IL155483A0 - Cyanoguanidine prodrugs - Google Patents
Cyanoguanidine prodrugsInfo
- Publication number
- IL155483A0 IL155483A0 IL15548301A IL15548301A IL155483A0 IL 155483 A0 IL155483 A0 IL 155483A0 IL 15548301 A IL15548301 A IL 15548301A IL 15548301 A IL15548301 A IL 15548301A IL 155483 A0 IL155483 A0 IL 155483A0
- Authority
- IL
- Israel
- Prior art keywords
- cyanoguanidine
- prodrugs
- cyanoguanidine prodrugs
- Prior art date
Links
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25207800P | 2000-11-21 | 2000-11-21 | |
| PCT/DK2001/000750 WO2002042265A2 (en) | 2000-11-21 | 2001-11-14 | Cyanoguanidine prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL155483A0 true IL155483A0 (en) | 2003-11-23 |
Family
ID=22954502
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15548301A IL155483A0 (en) | 2000-11-21 | 2001-11-14 | Cyanoguanidine prodrugs |
| IL155483A IL155483A (en) | 2000-11-21 | 2003-04-15 | Prodrugs of cyanoguanidine pyridinium and dihydropyridinylidene derivatives and pharmaceutical compositions comprising them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL155483A IL155483A (en) | 2000-11-21 | 2003-04-15 | Prodrugs of cyanoguanidine pyridinium and dihydropyridinylidene derivatives and pharmaceutical compositions comprising them |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6525077B2 (es) |
| EP (2) | EP1339686B1 (es) |
| JP (1) | JP4521157B2 (es) |
| KR (1) | KR100871577B1 (es) |
| CN (1) | CN100368401C (es) |
| AU (3) | AU1494702A (es) |
| BR (1) | BR0115514A (es) |
| CA (1) | CA2426601C (es) |
| CZ (1) | CZ305764B6 (es) |
| ES (2) | ES2549260T3 (es) |
| HU (1) | HU230544B1 (es) |
| IL (2) | IL155483A0 (es) |
| MX (1) | MXPA03004394A (es) |
| PL (1) | PL224371B1 (es) |
| RU (1) | RU2312858C2 (es) |
| WO (2) | WO2002042265A2 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711123D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| AU2003223932A1 (en) * | 2002-05-17 | 2003-12-02 | Leo Pharma A/S | Cyanoguanidine produgs |
| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| RU2326867C2 (ru) * | 2002-05-17 | 2008-06-20 | Лео Фарма А/С | Цианогуанидиновые производные, способ лечения и фармацевтическая композиция на их основе |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| JP2006523237A (ja) * | 2003-04-03 | 2006-10-12 | セマフォア ファーマシューティカルズ， インコーポレイテッド | Ｐｉ−３キナーゼインヒビタープロドラッグ |
| US8053446B2 (en) | 2004-12-22 | 2011-11-08 | Leo Pharma A/S | Cyanoguanidine compounds |
| US9296697B2 (en) | 2005-08-24 | 2016-03-29 | Abbott Laboratories | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors |
| US8173677B2 (en) * | 2007-09-26 | 2012-05-08 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| EP2197443A4 (en) * | 2007-09-26 | 2014-01-01 | Gemin X Pharmaceuticals Canada Inc | COMPOSITIONS AND METHOD FOR LEADING NAD + MIRRORS USING A NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE HEMMER |
| US8101606B2 (en) | 2007-11-12 | 2012-01-24 | Washington University | Neurofibromin pathway modulators |
| WO2010023307A1 (en) | 2008-08-29 | 2010-03-04 | Topotarget A/S | Novel urea and thiourea derivatives |
| EP2394649A4 (en) | 2009-02-06 | 2012-08-15 | Tianjin Hemay Bio Tech Co Ltd | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDYL-CYANOGUANIDINES, PREPARATION METHODS AND USES THEREOF |
| EP2453883A1 (en) | 2009-07-17 | 2012-05-23 | Topo Target A/S | Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors |
| US9224007B2 (en) * | 2009-09-15 | 2015-12-29 | International Business Machines Corporation | Search engine with privacy protection |
| US9600134B2 (en) | 2009-12-29 | 2017-03-21 | International Business Machines Corporation | Selecting portions of computer-accessible documents for post-selection processing |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| WO2011121055A1 (en) | 2010-03-31 | 2011-10-06 | Topotarget A/S | Pyridinyl derivatives comprising a cyanoguanidine or squaric acid moiety |
| CN103261160A (zh) | 2010-09-03 | 2013-08-21 | 福马Tm有限责任公司 | 用于抑制nampt的胍化合物和组合物 |
| EP2693876B1 (en) * | 2011-04-08 | 2020-01-15 | Sphaera Pharma Pte. Ltd | Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds |
| US9195853B2 (en) | 2012-01-15 | 2015-11-24 | International Business Machines Corporation | Automated document redaction |
| CN106905297A (zh) * | 2012-06-15 | 2017-06-30 | 加利福尼亚大学董事会 | 用于脑癌的新颖治疗剂 |
| KR20150024932A (ko) * | 2012-06-27 | 2015-03-09 | 알츠하이머즈 인스티튜트 오브 아메리카, 인크. | 화합물 및 그의 치료 용도 |
| AU2013326850B2 (en) * | 2012-10-04 | 2017-09-21 | Inhibikase Therapeutics, Inc. | Novel compounds, their preparation and their uses |
| US9892278B2 (en) | 2012-11-14 | 2018-02-13 | International Business Machines Corporation | Focused personal identifying information redaction |
| US10227333B2 (en) | 2015-02-11 | 2019-03-12 | Curtana Pharmaceuticals, Inc. | Inhibition of OLIG2 activity |
| JP2018510138A (ja) | 2015-02-27 | 2018-04-12 | カーテナ ファーマシューティカルズ，インク． | Ｏｌｉｇ２活性の阻害 |
| WO2017162536A1 (en) | 2016-03-21 | 2017-09-28 | H. Lundbeck A/S | Vortioxetine prodrugs |
| WO2018199174A1 (ja) * | 2017-04-25 | 2018-11-01 | 生化学工業株式会社 | 第３級アミン化合物又はイミン化合物－ポリマーコンジュゲートとその製造方法 |
| EP3590927A1 (en) * | 2018-07-05 | 2020-01-08 | Bayer Animal Health GmbH | Novel compounds for controlling arthropods |
| US11174229B2 (en) | 2018-10-29 | 2021-11-16 | Kempharm, Inc. | D-amphetamine compounds, compositions, and processes for making and using the same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05501103A (ja) * | 1989-06-26 | 1993-03-04 | ザ・リサーチ・ファウンデーション・オヴ・ステイト・ユニヴァーシティ・オヴ・ニューヨーク | ビス―アシルオキシメチル誘導体 |
| GB9219472D0 (en) | 1992-09-15 | 1992-10-28 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9607219D0 (en) * | 1996-04-04 | 1996-06-12 | Smithkline Beecham Plc | Novel compounds |
| GB9711124D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711119D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711123D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711125D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| WO2000061561A1 (en) * | 1999-04-09 | 2000-10-19 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
| AU4076500A (en) * | 1999-04-09 | 2000-11-14 | Shionogi Bioresearch Corp. | (n)-substituted cyanoguanidine compounds |
-
2001
- 2001-11-12 AU AU1494702A patent/AU1494702A/xx active Pending
- 2001-11-14 ES ES01983436.5T patent/ES2549260T3/es not_active Expired - Lifetime
- 2001-11-14 CN CNB018192440A patent/CN100368401C/zh not_active Expired - Lifetime
- 2001-11-14 ES ES15150976.7T patent/ES2643083T3/es not_active Expired - Lifetime
- 2001-11-14 RU RU2003118446/04A patent/RU2312858C2/ru active
- 2001-11-14 PL PL362864A patent/PL224371B1/pl unknown
- 2001-11-14 IL IL15548301A patent/IL155483A0/xx unknown
- 2001-11-14 MX MXPA03004394A patent/MXPA03004394A/es active IP Right Grant
- 2001-11-14 CA CA2426601A patent/CA2426601C/en not_active Expired - Lifetime
- 2001-11-14 AU AU2002214947A patent/AU2002214947B2/en not_active Expired
- 2001-11-14 HU HU0400564A patent/HU230544B1/hu unknown
- 2001-11-14 EP EP01983436.5A patent/EP1339686B1/en not_active Expired - Lifetime
- 2001-11-14 JP JP2002544401A patent/JP4521157B2/ja not_active Expired - Lifetime
- 2001-11-14 KR KR1020037006880A patent/KR100871577B1/ko not_active Expired - Lifetime
- 2001-11-14 CZ CZ2003-1303A patent/CZ305764B6/cs not_active IP Right Cessation
- 2001-11-14 WO PCT/DK2001/000750 patent/WO2002042265A2/en not_active Ceased
- 2001-11-14 BR BR0115514-8A patent/BR0115514A/pt not_active Application Discontinuation
- 2001-11-14 EP EP15150976.7A patent/EP2894149B1/en not_active Expired - Lifetime
- 2001-11-20 WO PCT/DK2001/000770 patent/WO2002042276A1/en not_active Ceased
- 2001-11-20 AU AU2002223511A patent/AU2002223511A1/en not_active Abandoned
- 2001-11-20 US US09/988,819 patent/US6525077B2/en not_active Expired - Lifetime
-
2003
- 2003-04-15 IL IL155483A patent/IL155483A/en active IP Right Grant
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