IL148559A0 - Taxane prodrugs - Google Patents
Taxane prodrugsInfo
- Publication number
- IL148559A0 IL148559A0 IL14855900A IL14855900A IL148559A0 IL 148559 A0 IL148559 A0 IL 148559A0 IL 14855900 A IL14855900 A IL 14855900A IL 14855900 A IL14855900 A IL 14855900A IL 148559 A0 IL148559 A0 IL 148559A0
- Authority
- IL
- Israel
- Prior art keywords
- taxane prodrugs
- taxane
- prodrugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15357999P | 1999-09-13 | 1999-09-13 | |
| US09/476,974 US6380405B1 (en) | 1999-09-13 | 1999-12-31 | Taxane prodrugs |
| PCT/US2000/024523 WO2001019407A2 (fr) | 1999-09-13 | 2000-09-07 | Promedicaments a base de taxane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL148559A0 true IL148559A0 (en) | 2002-09-12 |
Family
ID=26850672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14855900A IL148559A0 (en) | 1999-09-13 | 2000-09-07 | Taxane prodrugs |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6380405B1 (fr) |
| EP (1) | EP1214096A2 (fr) |
| JP (1) | JP2003509386A (fr) |
| KR (1) | KR20020082458A (fr) |
| CN (1) | CN1390142A (fr) |
| AU (2) | AU784395B2 (fr) |
| BR (1) | BR0013949A (fr) |
| CA (1) | CA2384646A1 (fr) |
| CZ (1) | CZ2002929A3 (fr) |
| HK (1) | HK1046856A1 (fr) |
| HU (1) | HUP0300093A2 (fr) |
| IL (1) | IL148559A0 (fr) |
| MX (1) | MXPA02002711A (fr) |
| NO (1) | NO20021212L (fr) |
| PL (1) | PL354779A1 (fr) |
| WO (1) | WO2001019407A2 (fr) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713454B1 (en) * | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
| US6541508B2 (en) * | 1999-09-13 | 2003-04-01 | Nobex Corporation | Taxane prodrugs |
| EP1274460A4 (fr) * | 2000-04-15 | 2005-06-29 | Kolon Inc | Compose de promedicament aqueux comprenant une fraction de paclitaxel ou ses derives, procede de preparation dudit compose et composition pharmaceutique le contenant |
| DK2939696T3 (en) | 2001-10-18 | 2016-05-23 | Nektar Therapeutics | Polymer Conjugates of Opioid Antagonists |
| US6593334B1 (en) | 2002-05-02 | 2003-07-15 | The University Of North Carolina At Chapel Hill | Camptothecin-taxoid conjugates as antimitotic and antitumor agents |
| GR1004274B (el) * | 2002-07-16 | 2003-06-23 | Medexis ���� | Συμπλοκα στεροειδων ορμονων με πρωτεινες: νεες ουσιες για την ειδικη ανιχνευση και καταστροφη καρκινικων κυτταρων προερχομενων απο στερεους ογκους και αιματολογικες κακοηθειες |
| NZ538498A (en) * | 2002-07-30 | 2009-02-28 | Childrens Medical Center | Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors |
| WO2004065362A2 (fr) * | 2002-08-16 | 2004-08-05 | University Of Massachusetts | Composes pyridine et composes ligands connexes, composites a nanoparticules fonctionnalises, et procedes d'elaboration |
| AU2002951833A0 (en) * | 2002-10-02 | 2002-10-24 | Novogen Research Pty Ltd | Compositions and therapeutic methods invloving platinum complexes |
| WO2004043396A2 (fr) * | 2002-11-09 | 2004-05-27 | Nobex Corporation | Promedicaments contenant du carbamate modifie et methodes de synthese de ces derniers |
| BRPI0412265A (pt) | 2003-07-23 | 2006-09-05 | Novartis Ag | uso de calcitonina em osteoartrite |
| EP1686981A4 (fr) * | 2003-11-19 | 2011-02-23 | Novogen Res Pty Ltd | Compositions et procedes de radiotherapie et de chimiotherapie combinatoires |
| US7786133B2 (en) * | 2003-12-16 | 2010-08-31 | Nektar Therapeutics | Chemically modified small molecules |
| US20060182692A1 (en) * | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| ES2308451T3 (es) | 2004-02-18 | 2008-12-01 | Gpc Biotech Ag | Satraplatino para el tratamiento de tumores resistentes o refractarios. |
| EP1750673B1 (fr) * | 2004-05-17 | 2009-12-02 | Tekmira Pharmaceuticals Corporation | Formulations liposomales comprenant de la dihydrosphingomyéline, et procedés d'utilisation correspondants |
| WO2006002119A2 (fr) | 2004-06-18 | 2006-01-05 | Gpc Biotech, Inc. | Utilisation d'inhibiteurs de kinase et leurs compositions |
| US8329958B2 (en) | 2004-07-02 | 2012-12-11 | Biocon Limited | Combinatorial synthesis of PEG oligomer libraries |
| US20060135468A1 (en) | 2004-09-02 | 2006-06-22 | Bionaut Pharmaceuticals, Inc. | Treatment of refractory cancers using NA+/K+ ATPase inhibitors |
| KR101203475B1 (ko) | 2004-09-22 | 2012-11-21 | 니폰 가야꾸 가부시끼가이샤 | 신규 블록 공중합체, 미셀 제제물 및 이를 유효성분으로함유하는 항암제 |
| US20080312162A1 (en) * | 2004-10-08 | 2008-12-18 | The Ohio State University | Methods and Compositions for Enzyme-Specific Activation of Carbohydrate-Conjugated Prodrugs |
| CN100361985C (zh) * | 2004-10-26 | 2008-01-16 | 中国科学院长春应用化学研究所 | 可生物降解聚合物的紫杉醇前药及其合成方法 |
| JP2008543789A (ja) * | 2005-06-17 | 2008-12-04 | ホスピラ オーストラリア ピーティーワイ エルティーディー | ドセタキセルの液体薬学的処方物 |
| CN1895676B (zh) * | 2005-07-14 | 2010-11-10 | 上海艾力斯医药科技有限公司 | 聚乙二醇为载体的紫杉醇或多烯紫杉醇的前药 |
| JP2009515993A (ja) | 2005-11-17 | 2009-04-16 | ノバルティス アクチエンゲゼルシャフト | 医薬組成物 |
| CN100431610C (zh) * | 2006-01-24 | 2008-11-12 | 中国科学院长春应用化学研究所 | 两亲性三嵌段共聚物-紫杉醇键合药及其制备方法 |
| US8323669B2 (en) | 2006-03-28 | 2012-12-04 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of taxane |
| CA2652656A1 (fr) | 2006-05-18 | 2007-11-29 | Nippon Kayaku Kabushiki Kaisha | Conjugue de podophyllotoxines a poids moleculaire eleve |
| JP5503872B2 (ja) | 2006-11-06 | 2014-05-28 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
| JP5548365B2 (ja) | 2006-11-08 | 2014-07-16 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
| US8318795B2 (en) * | 2007-03-01 | 2012-11-27 | Cedars-Sinai Medical Center | Antioxidant polymers containing [1,2]-dithiolane moieties and uses thereof |
| US7776827B2 (en) * | 2007-07-27 | 2010-08-17 | Immuneregen Biosciences, Inc. | Method of using substance P analogs for treatment amelioration of myelodysplastic syndrome |
| USRE46190E1 (en) | 2007-09-28 | 2016-11-01 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
| US9028874B2 (en) * | 2008-01-03 | 2015-05-12 | Cedars-Sinai Medical Center | Antioxidant nanosphere comprising [1,2]-dithiolane moieties |
| US8920788B2 (en) | 2008-03-18 | 2014-12-30 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of physiologically active substances |
| WO2009136572A1 (fr) | 2008-05-08 | 2009-11-12 | 日本化薬株式会社 | Conjugué de polymère avec l'acide folique ou un dérivé de l'acide folique |
| WO2009148698A1 (fr) * | 2008-06-02 | 2009-12-10 | Cedars-Sinai Medical Center | Promédicaments de dimension nanométrique de nsaids |
| ES2529060T3 (es) | 2008-11-24 | 2015-02-16 | Cedars-Sinai Medical Center | Derivados antioxidantes de la camptotecina y nanoesferas antineoplásicas antioxidantes de los mismos |
| CA2754909A1 (fr) | 2009-03-11 | 2010-09-16 | Ambit Biosciences Corp. | Combinaison d'une indazolylaminopyrrolotriazine et d'un taxane pour un traitement du cancer |
| CN102421827B (zh) | 2009-05-15 | 2014-07-30 | 日本化药株式会社 | 具有羟基的生理活性物质的高分子结合体 |
| BR112013007113B1 (pt) | 2010-09-30 | 2020-09-24 | Astrazeneca Ab | Sal de oxalato do conjugado naloxol-polietilenoglicol cristalino |
| US9018323B2 (en) | 2010-11-17 | 2015-04-28 | Nippon Kayaku Kabushiki Kaisha | Polymer derivative of cytidine metabolic antagonist |
| WO2012137225A1 (fr) * | 2011-04-08 | 2012-10-11 | Sphaera Pharma Pvt. Ltd | Réactifs de méthylformyle substitué et procédé d'utilisation de ceux-ci pour modifier des propriétés physicochimiques et/ou pharmacocinétiques de composés |
| CN102276826B (zh) * | 2011-06-03 | 2013-01-02 | 中国科学院长春应用化学研究所 | 抗肿瘤前药及其制备方法 |
| CA2847114C (fr) | 2011-09-11 | 2018-08-21 | Nippon Kayaku Kabushiki Kaisha | Procede de preparation de copolymere a blocs |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5411947A (en) | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
| US5407683A (en) | 1990-06-01 | 1995-04-18 | Research Corporation Technologies, Inc. | Pharmaceutical solutions and emulsions containing taxol |
| WO1993024476A1 (fr) | 1992-06-04 | 1993-12-09 | Clover Consolidated, Limited | Vehicules polymeres solubles dans l'eau servant a la liberation de medicaments |
| US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| WO1994005282A1 (fr) | 1992-09-04 | 1994-03-17 | The Scripps Research Institute | Derives de taxol hydrosolubles |
| US5439686A (en) | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
| AU6400094A (en) | 1993-03-09 | 1994-09-26 | Enzon, Inc. | Taxol polyalkylene oxide conjugates of taxol and taxol intermediates |
| JPH0782291A (ja) | 1993-09-13 | 1995-03-28 | Microbial Chem Res Found | 水溶性アンスラサイクリン誘導体 |
| US5824701A (en) * | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
| US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5840900A (en) | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| CZ297979B6 (cs) | 1996-03-12 | 2007-05-16 | Pg-Txl Company, L. P. | Kompozice obsahující protinádorové lécivo konjugované s ve vode rozpustným polymerem, její pouzití pro výrobu léciva a implantovatelná lékarská pomucka |
| ATE310538T1 (de) | 1996-04-15 | 2005-12-15 | Asahi Chemical Ind | Arzneimittelkomplexe enthaltend taxan- verbindungen oder steroiden |
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| SK182599A3 (en) | 1997-06-20 | 2000-07-11 | Baker Norton Pharma | Soluble prodrugs of paclitaxel |
| AU1825299A (en) | 1997-12-17 | 1999-07-05 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| WO1999048536A2 (fr) * | 1998-03-23 | 1999-09-30 | Conjuchem, Inc. | Apport local d'agents therapeutiques a action prolongee |
| AU772074B2 (en) | 1999-04-28 | 2004-04-08 | Vectramed, Inc. | Enzymatically activated polymeric drug conjugates |
| MXPA02001857A (es) | 1999-08-24 | 2003-07-14 | Cellgate Inc | Composiciones y metodos para incrementar la entrega de drogas a traves y dentro de tejidos epiteliales. |
| US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
-
1999
- 1999-12-31 US US09/476,974 patent/US6380405B1/en not_active Expired - Fee Related
-
2000
- 2000-09-07 BR BR0013949-1A patent/BR0013949A/pt not_active Application Discontinuation
- 2000-09-07 PL PL00354779A patent/PL354779A1/xx unknown
- 2000-09-07 HU HU0300093A patent/HUP0300093A2/hu unknown
- 2000-09-07 AU AU69512/00A patent/AU784395B2/en not_active Ceased
- 2000-09-07 JP JP2001523038A patent/JP2003509386A/ja active Pending
- 2000-09-07 WO PCT/US2000/024523 patent/WO2001019407A2/fr not_active Application Discontinuation
- 2000-09-07 EP EP00957966A patent/EP1214096A2/fr not_active Withdrawn
- 2000-09-07 CN CN00815507A patent/CN1390142A/zh active Pending
- 2000-09-07 CZ CZ2002929A patent/CZ2002929A3/cs unknown
- 2000-09-07 CA CA002384646A patent/CA2384646A1/fr not_active Abandoned
- 2000-09-07 MX MXPA02002711A patent/MXPA02002711A/es unknown
- 2000-09-07 KR KR1020027003277A patent/KR20020082458A/ko not_active Application Discontinuation
- 2000-09-07 IL IL14855900A patent/IL148559A0/xx unknown
-
2002
- 2002-03-12 NO NO20021212A patent/NO20021212L/no unknown
- 2002-11-21 HK HK02108431.8A patent/HK1046856A1/zh unknown
-
2006
- 2006-06-20 AU AU2006202613A patent/AU2006202613A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02002711A (es) | 2002-07-30 |
| KR20020082458A (ko) | 2002-10-31 |
| HUP0300093A2 (en) | 2003-05-28 |
| JP2003509386A (ja) | 2003-03-11 |
| EP1214096A2 (fr) | 2002-06-19 |
| CZ2002929A3 (cs) | 2002-08-14 |
| US6380405B1 (en) | 2002-04-30 |
| PL354779A1 (en) | 2004-02-23 |
| CN1390142A (zh) | 2003-01-08 |
| WO2001019407A2 (fr) | 2001-03-22 |
| HK1046856A1 (zh) | 2003-01-30 |
| AU784395B2 (en) | 2006-03-23 |
| CA2384646A1 (fr) | 2001-03-22 |
| NO20021212L (no) | 2002-05-13 |
| BR0013949A (pt) | 2002-05-14 |
| AU6951200A (en) | 2001-04-17 |
| AU2006202613A1 (en) | 2006-07-13 |
| NO20021212D0 (no) | 2002-03-12 |
| WO2001019407A3 (fr) | 2002-01-17 |
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