HUP0300093A2 - Taxane prodrugs - Google Patents

Taxane prodrugs

Info

Publication number
HUP0300093A2
HUP0300093A2 HU0300093A HUP0300093A HUP0300093A2 HU P0300093 A2 HUP0300093 A2 HU P0300093A2 HU 0300093 A HU0300093 A HU 0300093A HU P0300093 A HUP0300093 A HU P0300093A HU P0300093 A2 HUP0300093 A2 HU P0300093A2
Authority
HU
Hungary
Prior art keywords
polyethylene glycol
oligomers
taxane
salt
taxane prodrugs
Prior art date
Application number
HU0300093A
Other languages
English (en)
Inventor
Gary S Bartley
Nnochiri N Ekwuribe
Christopher H Price
Original Assignee
Nobex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp filed Critical Nobex Corp
Publication of HUP0300093A2 publication Critical patent/HUP0300093A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány általában taxán prodrugokat nyújt, amelyek legalább egy,hidrolizálható kötés(ek)sel egy vagy több polietilén-glikololigomerhez kapcsolódó taxánból állnak, az oligomerek 1-25 polietilén-glikol-egységből álló, egyenes vagy elágazó láncú polietilén-glikololigomereket, és adott esetben egy sóképző csoportot tartalmazócsoportból választhatók. A polietilén-glikol oligomer előnyösen egysóképző csoportot tartalmaz, amely előnyösen ammónium- éskarboxilátcsoport közül választható. Ó
HU0300093A 1999-09-13 2000-09-07 Taxane prodrugs HUP0300093A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15357999P 1999-09-13 1999-09-13
US09/476,974 US6380405B1 (en) 1999-09-13 1999-12-31 Taxane prodrugs
PCT/US2000/024523 WO2001019407A2 (en) 1999-09-13 2000-09-07 Taxane prodrugs

Publications (1)

Publication Number Publication Date
HUP0300093A2 true HUP0300093A2 (en) 2003-05-28

Family

ID=26850672

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300093A HUP0300093A2 (en) 1999-09-13 2000-09-07 Taxane prodrugs

Country Status (16)

Country Link
US (1) US6380405B1 (hu)
EP (1) EP1214096A2 (hu)
JP (1) JP2003509386A (hu)
KR (1) KR20020082458A (hu)
CN (1) CN1390142A (hu)
AU (2) AU784395B2 (hu)
BR (1) BR0013949A (hu)
CA (1) CA2384646A1 (hu)
CZ (1) CZ2002929A3 (hu)
HK (1) HK1046856A1 (hu)
HU (1) HUP0300093A2 (hu)
IL (1) IL148559A0 (hu)
MX (1) MXPA02002711A (hu)
NO (1) NO20021212L (hu)
PL (1) PL354779A1 (hu)
WO (1) WO2001019407A2 (hu)

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JP2009515993A (ja) 2005-11-17 2009-04-16 ノバルティス アクチエンゲゼルシャフト 医薬組成物
CN100431610C (zh) * 2006-01-24 2008-11-12 中国科学院长春应用化学研究所 两亲性三嵌段共聚物-紫杉醇键合药及其制备方法
KR20080106254A (ko) * 2006-03-28 2008-12-04 니폰 가야꾸 가부시끼가이샤 탁산류의 고분자 결합체
WO2007135910A1 (ja) 2006-05-18 2007-11-29 Nippon Kayaku Kabushiki Kaisha ポドフィロトキシン類の高分子結合体
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
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JP2010520333A (ja) * 2007-03-01 2010-06-10 セダーズ−シナイ メディカル センター 〔１，２〕−ジチオラン部分を含有する抗酸化剤重合体およびその使用
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Also Published As

Publication number Publication date
CA2384646A1 (en) 2001-03-22
AU784395B2 (en) 2006-03-23
AU2006202613A1 (en) 2006-07-13
MXPA02002711A (es) 2002-07-30
CN1390142A (zh) 2003-01-08
NO20021212D0 (no) 2002-03-12
WO2001019407A3 (en) 2002-01-17
PL354779A1 (en) 2004-02-23
CZ2002929A3 (cs) 2002-08-14
NO20021212L (no) 2002-05-13
WO2001019407A2 (en) 2001-03-22
JP2003509386A (ja) 2003-03-11
IL148559A0 (en) 2002-09-12
KR20020082458A (ko) 2002-10-31
HK1046856A1 (zh) 2003-01-30
EP1214096A2 (en) 2002-06-19
US6380405B1 (en) 2002-04-30
AU6951200A (en) 2001-04-17
BR0013949A (pt) 2002-05-14

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