IL158361A0 - Use of 2-alpha-cyano-4-alpha, 5-alpha-epoxyandrostan-17-beta-ol-3 one derivatives for lowering levels of serum cortisol and for the treatment of clinical conditions associated therewith - Google Patents
Use of 2-alpha-cyano-4-alpha, 5-alpha-epoxyandrostan-17-beta-ol-3 one derivatives for lowering levels of serum cortisol and for the treatment of clinical conditions associated therewithInfo
- Publication number
- IL158361A0 IL158361A0 IL15836102A IL15836102A IL158361A0 IL 158361 A0 IL158361 A0 IL 158361A0 IL 15836102 A IL15836102 A IL 15836102A IL 15836102 A IL15836102 A IL 15836102A IL 158361 A0 IL158361 A0 IL 158361A0
- Authority
- IL
- Israel
- Prior art keywords
- alpha
- treatment
- alkyl
- hydrogen
- epoxyandrostan
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0108865A GB2375958B (en) | 2001-04-09 | 2001-04-09 | The use of steroids to lower the levels of cortisol |
PCT/GB2002/001653 WO2002080930A1 (en) | 2001-04-09 | 2002-04-09 | Intermittent lowering of levels of cortisol and other adrenalhormones as treatment of clinical conditions associated with abnormal concentrations of such hormones in man and animals |
Publications (1)
Publication Number | Publication Date |
---|---|
IL158361A0 true IL158361A0 (en) | 2004-05-12 |
Family
ID=9912534
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15836102A IL158361A0 (en) | 2001-04-09 | 2002-04-09 | Use of 2-alpha-cyano-4-alpha, 5-alpha-epoxyandrostan-17-beta-ol-3 one derivatives for lowering levels of serum cortisol and for the treatment of clinical conditions associated therewith |
IL158361A IL158361A (en) | 2001-04-09 | 2003-10-09 | Annals of @@@ α-cyano-@ α @ E – α epoxyandrostane - @@ β– and @@ - van @@ for continuous treatment of horse laminitis, Cushing's syndrome and Cushing's disease |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL158361A IL158361A (en) | 2001-04-09 | 2003-10-09 | Annals of @@@ α-cyano-@ α @ E – α epoxyandrostane - @@ β– and @@ - van @@ for continuous treatment of horse laminitis, Cushing's syndrome and Cushing's disease |
Country Status (18)
Country | Link |
---|---|
US (1) | US9283235B2 (xx) |
EP (1) | EP1385527B2 (xx) |
JP (1) | JP5006502B2 (xx) |
AT (1) | ATE363285T1 (xx) |
AU (1) | AU2002242906B2 (xx) |
CA (1) | CA2443633C (xx) |
CY (1) | CY1106818T1 (xx) |
DE (1) | DE60220400T9 (xx) |
DK (1) | DK1385527T4 (xx) |
ES (1) | ES2287252T5 (xx) |
GB (1) | GB2375958B (xx) |
IL (2) | IL158361A0 (xx) |
MX (1) | MXPA03009236A (xx) |
NZ (1) | NZ529141A (xx) |
PT (1) | PT1385527E (xx) |
SI (1) | SI1385527T2 (xx) |
WO (1) | WO2002080930A1 (xx) |
ZA (1) | ZA200308567B (xx) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2468282A3 (en) | 2005-07-12 | 2012-09-12 | DMI Biosciences, Inc. | Methods and products for treatment of diseases |
FR2931678B1 (fr) * | 2008-05-27 | 2010-10-01 | Cll Pharma | Utilisation du trilistane pour le traitement de la depression |
CA2742964C (en) * | 2008-11-07 | 2020-07-07 | University Of Sheffield | Medicament and method of diagnosis |
PL2425839T3 (pl) | 2009-06-22 | 2015-03-31 | Ampio Pharmaceuticals Inc | Sposób leczenia chorób |
SG10201403388SA (en) * | 2009-06-22 | 2014-10-30 | Ampio Pharmaceuticals Inc | Methods and products for treatment of diseases |
US20120263660A1 (en) * | 2011-04-18 | 2012-10-18 | Pop Test Cortisol Llc | Hair Loss Treatment |
JP2016503794A (ja) | 2012-12-19 | 2016-02-08 | アンピオ ファーマシューティカルズ,インコーポレイテッド | 疾患の治療のための方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1123770A (en) * | 1966-11-15 | 1968-08-14 | Sterling Drug Inc | 2-cyano-3-oxo-steroids |
US3296255A (en) * | 1963-11-29 | 1967-01-03 | Sterling Drug Inc | 2-cyano steroids |
US3296295A (en) * | 1964-05-22 | 1967-01-03 | Squibb & Sons Inc | Norsteroids |
US4029776A (en) * | 1975-12-19 | 1977-06-14 | Sterling Drug Inc. | Therapeutic composition and method of use thereof |
FR2408345A1 (fr) * | 1976-11-30 | 1979-06-08 | Besins Jean Louis | Nouvelle composition a action anti-conceptionnelle |
US4062954A (en) * | 1976-12-27 | 1977-12-13 | Sterling Drug Inc. | Process for using a steroid compound |
US4160027A (en) * | 1977-12-20 | 1979-07-03 | Sterling Drug Inc. | Steroid cyanoketones and intermediates |
US4331663A (en) * | 1981-06-19 | 1982-05-25 | Sterling Drug Inc. | 4α,5α-Epoxy-3,20-dioxopregnane-2α,16α-dicarbonitrile and intermediates and process for preparation, method of use and compositions thereof |
JPS5995300A (ja) * | 1982-11-02 | 1984-06-01 | スタ−リング・ドラッグ・インコ−ポレ−テッド | コントロ−ルされた粒度の2−シアノ−4,5−エポキシ−3−オキソ−ステロイド類およびそれらの組成物 |
JPS5971578U (ja) * | 1982-11-04 | 1984-05-15 | アンプ インコ−ポレ−テツド | 電気コネクタ組立体 |
GB8328929D0 (en) * | 1983-10-29 | 1983-11-30 | Sterwin Ag | Steroid compounds |
GB2155018B (en) * | 1984-02-25 | 1988-04-07 | Sterwin Ag | 2x-cyano-4d,5x-epoxy-androstane -3,17-dione |
GB8404980D0 (en) * | 1984-02-25 | 1984-03-28 | Sterwin Ag | Steroid compound |
GB8414221D0 (en) * | 1984-06-04 | 1984-07-11 | Sterwin Ag | Unit dosage form |
US4755595A (en) * | 1985-11-01 | 1988-07-05 | Sterling Drug Inc. | Enhanced production of 4,5-unsaturated steroids utilizing methanol solvation |
US5795881A (en) * | 1987-06-16 | 1998-08-18 | Schering Aktiengesellschaft | Combined use of an antigestagen and a progesterone synthesis inhibitor of the trilostane and epostane type |
US4857333A (en) * | 1988-05-12 | 1989-08-15 | Harold Robert G | Food product for administering medication to animals |
DE69022722T2 (de) * | 1989-03-10 | 1996-05-02 | Endorecherche Inc | Kombinationstherapie zur behandlung von estrogenempfindlichen erkrankungen. |
US5372996A (en) * | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
GB2345851B (en) * | 2000-01-18 | 2004-05-26 | Gavin Paul Vinson | A combination of trilostane or keto-trilostane and an anti-oestrogen for the treatment of an oestrogen-dependent cancer or tumour |
US20020055512A1 (en) * | 2000-01-21 | 2002-05-09 | Cortendo Ab. | Compositions for delivery of a cortisol antagonist |
GB0001449D0 (en) | 2000-01-21 | 2000-03-08 | Cortendo Ab | Compositions |
PL360153A1 (en) | 2000-05-15 | 2004-09-06 | Pharmacia & Upjohn S.P.A. | Aromatase inhibitors and monoclonal anti-her2 antibodies as antitumors agents |
GB0017635D0 (en) | 2000-07-18 | 2000-09-06 | Pharmacia & Upjohn Spa | Antitumor combined therapy |
US20030050291A1 (en) * | 2001-06-12 | 2003-03-13 | Yadon Arad | Adrenal enzyme inhibitors |
-
2001
- 2001-04-09 GB GB0108865A patent/GB2375958B/en not_active Expired - Lifetime
-
2002
- 2002-04-09 JP JP2002578969A patent/JP5006502B2/ja not_active Expired - Lifetime
- 2002-04-09 CA CA2443633A patent/CA2443633C/en not_active Expired - Lifetime
- 2002-04-09 PT PT02708546T patent/PT1385527E/pt unknown
- 2002-04-09 ES ES02708546T patent/ES2287252T5/es not_active Expired - Lifetime
- 2002-04-09 IL IL15836102A patent/IL158361A0/xx unknown
- 2002-04-09 AT AT02708546T patent/ATE363285T1/de active
- 2002-04-09 AU AU2002242906A patent/AU2002242906B2/en not_active Expired
- 2002-04-09 MX MXPA03009236A patent/MXPA03009236A/es active IP Right Grant
- 2002-04-09 DE DE60220400T patent/DE60220400T9/de active Active
- 2002-04-09 SI SI200230590T patent/SI1385527T2/sl unknown
- 2002-04-09 WO PCT/GB2002/001653 patent/WO2002080930A1/en active IP Right Grant
- 2002-04-09 NZ NZ529141A patent/NZ529141A/en not_active IP Right Cessation
- 2002-04-09 US US10/474,868 patent/US9283235B2/en active Active
- 2002-04-09 DK DK02708546.3T patent/DK1385527T4/da active
- 2002-04-09 EP EP02708546A patent/EP1385527B2/en not_active Expired - Lifetime
-
2003
- 2003-10-09 IL IL158361A patent/IL158361A/en active IP Right Grant
- 2003-11-03 ZA ZA2003/08567A patent/ZA200308567B/en unknown
-
2007
- 2007-08-14 CY CY20071101087T patent/CY1106818T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
SI1385527T2 (sl) | 2012-03-30 |
CY1106818T1 (el) | 2012-05-23 |
IL158361A (en) | 2013-07-31 |
ATE363285T1 (de) | 2007-06-15 |
PT1385527E (pt) | 2007-08-21 |
CA2443633C (en) | 2010-06-22 |
DE60220400T3 (de) | 2012-03-22 |
CA2443633A1 (en) | 2002-10-17 |
EP1385527B2 (en) | 2011-11-23 |
JP2004529142A (ja) | 2004-09-24 |
DE60220400T9 (de) | 2012-08-30 |
GB0108865D0 (en) | 2001-05-30 |
DE60220400D1 (de) | 2007-07-12 |
DE60220400T2 (de) | 2008-01-31 |
GB2375958A (en) | 2002-12-04 |
NZ529141A (en) | 2005-09-30 |
DK1385527T4 (da) | 2012-01-16 |
WO2002080930A1 (en) | 2002-10-17 |
DK1385527T3 (da) | 2007-10-29 |
MXPA03009236A (es) | 2004-11-12 |
ES2287252T5 (es) | 2012-03-26 |
GB2375958B (en) | 2005-03-02 |
AU2002242906B2 (en) | 2009-07-02 |
ZA200308567B (en) | 2006-04-29 |
SI1385527T1 (sl) | 2007-10-31 |
ES2287252T3 (es) | 2007-12-16 |
EP1385527B1 (en) | 2007-05-30 |
US9283235B2 (en) | 2016-03-15 |
US20040204392A1 (en) | 2004-10-14 |
EP1385527A1 (en) | 2004-02-04 |
JP5006502B2 (ja) | 2012-08-22 |
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