ZA200408934B - Process for preparing 1,2,3,9-tetrahydro-9-3-Ä(2-methyl-1H-imidazol-1-yl)methylÜ-4H-Carbazol-4-one - Google Patents
Process for preparing 1,2,3,9-tetrahydro-9-3-Ä(2-methyl-1H-imidazol-1-yl)methylÜ-4H-Carbazol-4-oneInfo
- Publication number
- ZA200408934B ZA200408934B ZA200408934A ZA200408934A ZA200408934B ZA 200408934 B ZA200408934 B ZA 200408934B ZA 200408934 A ZA200408934 A ZA 200408934A ZA 200408934 A ZA200408934 A ZA 200408934A ZA 200408934 B ZA200408934 B ZA 200408934B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparing
- methylü
- carbazol
- imidazol
- tetrahydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37632302P | 2002-04-29 | 2002-04-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200408934B true ZA200408934B (en) | 2006-07-26 |
Family
ID=29401332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200408934A ZA200408934B (en) | 2002-04-29 | 2004-11-04 | Process for preparing 1,2,3,9-tetrahydro-9-3-Ä(2-methyl-1H-imidazol-1-yl)methylÜ-4H-Carbazol-4-one |
Country Status (19)
Country | Link |
---|---|
US (2) | US7098345B2 (xx) |
EP (1) | EP1499623B1 (xx) |
JP (1) | JP2005529142A (xx) |
KR (1) | KR20040104654A (xx) |
CN (1) | CN1665823A (xx) |
AT (1) | ATE364611T1 (xx) |
AU (1) | AU2003223764A1 (xx) |
CA (1) | CA2483566A1 (xx) |
DE (1) | DE60314400T2 (xx) |
DK (1) | DK1499623T3 (xx) |
ES (1) | ES2288606T3 (xx) |
HR (1) | HRP20041070A2 (xx) |
IL (1) | IL164904A0 (xx) |
MX (1) | MXPA04010846A (xx) |
NO (1) | NO20045192L (xx) |
PL (1) | PL373191A1 (xx) |
PT (1) | PT1499623E (xx) |
WO (1) | WO2003093281A1 (xx) |
ZA (1) | ZA200408934B (xx) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20030042038A (ko) * | 2000-10-30 | 2003-05-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 온단세트론 히드로클로라이드의 신규한 결정 형태 및용매화물 형태와 이들의 제조 방법 |
JP2005529908A (ja) * | 2002-04-30 | 2005-10-06 | テバ ジョジセルジャール レースベニュタールシャシャーグ | オンダンセトロンの新規結晶形、その製法、当該新規形を含有する医薬組成物、及び当該組成物を用いる吐気の治療方法 |
US20050131045A1 (en) * | 2002-04-30 | 2005-06-16 | Judith Aronhime | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them |
US7696356B2 (en) * | 2004-08-17 | 2010-04-13 | Taro Pharmaceutical Industries Limited | Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom |
US7547791B2 (en) * | 2004-10-26 | 2009-06-16 | Ipca Laboratories Ltd. | One-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1H-imidazole-1-yl)methyl]-4H-carbazol-4-O |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT79890B (en) | 1984-01-25 | 1987-02-03 | Glaxo Group Ltd | Process for preparing tetrahydro-methylimidazolylcarbazolones |
US4695578A (en) * | 1984-01-25 | 1987-09-22 | Glaxo Group Limited | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
DE3688296T2 (de) * | 1985-03-14 | 1993-11-04 | Beecham Group Plc | Arzneimittel zur behandlung von erbrechen. |
GB8518742D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
GB8518741D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
GB8518743D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
GB8518745D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
US4859662A (en) * | 1986-11-28 | 1989-08-22 | Glaxo Group Limited | Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances |
GB8630071D0 (en) | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
GB8816187D0 (en) * | 1988-07-07 | 1988-08-10 | Glaxo Group Ltd | Medicaments |
GB8914804D0 (en) | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
US5344658A (en) * | 1989-06-28 | 1994-09-06 | Glaxo Group Limited | Process and composition using ondansetron |
EP1022025A3 (en) * | 1991-06-26 | 2002-06-05 | Sepracor, Inc. | Method and compositions for treating emesis nausea and other disorders using optically pure R(+) ondansetron |
CA2106642C (en) * | 1992-10-14 | 2005-08-16 | Peter Bod | Carbazolone derivatives and process for preparing the same |
GB9423588D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
GB9423511D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
CN1045437C (zh) | 1994-12-29 | 1999-10-06 | 中国科学院上海有机化学研究所 | 恩丹西酮及其生理盐的合成 |
KR20030042038A (ko) | 2000-10-30 | 2003-05-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 온단세트론 히드로클로라이드의 신규한 결정 형태 및용매화물 형태와 이들의 제조 방법 |
EP1207160A1 (en) * | 2000-11-20 | 2002-05-22 | Hanmi Pharm. Co., Ltd. | Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one |
KR20030068583A (ko) | 2001-01-11 | 2003-08-21 | 테바 파마슈티컬 인더스트리즈 리미티드 | 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법 |
AU2002251329A1 (en) | 2002-04-25 | 2003-11-10 | Generics (Uk) Limited | Novel crystalline forms of celecoxib and other compounds |
JP2005529908A (ja) * | 2002-04-30 | 2005-10-06 | テバ ジョジセルジャール レースベニュタールシャシャーグ | オンダンセトロンの新規結晶形、その製法、当該新規形を含有する医薬組成物、及び当該組成物を用いる吐気の治療方法 |
-
2003
- 2003-04-29 JP JP2004501420A patent/JP2005529142A/ja active Pending
- 2003-04-29 MX MXPA04010846A patent/MXPA04010846A/es unknown
- 2003-04-29 DE DE60314400T patent/DE60314400T2/de not_active Expired - Fee Related
- 2003-04-29 PT PT03719968T patent/PT1499623E/pt unknown
- 2003-04-29 AT AT03719968T patent/ATE364611T1/de not_active IP Right Cessation
- 2003-04-29 PL PL03373191A patent/PL373191A1/xx not_active Application Discontinuation
- 2003-04-29 KR KR10-2004-7017346A patent/KR20040104654A/ko not_active Application Discontinuation
- 2003-04-29 ES ES03719968T patent/ES2288606T3/es not_active Expired - Lifetime
- 2003-04-29 CN CN038154684A patent/CN1665823A/zh active Pending
- 2003-04-29 EP EP03719968A patent/EP1499623B1/en not_active Expired - Lifetime
- 2003-04-29 WO PCT/US2003/013221 patent/WO2003093281A1/en active IP Right Grant
- 2003-04-29 CA CA002483566A patent/CA2483566A1/en not_active Abandoned
- 2003-04-29 AU AU2003223764A patent/AU2003223764A1/en not_active Abandoned
- 2003-04-29 US US10/425,450 patent/US7098345B2/en not_active Expired - Fee Related
- 2003-04-29 DK DK03719968T patent/DK1499623T3/da active
-
2004
- 2004-10-28 IL IL16490404A patent/IL164904A0/xx unknown
- 2004-11-04 ZA ZA200408934A patent/ZA200408934B/xx unknown
- 2004-11-16 HR HR20041070A patent/HRP20041070A2/hr not_active Application Discontinuation
- 2004-11-26 NO NO20045192A patent/NO20045192L/no not_active Application Discontinuation
-
2006
- 2006-07-07 US US11/482,486 patent/US20060252942A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PL373191A1 (en) | 2005-08-22 |
NO20045192L (no) | 2005-01-28 |
PT1499623E (pt) | 2007-08-10 |
DE60314400D1 (de) | 2007-07-26 |
DE60314400T2 (de) | 2008-02-07 |
US20050020655A1 (en) | 2005-01-27 |
AU2003223764A1 (en) | 2003-11-17 |
HRP20041070A2 (en) | 2005-02-28 |
WO2003093281A1 (en) | 2003-11-13 |
IL164904A0 (en) | 2005-12-18 |
EP1499623B1 (en) | 2007-06-13 |
ATE364611T1 (de) | 2007-07-15 |
US20060252942A1 (en) | 2006-11-09 |
EP1499623A1 (en) | 2005-01-26 |
CA2483566A1 (en) | 2003-11-13 |
CN1665823A (zh) | 2005-09-07 |
ES2288606T3 (es) | 2008-01-16 |
US7098345B2 (en) | 2006-08-29 |
DK1499623T3 (da) | 2007-10-08 |
MXPA04010846A (es) | 2005-01-25 |
KR20040104654A (ko) | 2004-12-10 |
JP2005529142A (ja) | 2005-09-29 |
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