IL164904A0 - Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-Ä(2-methyl-1H-imidazol-1-YL)methylÜ-4H-carbazol-4-one - Google Patents
Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-Ä(2-methyl-1H-imidazol-1-YL)methylÜ-4H-carbazol-4-oneInfo
- Publication number
- IL164904A0 IL164904A0 IL16490404A IL16490404A IL164904A0 IL 164904 A0 IL164904 A0 IL 164904A0 IL 16490404 A IL16490404 A IL 16490404A IL 16490404 A IL16490404 A IL 16490404A IL 164904 A0 IL164904 A0 IL 164904A0
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- preparing
- methylü
- carbazol
- imidazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37632302P | 2002-04-29 | 2002-04-29 | |
PCT/US2003/013221 WO2003093281A1 (en) | 2002-04-29 | 2003-04-29 | Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one |
Publications (1)
Publication Number | Publication Date |
---|---|
IL164904A0 true IL164904A0 (en) | 2005-12-18 |
Family
ID=29401332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16490404A IL164904A0 (en) | 2002-04-29 | 2004-10-28 | Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-Ä(2-methyl-1H-imidazol-1-YL)methylÜ-4H-carbazol-4-one |
Country Status (19)
Country | Link |
---|---|
US (2) | US7098345B2 (zh) |
EP (1) | EP1499623B1 (zh) |
JP (1) | JP2005529142A (zh) |
KR (1) | KR20040104654A (zh) |
CN (1) | CN1665823A (zh) |
AT (1) | ATE364611T1 (zh) |
AU (1) | AU2003223764A1 (zh) |
CA (1) | CA2483566A1 (zh) |
DE (1) | DE60314400T2 (zh) |
DK (1) | DK1499623T3 (zh) |
ES (1) | ES2288606T3 (zh) |
HR (1) | HRP20041070A2 (zh) |
IL (1) | IL164904A0 (zh) |
MX (1) | MXPA04010846A (zh) |
NO (1) | NO20045192L (zh) |
PL (1) | PL373191A1 (zh) |
PT (1) | PT1499623E (zh) |
WO (1) | WO2003093281A1 (zh) |
ZA (1) | ZA200408934B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2204358T1 (es) * | 2000-10-30 | 2004-05-01 | Teva Pharmaceutical Industries Ltd. | Nuevas formas de cristal y de disolvente de hidrocloruro de ondasetron y procedimientos para su preparacion. |
AU2003223763A1 (en) * | 2002-04-30 | 2003-11-17 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them |
US20050131045A1 (en) * | 2002-04-30 | 2005-06-16 | Judith Aronhime | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them |
US7696356B2 (en) * | 2004-08-17 | 2010-04-13 | Taro Pharmaceutical Industries Limited | Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom |
WO2006046253A1 (en) * | 2004-10-26 | 2006-05-04 | Ipca Laboratories Limited | A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE57809B1 (en) | 1984-01-25 | 1993-04-21 | Glaxo Group Ltd | 1,2,3,9-tetrahydro-3-(imidazol-1-ylmethyl)-4h-carbazol-4 one derivatives |
US4695578A (en) * | 1984-01-25 | 1987-09-22 | Glaxo Group Limited | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
EP0201165B1 (en) * | 1985-03-14 | 1994-07-20 | Beecham Group Plc | Medicaments for the treatment of emesis |
GB8518741D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
GB8518745D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
GB8518743D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
GB8518742D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
US4859662A (en) * | 1986-11-28 | 1989-08-22 | Glaxo Group Limited | Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances |
GB8630071D0 (en) * | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
GB8816187D0 (en) * | 1988-07-07 | 1988-08-10 | Glaxo Group Ltd | Medicaments |
GB8914804D0 (en) * | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
US5344658A (en) * | 1989-06-28 | 1994-09-06 | Glaxo Group Limited | Process and composition using ondansetron |
JPH06508836A (ja) * | 1991-06-26 | 1994-10-06 | セプラコア,インコーポレーテッド | 光学的に純粋なr(+)オンダンセトロンを使用する嘔吐、吐き気および他の障害の治療のための方法および組成物 |
CA2106642C (en) * | 1992-10-14 | 2005-08-16 | Peter Bod | Carbazolone derivatives and process for preparing the same |
GB9423511D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
GB9423588D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
CN1045437C (zh) | 1994-12-29 | 1999-10-06 | 中国科学院上海有机化学研究所 | 恩丹西酮及其生理盐的合成 |
ES2204358T1 (es) | 2000-10-30 | 2004-05-01 | Teva Pharmaceutical Industries Ltd. | Nuevas formas de cristal y de disolvente de hidrocloruro de ondasetron y procedimientos para su preparacion. |
EP1207160A1 (en) * | 2000-11-20 | 2002-05-22 | Hanmi Pharm. Co., Ltd. | Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one |
ZA200305338B (en) | 2001-01-11 | 2004-07-12 | Teva Pharma | An improved process for preparing pure ondansetron hydrochloride dihydrate. |
WO2003090730A1 (en) | 2002-04-25 | 2003-11-06 | Generics [Uk] Limited | Novel crystalline forms of celecoxib and other compounds |
AU2003223763A1 (en) * | 2002-04-30 | 2003-11-17 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them |
-
2003
- 2003-04-29 AU AU2003223764A patent/AU2003223764A1/en not_active Abandoned
- 2003-04-29 PT PT03719968T patent/PT1499623E/pt unknown
- 2003-04-29 AT AT03719968T patent/ATE364611T1/de not_active IP Right Cessation
- 2003-04-29 PL PL03373191A patent/PL373191A1/xx not_active Application Discontinuation
- 2003-04-29 CA CA002483566A patent/CA2483566A1/en not_active Abandoned
- 2003-04-29 CN CN038154684A patent/CN1665823A/zh active Pending
- 2003-04-29 DE DE60314400T patent/DE60314400T2/de not_active Expired - Fee Related
- 2003-04-29 ES ES03719968T patent/ES2288606T3/es not_active Expired - Lifetime
- 2003-04-29 DK DK03719968T patent/DK1499623T3/da active
- 2003-04-29 US US10/425,450 patent/US7098345B2/en not_active Expired - Fee Related
- 2003-04-29 MX MXPA04010846A patent/MXPA04010846A/es unknown
- 2003-04-29 EP EP03719968A patent/EP1499623B1/en not_active Expired - Lifetime
- 2003-04-29 JP JP2004501420A patent/JP2005529142A/ja active Pending
- 2003-04-29 KR KR10-2004-7017346A patent/KR20040104654A/ko not_active Application Discontinuation
- 2003-04-29 WO PCT/US2003/013221 patent/WO2003093281A1/en active IP Right Grant
-
2004
- 2004-10-28 IL IL16490404A patent/IL164904A0/xx unknown
- 2004-11-04 ZA ZA200408934A patent/ZA200408934B/xx unknown
- 2004-11-16 HR HR20041070A patent/HRP20041070A2/hr not_active Application Discontinuation
- 2004-11-26 NO NO20045192A patent/NO20045192L/no not_active Application Discontinuation
-
2006
- 2006-07-07 US US11/482,486 patent/US20060252942A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1499623A1 (en) | 2005-01-26 |
US7098345B2 (en) | 2006-08-29 |
US20060252942A1 (en) | 2006-11-09 |
WO2003093281A1 (en) | 2003-11-13 |
PL373191A1 (en) | 2005-08-22 |
ES2288606T3 (es) | 2008-01-16 |
KR20040104654A (ko) | 2004-12-10 |
US20050020655A1 (en) | 2005-01-27 |
CN1665823A (zh) | 2005-09-07 |
DK1499623T3 (da) | 2007-10-08 |
PT1499623E (pt) | 2007-08-10 |
NO20045192L (no) | 2005-01-28 |
EP1499623B1 (en) | 2007-06-13 |
DE60314400T2 (de) | 2008-02-07 |
CA2483566A1 (en) | 2003-11-13 |
HRP20041070A2 (en) | 2005-02-28 |
ATE364611T1 (de) | 2007-07-15 |
MXPA04010846A (es) | 2005-01-25 |
ZA200408934B (en) | 2006-07-26 |
JP2005529142A (ja) | 2005-09-29 |
DE60314400D1 (de) | 2007-07-26 |
AU2003223764A1 (en) | 2003-11-17 |
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