IL162058A0 - Hexacyclic compounds - Google Patents

Hexacyclic compounds

Info

Publication number
IL162058A0
IL162058A0 IL16205802A IL16205802A IL162058A0 IL 162058 A0 IL162058 A0 IL 162058A0 IL 16205802 A IL16205802 A IL 16205802A IL 16205802 A IL16205802 A IL 16205802A IL 162058 A0 IL162058 A0 IL 162058A0
Authority
IL
Israel
Prior art keywords
sup
compounds
hexacyclic compounds
hexacyclic
identified
Prior art date
Application number
IL16205802A
Other languages
English (en)
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of IL162058A0 publication Critical patent/IL162058A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL16205802A 2001-11-30 2002-11-25 Hexacyclic compounds IL162058A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01128361 2001-11-30
PCT/EP2002/013216 WO2003045952A2 (en) 2001-11-30 2002-11-25 Condensed camptothecins as antitumor agents

Publications (1)

Publication Number Publication Date
IL162058A0 true IL162058A0 (en) 2005-11-20

Family

ID=8179394

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16205802A IL162058A0 (en) 2001-11-30 2002-11-25 Hexacyclic compounds

Country Status (29)

Country Link
US (2) US6825194B2 (pl)
EP (1) EP1480984B9 (pl)
JP (1) JP4305909B2 (pl)
KR (1) KR100895746B1 (pl)
CN (1) CN100338066C (pl)
AT (1) ATE398131T1 (pl)
AU (1) AU2002356720B2 (pl)
BR (1) BR0214615A (pl)
CA (1) CA2468824C (pl)
DE (1) DE60227113D1 (pl)
ES (1) ES2307830T3 (pl)
GT (1) GT200200250A (pl)
HK (2) HK1072935A1 (pl)
HU (1) HUP0500062A3 (pl)
IL (1) IL162058A0 (pl)
MX (1) MXPA04005185A (pl)
MY (1) MY136138A (pl)
NO (1) NO329005B1 (pl)
NZ (1) NZ533568A (pl)
PA (1) PA8558901A1 (pl)
PE (1) PE20030725A1 (pl)
PL (1) PL207510B1 (pl)
RS (1) RS51051B (pl)
RU (1) RU2299212C2 (pl)
TW (1) TWI258481B (pl)
UA (1) UA80409C2 (pl)
UY (1) UY27560A1 (pl)
WO (1) WO2003045952A2 (pl)
ZA (1) ZA200404522B (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1777611A (zh) * 2003-02-21 2006-05-24 中外制药株式会社 制备六环喜树碱衍生物的方法
CA2563502A1 (en) 2004-04-09 2005-10-20 Chugai Seiyaku Kabushiki Kaisha Novel water-soluble prodrug
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
CN101340913A (zh) * 2005-10-19 2009-01-07 中外制药株式会社 包含新颖的水溶性前药的胰腺癌、卵巢癌或肝癌的预防或治疗剂
KR102498681B1 (ko) 2019-03-29 2023-02-09 메디뮨 리미티드 화합물 및 이의 접합체

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
JP3359955B2 (ja) * 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
CA2280905C (en) 1997-02-14 2006-08-29 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
GB9715821D0 (en) * 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives

Also Published As

Publication number Publication date
MY136138A (en) 2008-08-29
GT200200250A (es) 2004-01-15
PE20030725A1 (es) 2003-08-28
RS47004A (en) 2007-02-05
BR0214615A (pt) 2004-09-14
WO2003045952A3 (en) 2003-10-16
UA80409C2 (en) 2007-09-25
EP1480984B1 (en) 2008-06-11
NO20042729L (no) 2004-08-27
RS51051B (sr) 2010-10-31
TWI258481B (en) 2006-07-21
PL207510B1 (pl) 2010-12-31
ATE398131T1 (de) 2008-07-15
RU2004119841A (ru) 2005-03-27
CA2468824A1 (en) 2003-06-05
AU2002356720B2 (en) 2009-01-29
US20050059679A1 (en) 2005-03-17
PL370479A1 (pl) 2005-05-30
WO2003045952A2 (en) 2003-06-05
PA8558901A1 (es) 2003-06-30
US6825194B2 (en) 2004-11-30
AU2002356720A1 (en) 2003-06-10
HUP0500062A2 (hu) 2005-04-28
DE60227113D1 (de) 2008-07-24
HK1077303A1 (en) 2006-02-10
KR20040062976A (ko) 2004-07-09
TW200408642A (en) 2004-06-01
UY27560A1 (es) 2003-05-30
CA2468824C (en) 2011-01-11
EP1480984A2 (en) 2004-12-01
JP2005511643A (ja) 2005-04-28
CN1617874A (zh) 2005-05-18
NO329005B1 (no) 2010-07-19
HUP0500062A3 (en) 2012-12-28
KR100895746B1 (ko) 2009-04-30
EP1480984B9 (en) 2009-03-11
NZ533568A (en) 2006-01-27
JP4305909B2 (ja) 2009-07-29
US7109195B2 (en) 2006-09-19
US20030144304A1 (en) 2003-07-31
CN100338066C (zh) 2007-09-19
ZA200404522B (en) 2005-01-04
ES2307830T3 (es) 2008-12-01
MXPA04005185A (es) 2004-08-11
RU2299212C2 (ru) 2007-05-20
HK1072935A1 (en) 2005-09-16

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees