IL164048A0 - Primitive and proximal hepatic stemcells - Google Patents

Primitive and proximal hepatic stemcells

Info

Publication number
IL164048A0
IL164048A0 IL16404803A IL16404803A IL164048A0 IL 164048 A0 IL164048 A0 IL 164048A0 IL 16404803 A IL16404803 A IL 16404803A IL 16404803 A IL16404803 A IL 16404803A IL 164048 A0 IL164048 A0 IL 164048A0
Authority
IL
Israel
Prior art keywords
stemcells
primitive
proximal hepatic
hepatic
proximal
Prior art date
Application number
IL16404803A
Other languages
English (en)
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of IL164048A0 publication Critical patent/IL164048A0/xx

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL16404803A 2002-03-15 2003-03-14 Primitive and proximal hepatic stemcells IL164048A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36536102P 2002-03-15 2002-03-15
PCT/US2003/007852 WO2003078588A2 (en) 2002-03-15 2003-03-14 Primitive and proximal hepatic stem cells

Publications (1)

Publication Number Publication Date
IL164048A0 true IL164048A0 (en) 2005-12-18

Family

ID=28042021

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16404803A IL164048A0 (en) 2002-03-15 2003-03-14 Primitive and proximal hepatic stemcells

Country Status (18)

Country Link
US (4) US7413897B2 (zh)
EP (2) EP3023491A1 (zh)
JP (2) JP4723811B2 (zh)
KR (1) KR101119878B1 (zh)
CN (3) CN1742082B (zh)
AU (2) AU2003233399B2 (zh)
CA (1) CA2479510C (zh)
CY (1) CY1118167T1 (zh)
DK (1) DK1490480T3 (zh)
ES (1) ES2569951T3 (zh)
HK (1) HK1209783A1 (zh)
HU (1) HUE032238T2 (zh)
IL (1) IL164048A0 (zh)
MX (1) MXPA04009031A (zh)
PL (1) PL372619A1 (zh)
RU (1) RU2327479C2 (zh)
SI (1) SI1490480T1 (zh)
WO (1) WO2003078588A2 (zh)

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ATE506431T1 (de) * 2004-04-23 2011-05-15 Bioe Llc Mehrfachlinien-vorläuferzellen
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
WO2006126219A1 (en) * 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
RU2008124158A (ru) 2005-11-16 2010-01-10 Юниверсити Оф Норт Каролина Эт Чепел Хилл (Us) Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников
TW200800241A (en) 2005-12-22 2008-01-01 Vesta Therapeutics Inc Method of using hepatic progenitors in treating liver dysfunction
EP2019858B1 (en) * 2006-04-17 2012-06-13 BioE LLC Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
CA2650594A1 (en) * 2006-04-25 2007-11-08 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Adipose derived adult stem cells in hepatic regeneration
CA2872716C (en) * 2006-05-26 2017-12-05 University Of North Carolina At Chapel Hill Hepatic stellate cell precursors and methods of isolating same
EP2171040A4 (en) * 2007-06-15 2010-08-04 Univ North Carolina PARACRINE SIGNALS FROM MESENCHYMAL NOURISHING CELLS AND REGULATION OF THE EXPANSION AND DIFFERENTIATION OF STEM CELLS USING THESE SIGNALS
CN101835479A (zh) * 2007-07-25 2010-09-15 佰欧益有限公司 多系祖细胞分化为软骨细胞
US20100087000A1 (en) * 2008-05-02 2010-04-08 Vesta Therapeutics, Inc. Hepatic progenitor cell and method of isolating same
EP2295537A4 (en) * 2008-05-14 2011-11-30 Public Univ Corp Yokohama City HUMAN HEPATIC STRAIN CELL, PREPARATION METHOD THEREFOR, METHOD OF INDUCING ITS DIFFERENTIATION AND METHOD OF USE
WO2009143241A2 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of multi-lineage progenitor cells to pancreatic cells
ES2862623T3 (es) * 2008-05-22 2021-10-07 Vesta Therapeutics Inc Método de diferenciación de células progenitoras de mamíferos en células pancreáticas de los islotes productoras de insulina
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
CA3169831A1 (en) * 2009-10-30 2011-05-05 Lola M. Reid Multipotent stem cells from the extrahepatic biliary tree and methods of isolating same
US9341550B2 (en) * 2010-11-19 2016-05-17 On-Chip Biotechnologies Co., Ltd. Method for detecting low concentrations of specific cell from high concentrations of cell populations, and method for collecting and analyzing detected cell
EP2714894B1 (en) * 2011-05-27 2019-10-30 DePuy Synthes Products, Inc. Bioartificial proximal tubule systems and methods of use
PT2788009T (pt) 2011-12-08 2016-08-31 Yeda Res & Dev Células pulmonares fetais de mamíferos e uso terapêutico das mesmas
WO2013192342A1 (en) * 2012-06-20 2013-12-27 Celula, Inc. Materials and methods for processing cell populations
JP6510162B2 (ja) * 2013-01-21 2019-05-08 テルモ株式会社 シート状細胞培養物の製造方法
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
ES2767062T3 (es) * 2013-09-19 2020-06-16 Univ Leland Stanford Junior Métodos y composiciones para producir células similares a hepatocitos
JP6643993B2 (ja) 2013-12-16 2020-02-12 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 膵島様細胞構造体及びそれを調製する方法
JP6595157B2 (ja) * 2014-03-04 2019-10-23 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
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EP4026563A1 (en) 2015-06-18 2022-07-13 Yeda Research and Development Co. Ltd Conditioning protocols and use of same for tissue regeneration
CN105483077A (zh) * 2015-12-24 2016-04-13 福州市传染病医院 一种提高肝细胞增殖活性的细胞培养方法
JP2019134682A (ja) * 2016-06-01 2019-08-15 国立研究開発法人医薬基盤・健康・栄養研究所 肝幹細胞様細胞の調製方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
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CN1742082B (zh) * 2002-03-15 2015-01-21 北卡罗来纳大学查伯山分校 原肝干细胞和近肝干细胞

Also Published As

Publication number Publication date
DK1490480T3 (en) 2016-04-11
US20040018621A1 (en) 2004-01-29
JP5463271B2 (ja) 2014-04-09
US20070099297A1 (en) 2007-05-03
CY1118167T1 (el) 2017-06-28
AU2003233399A1 (en) 2003-09-29
CN1742082A (zh) 2006-03-01
CA2479510A1 (en) 2003-09-25
KR20060010693A (ko) 2006-02-02
CA2479510C (en) 2019-10-29
AU2008202656B2 (en) 2011-03-17
WO2003078588A2 (en) 2003-09-25
CN104630129A (zh) 2015-05-20
US20140302601A1 (en) 2014-10-09
EP1490480A4 (en) 2006-06-14
HUE032238T2 (en) 2017-09-28
EP3023491A1 (en) 2016-05-25
AU2003233399B2 (en) 2008-03-20
HK1209783A1 (zh) 2016-04-08
JP2005520513A (ja) 2005-07-14
PL372619A1 (en) 2005-07-25
AU2008202656B8 (en) 2011-12-15
MXPA04009031A (es) 2005-12-12
JP2011087591A (ja) 2011-05-06
RU2327479C2 (ru) 2008-06-27
WO2003078588A9 (en) 2003-12-11
AU2008202656A1 (en) 2008-07-10
US20170096641A1 (en) 2017-04-06
EP1490480B1 (en) 2016-02-03
WO2003078588A3 (en) 2004-04-01
CN1742082B (zh) 2015-01-21
AU2008202656A8 (en) 2011-12-15
SI1490480T1 (sl) 2016-06-30
ES2569951T3 (es) 2016-05-13
KR101119878B1 (ko) 2012-03-09
US7413897B2 (en) 2008-08-19
US8691523B2 (en) 2014-04-08
RU2005125598A (ru) 2006-01-27
JP4723811B2 (ja) 2011-07-13
EP1490480A2 (en) 2004-12-29

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