396T3/da active
- 1994-05-16 WO PCT/GB1994/001040 patent/WO1994026413A1/en active IP Right Grant
- 1994-05-16 DE DE0650396T patent/DE650396T1/de active Pending
-
1995
- 1995-01-13 FI FI950154A patent/FI110488B/fi active
-
1996
- 1996-11-01 US US08/742,497 patent/US5989854A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE162216T1 (de) | 1998-01-15 |
CA2139409C (en) | 2005-01-04 |
WO1994026413A1 (en) | 1994-11-24 |
DE69407923T2 (de) | 1998-04-30 |
EP0650396A1 (en) | 1995-05-03 |
JP3152933B2 (ja) | 2001-04-03 |
FI950154A (fi) | 1995-01-13 |
CA2139409A1 (en) | 1994-11-24 |
DE650396T1 (de) | 1995-11-30 |
JPH07509405A (ja) | 1995-10-19 |
FI950154A0 (fi) | 1995-01-13 |
US5989854A (en) | 1999-11-23 |
DK0650396T3 (da) | 1998-09-14 |
FI110488B (fi) | 2003-02-14 |
ES2072847T1 (es) | 1995-08-01 |
US5665562A (en) | 1997-09-09 |
EP0650396B1 (en) | 1998-01-14 |
DE69407923D1 (de) | 1998-02-19 |
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