IL160204A0 - Diamine derivatives - Google Patents

Diamine derivatives

Info

Publication number
IL160204A0
IL160204A0 IL16020402A IL16020402A IL160204A0 IL 160204 A0 IL160204 A0 IL 160204A0 IL 16020402 A IL16020402 A IL 16020402A IL 16020402 A IL16020402 A IL 16020402A IL 160204 A0 IL160204 A0 IL 160204A0
Authority
IL
Israel
Prior art keywords
alkyl
optionally substituted
dialkyl
alkoxy
alkylene
Prior art date
Application number
IL16020402A
Other languages
English (en)
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2002/002683 external-priority patent/WO2003000657A1/ja
Priority claimed from PCT/JP2002/006141 external-priority patent/WO2003000680A1/ja
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of IL160204A0 publication Critical patent/IL160204A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL16020402A 2001-08-09 2002-08-08 Diamine derivatives IL160204A0 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001243046 2001-08-09
JP2001311808 2001-10-09
JP2001398708 2001-12-28
PCT/JP2002/002683 WO2003000657A1 (fr) 2001-06-20 2002-03-20 Derives de diamine
PCT/JP2002/006141 WO2003000680A1 (fr) 2001-06-20 2002-06-20 Derives de diamine
PCT/JP2002/008119 WO2003016302A1 (fr) 2001-08-09 2002-08-08 Derives de diamine

Publications (1)

Publication Number Publication Date
IL160204A0 true IL160204A0 (en) 2004-07-25

Family

ID=32600712

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16020402A IL160204A0 (en) 2001-08-09 2002-08-08 Diamine derivatives
IL160204A IL160204A (en) 2001-08-09 2004-02-04 DIAMINE DERIVATIVES, SALTS THEREOF AND SOLVATES AND N-OXIDES THEREOF WHICH EXIBIT POTENT FXa-INHIBITING EFFECT AND ANTICOAGULANT EFFECT

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL160204A IL160204A (en) 2001-08-09 2004-02-04 DIAMINE DERIVATIVES, SALTS THEREOF AND SOLVATES AND N-OXIDES THEREOF WHICH EXIBIT POTENT FXa-INHIBITING EFFECT AND ANTICOAGULANT EFFECT

Country Status (16)

Country Link
EP (1) EP1415992B1 (pt)
JP (1) JP4331595B2 (pt)
KR (1) KR100908966B1 (pt)
CN (1) CN100545160C (pt)
AT (1) ATE556066T1 (pt)
AU (1) AU2002328596B2 (pt)
BR (1) BR0211565A (pt)
CA (1) CA2456841A1 (pt)
ES (1) ES2383749T3 (pt)
HK (1) HK1095814A1 (pt)
IL (2) IL160204A0 (pt)
MX (1) MXPA04001272A (pt)
NO (1) NO327003B1 (pt)
PL (1) PL368402A1 (pt)
RU (1) RU2314303C2 (pt)
WO (1) WO2003016302A1 (pt)

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TWI288745B (en) 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
PL214669B1 (pl) * 2001-06-20 2013-08-30 Daiichi Sankyo Company Pochodne diaminy, kompozycja je zawierajaca oraz ich zastosowanie
WO2003000657A1 (fr) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Derives de diamine
TW200500366A (en) * 2002-12-25 2005-01-01 Daiichi Seiyaku Co Diamine derivatives
US7291615B2 (en) 2003-05-01 2007-11-06 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US7378409B2 (en) 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
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RU2361862C2 (ru) 2003-12-29 2009-07-20 Сепракор Инк. Пиррольные и пиразольные ингибиторы daao
BRPI0615775B1 (pt) 2005-09-16 2021-08-10 Daiichi Sankyo Company, Limited Processos para a produção de compostos derivados de diamida oticamente ativos
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RU2470011C2 (ru) 2007-05-31 2012-12-20 Сепракор Инк. Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов
JP5683273B2 (ja) * 2008-12-12 2015-03-11 第一三共株式会社 光学活性カルボン酸の製造方法
BRPI0923109A8 (pt) * 2008-12-17 2016-06-07 Daiichi Sankyo Co Ltd método para a produção de derivados de diamina
WO2010082531A1 (ja) 2009-01-13 2010-07-22 第一三共株式会社 活性化血液凝固因子阻害剤
JP5666424B2 (ja) 2009-03-10 2015-02-12 第一三共株式会社 ジアミン誘導体の製造方法
WO2010104106A1 (ja) 2009-03-13 2010-09-16 第一三共株式会社 光学活性なジアミン誘導体の製造方法
WO2010131663A1 (ja) * 2009-05-15 2010-11-18 第一三共株式会社 オキサミド誘導体
SG176934A1 (en) 2009-06-18 2012-01-30 Daiichi Sankyo Co Ltd Pharmaceutical composition having improved solubility
WO2011059080A1 (ja) * 2009-11-16 2011-05-19 第一三共株式会社 同位体置換されたジアミン誘導体
WO2011102504A1 (ja) 2010-02-22 2011-08-25 第一三共株式会社 経口用徐放性固形製剤
TW201200165A (en) 2010-02-22 2012-01-01 Daiichi Sankyo Co Ltd Oral solid extended release dosage form
WO2011102505A1 (ja) 2010-02-22 2011-08-25 第一三共株式会社 経口用徐放性固形製剤
CN102791271B (zh) 2010-03-19 2014-05-14 第一三共株式会社 抗凝剂的溶出改善方法
BR112012023649B1 (pt) 2010-03-19 2021-06-08 Daiichi Sankyo Company, Limited Método para produção de cristais de forma ii de monoidrato de n1 -(5-cloropiridin-2-il)-n2 -((1s,2r,4s)-4-[(dimetilamino) carbonil]-2-{[(5-metil-4,5,6,7-tetrahidrotiazol[5,4-c]piridin-2-il) carbonil] amino}ciclohexil)etanodiamida p-toluenossulfonato
WO2011149110A1 (en) 2010-05-28 2011-12-01 Daiichi Sankyo Company, Limited Novel composition for the prevention and/or treatment of thromboembolism
CA2859191C (en) 2010-07-02 2016-05-17 Daiichi Sankyo Company, Limited Process for preparation of optically active diamine derivative salt
CA2807459C (en) 2010-08-04 2015-09-08 Daiichi Sankyo Company, Limited Process for preparing a compound by a novel sandmeyer-like reaction using a nitroxide radical compound as a reaction catalyst
ES2673182T3 (es) 2011-08-10 2018-06-20 Daiichi Sankyo Company, Limited Composición farmacéutica que contiene un derivado de diamina
CN104768552A (zh) 2012-09-03 2015-07-08 第一三共株式会社 含有盐酸氢吗啡酮的口服持续释放药物组合物
TWI602803B (zh) 2013-03-29 2017-10-21 第一三共股份有限公司 光學活性二胺衍生物之製造方法
WO2014157612A1 (ja) 2013-03-29 2014-10-02 第一三共株式会社 （１ｓ，４ｓ，５ｓ）－４－ブロモ－６－オキサビシクロ［３．２．１］オクタン－７－オンの製造方法
CN106459087B (zh) 2014-02-18 2019-04-09 第一三共株式会社 活化的凝血因子X (FXa)抑制剂的制备方法
JP2017210468A (ja) * 2016-05-23 2017-11-30 宇部興産株式会社 ヨードラクトン化合物の製造方法
JP6696474B2 (ja) * 2016-06-24 2020-05-20 宇部興産株式会社 オキサビシクロオクタン化合物の製造方法
CN106467475A (zh) * 2016-08-29 2017-03-01 上海大学 邻位双叠氮化合物的制备方法
CN107573256B (zh) * 2017-09-26 2020-02-21 安徽国星生物化学有限公司 一种对氯苯肼盐酸盐连续化生产方法及其装置
WO2020094008A1 (zh) * 2018-11-06 2020-05-14 天津药物研究院有限公司 2-氧代-1，2-二氢喹啉类衍生物、其制备方法及其在医药上的应用
CN111606827B (zh) * 2020-06-23 2022-10-25 内蒙古京东药业有限公司 一种制备依度沙班手性胺中间体的方法
CN111763222B (zh) * 2020-08-03 2021-05-25 珠海市海瑞德新材料科技有限公司 用于制备依度沙班游离碱的中间体及其制备方法和应用
EP4262760A1 (en) 2020-12-18 2023-10-25 KRKA, d.d., Novo mesto Edoxaban formulation containing no sugar alcohols

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Also Published As

Publication number Publication date
KR100908966B1 (ko) 2009-07-22
CN100545160C (zh) 2009-09-30
ES2383749T3 (es) 2012-06-26
PL368402A1 (en) 2005-03-21
IL160204A (en) 2010-11-30
EP1415992B1 (en) 2012-05-02
EP1415992A1 (en) 2004-05-06
WO2003016302A1 (fr) 2003-02-27
BR0211565A (pt) 2004-06-29
JP4331595B2 (ja) 2009-09-16
HK1095814A1 (en) 2007-05-18
CA2456841A1 (en) 2003-02-27
JPWO2003016302A1 (ja) 2004-12-02
NO327003B1 (no) 2009-04-06
AU2002328596B2 (en) 2007-09-20
KR20040023720A (ko) 2004-03-18
RU2004106625A (ru) 2005-06-27
NO20040557L (no) 2004-04-02
MXPA04001272A (es) 2004-05-27
CN1894238A (zh) 2007-01-10
EP1415992A4 (en) 2006-07-26
RU2314303C2 (ru) 2008-01-10
ATE556066T1 (de) 2012-05-15

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