ES2072847T1 - Dispositivos y metodos para la medicion de procesos bioquimicos celulares. - Google Patents

Dispositivos y metodos para la medicion de procesos bioquimicos celulares.

Info

Publication number
ES2072847T1
ES2072847T1 ES94915227T ES94915227T ES2072847T1 ES 2072847 T1 ES2072847 T1 ES 2072847T1 ES 94915227 T ES94915227 T ES 94915227T ES 94915227 T ES94915227 T ES 94915227T ES 2072847 T1 ES2072847 T1 ES 2072847T1
Authority
ES
Spain
Prior art keywords
pct
methods
devices
biochemical processes
measuring cellular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES94915227T
Other languages
English (en)
Other versions
ES2072847T3 (es
Inventor
Neil David Cook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
Amersham International PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham International PLC filed Critical Amersham International PLC
Publication of ES2072847T1 publication Critical patent/ES2072847T1/es
Application granted granted Critical
Publication of ES2072847T3 publication Critical patent/ES2072847T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/20—Material Coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

APARATO Y METODO PARA ESTUDIAR PROCESOS CELULARES QUE COMPRENDE UN RECIPIENTE QUE TIENE UNA BASE INCLUYENDO UNA CAPA QUE COMPRENDE UNA SUSTANCIA CENTELLEANTE Y QUE ESTA ADAPTADA PARA UNION Y/O CRECIMIENTO DE LAS CELULAS. LOS PROCESOS CELULARES SON EXAMINADOS POR CENTELLEO EN LAS PROXIMIDADES DE LA MUESTRA DE ENSAYO USANDO UN REACTIVO ETIQUETADO CON UN RADIOISOTOPO.
ES94915227T 1993-05-17 1994-05-16 Dispositivos y metodos para la medida de procesos bioquimicos celulares. Expired - Lifetime ES2072847T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93303806 1993-05-17

Publications (2)

Publication Number Publication Date
ES2072847T1 true ES2072847T1 (es) 1995-08-01
ES2072847T3 ES2072847T3 (es) 1998-03-01

Family

ID=8214414

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94915227T Expired - Lifetime ES2072847T3 (es) 1993-05-17 1994-05-16 Dispositivos y metodos para la medida de procesos bioquimicos celulares.

Country Status (10)

Country Link
US (2) US5665562A (es)
EP (1) EP0650396B1 (es)
JP (1) JP3152933B2 (es)
AT (1) ATE162216T1 (es)
CA (1) CA2139409C (es)
DE (2) DE69407923T2 (es)
DK (1) DK0650396T3 (es)
ES (1) ES2072847T3 (es)
FI (1) FI110488B (es)
WO (1) WO1994026413A1 (es)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0716635B2 (ja) * 1993-01-27 1995-03-01 旭サナック株式会社 建築用塗材吹付機
DE69407923T2 (de) * 1993-05-17 1998-04-30 Amersham Int Plc Vorrichtung und verfahren zum nachweis zellularer und biochemischer prozesse
JP3315269B2 (ja) * 1994-10-07 2002-08-19 アロカ株式会社 放射性試料測定用プレート
US5792426A (en) * 1994-10-11 1998-08-11 Schweizerische Eidgenossenschaft Vertreten Durch Das Ac-Laboratorium Spiez Der Gruppe Rustung Multi-well titerplate for instrumental analysis
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
US5925562A (en) * 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
ATE254965T1 (de) * 1995-04-25 2003-12-15 Discovery Partners Internation Fernprogrammierbare matrizen mit speichern und verwendungen davon
JP3118528B2 (ja) 1996-01-26 2000-12-18 東邦レーヨン株式会社 ステアリングホイールおよびその製造方法
US5739001A (en) * 1996-10-29 1998-04-14 E. I. Du Pont De Nemours And Company Solid phase cell-based assay
GB2319836B (en) * 1996-11-25 2001-04-04 Porvair Plc Microplates
EP0863402B1 (en) 1997-03-03 2005-09-14 Amersham Biosciences UK Limited In-situ cell extraction and assay method
DE19712484C2 (de) * 1997-03-25 1999-07-08 Greiner Gmbh Microplatte mit transparentem Boden und Verfahren zu deren Herstellung
JP2001524214A (ja) * 1997-05-02 2001-11-27 ジェン−プロウブ インコーポレイテッド 反応容器装置
US5910403A (en) * 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
ATE274189T1 (de) * 1997-08-18 2004-09-15 Amersham Plc Annäherungs-szintillationstest
US6077669A (en) * 1997-11-04 2000-06-20 Becton Dickinson And Company Kit and method for fluorescence based detection assay
ATE446141T1 (de) * 1997-11-14 2009-11-15 Gen Probe Inc Arbeitsgerät zur analyse
US6066446A (en) * 1997-12-19 2000-05-23 Nen Life Science Products, Inc. Assay member and method for its manufacture
US6977141B2 (en) 1998-02-10 2005-12-20 Vicuron Pharmaceuticals Inc. Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US6463647B1 (en) * 1998-03-18 2002-10-15 Corning Incorporated Method of making an extruded high density assay plate
DK1066112T3 (da) * 1998-03-27 2003-03-17 Aventis Pharma Gmbh Miniature-mikrotiterplade til screening med stor kapacitet
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
NZ507722A (en) * 1998-05-15 2003-05-30 Astrazeneca Ab A scintillation proximity assay for the detection of peptidoglycan synthesis
DE19822827A1 (de) * 1998-05-20 2001-01-18 Forschungszentrum Juelich Gmbh Verfahren zur Durchführung einer Messung der Interaktion von Chemikalien mit Zellen
US6057092A (en) * 1998-08-31 2000-05-02 Trellis Bioinformatics, Inc. Cellular transport detection method
GB2342350A (en) * 1998-10-05 2000-04-12 Univ Nottingham Trent Solid supports containing oxazole scintillants
AU2001240074B2 (en) * 2000-03-06 2006-02-23 Bioseek, Inc. Function homology screening
WO2001080997A1 (en) * 2000-04-19 2001-11-01 Corning Incorporated Multi-well plate and method of manufacture
US7347977B2 (en) * 2000-06-08 2008-03-25 Eppendorf Ag Microtitration plate
JP4282251B2 (ja) 2000-08-02 2009-06-17 富士フイルム株式会社 生化学解析用ユニットおよびそれを用いた生化学解析方法
GB0027516D0 (en) * 2000-11-10 2000-12-27 Amersham Pharm Biotech Uk Ltd Support and method for cell based assays
US7378280B2 (en) * 2000-11-16 2008-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
WO2002052274A2 (fr) * 2000-12-26 2002-07-04 Molecular Engines Laboratories Procede de criblage base sur les partenaires de liaison de tsap6
DE10108892B4 (de) * 2001-02-23 2005-08-18 Graffinity Pharmaceuticals Ag Synthesevorrichtung und Verfahren zu deren Herstellung
PL367715A1 (en) * 2001-09-20 2005-03-07 3-Dimensional Pharmaceuticals, Inc. Conductive microtiter plate
JP2005515452A (ja) 2001-10-24 2005-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アイソトープで標識された水を用いるヒトおよび実験系におけるタンパク質合成速度の測定
WO2003068919A2 (en) * 2002-02-12 2003-08-21 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
US20030183958A1 (en) * 2002-03-28 2003-10-02 Becton, Dickinson And Company Multi-well plate fabrication
AU2003234688A1 (en) * 2002-04-05 2003-10-27 The Regents Of The University Of California Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
CN100377786C (zh) * 2002-04-15 2008-04-02 库尔选项公司 热传导性生物测定盘及其制造方法
AU2003245513A1 (en) * 2002-06-14 2003-12-31 Pierce Biotechnology, Inc. Homogenous assay for enzymatic activity
EP1534075B1 (en) * 2002-07-12 2009-09-30 Morehouse School of Medicine Method for identifying salt-sensitive persons
EP1546364A4 (en) 2002-07-30 2006-09-06 Univ California METHOD FOR THE LARGE-SCALE AUTOMATIC MEASUREMENT OF PROTEOMIC OR ORGANOMOMIC MOLECULAR FLOW RATES BY MASS SPECTROMETRY
US20060105339A1 (en) * 2002-09-04 2006-05-18 Marc Hellerstein Methods for measuring the rates of replication and death of microbial infectious agents in an infected
DE60324950D1 (de) * 2002-09-13 2009-01-08 Univ California Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
CA2504313C (en) 2002-11-04 2012-01-17 Marc K. Hellerstein Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
US20050202406A1 (en) * 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2005087943A1 (en) * 2004-03-11 2005-09-22 The Regents Of The University Of California Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients
US20050238577A1 (en) * 2004-03-29 2005-10-27 The Regents Of The University Of California Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
TW200711660A (en) * 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
EP2261718B1 (de) * 2005-08-01 2018-08-01 ibidi GmbH Verfahren zur Herstellung einer Probenkammer
ES2331019T3 (es) * 2005-12-09 2009-12-18 F. Hoffmann-La Roche Ag Ensayo de proximidad de centelleo.
EP2522716B1 (en) * 2010-01-08 2019-08-28 Sumitomo Bakelite Company Limited Culture vessel for formation of aggregated cell mass
US20140242600A1 (en) * 2011-06-08 2014-08-28 The Board Of Trustees Of The Leland Stanford Junior University Imaging the heterogeneous uptake of radiolabeled molecules in single living cells
US10386371B2 (en) 2011-09-08 2019-08-20 The Regents Of The University Of California Metabolic flux measurement, imaging and microscopy
CA2858368A1 (en) 2011-12-07 2013-06-13 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
US9790465B2 (en) * 2013-04-30 2017-10-17 Corning Incorporated Spheroid cell culture well article and methods thereof
JP6684715B2 (ja) * 2014-02-18 2020-04-22 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド リソソーム酵素のための基質クリアランスアッセイ
CN107109328B (zh) 2014-10-29 2021-02-05 康宁股份有限公司 细胞培养插入件
JP6930914B2 (ja) 2014-10-29 2021-09-01 コーニング インコーポレイテッド 灌流バイオリアクタ・プラットフォーム
US11136723B2 (en) 2017-02-27 2021-10-05 Westrock Mwv, Llc Heat sealable barrier paperboard
CN111094536B (zh) 2017-07-14 2024-03-29 康宁股份有限公司 用于3d培养的细胞培养容器及培养3d细胞的方法
EP3652290B1 (en) 2017-07-14 2022-05-04 Corning Incorporated 3d cell culture vessels for manual or automatic media exchange
US11767499B2 (en) 2017-07-14 2023-09-26 Corning Incorporated Cell culture vessel
US11857970B2 (en) 2017-07-14 2024-01-02 Corning Incorporated Cell culture vessel
JP7353263B2 (ja) 2018-07-13 2023-09-29 コーニング インコーポレイテッド 安定化装置を備えた細胞培養容器
EP3649227A1 (en) 2018-07-13 2020-05-13 Corning Incorporated Fluidic devices including microplates with interconnected wells
PL3649226T3 (pl) 2018-07-13 2022-05-16 Corning Incorporated Płytki mikrodołkowe z boczną ścianką zawierającą powierzchnię dostarczającą płynną pożywkę

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000252A (en) * 1974-01-04 1976-12-28 Kenneth Kosak Immunoscintillation cell
US4382074A (en) * 1978-03-27 1983-05-03 Hiram Hart Scintillation proximity assay
ES8501998A1 (es) * 1982-10-12 1984-12-16 Dynatech Lab Un recipiente que tiene al menos una cavidad o pocillo para contener al menos una muestra de ensayo durante una medicion fluometrica.
US4588698A (en) * 1982-10-19 1986-05-13 University Patents, Inc. Encapsulated scintillators for measuring the concentration of tritiated solutes
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
SE8803602D0 (sv) * 1988-10-11 1988-10-11 Wallac Oy A sample plate with a plurality of sample wells or vials intended for radiolabeled binding assays
JPH04335154A (ja) * 1991-05-09 1992-11-24 S R L:Kk 薬物スクリ−ニング方法
DK0576090T3 (da) * 1992-06-22 2001-11-12 Packard Instr Bv Klæbende plastscintillator
DE69407923T2 (de) * 1993-05-17 1998-04-30 Amersham Int Plc Vorrichtung und verfahren zum nachweis zellularer und biochemischer prozesse

Also Published As

Publication number Publication date
JP3152933B2 (ja) 2001-04-03
US5665562A (en) 1997-09-09
CA2139409C (en) 2005-01-04
FI950154A0 (fi) 1995-01-13
DK0650396T3 (da) 1998-09-14
FI110488B (fi) 2003-02-14
FI950154A (fi) 1995-01-13
ATE162216T1 (de) 1998-01-15
WO1994026413A1 (en) 1994-11-24
CA2139409A1 (en) 1994-11-24
JPH07509405A (ja) 1995-10-19
ES2072847T3 (es) 1998-03-01
DE69407923T2 (de) 1998-04-30
EP0650396B1 (en) 1998-01-14
DE650396T1 (de) 1995-11-30
EP0650396A1 (en) 1995-05-03
US5989854A (en) 1999-11-23
DE69407923D1 (de) 1998-02-19

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