IL159674A0 - Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences - Google Patents

Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences

Info

Publication number
IL159674A0
IL159674A0 IL15967402A IL15967402A IL159674A0 IL 159674 A0 IL159674 A0 IL 159674A0 IL 15967402 A IL15967402 A IL 15967402A IL 15967402 A IL15967402 A IL 15967402A IL 159674 A0 IL159674 A0 IL 159674A0
Authority
IL
Israel
Prior art keywords
dna sequences
detecting
methods
gene transcription
transcription regulatory
Prior art date
Application number
IL15967402A
Other languages
English (en)
Original Assignee
Chromagenics Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01202581A external-priority patent/EP1273666A1/fr
Application filed by Chromagenics Bv filed Critical Chromagenics Bv
Publication of IL159674A0 publication Critical patent/IL159674A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL15967402A 2001-07-04 2002-06-14 Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences IL159674A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP01202581A EP1273666A1 (fr) 2001-07-04 2001-07-04 Procédé de séléction d'une séquence d'ADN avec une activité de modulation de la transcription utilisant un vecteur comportant un élement a activité transcripto-répréssive
US30319901P 2001-07-05 2001-07-05
PCT/NL2002/000390 WO2003004704A2 (fr) 2001-07-04 2002-06-14 Sequences d'adn comprenant des qualites de regulation de la transcription genique et methodes de detection et d'utilisation de ces sequences d'adn
US10/190,312 US7192741B2 (en) 2001-07-04 2002-07-05 DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences

Publications (1)

Publication Number Publication Date
IL159674A0 true IL159674A0 (en) 2004-06-20

Family

ID=47915807

Family Applications (4)

Application Number Title Priority Date Filing Date
IL15967402A IL159674A0 (en) 2001-07-04 2002-06-14 Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences
IL159674A IL159674A (en) 2001-07-04 2004-01-01 DNA sequences that have the ability to regulate transcription and methods for detecting and using these sequences
IL193373A IL193373A (en) 2001-07-04 2008-08-11 Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences
IL193374A IL193374A (en) 2001-07-04 2008-08-11 Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL159674A IL159674A (en) 2001-07-04 2004-01-01 DNA sequences that have the ability to regulate transcription and methods for detecting and using these sequences
IL193373A IL193373A (en) 2001-07-04 2008-08-11 Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences
IL193374A IL193374A (en) 2001-07-04 2008-08-11 Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences

Country Status (22)

Country Link
US (9) US7192741B2 (fr)
EP (8) EP1806407B1 (fr)
JP (3) JP4500044B2 (fr)
KR (2) KR100942117B1 (fr)
CN (1) CN1266282C (fr)
AT (8) ATE466941T1 (fr)
AU (3) AU2002314629B2 (fr)
BR (1) BRPI0210771B8 (fr)
CA (2) CA2812799C (fr)
CY (1) CY1107678T1 (fr)
DE (8) DE60236379D1 (fr)
DK (8) DK1845162T3 (fr)
ES (8) ES2285630T3 (fr)
HK (1) HK1068652A1 (fr)
IL (4) IL159674A0 (fr)
MX (1) MXPA03011801A (fr)
NO (1) NO338477B1 (fr)
NZ (1) NZ530218A (fr)
PT (1) PT1600510E (fr)
SG (1) SG143066A1 (fr)
WO (1) WO2003004704A2 (fr)
ZA (1) ZA200309599B (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE466941T1 (de) 2001-07-04 2010-05-15 Chromagenics Bv Dns-sequenzen mit anti-repressor-aktivität
ATE500331T1 (de) 2002-06-14 2011-03-15 Chromagenics Bv Verfahren zur gleichzeitigen herstellung von multiplen proteinen; vektoren und zellen, die hierfür verwendung finden
WO2003106674A2 (fr) * 2002-06-14 2003-12-24 Chromagenics B.V. Moyens et procedes de regulation de l'expression genique
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
JP4836451B2 (ja) 2002-07-18 2011-12-14 メルス ベー ヴェー 抗体混合物の組換え生産
DK1573058T3 (da) 2002-12-18 2012-01-16 Chromagenics Bv Fremgangsmåde til forbedring af proteinproduktion
WO2004056986A2 (fr) 2002-12-20 2004-07-08 Chromagenics B.V. Moyens et methodes de production d'une proteine a l'aide de systemes d'ouverture de la chromatine permettant de rendre la chromatine plus accessible aux facteurs de transcription
WO2004106375A1 (fr) 2003-05-30 2004-12-09 Merus Biopharmaceuticals B.V. I.O. Banque de fab pour la preparation de fab anti-vegf et antirabique
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
DK1670925T3 (da) 2003-10-02 2013-07-08 Crucell Holland Bv Pakningsceller til rekombinat adenovirus
WO2005059149A2 (fr) * 2003-12-12 2005-06-30 Chromagenics B.V. Fabrication amelioree de proteines
AU2005205412B2 (en) 2004-01-20 2011-08-11 Merus N.V. Mixtures of binding proteins
NZ551510A (en) * 2004-07-08 2009-10-30 Chromagenics Bv Anti-repressor sequences for improving expression of nucleic acid
EP1786908B1 (fr) * 2004-08-18 2010-03-03 Bayer CropScience AG Vegetaux a activite plastidique accrue de l'enzyme r3 de phosphorylation de l'amidon
US20060195935A1 (en) 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20060172382A1 (en) 2004-11-08 2006-08-03 Chromagenics B.V. Selection of host cells expressing protein at high levels
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
MX2007004595A (es) * 2004-11-08 2007-08-15 Chromagenics Bv Seleccion de celulas hospederas que expresan proteinas en altas concentraciones.
US20100136616A1 (en) * 2004-11-08 2010-06-03 Chromagenics B.V. Selection of Host Cells Expressing Protein at High Levels
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
JP5098014B2 (ja) * 2004-11-18 2012-12-12 国立大学法人広島大学 遺伝子増幅により形成された反復配列から、発現抑制されているタンパク質を発現させる方法、キット、および形質転換体
US7968700B2 (en) 2006-03-20 2011-06-28 Chromagenics B.V. Expression augmenting DNA fragments, use thereof, and methods for finding thereof
US20080124760A1 (en) 2006-07-26 2008-05-29 Barbara Enenkel Regulatory Nucleic Acid Elements
US20090142805A1 (en) * 2007-01-08 2009-06-04 Millipore Corporation High expression cell line that eliminates gene amplification
US9284563B2 (en) 2009-06-15 2016-03-15 Cellagenics B.V. Stringent selectable markers
US8566596B2 (en) 2010-08-24 2013-10-22 Cisco Technology, Inc. Pre-association mechanism to provide detailed description of wireless services
WO2012030218A1 (fr) 2010-09-01 2012-03-08 Cellagenics B.V. Fragments d'acide nucléique provenant d'un promoteur de la protéine ribosomale, destinés à améliorer l'expression génique
PT2838917T (pt) 2012-04-20 2019-09-12 Merus Nv Métodos e meios para a produção de moléculas similares a ig heterodiméricas
EP2869845B1 (fr) 2012-07-06 2019-08-28 Genmab B.V. Protéine dimérique ayant des mutations triples
DK2900694T3 (en) 2012-09-27 2018-11-19 Merus Nv BISPECIFIC IGG ANTIBODIES AS T-CELL ACTIVATORS
US10417380B1 (en) 2013-12-31 2019-09-17 Mckesson Corporation Systems and methods for determining and communicating a prescription benefit coverage denial to a prescriber
US10489552B2 (en) 2014-02-14 2019-11-26 Mckesson Corporation Systems and methods for determining and communicating patient incentive information to a prescriber
WO2015130173A1 (fr) 2014-02-28 2015-09-03 Merus B.V. Anticorps qui se lie à erbb-2 et erbb-3
NZ724013A (en) 2014-02-28 2019-11-29 Merus Nv Antibodies that bind egfr and erbb3
US10157262B1 (en) 2015-03-10 2018-12-18 Mckesson Corporation Systems and methods for determining patient financial responsibility for multiple prescription products
AU2016293942B2 (en) 2015-07-10 2022-06-16 Merus N.V. Human CD3 binding antibody
KR20180100305A (ko) 2015-10-23 2018-09-10 메뤼스 엔.페. 암 성장을 억제하는 결합 분자
US11514137B1 (en) 2016-03-30 2022-11-29 Mckesson Corporation Alternative therapy identification system
US10999224B1 (en) 2017-02-01 2021-05-04 Mckesson Corporation Method and apparatus for parsing an electronic message and constructing multiple differently prioritized messages therefrom
CA3058343A1 (fr) 2017-03-31 2018-10-04 Merus N.V. Anticorps bispecifiques de liaison a erbb-2/erbb-3 aux fins d'utilisation dans le traitement de cellules qui presente un gene de fusion nrg1
BR112020002695A2 (pt) 2017-08-09 2020-08-25 Merus N.V. anticorpos que se ligam à egfr e cmet
US10862832B1 (en) 2018-07-24 2020-12-08 Mckesson Corporation Computing system and method for automatically reversing an action indicated by an electronic message
US11043437B2 (en) 2019-01-07 2021-06-22 Applied Materials, Inc. Transparent substrate with light blocking edge exclusion zone
US11636548B1 (en) 2019-06-26 2023-04-25 Mckesson Corporation Method, apparatus, and computer program product for providing estimated prescription costs
US11562437B1 (en) 2019-06-26 2023-01-24 Mckesson Corporation Method, apparatus, and computer program product for providing estimated prescription costs
EP3772518A1 (fr) 2019-08-07 2021-02-10 Merus N.V. Domaines variables humains modifiés
WO2021155369A1 (fr) * 2020-01-31 2021-08-05 The Board Of Trustees Of The Leland Stanford Junior University Systèmes et procédés pour identifier des silenceurs génétiques et leurs applications
US11610240B1 (en) 2020-02-17 2023-03-21 Mckesson Corporation Method, apparatus, and computer program product for partitioning prescription transaction costs in an electronic prescription transaction
CN116462766A (zh) 2020-05-21 2023-07-21 美勒斯公司 用于生产ig样分子的方法和手段
US11587657B2 (en) 2020-09-04 2023-02-21 Mckesson Corporation Method, apparatus, and computer program product for performing an alternative evaluation procedure in response to an electronic message
CN113539357B (zh) * 2021-06-10 2024-04-30 阿里巴巴达摩院(杭州)科技有限公司 基因检测方法、模型训练方法、装置、设备及系统

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US719271A (en) * 1902-01-13 1903-01-27 Solomon P Smith Furnace.
US5610053A (en) 1993-04-07 1997-03-11 The United States Of America As Represented By The Department Of Health And Human Services DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells
US5972605A (en) * 1994-07-07 1999-10-26 Geron Corporation Assays for regulators of mammalian telomerase expression
WO1996030522A1 (fr) * 1995-03-24 1996-10-03 Shionogi & Co., Ltd. Molecule d'adn relative a la suppression d'une expression genique et nouvelle proteine
DE19539493A1 (de) * 1995-10-24 1997-04-30 Thomae Gmbh Dr K Starker homologer Promotor aus Hamster
US5773695A (en) 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
US6037525A (en) * 1996-08-01 2000-03-14 North Carolina State University Method for reducing expression variability of transgenes in plant cells
US5888809A (en) 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
WO2000005393A2 (fr) 1998-07-21 2000-02-03 Cobra Therapeutics Limited Polynucleotide comportant un element d'ouverture de la chromatine ubiquiste (ucoe)
DK1104490T3 (da) 1998-08-14 2008-01-02 Chromagenics Bv Fremgangsmåde til påvisning af en DNA-sekvens, DNA-sekvens, fremgangsmåde til fremstilling af en DNA-konstruktion samt anvendelse deraf
US6800457B2 (en) 1998-09-22 2004-10-05 Bristol-Myers Squibb Company Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
US6521419B1 (en) 1998-09-22 2003-02-18 Kanakaraju Koduri Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
US6395549B1 (en) 1998-10-22 2002-05-28 Medical College Of Georgia Research Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
AU784506B2 (en) * 1999-08-25 2006-04-13 Immunex Corporation Compositions and methods for improved cell culture
EP1263950A2 (fr) 2000-02-11 2002-12-11 Millennium Pharmaceuticals, Inc. Nouveaux recepteurs couples aux proteines/a une proteine g transmembranaires a sept regions
US6586205B1 (en) 2000-02-11 2003-07-01 Millennium Pharmaceuticals, Inc. 43239 a novel GPCR-like molecule and uses thereof
AU9006701A (en) 2000-09-20 2002-04-02 Cobra Therapeutics Ltd Polynucleotide
ATE466941T1 (de) 2001-07-04 2010-05-15 Chromagenics Bv Dns-sequenzen mit anti-repressor-aktivität
EP1273666A1 (fr) 2001-07-04 2003-01-08 Chromagenics B.V. Procédé de séléction d'une séquence d'ADN avec une activité de modulation de la transcription utilisant un vecteur comportant un élement a activité transcripto-répréssive
WO2003106674A2 (fr) * 2002-06-14 2003-12-24 Chromagenics B.V. Moyens et procedes de regulation de l'expression genique
ATE500331T1 (de) * 2002-06-14 2011-03-15 Chromagenics Bv Verfahren zur gleichzeitigen herstellung von multiplen proteinen; vektoren und zellen, die hierfür verwendung finden
DK1573058T3 (da) 2002-12-18 2012-01-16 Chromagenics Bv Fremgangsmåde til forbedring af proteinproduktion
WO2004056986A2 (fr) 2002-12-20 2004-07-08 Chromagenics B.V. Moyens et methodes de production d'une proteine a l'aide de systemes d'ouverture de la chromatine permettant de rendre la chromatine plus accessible aux facteurs de transcription

Also Published As

Publication number Publication date
ES2274045T3 (es) 2007-05-16
US20070037256A1 (en) 2007-02-15
DE60236332D1 (de) 2010-06-17
ATE358183T1 (de) 2007-04-15
KR100942117B1 (ko) 2010-02-12
AU2007234619A1 (en) 2007-12-13
ES2344073T3 (es) 2010-08-17
ES2344070T3 (es) 2010-08-17
EP1404872B1 (fr) 2006-10-18
BRPI0210771B1 (pt) 2015-12-22
US7736870B2 (en) 2010-06-15
US20070128717A1 (en) 2007-06-07
US7736868B2 (en) 2010-06-15
NO20040011L (no) 2004-03-03
NZ530218A (en) 2005-09-30
DE60236333D1 (de) 2010-06-17
IL193373A (en) 2010-12-30
ATE474053T1 (de) 2010-07-15
JP2004533262A (ja) 2004-11-04
IL193374A (en) 2010-12-30
DK1829971T3 (da) 2010-08-16
PT1600510E (pt) 2007-06-25
CY1107678T1 (el) 2013-04-18
DE60215502T2 (de) 2007-08-30
ES2348174T3 (es) 2010-11-30
DK1600510T3 (da) 2007-06-25
EP1808488A3 (fr) 2007-11-14
US7951586B2 (en) 2011-05-31
SG143066A1 (en) 2008-06-27
CA2812799C (fr) 2016-01-26
JP5014444B2 (ja) 2012-08-29
CN1266282C (zh) 2006-07-26
EP1829972A2 (fr) 2007-09-05
EP1829971A1 (fr) 2007-09-05
KR100942116B1 (ko) 2010-02-12
EP1806407B1 (fr) 2010-05-05
DK1806407T3 (da) 2010-08-16
ES2344072T3 (es) 2010-08-17
US20070031934A1 (en) 2007-02-08
DE60219221D1 (de) 2007-05-10
EP1829972B1 (fr) 2010-05-12
US7655441B2 (en) 2010-02-02
DE60236334D1 (de) 2010-06-17
EP1845162A1 (fr) 2007-10-17
DK1842919T3 (da) 2010-08-16
DE60236379D1 (de) 2010-06-24
EP1842919A1 (fr) 2007-10-10
EP1842919B1 (fr) 2010-05-05
WO2003004704A3 (fr) 2003-10-16
AU2011202193B2 (en) 2011-09-29
US20070031936A1 (en) 2007-02-08
CA2450020A1 (fr) 2003-01-16
US7749733B2 (en) 2010-07-06
KR20090037485A (ko) 2009-04-15
BRPI0210771B8 (pt) 2021-05-25
MXPA03011801A (es) 2005-03-07
US20070031933A1 (en) 2007-02-08
US20030199468A1 (en) 2003-10-23
DE60219221T2 (de) 2008-01-03
ATE343004T1 (de) 2006-11-15
ATE466941T1 (de) 2010-05-15
EP1845162B1 (fr) 2010-05-05
US20070031935A1 (en) 2007-02-08
ATE466942T1 (de) 2010-05-15
ATE466943T1 (de) 2010-05-15
BR0210771A (pt) 2004-07-13
EP1808488B1 (fr) 2010-07-14
ES2344071T3 (es) 2010-08-17
DK1829972T3 (da) 2010-09-13
ZA200309599B (en) 2006-05-31
US7192741B2 (en) 2007-03-20
IL159674A (en) 2009-02-11
DE60215502D1 (de) 2006-11-30
EP1404872A2 (fr) 2004-04-07
JP2010131024A (ja) 2010-06-17
JP5014443B2 (ja) 2012-08-29
AU2011202193A1 (en) 2011-06-02
EP1806407A2 (fr) 2007-07-11
ATE467682T1 (de) 2010-05-15
US20070026499A1 (en) 2007-02-01
DE60237048D1 (de) 2010-08-26
CA2812799A1 (fr) 2003-01-16
WO2003004704A2 (fr) 2003-01-16
US7736869B2 (en) 2010-06-15
CA2450020C (fr) 2013-08-13
DK1845162T3 (da) 2010-08-16
US20070026498A1 (en) 2007-02-01
EP1829972A3 (fr) 2007-10-24
ATE466944T1 (de) 2010-05-15
KR20090037960A (ko) 2009-04-16
US7659094B2 (en) 2010-02-09
EP1808488A2 (fr) 2007-07-18
DK1808488T3 (da) 2010-10-18
EP1600510A2 (fr) 2005-11-30
ES2285630T3 (es) 2007-11-16
CN1524128A (zh) 2004-08-25
EP1600510A3 (fr) 2006-02-22
EP1829971B1 (fr) 2010-05-05
EP1600510B1 (fr) 2007-03-28
JP4500044B2 (ja) 2010-07-14
JP2010131025A (ja) 2010-06-17
HK1068652A1 (en) 2005-04-29
DE60236331D1 (de) 2010-06-17
ES2344074T3 (es) 2010-08-17
NO338477B1 (no) 2016-08-22
EP1829971A3 (fr) 2008-06-04
US7662591B2 (en) 2010-02-16
EP1806407A3 (fr) 2008-06-04
DK1404872T3 (da) 2007-02-19
AU2007234619B2 (en) 2011-06-02
AU2002314629B2 (en) 2007-08-30

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