ZA200408934B - Process for preparing 1,2,3,9-tetrahydro-9-3-Ä(2-methyl-1H-imidazol-1-yl)methylÜ-4H-Carbazol-4-one - Google Patents

Process for preparing 1,2,3,9-tetrahydro-9-3-Ä(2-methyl-1H-imidazol-1-yl)methylÜ-4H-Carbazol-4-one

Info

Publication number
ZA200408934B
ZA200408934B ZA200408934A ZA200408934A ZA200408934B ZA 200408934 B ZA200408934 B ZA 200408934B ZA 200408934 A ZA200408934 A ZA 200408934A ZA 200408934 A ZA200408934 A ZA 200408934A ZA 200408934 B ZA200408934 B ZA 200408934B
Authority
ZA
South Africa
Prior art keywords
preparing
methylü
carbazol
imidazol
tetrahydro
Prior art date
Application number
ZA200408934A
Other languages
English (en)
Inventor
Sandor Molnar
Csaba Szabo
Sos E Mazaros
Szabolcs Salyi
Tivadar Tamas
Original Assignee
Teva Cryogyszergyar Reszvenyta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Cryogyszergyar Reszvenyta filed Critical Teva Cryogyszergyar Reszvenyta
Publication of ZA200408934B publication Critical patent/ZA200408934B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ZA200408934A 2002-04-29 2004-11-04 Process for preparing 1,2,3,9-tetrahydro-9-3-Ä(2-methyl-1H-imidazol-1-yl)methylÜ-4H-Carbazol-4-one ZA200408934B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37632302P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
ZA200408934B true ZA200408934B (en) 2006-07-26

Family

ID=29401332

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200408934A ZA200408934B (en) 2002-04-29 2004-11-04 Process for preparing 1,2,3,9-tetrahydro-9-3-Ä(2-methyl-1H-imidazol-1-yl)methylÜ-4H-Carbazol-4-one

Country Status (19)

Country Link
US (2) US7098345B2 (zh)
EP (1) EP1499623B1 (zh)
JP (1) JP2005529142A (zh)
KR (1) KR20040104654A (zh)
CN (1) CN1665823A (zh)
AT (1) ATE364611T1 (zh)
AU (1) AU2003223764A1 (zh)
CA (1) CA2483566A1 (zh)
DE (1) DE60314400T2 (zh)
DK (1) DK1499623T3 (zh)
ES (1) ES2288606T3 (zh)
HR (1) HRP20041070A2 (zh)
IL (1) IL164904A0 (zh)
MX (1) MXPA04010846A (zh)
NO (1) NO20045192L (zh)
PL (1) PL373191A1 (zh)
PT (1) PT1499623E (zh)
WO (1) WO2003093281A1 (zh)
ZA (1) ZA200408934B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002230935A1 (en) * 2000-10-30 2002-05-15 Teva Pharmaceutical Industries Ltd. Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
EP1465887A1 (en) * 2002-04-30 2004-10-13 Teva Gyogyszergyar Reszvenytarsasag Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them
US7696356B2 (en) * 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
EP1828141A4 (en) * 2004-10-26 2009-04-01 Ipca Lab Ltd STAINING METHOD FOR PREPARING THE ANTIEMETIC 1,2,3,9-TETRAHYDRO-9-METHYL-3 - [(2-METHYL) -1H-IMIDAZOLE-1-YL) METHYL] -4H-CARBAZOLE-4-ON

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3502508A1 (de) 1984-01-25 1985-08-14 Glaxo Group Ltd., London Heterocyclische verbindungen
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
DE3689974T2 (de) 1985-03-14 1994-11-03 Beecham Group Plc Arzneimittel zur Behandlung von Emesis.
GB8518741D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518742D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
US4859662A (en) 1986-11-28 1989-08-22 Glaxo Group Limited Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
GB8630071D0 (en) 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
GB8816187D0 (en) * 1988-07-07 1988-08-10 Glaxo Group Ltd Medicaments
US5344658A (en) 1989-06-28 1994-09-06 Glaxo Group Limited Process and composition using ondansetron
GB8914804D0 (en) 1989-06-28 1989-08-16 Glaxo Group Ltd Process
WO1993000074A1 (en) 1991-06-26 1993-01-07 Sepracor, Inc. Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
CA2106642C (en) 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
GB9423588D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
GB9423511D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
CN1045437C (zh) 1994-12-29 1999-10-06 中国科学院上海有机化学研究所 恩丹西酮及其生理盐的合成
AU2002230935A1 (en) 2000-10-30 2002-05-15 Teva Pharmaceutical Industries Ltd. Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation
EP1207160A1 (en) 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
MXPA03006215A (es) 2001-01-11 2005-02-17 Teva Pharma Un proceso mejorado para preparar clorhidrato de ondansetron dihidratado puro.
WO2003090730A1 (en) 2002-04-25 2003-11-06 Generics [Uk] Limited Novel crystalline forms of celecoxib and other compounds
EP1465887A1 (en) 2002-04-30 2004-10-13 Teva Gyogyszergyar Reszvenytarsasag Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them

Also Published As

Publication number Publication date
DE60314400D1 (de) 2007-07-26
EP1499623A1 (en) 2005-01-26
ATE364611T1 (de) 2007-07-15
IL164904A0 (en) 2005-12-18
CN1665823A (zh) 2005-09-07
PT1499623E (pt) 2007-08-10
PL373191A1 (en) 2005-08-22
WO2003093281A1 (en) 2003-11-13
US20060252942A1 (en) 2006-11-09
JP2005529142A (ja) 2005-09-29
DK1499623T3 (da) 2007-10-08
HRP20041070A2 (en) 2005-02-28
CA2483566A1 (en) 2003-11-13
AU2003223764A1 (en) 2003-11-17
EP1499623B1 (en) 2007-06-13
US20050020655A1 (en) 2005-01-27
US7098345B2 (en) 2006-08-29
KR20040104654A (ko) 2004-12-10
DE60314400T2 (de) 2008-02-07
NO20045192L (no) 2005-01-28
MXPA04010846A (es) 2005-01-25
ES2288606T3 (es) 2008-01-16

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