IL160289A0 - Modified transferrin fusion proteins - Google Patents
Modified transferrin fusion proteinsInfo
- Publication number
- IL160289A0 IL160289A0 IL16028902A IL16028902A IL160289A0 IL 160289 A0 IL160289 A0 IL 160289A0 IL 16028902 A IL16028902 A IL 16028902A IL 16028902 A IL16028902 A IL 16028902A IL 160289 A0 IL160289 A0 IL 160289A0
- Authority
- IL
- Israel
- Prior art keywords
- fusion proteins
- transferrin fusion
- modified transferrin
- transferrin
- modified
- Prior art date
Links
- 102000004338 Transferrin Human genes 0.000 title abstract 3
- 108090000901 Transferrin Proteins 0.000 title abstract 3
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 239000012581 transferrin Substances 0.000 title abstract 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 102000007238 Transferrin Receptors Human genes 0.000 abstract 1
- 108010033576 Transferrin Receptors Proteins 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31574501P | 2001-08-30 | 2001-08-30 | |
US33405901P | 2001-11-30 | 2001-11-30 | |
PCT/US2002/027637 WO2003020746A1 (fr) | 2001-08-30 | 2002-08-30 | Proteines de fusion de transferine modifiees |
Publications (1)
Publication Number | Publication Date |
---|---|
IL160289A0 true IL160289A0 (en) | 2004-07-25 |
Family
ID=26980047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16028902A IL160289A0 (en) | 2001-08-30 | 2002-08-30 | Modified transferrin fusion proteins |
Country Status (17)
Country | Link |
---|---|
US (1) | US20040023334A1 (fr) |
EP (1) | EP1427750B1 (fr) |
JP (2) | JP2005508623A (fr) |
KR (1) | KR20040059490A (fr) |
CN (1) | CN1628126A (fr) |
AT (1) | ATE490969T1 (fr) |
AU (1) | AU2002323501C1 (fr) |
BR (1) | BR0212256A (fr) |
CA (1) | CA2457520A1 (fr) |
DE (1) | DE60238541D1 (fr) |
DK (1) | DK1427750T3 (fr) |
IL (1) | IL160289A0 (fr) |
MX (1) | MXPA04001804A (fr) |
NZ (1) | NZ531207A (fr) |
RU (1) | RU2004109222A (fr) |
WO (1) | WO2003020746A1 (fr) |
ZA (1) | ZA200401079B (fr) |
Families Citing this family (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE490969T1 (de) * | 2001-08-30 | 2010-12-15 | Biorexis Pharmaceutical Corp | Modifizierte transferrin-fusionsproteine |
US7176278B2 (en) * | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
US8129504B2 (en) | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
ES2347144T3 (es) * | 2002-08-30 | 2010-10-26 | Biorexis Pharmaceutical Corporation | Proteinas de fusion de la transferrina modificada que comprenden dominos aino o carboxilo de transferrina duplicados. |
US20060105387A1 (en) * | 2002-08-30 | 2006-05-18 | Prior Christopher P | Transferrin fusion proteins libraries |
WO2004020588A2 (fr) * | 2002-08-30 | 2004-03-11 | Biorexis Pharmaceutical Corporation | Banques de proteines de fusion de la transferine |
AU2003296447A1 (en) | 2002-12-10 | 2004-06-30 | Agennix Incorporated | Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US20070060512A1 (en) * | 2003-03-04 | 2007-03-15 | Homayoun Sadeghi | Dipeptidyl-peptidase protected protein |
US7379700B2 (en) * | 2003-05-06 | 2008-05-27 | Canon Kabushiki Kaisha | Image reading apparatus with rotatable internal and external guides |
US8105615B2 (en) * | 2003-06-06 | 2012-01-31 | Agennix Incorporated | Lactoferrin as an adjuvant in cancer vaccines |
WO2005021579A2 (fr) * | 2003-08-28 | 2005-03-10 | Biorexis Pharmaceutical Corporation | Peptides mimetiques epo et proteines de fusion |
US20060205037A1 (en) * | 2003-08-28 | 2006-09-14 | Homayoun Sadeghi | Modified transferrin fusion proteins |
ES2380022T3 (es) * | 2003-12-03 | 2012-05-07 | Monika KRÖZ | Proteínas de fusión a interleucina-11 |
EP1768647B1 (fr) * | 2004-06-17 | 2012-08-08 | Virun, Inc. | Compositions comprenant une protéine adhérant aux muqueuses et principe actif pour la délivrance d'agents dans des muqueuses |
WO2006047744A2 (fr) * | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions de peptides en rapport avec la lactoferrine et utilisations |
US20090275481A1 (en) * | 2005-06-17 | 2009-11-05 | Pfizer, Inc. | Anchored Transferrin Fusion Protein Libraries |
US9829494B2 (en) | 2005-12-01 | 2017-11-28 | Adrenomed Ag | Methods of treatment using ADM antibodies |
CN101511868B (zh) | 2006-07-24 | 2013-03-06 | 比奥雷克西斯制药公司 | 毒蜥外泌肽融合蛋白 |
KR100744419B1 (ko) | 2006-08-03 | 2007-07-30 | 동부일렉트로닉스 주식회사 | 반도체 소자 및 반도체 소자의 제조 방법 |
CA2673085C (fr) | 2006-12-12 | 2013-10-15 | Biorexis Pharmaceutical Corporation | Bibliotheques de proteines hybrides de transferrine |
CA2695830A1 (fr) * | 2007-08-08 | 2009-02-12 | Novozymes Biopharma Dk A/S | Variants de transferrine et conjugues |
CA2698582C (fr) | 2008-05-23 | 2016-09-13 | Asubio Pharma Co., Ltd. | Peptide capable de prolonger la demi-vie de peptide d'interet dans le plasma |
JP5848127B2 (ja) | 2008-08-13 | 2016-01-27 | カリフォルニア インスティテュート オブ テクノロジー | 担体ナノ粒子ならびに関連する組成物、方法およびシステム |
EP2393834B1 (fr) | 2009-02-06 | 2013-04-17 | Novozymes Biopharma DK A/S | Procédé de purification |
EP2216341A1 (fr) | 2009-02-10 | 2010-08-11 | Novozymes Biopharma UK Limited | Variantes de la transferrine et conjugués |
AU2011262494B2 (en) * | 2010-06-04 | 2016-01-21 | Tiumbio Co., Ltd. | Fusion protein having factor VII activity |
KR101853405B1 (ko) * | 2010-10-20 | 2018-05-02 | 주식회사 티움바이오 | 인자 ix 활성을 갖는 융합 단백질 |
CA2818173C (fr) | 2010-11-30 | 2022-05-03 | Genentech, Inc. | Anticorps anti-recepteur de la barriere hemato-encephalique a faible affinite et leurs utilisations |
WO2012079043A2 (fr) * | 2010-12-10 | 2012-06-14 | California Institute Of Technology | Ciblage du mésangiome rénal avec des nanoparticules de diamètre défini |
TR201802686T4 (tr) | 2011-08-17 | 2018-03-21 | Univ Colorado Regents | Transferrin-tumstatin füzyon proteini ve bu proteinin üretilmesine ve kullanılmasına yönelik yöntemler. |
EP2780717B1 (fr) | 2011-11-16 | 2016-12-21 | sphingotec GmbH | Dosages d'adrénomédulline et procédés de détermination de l'adrénomédulline mature |
DK2780370T3 (da) | 2011-11-16 | 2019-10-28 | Adrenomed Ag | Anti-adrenomedullin (adm)-antistof eller anti-adm-antistoffragment eller anti-adm-ikke-ig skelet til anvendelse i terapi af en akut sygdom eller akut tilstand af en patient til at stabilisere kredsløbet |
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CA2457520A1 (fr) | 2003-03-13 |
BR0212256A (pt) | 2004-08-31 |
EP1427750A1 (fr) | 2004-06-16 |
DE60238541D1 (de) | 2011-01-20 |
AU2002323501B2 (en) | 2009-03-26 |
WO2003020746A1 (fr) | 2003-03-13 |
US20040023334A1 (en) | 2004-02-05 |
ATE490969T1 (de) | 2010-12-15 |
EP1427750A4 (fr) | 2006-01-18 |
ZA200401079B (en) | 2005-05-25 |
NZ531207A (en) | 2006-08-31 |
RU2004109222A (ru) | 2005-10-20 |
JP2005508623A (ja) | 2005-04-07 |
KR20040059490A (ko) | 2004-07-05 |
JP2010004891A (ja) | 2010-01-14 |
EP1427750B1 (fr) | 2010-12-08 |
CN1628126A (zh) | 2005-06-15 |
DK1427750T3 (da) | 2011-02-14 |
AU2002323501C1 (en) | 2010-04-29 |
MXPA04001804A (es) | 2005-03-07 |
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