IL166444A0 - Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry - Google Patents

Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry

Info

Publication number
IL166444A0
IL166444A0 IL16644405A IL16644405A IL166444A0 IL 166444 A0 IL166444 A0 IL 166444A0 IL 16644405 A IL16644405 A IL 16644405A IL 16644405 A IL16644405 A IL 16644405A IL 166444 A0 IL166444 A0 IL 166444A0
Authority
IL
Israel
Prior art keywords
organeome
proteome
mass spectrometry
flux rates
scale measurement
Prior art date
Application number
IL16644405A
Other languages
English (en)
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of IL166444A0 publication Critical patent/IL166444A0/xx

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0002General or multifunctional contrast agents, e.g. chelated agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/15Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Primary Health Care (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Business, Economics & Management (AREA)
  • Tourism & Hospitality (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Child & Adolescent Psychology (AREA)
  • Economics (AREA)
  • Human Resources & Organizations (AREA)
IL16644405A 2002-07-30 2005-01-23 Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry IL166444A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39995002P 2002-07-30 2002-07-30
PCT/US2003/023340 WO2004011426A2 (en) 2002-07-30 2003-07-25 Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry

Publications (1)

Publication Number Publication Date
IL166444A0 true IL166444A0 (en) 2006-01-15

Family

ID=31188647

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16644405A IL166444A0 (en) 2002-07-30 2005-01-23 Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry

Country Status (7)

Country Link
US (5) US20060094057A1 (xx)
EP (1) EP1546364A4 (xx)
JP (1) JP4804753B2 (xx)
AU (1) AU2003256819B2 (xx)
CA (1) CA2494715C (xx)
IL (1) IL166444A0 (xx)
WO (1) WO2004011426A2 (xx)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910403A (en) 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
ATE502578T1 (de) 2001-10-24 2011-04-15 Univ California Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser
WO2003068919A2 (en) 2002-02-12 2003-08-21 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
CA2494715C (en) 2002-07-30 2014-07-08 The Regents Of The University Of California Method for automated, large-scale measurement of the molecular flux rates using mass spectrometry
US20060105339A1 (en) * 2002-09-04 2006-05-18 Marc Hellerstein Methods for measuring the rates of replication and death of microbial infectious agents in an infected
SG149699A1 (en) 2002-09-13 2009-02-27 Univ California Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
JP4611025B2 (ja) * 2002-11-04 2011-01-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験
US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) * 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
EP1708758A4 (en) * 2004-01-15 2008-04-02 Cedars Sinai Medical Center SYSTEM AND METHOD FOR EXPRESSION PROTEOMICS BASED ON ISOTOPIC RATIO MODIFICATION
US8510054B2 (en) * 2004-02-05 2013-08-13 Ajinomoto Co., Inc. Intracellular metabolic flux analysis method using substrate labeled with isotope
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
EP1723252A4 (en) * 2004-03-11 2009-07-29 Univ California TIMELY AND SPATIAL CHARACTERIZATION OF BIOSYNTHETIC EVENTS IN LIVING ORGANISMS THROUGH ISOTOPEN FINGERPRINTING UNDER CONDITIONS OF IMPROPER ISOTOPE GRADIENTS
WO2005094327A2 (en) * 2004-03-29 2005-10-13 The Regents Of The University Of California Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling
JP4118918B2 (ja) * 2005-02-28 2008-07-16 シャープ株式会社 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
TW200711660A (en) 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
KR20070092939A (ko) * 2007-08-27 2007-09-14 최원철 동위원소의 측정에 의한 암진단 방법
JP2014526685A (ja) 2011-09-08 2014-10-06 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 代謝流量測定、画像化、および顕微鏡法
CA2858368A1 (en) 2011-12-07 2013-06-13 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
US20130338932A1 (en) * 2012-06-13 2013-12-19 Agilent Technologies, Inc. Computational method for mapping peptides to proteins using sequencing data
US9557334B2 (en) 2012-10-25 2017-01-31 Run Them Sweet Llc Formulations and methods to provide nutrition to human and other patients
EP2912161A4 (en) * 2012-10-25 2016-08-24 Run Them Sweet Llc METHODS AND SYSTEMS FOR ESTIMATING NUTRITIONAL NEEDS OF HUMAN PATIENTS AND OTHER PATIENTS AND FOR MANAGING SUCH NUTRITIONAL NEEDS
US9366678B2 (en) * 2012-10-25 2016-06-14 Wisconsin Alumni Research Foundation Neutron encoded mass tags for analyte quantification
US9134319B2 (en) * 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
US10627407B2 (en) 2015-03-12 2020-04-21 Mars, Incorporated Ultra high resolution mass spectrometry and methods of using the same
US9697994B1 (en) 2015-04-09 2017-07-04 Ricarez Biosciences, LLC Use of stable label compounds with accelerator mass spectrometry
US20160363580A1 (en) * 2015-06-11 2016-12-15 The Texas A&M University System Methods of Metabolic Kinetic Phenotyping and Uses Thereof
US10770276B2 (en) 2015-08-31 2020-09-08 Yale University Techniques of mass spectrometry for isotopomer analysis and related systems and methods
WO2017044504A2 (en) * 2015-09-08 2017-03-16 Hellerstein Marc K Measurement of protein molecular flux rates by quantifying isotopologue abundances in immonium ion fragments using high resolution mass spectrometry
US20180259531A1 (en) * 2015-09-08 2018-09-13 Kinemed, Inc. Measurement of molecular flux rates by quantifying isotopologue abundances using high resolution mass spectrometry
US10607723B2 (en) 2016-07-05 2020-03-31 University Of Kentucky Research Foundation Method and system for identification of metabolites using mass spectra
EP3529724B1 (en) 2016-10-20 2024-07-03 Vito NV Monoisotopic mass determination of macromolecules via mass spectrometry
CN110196288A (zh) * 2018-02-26 2019-09-03 中国科学院上海生命科学研究院 一种动态代谢流量分析技术的建立与应用

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065552A (en) * 1975-05-05 1977-12-27 Giovanni Giacomo Costa Method of detecting malignant neoplasms
US4332784A (en) 1979-02-06 1982-06-01 The Radiochemical Centre Limited Dual isotope assays
SU968036A1 (ru) 1980-03-10 1982-10-23 Научно-исследовательский институт медицинской радиологии АМН СССР Способ получени меченого белка
US5317098A (en) * 1986-03-17 1994-05-31 Hiroaki Shizuya Non-radioisotope tagging of fragments
EP0248924B1 (en) * 1986-06-09 1989-11-23 Bruker Analytische Messtechnik GmbH Method for determining the turnover of organic material in living tissue and nmr spectrometer for performing this method
US4940658A (en) * 1986-11-20 1990-07-10 University Patents, Inc. Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency
AU1966188A (en) * 1987-08-07 1989-03-09 Mallinckrodt, Inc. Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
US5042488A (en) * 1987-09-29 1991-08-27 The Washington University Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ
US6004781A (en) * 1988-01-22 1999-12-21 The General Hospital Corporation Nucleic acid encoding Ig-CD4 fusion proteins
JPH04504049A (ja) 1989-03-20 1992-07-23 アンティキャンサー インコーポレイテッド インビトロにおける組織の生存能力及び増殖能力を測定する、自生状態法及びシステム
GB2229718B (en) * 1989-03-22 1993-01-06 Inst Molekularnoi Genetik Method for preparing hydrogen-isotape labelled biologically active organic compounds
US5217903A (en) * 1990-05-15 1993-06-08 Trustees Of Boston University Measuring connective tissue breakdown products in body fluids
CA2027714C (en) * 1990-07-13 2003-01-28 Kenneth W. Turtletaub Method of measurement in biological systems
US5209919A (en) * 1990-07-13 1993-05-11 Regents Of The University Of California Method of measurement in biological systems
US5597548A (en) * 1990-07-18 1997-01-28 Board Of Regents, The University Of Texas System 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling
HU208084B (en) 1991-10-31 1993-08-30 Hyd Kutato Fejlesztoe Kft Process for producing compositions suitable for curing tumorous diseases
US5394236A (en) * 1992-02-03 1995-02-28 Rutgers, The State University Methods and apparatus for isotopic analysis
CA2117749A1 (en) 1992-04-08 1993-10-28 Paavo Kai Johannes Kinnunen Composition for therapeutic or diagnostic use, process for its preparation and its use
US5338686A (en) * 1992-04-29 1994-08-16 Hellerstein Marc K Method for measuring in vivo synthesis of biopolymers
JP2960832B2 (ja) * 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト エストラジオールの投与システム
US5366885A (en) 1992-06-09 1994-11-22 Barranco Iii Sam C Method and kit for testing tumors for drug sensitivity
US5432058A (en) 1992-09-30 1995-07-11 Lange, Iii; Louis G. Method for measuring human cholesterol absorption using metabolically stable isotopes
US5506147A (en) * 1993-04-15 1996-04-09 Kolhouse; J. Fred Non-invasive evaluation of maldigestion and malaborption
JP3152933B2 (ja) * 1993-05-17 2001-04-03 アマーシャム・インターナショナル・ピーエルシー 細胞生化学プロセスを測定するための装置および方法
US5439803A (en) 1993-08-13 1995-08-08 The Regents Of The University Of Michigan Isotope and assay for glycolysis and the pentose phosphate pathway
EP0728019A4 (en) 1993-11-08 1999-07-07 Peptide Delivery Systems Pty L MARKED DIAGNOSTIC COMPOSITIONS AND METHODS OF USE THEREOF
DE69629097T2 (de) * 1995-08-08 2004-03-18 Otsuka Pharmaceutical Co., Ltd. Diagnostische zusammensetzungen und deren anwendung in der diagnose von zentralnervösen anomalien
US5922554A (en) 1995-10-30 1999-07-13 The Regents Of The University Of California Inhibition of cellular uptake of cholesterol
DE69716838T2 (de) * 1996-08-27 2003-04-10 Tokyo Gas Co. Ltd., Tokio/Tokyo Diagnostisches Mittel für Diabetes
EP0979306A4 (en) * 1997-02-14 2004-09-01 Univ George Washington ASSAY FOR THE MEASUREMENT OF DNA SYNTHESIS RATES
CA2283177A1 (en) * 1997-03-14 1998-09-24 Fred P. Abramson A device for continuous isotope ratio monitoring following fluorine based chemical reactions
US5910403A (en) 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
US5961470A (en) 1997-07-09 1999-10-05 Wagner; David A. Breath test for assessing hepatic function
US6329208B1 (en) * 1997-07-16 2001-12-11 Board Of Regents, The University Of Texas System Methods for determining gluconeogenesis, anapleurosis and pyruvate recycling
CA2249173C (en) * 1997-10-06 2008-12-16 Tokyo Gas Co., Ltd. Diagnostic agent for liver function
US5924995A (en) * 1997-11-10 1999-07-20 Meretek Diagnostics Non-invasive method for the functional assessment of infants and children with an inherited metabolic disorder
US6461870B2 (en) * 1998-05-06 2002-10-08 Isotechnika Inc. 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
WO1999056790A2 (en) 1998-05-06 1999-11-11 Isotechnika, Inc. 13c glucose breath test for the diagnosis of diabetes
US6284219B1 (en) * 1998-06-30 2001-09-04 Phenome Sciences Inc. In vivo determination of metabolic function for use in therapy management
US6625547B1 (en) * 1998-08-05 2003-09-23 Washington State University Research Foundation Relative rates of cytochrome p450 metabolism
WO2000011208A1 (en) * 1998-08-25 2000-03-02 University Of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
DE19839491A1 (de) * 1998-08-29 2000-03-02 Hermann Heumann Verfahren zur Markierung von Biopolymeren mit Isotopen
WO2000013025A1 (en) * 1998-08-31 2000-03-09 University Of Washington Stable isotope metabolic labeling for analysis of biopolymers
US6693186B2 (en) * 1998-09-01 2004-02-17 Antex Biologics Inc Neisseria meningitidis polypeptide, nucleic acid sequence and uses thereof
US6887712B1 (en) * 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
JP4723725B2 (ja) * 1999-04-20 2011-07-13 ターゲット ディスカバリー, インコーポレイテッド 代謝経路を分析するための方法
US20030119069A1 (en) * 1999-04-20 2003-06-26 Target Discovery, Inc. Labeling of protein samples
US6764817B1 (en) 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
US6391649B1 (en) * 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
US7057168B2 (en) * 1999-07-21 2006-06-06 Sionex Corporation Systems for differential ion mobility analysis
US6653090B1 (en) 1999-11-05 2003-11-25 University Of Alberta Methods for measuring the metabolism of and screening for drugs in isolated hearts
JP2001211782A (ja) * 2000-02-02 2001-08-07 Masa Yamamoto tob遺伝子欠損ノックアウト非ヒト哺乳動物
CA2405722A1 (en) * 2000-04-13 2001-11-08 Thermo Finnigan Llc Proteomic analysis by parallel mass spectrometry
WO2001080715A2 (en) 2000-04-21 2001-11-01 The Trustees Of Columbia University In The City Of New York Methods for identifying compounds useful for preventing acute clinical vascular events in a subject
ATE344456T1 (de) * 2000-05-05 2006-11-15 Purdue Research Foundation Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen
WO2001087352A1 (en) * 2000-05-18 2001-11-22 Metabolic Solutions, Inc. Reverse isotope dilution assay and lactose intolerance assay
US6680203B2 (en) * 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
US7048907B2 (en) * 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
GB0106923D0 (en) 2001-03-20 2001-05-09 Univ Dundee Liver function test
US7256047B2 (en) 2001-05-01 2007-08-14 Board Of Regents, The University Of Texas System Measurement of gluconeogenesis and intermediary metabolism using stable isotopes
CA2451795A1 (en) 2001-06-26 2003-01-09 Paul M. Mathews Cell-based high-throughput screening methods
JP2003079270A (ja) 2001-09-10 2003-03-18 Japan Science & Technology Corp ミエリン発達障害モデル非ヒト動物
US6835927B2 (en) * 2001-10-15 2004-12-28 Surromed, Inc. Mass spectrometric quantification of chemical mixture components
ATE502578T1 (de) 2001-10-24 2011-04-15 Univ California Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser
EP1456667B2 (en) * 2001-12-08 2010-01-20 Micromass UK Limited Method of mass spectrometry
US7635841B2 (en) * 2001-12-12 2009-12-22 Micromass Uk Limited Method of mass spectrometry
WO2003068919A2 (en) 2002-02-12 2003-08-21 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
US20060100903A1 (en) * 2002-03-22 2006-05-11 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Method of enhancing the efficiency of a pharmaceutical business
US20030180710A1 (en) 2002-03-22 2003-09-25 Lee Wai-Nang Paul Method of enhancing the efficiency of a pharmaceutical business
US20050281745A1 (en) * 2002-03-22 2005-12-22 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development
US20030180800A1 (en) 2002-03-22 2003-09-25 Lee Wai-Nang Paul Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development
WO2003087314A2 (en) 2002-04-05 2003-10-23 The Regents Of The University Of California Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
US20030211036A1 (en) * 2002-05-07 2003-11-13 Hadassa Degani Method and apparatus for monitoring and quantitatively evaluating tumor perfusion
AU2003253702A1 (en) 2002-06-26 2004-01-19 The Regents Of The University Of California Methods and kits for determining energy expenditure in living organisms by metabolic water production
US7510880B2 (en) * 2002-06-26 2009-03-31 Gross Richard W Multidimensional mass spectrometry of serum and cellular lipids directly from biologic extracts
CA2494715C (en) * 2002-07-30 2014-07-08 The Regents Of The University Of California Method for automated, large-scale measurement of the molecular flux rates using mass spectrometry
AU2003265448A1 (en) 2002-08-16 2004-03-03 The Regents Of The University Of California Dynamic hepatic recycling glucose tolerance test
US20060105339A1 (en) 2002-09-04 2006-05-18 Marc Hellerstein Methods for measuring the rates of replication and death of microbial infectious agents in an infected
SG149699A1 (en) 2002-09-13 2009-02-27 Univ California Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis
US20070248540A1 (en) 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
EP1545628A4 (en) 2002-09-16 2010-07-28 Univ California BIOCHEMICAL METHOD FOR MEASURING THE METABOLIC FITNESS OF WOVEN OR THE WHOLE ORGANISM
US7084396B2 (en) * 2002-10-29 2006-08-01 Target Discovery, Inc. Method for increasing ionization efficiency in mass spectroscopy
JP4611025B2 (ja) 2002-11-04 2011-01-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験
US20040121305A1 (en) * 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
US6906320B2 (en) * 2003-04-02 2005-06-14 Merck & Co., Inc. Mass spectrometry data analysis techniques
US20050014181A1 (en) * 2003-06-18 2005-01-20 Galis Zorina S. Methods and compositions for the assessment of polymer assembly
WO2005001736A2 (en) * 2003-06-30 2005-01-06 Ajinomoto Co., Inc. Intracellular metabolic flux analysis method using substrate labeled with isotope
US7262020B2 (en) 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
WO2005009597A2 (en) 2003-07-03 2005-02-03 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
US8510054B2 (en) * 2004-02-05 2013-08-13 Ajinomoto Co., Inc. Intracellular metabolic flux analysis method using substrate labeled with isotope
WO2006028492A2 (en) 2004-02-13 2006-03-16 Nuvelo, Inc. hC1Q/TNF7 AND USES THEREOF
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
EP1723252A4 (en) 2004-03-11 2009-07-29 Univ California TIMELY AND SPATIAL CHARACTERIZATION OF BIOSYNTHETIC EVENTS IN LIVING ORGANISMS THROUGH ISOTOPEN FINGERPRINTING UNDER CONDITIONS OF IMPROPER ISOTOPE GRADIENTS
WO2005094327A2 (en) 2004-03-29 2005-10-13 The Regents Of The University Of California Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling
WO2005098024A1 (en) 2004-03-30 2005-10-20 Kinemed, Inc. In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes
JP4654592B2 (ja) * 2004-04-02 2011-03-23 味の素株式会社 代謝フラックスの決定方法
EP1824516A4 (en) * 2004-10-29 2008-11-05 Target Discovery Inc GLYCAN ANALYSIS WITH DEUTERATED GLUCOSE
WO2006081521A2 (en) 2005-01-26 2006-08-03 The Regents Of The University Of Colorado Methods for diagnosis and intervention of hepatic disorders
CA2604057C (en) 2005-04-06 2014-02-11 Randall John Bateman Methods for measuring the metabolism of neurally derived biomolecules in vivo
US20060251576A1 (en) 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
TW200711660A (en) 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development

Also Published As

Publication number Publication date
US8481478B2 (en) 2013-07-09
AU2003256819B2 (en) 2009-11-12
EP1546364A2 (en) 2005-06-29
US20060094057A1 (en) 2006-05-04
US8129335B2 (en) 2012-03-06
JP4804753B2 (ja) 2011-11-02
US20120190560A1 (en) 2012-07-26
AU2003256819A1 (en) 2004-02-16
US8969287B2 (en) 2015-03-03
US20150233938A1 (en) 2015-08-20
CA2494715C (en) 2014-07-08
US20140005074A1 (en) 2014-01-02
WO2004011426A3 (en) 2004-10-07
EP1546364A4 (en) 2006-09-06
US20100172834A1 (en) 2010-07-08
CA2494715A1 (en) 2004-02-05
JP2005534906A (ja) 2005-11-17
WO2004011426A2 (en) 2004-02-05

Similar Documents

Publication Publication Date Title
IL166444A0 (en) Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
AU2002338589A1 (en) Method for determining gas accumulation rates
IL212234A0 (en) Mass spectroscopy ionization method
AU2002367180A1 (en) Concentration measuring method
EP1726944A4 (en) SAMPLE TARGET WITH SURFACE-TREATED LEVEL FOR HOLDING THE SAMPLE AND METHOD FOR THE PRODUCTION THEREOF AND MASS SPECTROMETER USING THE SAMPLE ARGET
GB2420009B (en) Method and apparatus for mass spectrometry
GB0201423D0 (en) Improved method and equipment for measuring vapour flux from surfaces
EP1585967A4 (en) METHOD FOR DETECTING NUCLEIC ACID SEQUENCE VARIATIONS
GB0223274D0 (en) Method and equipment for measuring vapour flux from surfaces
FI20031658A0 (fi) Menetelmä ja laitteisto näytteiden tutkimiseksi massaspektrometrisesti
EP1637884A4 (en) METHOD FOR MEASURING AN AFFINITY-RELATED SUBSTANCE
AU2002326036A1 (en) Method for determining cell cycle position
AU2003303869A1 (en) Methods for nucleic acid analysis
AU2003213107A8 (en) Methods for analysis of molecular events
AU2002228515A1 (en) Method for measuring the pipeline creeping
AU2003233330A8 (en) Method for quantifying molecules
GB0316539D0 (en) Compound testing method
EP1512972A4 (en) IMMUNE RESPONSE MEASURING METHOD
GB2402808B (en) Method and device for the mass-spectrometric analysis of gases
AU2003227526A8 (en) Method for measuring thermal diffusity
GB0409405D0 (en) Method for detecting procoagulant conditions
AU2003300199A8 (en) Method for identifying peptides by mass spectrometry
EP1486768A4 (en) ACCELERATED MEASUREMENT TEST METHOD
AU2002346975A1 (en) Method for analysing the sequence of polypeptides
TW551257U (en) Improved magnet apparatus for tool