ES2119369T3 - Dispositivo sensor para un ensayo sandwich. - Google Patents
Dispositivo sensor para un ensayo sandwich.Info
- Publication number
- ES2119369T3 ES2119369T3 ES95902906T ES95902906T ES2119369T3 ES 2119369 T3 ES2119369 T3 ES 2119369T3 ES 95902906 T ES95902906 T ES 95902906T ES 95902906 T ES95902906 T ES 95902906T ES 2119369 T3 ES2119369 T3 ES 2119369T3
- Authority
- ES
- Spain
- Prior art keywords
- specific binding
- binding partner
- ligand
- zone
- known amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)
- Geophysics And Detection Of Objects (AREA)
- Glass Compositions (AREA)
- Window Of Vehicle (AREA)
- Control Of Combustion (AREA)
- Joints Allowing Movement (AREA)
Abstract
SE PRESENTAN DISPOSITIVOS SENSORES PARA SU USO EN EL ENSAYO DE UN LIGANTE EN UNA MUESTRA, LOS DISPOSITIVOS COMPRENDEN: I) UNA ZONA DISCRETA ("LA ZONA DE MEDIDA") SOBRE UNA REGION EN LA CUAL ("LA REGION DE MEDIDA") SE INMOVILIZA DIRECTA O INDIRECTAMENTE UN PRIMER COMPAÑERO DE UNION ESPECIFICO PARA EL LIGANTE BAJO ENSAYO (O UN REACTIVO PRECOMPLEJADO CON O CAPAZ DE FORMAR UN COMPLEJO CON UN COMPAÑERO DE UNION ESPECIFICO PARA EL LIGANTE BAJO ENSAYO), LA ZONA CONTIENE ADICIONALMENTE, EN FORMA LIBERABLE, UNA PRIMERA CANTIDAD CONOCIDA DE UN SEGUNDO COMPAÑERO DE UNION ESPECIFICA OPCIONALMENTE ETIQUETADO PARA EL LIGANTE BAJO ENSAYO, EL SEGUNDO COMPAÑERO DE UNION ESPECIFICA SE DIRIGE A UN EPITOPO DEL LIGANTE BAJO ENSAYO DIFERENTE DEL EPITOPO AL CUAL SE DIRIGE EL PRIMER COMPAÑERO DE UNION ESPECIFICA; Y II) UNA SEGUNDA ZONA DISCRETA ("LA ZONA DE REFERENCIA") SOBRE UNA REGION DE LA CUAL SE INMOVILIZA DIRECTA O INDIRECTAMENTE UN PRIMER COMPAÑERO DE UNION ESPECIFICA DEL LIGANTE BAJO ENSAYO (O UN REACTIVOPRECOMPLEJADO CON O CAPAZ DE FORMAR UN COMPLEJO CON UN COMPAÑERO DE UNION ESPECIFICA PARA EL LIGANTE BAJO ENSAYO), LA ZONA ADICIONALMENTE CONTIENE, EN FORMA LIBERABLE, UNA CANTIDAD CONOCIDA DE UN ANALOGO DEL LIGANTE Y SEPARADAMENTE CONTIENE, EN FORMA LIBERABLE, UNA SEGUNDA CANTIDAD CONOCIDA DE UN SEGUNDO COMPAÑERO DE UNION ESPECIFICA OPCIONALMENTE ETIQUETADO PARA EL LIGANTE BAJO ENSAYO SEGUN SE HA DEFINIDO ANTERIORMENTE, LA SEGUNDA CANTIDAD CONOCIDA ES INFERIOR QUE LA MENCIONADA PRIMERA CANTIDAD CONOCIDA EN LA ZONA DE MEDIDA. TAMBIEN SE DESCRIBEN METODOS PARA UN ENSAYO DE ESTRATIFICACION QUE UTILIZA LOS DISPOSITIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939325718A GB9325718D0 (en) | 1993-12-16 | 1993-12-16 | Sensor device for sandwich assay |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2119369T3 true ES2119369T3 (es) | 1998-10-01 |
Family
ID=10746687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95902906T Expired - Lifetime ES2119369T3 (es) | 1993-12-16 | 1994-12-15 | Dispositivo sensor para un ensayo sandwich. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5856203A (es) |
EP (1) | EP0734527B1 (es) |
JP (1) | JP3458860B2 (es) |
AT (1) | ATE169117T1 (es) |
AU (1) | AU689174B2 (es) |
CA (1) | CA2177362C (es) |
DE (1) | DE69412137T2 (es) |
DK (1) | DK0734527T3 (es) |
ES (1) | ES2119369T3 (es) |
GB (1) | GB9325718D0 (es) |
WO (1) | WO1995016914A1 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7635597B2 (en) * | 1995-08-09 | 2009-12-22 | Bayer Healthcare Llc | Dry reagent particle assay and device having multiple test zones and method therefor |
AU5479998A (en) * | 1996-11-11 | 1998-06-03 | Novartis Ag | Use of biosensors to diagnose plant diseases |
SE9704933D0 (sv) * | 1997-12-30 | 1997-12-30 | Pharmacia & Upjohn Diag Ab | Metod som utnyttjar en ny kalibrator och test kit som innehåller kalibratorn |
US6379909B1 (en) * | 1998-06-24 | 2002-04-30 | Alk-Abello A/S | Method of detecting an antibody in a liquid sample |
US6136610A (en) * | 1998-11-23 | 2000-10-24 | Praxsys Biosystems, Inc. | Method and apparatus for performing a lateral flow assay |
US6602719B1 (en) | 1999-03-26 | 2003-08-05 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6551842B1 (en) | 1999-03-26 | 2003-04-22 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6511814B1 (en) * | 1999-03-26 | 2003-01-28 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
CA2376325A1 (en) * | 1999-08-19 | 2001-03-01 | Yang Zhao | Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks |
EP1335200A4 (en) * | 2000-05-11 | 2004-03-24 | Matsushita Ecology Sys Co | CHEMICAL SENSOR DEVICE |
DE10043113C2 (de) | 2000-08-31 | 2002-12-19 | Pe Diagnostik Gmbh | Verfahren zur Verbesserung der Messgenauigkeit bei Sensoren, insbesondere Bio-Sensoren, die Fluoreszenzstrahlung auswerten |
US6689615B1 (en) | 2000-10-04 | 2004-02-10 | James Murto | Methods and devices for processing blood samples |
DE10058579A1 (de) * | 2000-11-18 | 2002-06-13 | Sentronic Gmbh Ges Fuer Optisc | Vorrichtung und Verfahren zur optischen Messung von Konzentrationen eines Stoffes |
US7407746B2 (en) * | 2001-02-08 | 2008-08-05 | Ngk Insulators, Ltd. | Biochip and method for producing the same |
FR2823999B1 (fr) * | 2001-04-27 | 2003-06-27 | Commissariat Energie Atomique | Dispositif miniature de separation et d'isolement d'objets biologiques et utilisations |
US7790439B2 (en) * | 2001-08-09 | 2010-09-07 | Panasonic Corporation | Biosensor and measurement method |
SE0103072D0 (sv) * | 2001-09-17 | 2001-09-17 | Pharmacia Diagnostics Ab | Multi-analyte assay device with multi-spot detection zone |
US20030154149A1 (en) * | 2002-02-13 | 2003-08-14 | Dilip Gajendragadkar | System and method of creating and executing a restricted stock sale plan |
JP3878144B2 (ja) * | 2003-03-19 | 2007-02-07 | 富士フイルムホールディングス株式会社 | 生化学解析用ユニット |
US7329536B2 (en) * | 2003-06-05 | 2008-02-12 | Oakland University | Piezoimmunosensor |
US8128871B2 (en) | 2005-04-22 | 2012-03-06 | Alverix, Inc. | Lateral flow assay systems and methods |
DE102004023402A1 (de) * | 2004-05-12 | 2005-12-08 | Roche Diagnostics Gmbh | Verfahren zur Erhöhung des dynamischen Messbereichs von auf spezifischen Bindereaktionen basierenden, insbesondere immunologischen Testelementen |
CA2475240A1 (en) * | 2004-07-20 | 2006-01-20 | Biophys, Inc. | Method and device to measure dynamic internal calibration true dose response curves |
CA2475456A1 (en) * | 2004-07-20 | 2006-01-20 | Biophys, Inc. | Method and device to optimize analyte and antibody substrate binding by least energy adsorption |
CN101031798B (zh) | 2004-07-29 | 2012-06-27 | 瑞莱诊断体系有限公司 | 侧向流系统和测定 |
JPWO2006043387A1 (ja) * | 2004-09-28 | 2008-05-22 | 第一化学薬品株式会社 | 検体の免疫学的検査方法及びその方法に用いる検査器具 |
US20060068501A1 (en) * | 2004-09-30 | 2006-03-30 | Nj International Llc | Apparatus and methods for steroid hormone testing |
TW200617393A (en) * | 2004-11-22 | 2006-06-01 | Univ Nat Cheng Kung | Method for testing lectin |
US7939342B2 (en) * | 2005-03-30 | 2011-05-10 | Kimberly-Clark Worldwide, Inc. | Diagnostic test kits employing an internal calibration system |
US10041941B2 (en) | 2005-04-22 | 2018-08-07 | Alverix, Inc. | Assay test strips with multiple labels and reading same |
US7439079B2 (en) * | 2005-04-29 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Assay devices having detection capabilities within the hook effect region |
US7829347B2 (en) | 2005-08-31 | 2010-11-09 | Kimberly-Clark Worldwide, Inc. | Diagnostic test kits with improved detection accuracy |
WO2007048436A1 (de) * | 2005-10-29 | 2007-05-03 | Bayer Technology Services Gmbh | Verfahren zur bestimmung eines oder mehrerer analyten in komplex zusammengesetzten proben biologischen ursprungs und dessen verwendung |
WO2011001337A1 (en) | 2009-06-30 | 2011-01-06 | Koninklijke Philips Electronics N. V. | Magnetic sensor device, method of operating such a device and sample |
WO2013036913A1 (en) * | 2011-09-08 | 2013-03-14 | Nexus Dx, Inc. | A multilevel analyte assay |
US10073098B2 (en) | 2015-03-06 | 2018-09-11 | Genentech, Inc. | Ultrapurified DsbA and DsbC and methods of making and using the same |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3588124T2 (de) * | 1984-06-13 | 1997-02-20 | Applied Research Systems | Vorrichtung, mit Verwendung in chemischen Prüfverfahren |
US5141868A (en) * | 1984-06-13 | 1992-08-25 | Internationale Octrooi Maatschappij "Octropa" Bv | Device for use in chemical test procedures |
GB8911462D0 (en) * | 1989-05-18 | 1989-07-05 | Ares Serono Res & Dev Ltd | Devices for use in chemical test procedures |
GB9025471D0 (en) * | 1990-11-22 | 1991-01-09 | Ares Serono Res & Dev Ltd | Method of assay |
CA2069537A1 (en) * | 1991-06-07 | 1992-12-08 | Thomas A. Cook | Multiple output referencing system for evanescent wave sensor |
GB9212302D0 (en) * | 1992-06-10 | 1992-07-22 | Applied Research Systems | Method for improving measurement precision in evanescent wave optical biosensor assays |
US5512492A (en) * | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
-
1993
- 1993-12-16 GB GB939325718A patent/GB9325718D0/en active Pending
-
1994
- 1994-12-15 WO PCT/GB1994/002741 patent/WO1995016914A1/en active IP Right Grant
- 1994-12-15 ES ES95902906T patent/ES2119369T3/es not_active Expired - Lifetime
- 1994-12-15 DK DK95902906T patent/DK0734527T3/da active
- 1994-12-15 US US08/663,243 patent/US5856203A/en not_active Expired - Fee Related
- 1994-12-15 AT AT95902906T patent/ATE169117T1/de not_active IP Right Cessation
- 1994-12-15 CA CA002177362A patent/CA2177362C/en not_active Expired - Fee Related
- 1994-12-15 DE DE69412137T patent/DE69412137T2/de not_active Expired - Fee Related
- 1994-12-15 EP EP95902906A patent/EP0734527B1/en not_active Expired - Lifetime
- 1994-12-15 JP JP51661495A patent/JP3458860B2/ja not_active Expired - Fee Related
- 1994-12-15 AU AU11988/95A patent/AU689174B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
DE69412137T2 (de) | 1999-01-21 |
DE69412137D1 (de) | 1998-09-03 |
CA2177362A1 (en) | 1995-06-22 |
AU1198895A (en) | 1995-07-03 |
JP3458860B2 (ja) | 2003-10-20 |
WO1995016914A1 (en) | 1995-06-22 |
ATE169117T1 (de) | 1998-08-15 |
AU689174B2 (en) | 1998-03-26 |
CA2177362C (en) | 2005-09-20 |
EP0734527B1 (en) | 1998-07-29 |
EP0734527A1 (en) | 1996-10-02 |
US5856203A (en) | 1999-01-05 |
JPH09510774A (ja) | 1997-10-28 |
GB9325718D0 (en) | 1994-02-16 |
DK0734527T3 (da) | 1999-05-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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