DK1499623T3 - Fremgangsmåde til fremstilling af 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-on - Google Patents

Fremgangsmåde til fremstilling af 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-on

Info

Publication number
DK1499623T3
DK1499623T3 DK03719968T DK03719968T DK1499623T3 DK 1499623 T3 DK1499623 T3 DK 1499623T3 DK 03719968 T DK03719968 T DK 03719968T DK 03719968 T DK03719968 T DK 03719968T DK 1499623 T3 DK1499623 T3 DK 1499623T3
Authority
DK
Denmark
Prior art keywords
methyl
carbazol
imidazol
tetrahydro
preparation
Prior art date
Application number
DK03719968T
Other languages
English (en)
Inventor
Sandor Molnar
Csaba Szabo
Sos Erzsebet Meszaros
Szabolcs Salyi
Tivadar Tamas
Original Assignee
Teva Gyogyszerg Ar Zartkoeruee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszerg Ar Zartkoeruee filed Critical Teva Gyogyszerg Ar Zartkoeruee
Application granted granted Critical
Publication of DK1499623T3 publication Critical patent/DK1499623T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DK03719968T 2002-04-29 2003-04-29 Fremgangsmåde til fremstilling af 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-on DK1499623T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37632302P 2002-04-29 2002-04-29
PCT/US2003/013221 WO2003093281A1 (en) 2002-04-29 2003-04-29 Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one

Publications (1)

Publication Number Publication Date
DK1499623T3 true DK1499623T3 (da) 2007-10-08

Family

ID=29401332

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03719968T DK1499623T3 (da) 2002-04-29 2003-04-29 Fremgangsmåde til fremstilling af 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-on

Country Status (19)

Country Link
US (2) US7098345B2 (da)
EP (1) EP1499623B1 (da)
JP (1) JP2005529142A (da)
KR (1) KR20040104654A (da)
CN (1) CN1665823A (da)
AT (1) ATE364611T1 (da)
AU (1) AU2003223764A1 (da)
CA (1) CA2483566A1 (da)
DE (1) DE60314400T2 (da)
DK (1) DK1499623T3 (da)
ES (1) ES2288606T3 (da)
HR (1) HRP20041070A2 (da)
IL (1) IL164904A0 (da)
MX (1) MXPA04010846A (da)
NO (1) NO20045192L (da)
PL (1) PL373191A1 (da)
PT (1) PT1499623E (da)
WO (1) WO2003093281A1 (da)
ZA (1) ZA200408934B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030042038A (ko) * 2000-10-30 2003-05-27 테바 파마슈티컬 인더스트리즈 리미티드 온단세트론 히드로클로라이드의 신규한 결정 형태 및용매화물 형태와 이들의 제조 방법
JP2005529908A (ja) * 2002-04-30 2005-10-06 テバ ジョジセルジャール レースベニュタールシャシャーグ オンダンセトロンの新規結晶形、その製法、当該新規形を含有する医薬組成物、及び当該組成物を用いる吐気の治療方法
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
US7696356B2 (en) * 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
US7547791B2 (en) * 2004-10-26 2009-06-16 Ipca Laboratories Ltd. One-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1H-imidazole-1-yl)methyl]-4H-carbazol-4-O

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT79890B (en) 1984-01-25 1987-02-03 Glaxo Group Ltd Process for preparing tetrahydro-methylimidazolylcarbazolones
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
DE3688296T2 (de) * 1985-03-14 1993-11-04 Beecham Group Plc Arzneimittel zur behandlung von erbrechen.
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518745D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
US4859662A (en) * 1986-11-28 1989-08-22 Glaxo Group Limited Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
GB8630071D0 (en) 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
GB8816187D0 (en) * 1988-07-07 1988-08-10 Glaxo Group Ltd Medicaments
GB8914804D0 (en) 1989-06-28 1989-08-16 Glaxo Group Ltd Process
US5344658A (en) * 1989-06-28 1994-09-06 Glaxo Group Limited Process and composition using ondansetron
EP1022025A3 (en) * 1991-06-26 2002-06-05 Sepracor, Inc. Method and compositions for treating emesis nausea and other disorders using optically pure R(+) ondansetron
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
GB9423511D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
CN1045437C (zh) 1994-12-29 1999-10-06 中国科学院上海有机化学研究所 恩丹西酮及其生理盐的合成
KR20030042038A (ko) 2000-10-30 2003-05-27 테바 파마슈티컬 인더스트리즈 리미티드 온단세트론 히드로클로라이드의 신규한 결정 형태 및용매화물 형태와 이들의 제조 방법
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
KR20030068583A (ko) 2001-01-11 2003-08-21 테바 파마슈티컬 인더스트리즈 리미티드 순수한 온단세트론 하이드로클로라이드 이수화물의 개선된제조 방법
AU2002251329A1 (en) 2002-04-25 2003-11-10 Generics (Uk) Limited Novel crystalline forms of celecoxib and other compounds
JP2005529908A (ja) * 2002-04-30 2005-10-06 テバ ジョジセルジャール レースベニュタールシャシャーグ オンダンセトロンの新規結晶形、その製法、当該新規形を含有する医薬組成物、及び当該組成物を用いる吐気の治療方法

Also Published As

Publication number Publication date
PL373191A1 (en) 2005-08-22
NO20045192L (no) 2005-01-28
PT1499623E (pt) 2007-08-10
DE60314400D1 (de) 2007-07-26
DE60314400T2 (de) 2008-02-07
US20050020655A1 (en) 2005-01-27
AU2003223764A1 (en) 2003-11-17
HRP20041070A2 (en) 2005-02-28
WO2003093281A1 (en) 2003-11-13
IL164904A0 (en) 2005-12-18
EP1499623B1 (en) 2007-06-13
ATE364611T1 (de) 2007-07-15
US20060252942A1 (en) 2006-11-09
EP1499623A1 (en) 2005-01-26
CA2483566A1 (en) 2003-11-13
CN1665823A (zh) 2005-09-07
ES2288606T3 (es) 2008-01-16
US7098345B2 (en) 2006-08-29
ZA200408934B (en) 2006-07-26
MXPA04010846A (es) 2005-01-25
KR20040104654A (ko) 2004-12-10
JP2005529142A (ja) 2005-09-29

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