IL166444A0 - Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry - Google Patents
Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometryInfo
- Publication number
- IL166444A0 IL166444A0 IL16644405A IL16644405A IL166444A0 IL 166444 A0 IL166444 A0 IL 166444A0 IL 16644405 A IL16644405 A IL 16644405A IL 16644405 A IL16644405 A IL 16644405A IL 166444 A0 IL166444 A0 IL 166444A0
- Authority
- IL
- Israel
- Prior art keywords
- organeome
- proteome
- mass spectrometry
- flux rates
- scale measurement
- Prior art date
Links
Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Primary Health Care (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Business, Economics & Management (AREA)
- Tourism & Hospitality (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Child & Adolescent Psychology (AREA)
- Economics (AREA)
- Human Resources & Organizations (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39995002P | 2002-07-30 | 2002-07-30 | |
PCT/US2003/023340 WO2004011426A2 (en) | 2002-07-30 | 2003-07-25 | Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
Publications (1)
Publication Number | Publication Date |
---|---|
IL166444A0 true IL166444A0 (en) | 2006-01-15 |
Family
ID=31188647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16644405A IL166444A0 (en) | 2002-07-30 | 2005-01-23 | Method for automated large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
Country Status (7)
Country | Link |
---|---|
US (5) | US20060094057A1 (xx) |
EP (1) | EP1546364A4 (xx) |
JP (1) | JP4804753B2 (xx) |
AU (1) | AU2003256819B2 (xx) |
CA (1) | CA2494715C (xx) |
IL (1) | IL166444A0 (xx) |
WO (1) | WO2004011426A2 (xx) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5910403A (en) | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
ATE502578T1 (de) | 2001-10-24 | 2011-04-15 | Univ California | Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser |
WO2003068919A2 (en) | 2002-02-12 | 2003-08-21 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
CA2494715C (en) | 2002-07-30 | 2014-07-08 | The Regents Of The University Of California | Method for automated, large-scale measurement of the molecular flux rates using mass spectrometry |
US20060105339A1 (en) * | 2002-09-04 | 2006-05-18 | Marc Hellerstein | Methods for measuring the rates of replication and death of microbial infectious agents in an infected |
SG149699A1 (en) | 2002-09-13 | 2009-02-27 | Univ California | Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis |
US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
JP4611025B2 (ja) * | 2002-11-04 | 2011-01-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験 |
US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
EP1708758A4 (en) * | 2004-01-15 | 2008-04-02 | Cedars Sinai Medical Center | SYSTEM AND METHOD FOR EXPRESSION PROTEOMICS BASED ON ISOTOPIC RATIO MODIFICATION |
US8510054B2 (en) * | 2004-02-05 | 2013-08-13 | Ajinomoto Co., Inc. | Intracellular metabolic flux analysis method using substrate labeled with isotope |
TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
EP1723252A4 (en) * | 2004-03-11 | 2009-07-29 | Univ California | TIMELY AND SPATIAL CHARACTERIZATION OF BIOSYNTHETIC EVENTS IN LIVING ORGANISMS THROUGH ISOTOPEN FINGERPRINTING UNDER CONDITIONS OF IMPROPER ISOTOPE GRADIENTS |
WO2005094327A2 (en) * | 2004-03-29 | 2005-10-13 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
JP4118918B2 (ja) * | 2005-02-28 | 2008-07-16 | シャープ株式会社 | 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体 |
US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
KR20070092939A (ko) * | 2007-08-27 | 2007-09-14 | 최원철 | 동위원소의 측정에 의한 암진단 방법 |
JP2014526685A (ja) | 2011-09-08 | 2014-10-06 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 代謝流量測定、画像化、および顕微鏡法 |
CA2858368A1 (en) | 2011-12-07 | 2013-06-13 | Glaxosmithkline Llc | Methods for determining total body skeletal muscle mass |
US20130338932A1 (en) * | 2012-06-13 | 2013-12-19 | Agilent Technologies, Inc. | Computational method for mapping peptides to proteins using sequencing data |
US9557334B2 (en) | 2012-10-25 | 2017-01-31 | Run Them Sweet Llc | Formulations and methods to provide nutrition to human and other patients |
EP2912161A4 (en) * | 2012-10-25 | 2016-08-24 | Run Them Sweet Llc | METHODS AND SYSTEMS FOR ESTIMATING NUTRITIONAL NEEDS OF HUMAN PATIENTS AND OTHER PATIENTS AND FOR MANAGING SUCH NUTRITIONAL NEEDS |
US9366678B2 (en) * | 2012-10-25 | 2016-06-14 | Wisconsin Alumni Research Foundation | Neutron encoded mass tags for analyte quantification |
US9134319B2 (en) * | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
US10627407B2 (en) | 2015-03-12 | 2020-04-21 | Mars, Incorporated | Ultra high resolution mass spectrometry and methods of using the same |
US9697994B1 (en) | 2015-04-09 | 2017-07-04 | Ricarez Biosciences, LLC | Use of stable label compounds with accelerator mass spectrometry |
US20160363580A1 (en) * | 2015-06-11 | 2016-12-15 | The Texas A&M University System | Methods of Metabolic Kinetic Phenotyping and Uses Thereof |
US10770276B2 (en) | 2015-08-31 | 2020-09-08 | Yale University | Techniques of mass spectrometry for isotopomer analysis and related systems and methods |
WO2017044504A2 (en) * | 2015-09-08 | 2017-03-16 | Hellerstein Marc K | Measurement of protein molecular flux rates by quantifying isotopologue abundances in immonium ion fragments using high resolution mass spectrometry |
US20180259531A1 (en) * | 2015-09-08 | 2018-09-13 | Kinemed, Inc. | Measurement of molecular flux rates by quantifying isotopologue abundances using high resolution mass spectrometry |
US10607723B2 (en) | 2016-07-05 | 2020-03-31 | University Of Kentucky Research Foundation | Method and system for identification of metabolites using mass spectra |
EP3529724B1 (en) | 2016-10-20 | 2024-07-03 | Vito NV | Monoisotopic mass determination of macromolecules via mass spectrometry |
CN110196288A (zh) * | 2018-02-26 | 2019-09-03 | 中国科学院上海生命科学研究院 | 一种动态代谢流量分析技术的建立与应用 |
Family Cites Families (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4065552A (en) * | 1975-05-05 | 1977-12-27 | Giovanni Giacomo Costa | Method of detecting malignant neoplasms |
US4332784A (en) | 1979-02-06 | 1982-06-01 | The Radiochemical Centre Limited | Dual isotope assays |
SU968036A1 (ru) | 1980-03-10 | 1982-10-23 | Научно-исследовательский институт медицинской радиологии АМН СССР | Способ получени меченого белка |
US5317098A (en) * | 1986-03-17 | 1994-05-31 | Hiroaki Shizuya | Non-radioisotope tagging of fragments |
EP0248924B1 (en) * | 1986-06-09 | 1989-11-23 | Bruker Analytische Messtechnik GmbH | Method for determining the turnover of organic material in living tissue and nmr spectrometer for performing this method |
US4940658A (en) * | 1986-11-20 | 1990-07-10 | University Patents, Inc. | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency |
AU1966188A (en) * | 1987-08-07 | 1989-03-09 | Mallinckrodt, Inc. | Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound |
US5042488A (en) * | 1987-09-29 | 1991-08-27 | The Washington University | Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ |
US6004781A (en) * | 1988-01-22 | 1999-12-21 | The General Hospital Corporation | Nucleic acid encoding Ig-CD4 fusion proteins |
JPH04504049A (ja) | 1989-03-20 | 1992-07-23 | アンティキャンサー インコーポレイテッド | インビトロにおける組織の生存能力及び増殖能力を測定する、自生状態法及びシステム |
GB2229718B (en) * | 1989-03-22 | 1993-01-06 | Inst Molekularnoi Genetik | Method for preparing hydrogen-isotape labelled biologically active organic compounds |
US5217903A (en) * | 1990-05-15 | 1993-06-08 | Trustees Of Boston University | Measuring connective tissue breakdown products in body fluids |
CA2027714C (en) * | 1990-07-13 | 2003-01-28 | Kenneth W. Turtletaub | Method of measurement in biological systems |
US5209919A (en) * | 1990-07-13 | 1993-05-11 | Regents Of The University Of California | Method of measurement in biological systems |
US5597548A (en) * | 1990-07-18 | 1997-01-28 | Board Of Regents, The University Of Texas System | 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling |
HU208084B (en) | 1991-10-31 | 1993-08-30 | Hyd Kutato Fejlesztoe Kft | Process for producing compositions suitable for curing tumorous diseases |
US5394236A (en) * | 1992-02-03 | 1995-02-28 | Rutgers, The State University | Methods and apparatus for isotopic analysis |
CA2117749A1 (en) | 1992-04-08 | 1993-10-28 | Paavo Kai Johannes Kinnunen | Composition for therapeutic or diagnostic use, process for its preparation and its use |
US5338686A (en) * | 1992-04-29 | 1994-08-16 | Hellerstein Marc K | Method for measuring in vivo synthesis of biopolymers |
JP2960832B2 (ja) * | 1992-05-08 | 1999-10-12 | ペルマテック テクノロジー アクチェンゲゼルシャフト | エストラジオールの投与システム |
US5366885A (en) | 1992-06-09 | 1994-11-22 | Barranco Iii Sam C | Method and kit for testing tumors for drug sensitivity |
US5432058A (en) | 1992-09-30 | 1995-07-11 | Lange, Iii; Louis G. | Method for measuring human cholesterol absorption using metabolically stable isotopes |
US5506147A (en) * | 1993-04-15 | 1996-04-09 | Kolhouse; J. Fred | Non-invasive evaluation of maldigestion and malaborption |
JP3152933B2 (ja) * | 1993-05-17 | 2001-04-03 | アマーシャム・インターナショナル・ピーエルシー | 細胞生化学プロセスを測定するための装置および方法 |
US5439803A (en) | 1993-08-13 | 1995-08-08 | The Regents Of The University Of Michigan | Isotope and assay for glycolysis and the pentose phosphate pathway |
EP0728019A4 (en) | 1993-11-08 | 1999-07-07 | Peptide Delivery Systems Pty L | MARKED DIAGNOSTIC COMPOSITIONS AND METHODS OF USE THEREOF |
DE69629097T2 (de) * | 1995-08-08 | 2004-03-18 | Otsuka Pharmaceutical Co., Ltd. | Diagnostische zusammensetzungen und deren anwendung in der diagnose von zentralnervösen anomalien |
US5922554A (en) | 1995-10-30 | 1999-07-13 | The Regents Of The University Of California | Inhibition of cellular uptake of cholesterol |
DE69716838T2 (de) * | 1996-08-27 | 2003-04-10 | Tokyo Gas Co. Ltd., Tokio/Tokyo | Diagnostisches Mittel für Diabetes |
EP0979306A4 (en) * | 1997-02-14 | 2004-09-01 | Univ George Washington | ASSAY FOR THE MEASUREMENT OF DNA SYNTHESIS RATES |
CA2283177A1 (en) * | 1997-03-14 | 1998-09-24 | Fred P. Abramson | A device for continuous isotope ratio monitoring following fluorine based chemical reactions |
US5910403A (en) | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
US5961470A (en) | 1997-07-09 | 1999-10-05 | Wagner; David A. | Breath test for assessing hepatic function |
US6329208B1 (en) * | 1997-07-16 | 2001-12-11 | Board Of Regents, The University Of Texas System | Methods for determining gluconeogenesis, anapleurosis and pyruvate recycling |
CA2249173C (en) * | 1997-10-06 | 2008-12-16 | Tokyo Gas Co., Ltd. | Diagnostic agent for liver function |
US5924995A (en) * | 1997-11-10 | 1999-07-20 | Meretek Diagnostics | Non-invasive method for the functional assessment of infants and children with an inherited metabolic disorder |
US6461870B2 (en) * | 1998-05-06 | 2002-10-08 | Isotechnika Inc. | 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control |
WO1999056790A2 (en) | 1998-05-06 | 1999-11-11 | Isotechnika, Inc. | 13c glucose breath test for the diagnosis of diabetes |
US6284219B1 (en) * | 1998-06-30 | 2001-09-04 | Phenome Sciences Inc. | In vivo determination of metabolic function for use in therapy management |
US6625547B1 (en) * | 1998-08-05 | 2003-09-23 | Washington State University Research Foundation | Relative rates of cytochrome p450 metabolism |
WO2000011208A1 (en) * | 1998-08-25 | 2000-03-02 | University Of Washington | Rapid quantitative analysis of proteins or protein function in complex mixtures |
DE19839491A1 (de) * | 1998-08-29 | 2000-03-02 | Hermann Heumann | Verfahren zur Markierung von Biopolymeren mit Isotopen |
WO2000013025A1 (en) * | 1998-08-31 | 2000-03-09 | University Of Washington | Stable isotope metabolic labeling for analysis of biopolymers |
US6693186B2 (en) * | 1998-09-01 | 2004-02-17 | Antex Biologics Inc | Neisseria meningitidis polypeptide, nucleic acid sequence and uses thereof |
US6887712B1 (en) * | 1998-11-09 | 2005-05-03 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
JP4723725B2 (ja) * | 1999-04-20 | 2011-07-13 | ターゲット ディスカバリー, インコーポレイテッド | 代謝経路を分析するための方法 |
US20030119069A1 (en) * | 1999-04-20 | 2003-06-26 | Target Discovery, Inc. | Labeling of protein samples |
US6764817B1 (en) | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
US6391649B1 (en) * | 1999-05-04 | 2002-05-21 | The Rockefeller University | Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy |
US7057168B2 (en) * | 1999-07-21 | 2006-06-06 | Sionex Corporation | Systems for differential ion mobility analysis |
US6653090B1 (en) | 1999-11-05 | 2003-11-25 | University Of Alberta | Methods for measuring the metabolism of and screening for drugs in isolated hearts |
JP2001211782A (ja) * | 2000-02-02 | 2001-08-07 | Masa Yamamoto | tob遺伝子欠損ノックアウト非ヒト哺乳動物 |
CA2405722A1 (en) * | 2000-04-13 | 2001-11-08 | Thermo Finnigan Llc | Proteomic analysis by parallel mass spectrometry |
WO2001080715A2 (en) | 2000-04-21 | 2001-11-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying compounds useful for preventing acute clinical vascular events in a subject |
ATE344456T1 (de) * | 2000-05-05 | 2006-11-15 | Purdue Research Foundation | Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen |
WO2001087352A1 (en) * | 2000-05-18 | 2001-11-22 | Metabolic Solutions, Inc. | Reverse isotope dilution assay and lactose intolerance assay |
US6680203B2 (en) * | 2000-07-10 | 2004-01-20 | Esperion Therapeutics, Inc. | Fourier transform mass spectrometry of complex biological samples |
US7048907B2 (en) * | 2001-02-05 | 2006-05-23 | Biophysics Assay Laboratory, Inc. | Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products |
GB0106923D0 (en) | 2001-03-20 | 2001-05-09 | Univ Dundee | Liver function test |
US7256047B2 (en) | 2001-05-01 | 2007-08-14 | Board Of Regents, The University Of Texas System | Measurement of gluconeogenesis and intermediary metabolism using stable isotopes |
CA2451795A1 (en) | 2001-06-26 | 2003-01-09 | Paul M. Mathews | Cell-based high-throughput screening methods |
JP2003079270A (ja) | 2001-09-10 | 2003-03-18 | Japan Science & Technology Corp | ミエリン発達障害モデル非ヒト動物 |
US6835927B2 (en) * | 2001-10-15 | 2004-12-28 | Surromed, Inc. | Mass spectrometric quantification of chemical mixture components |
ATE502578T1 (de) | 2001-10-24 | 2011-04-15 | Univ California | Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser |
EP1456667B2 (en) * | 2001-12-08 | 2010-01-20 | Micromass UK Limited | Method of mass spectrometry |
US7635841B2 (en) * | 2001-12-12 | 2009-12-22 | Micromass Uk Limited | Method of mass spectrometry |
WO2003068919A2 (en) | 2002-02-12 | 2003-08-21 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
US20060100903A1 (en) * | 2002-03-22 | 2006-05-11 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Method of enhancing the efficiency of a pharmaceutical business |
US20030180710A1 (en) | 2002-03-22 | 2003-09-25 | Lee Wai-Nang Paul | Method of enhancing the efficiency of a pharmaceutical business |
US20050281745A1 (en) * | 2002-03-22 | 2005-12-22 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development |
US20030180800A1 (en) | 2002-03-22 | 2003-09-25 | Lee Wai-Nang Paul | Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development |
WO2003087314A2 (en) | 2002-04-05 | 2003-10-23 | The Regents Of The University Of California | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
US20030211036A1 (en) * | 2002-05-07 | 2003-11-13 | Hadassa Degani | Method and apparatus for monitoring and quantitatively evaluating tumor perfusion |
AU2003253702A1 (en) | 2002-06-26 | 2004-01-19 | The Regents Of The University Of California | Methods and kits for determining energy expenditure in living organisms by metabolic water production |
US7510880B2 (en) * | 2002-06-26 | 2009-03-31 | Gross Richard W | Multidimensional mass spectrometry of serum and cellular lipids directly from biologic extracts |
CA2494715C (en) * | 2002-07-30 | 2014-07-08 | The Regents Of The University Of California | Method for automated, large-scale measurement of the molecular flux rates using mass spectrometry |
AU2003265448A1 (en) | 2002-08-16 | 2004-03-03 | The Regents Of The University Of California | Dynamic hepatic recycling glucose tolerance test |
US20060105339A1 (en) | 2002-09-04 | 2006-05-18 | Marc Hellerstein | Methods for measuring the rates of replication and death of microbial infectious agents in an infected |
SG149699A1 (en) | 2002-09-13 | 2009-02-27 | Univ California | Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis |
US20070248540A1 (en) | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
EP1545628A4 (en) | 2002-09-16 | 2010-07-28 | Univ California | BIOCHEMICAL METHOD FOR MEASURING THE METABOLIC FITNESS OF WOVEN OR THE WHOLE ORGANISM |
US7084396B2 (en) * | 2002-10-29 | 2006-08-01 | Target Discovery, Inc. | Method for increasing ionization efficiency in mass spectroscopy |
JP4611025B2 (ja) | 2002-11-04 | 2011-01-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験 |
US20040121305A1 (en) * | 2002-12-18 | 2004-06-24 | Wiegand Roger Charles | Generation of efficacy, toxicity and disease signatures and methods of use thereof |
US6906320B2 (en) * | 2003-04-02 | 2005-06-14 | Merck & Co., Inc. | Mass spectrometry data analysis techniques |
US20050014181A1 (en) * | 2003-06-18 | 2005-01-20 | Galis Zorina S. | Methods and compositions for the assessment of polymer assembly |
WO2005001736A2 (en) * | 2003-06-30 | 2005-01-06 | Ajinomoto Co., Inc. | Intracellular metabolic flux analysis method using substrate labeled with isotope |
US7262020B2 (en) | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
WO2005009597A2 (en) | 2003-07-03 | 2005-02-03 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
US20050202406A1 (en) | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
US8510054B2 (en) * | 2004-02-05 | 2013-08-13 | Ajinomoto Co., Inc. | Intracellular metabolic flux analysis method using substrate labeled with isotope |
WO2006028492A2 (en) | 2004-02-13 | 2006-03-16 | Nuvelo, Inc. | hC1Q/TNF7 AND USES THEREOF |
TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
EP1723252A4 (en) | 2004-03-11 | 2009-07-29 | Univ California | TIMELY AND SPATIAL CHARACTERIZATION OF BIOSYNTHETIC EVENTS IN LIVING ORGANISMS THROUGH ISOTOPEN FINGERPRINTING UNDER CONDITIONS OF IMPROPER ISOTOPE GRADIENTS |
WO2005094327A2 (en) | 2004-03-29 | 2005-10-13 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
WO2005098024A1 (en) | 2004-03-30 | 2005-10-20 | Kinemed, Inc. | In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes |
JP4654592B2 (ja) * | 2004-04-02 | 2011-03-23 | 味の素株式会社 | 代謝フラックスの決定方法 |
EP1824516A4 (en) * | 2004-10-29 | 2008-11-05 | Target Discovery Inc | GLYCAN ANALYSIS WITH DEUTERATED GLUCOSE |
WO2006081521A2 (en) | 2005-01-26 | 2006-08-03 | The Regents Of The University Of Colorado | Methods for diagnosis and intervention of hepatic disorders |
CA2604057C (en) | 2005-04-06 | 2014-02-11 | Randall John Bateman | Methods for measuring the metabolism of neurally derived biomolecules in vivo |
US20060251576A1 (en) | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
-
2003
- 2003-07-25 CA CA2494715A patent/CA2494715C/en not_active Expired - Fee Related
- 2003-07-25 JP JP2004524832A patent/JP4804753B2/ja not_active Expired - Fee Related
- 2003-07-25 AU AU2003256819A patent/AU2003256819B2/en not_active Ceased
- 2003-07-25 EP EP03771855A patent/EP1546364A4/en not_active Withdrawn
- 2003-07-25 US US10/523,250 patent/US20060094057A1/en not_active Abandoned
- 2003-07-25 WO PCT/US2003/023340 patent/WO2004011426A2/en active Application Filing
-
2005
- 2005-01-23 IL IL16644405A patent/IL166444A0/xx unknown
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2009
- 2009-08-03 US US12/534,807 patent/US8129335B2/en not_active Expired - Fee Related
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2012
- 2012-03-01 US US13/410,183 patent/US8481478B2/en not_active Expired - Lifetime
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2013
- 2013-06-19 US US13/922,207 patent/US8969287B2/en not_active Expired - Fee Related
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2015
- 2015-01-26 US US14/605,900 patent/US20150233938A1/en not_active Abandoned
Also Published As
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US8481478B2 (en) | 2013-07-09 |
AU2003256819B2 (en) | 2009-11-12 |
EP1546364A2 (en) | 2005-06-29 |
US20060094057A1 (en) | 2006-05-04 |
US8129335B2 (en) | 2012-03-06 |
JP4804753B2 (ja) | 2011-11-02 |
US20120190560A1 (en) | 2012-07-26 |
AU2003256819A1 (en) | 2004-02-16 |
US8969287B2 (en) | 2015-03-03 |
US20150233938A1 (en) | 2015-08-20 |
CA2494715C (en) | 2014-07-08 |
US20140005074A1 (en) | 2014-01-02 |
WO2004011426A3 (en) | 2004-10-07 |
EP1546364A4 (en) | 2006-09-06 |
US20100172834A1 (en) | 2010-07-08 |
CA2494715A1 (en) | 2004-02-05 |
JP2005534906A (ja) | 2005-11-17 |
WO2004011426A2 (en) | 2004-02-05 |
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