IL145748A0 - Substituted bicyclic heteroaryl compounds as integrin antagonists - Google Patents
Substituted bicyclic heteroaryl compounds as integrin antagonistsInfo
- Publication number
- IL145748A0 IL145748A0 IL14574800A IL14574800A IL145748A0 IL 145748 A0 IL145748 A0 IL 145748A0 IL 14574800 A IL14574800 A IL 14574800A IL 14574800 A IL14574800 A IL 14574800A IL 145748 A0 IL145748 A0 IL 145748A0
- Authority
- IL
- Israel
- Prior art keywords
- linkage
- optionally substituted
- direct bond
- compounds
- alkylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Metal-Oxide And Bipolar Metal-Oxide Semiconductor Integrated Circuits (AREA)
- Semiconductor Integrated Circuits (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9908355.2A GB9908355D0 (en) | 1999-04-12 | 1999-04-12 | Chemical compounds |
US14147099P | 1999-06-29 | 1999-06-29 | |
PCT/GB2000/001393 WO2000061580A1 (en) | 1999-04-12 | 2000-04-12 | Substituted bicyclic heteroaryl compounds as integrin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
IL145748A0 true IL145748A0 (en) | 2002-07-25 |
Family
ID=26315408
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14574800A IL145748A0 (en) | 1999-04-12 | 2000-04-12 | Substituted bicyclic heteroaryl compounds as integrin antagonists |
IL145748A IL145748A (en) | 1999-04-12 | 2001-10-04 | Dual-ring troaryl compounds are converted as integrin antagonists |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL145748A IL145748A (en) | 1999-04-12 | 2001-10-04 | Dual-ring troaryl compounds are converted as integrin antagonists |
Country Status (24)
Country | Link |
---|---|
US (1) | US6706738B2 (hr) |
EP (1) | EP1183254B1 (hr) |
KR (1) | KR20010110750A (hr) |
CN (1) | CN1350534A (hr) |
AT (1) | ATE286896T1 (hr) |
AU (1) | AU769554B2 (hr) |
BG (1) | BG106083A (hr) |
BR (1) | BR0010599A (hr) |
CA (1) | CA2369728A1 (hr) |
CZ (1) | CZ20013661A3 (hr) |
DE (1) | DE60017389T2 (hr) |
EE (1) | EE200100528A (hr) |
ES (1) | ES2231179T3 (hr) |
HK (1) | HK1044937A1 (hr) |
HR (1) | HRP20010732A2 (hr) |
HU (1) | HUP0200803A3 (hr) |
IL (2) | IL145748A0 (hr) |
MX (1) | MXPA01010231A (hr) |
NO (1) | NO20014951L (hr) |
NZ (1) | NZ514602A (hr) |
PL (1) | PL351433A1 (hr) |
SK (1) | SK14372001A3 (hr) |
TR (1) | TR200102959T2 (hr) |
WO (1) | WO2000061580A1 (hr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4212358B2 (ja) | 2000-12-28 | 2009-01-21 | 第一三共株式会社 | Vla−4阻害薬 |
DE60329910D1 (de) * | 2002-03-29 | 2009-12-17 | Novartis Vaccines & Diagnostic | Substituierte benzazole und ihre verwendung als raf-kinase-hemmer |
JP4676884B2 (ja) | 2003-07-24 | 2011-04-27 | 第一三共株式会社 | シクロヘキサンカルボン酸類 |
WO2005073224A2 (en) | 2004-01-23 | 2005-08-11 | Amgen Inc | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
TW200536851A (en) | 2004-01-23 | 2005-11-16 | Amgen Inc | Compounds and methods of use |
MX2007001890A (es) * | 2004-08-16 | 2009-02-12 | Procter & Gamble | Compuestos de fenol 2-(amino sustituido)-5, 6-sustituido, composiciones de teñido que las comprenden y su uso. |
DE102004041137A1 (de) * | 2004-08-25 | 2006-03-02 | Wella Ag | o-Aminophenol-Derivate und diese Verbindungen enthaltende Färbemittel |
US7235688B1 (en) | 2004-11-04 | 2007-06-26 | University Of Notre Dame Du Lac | Process for preparing histone deacetylase inhibitors and intermediates thereof |
US20070021612A1 (en) * | 2004-11-04 | 2007-01-25 | University Of Notre Dame Du Lac | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof |
EP1827434B1 (en) | 2004-11-30 | 2014-01-15 | Amgen Inc. | Quinolines and quinazoline analogs and their use as medicaments for treating cancer |
US7514460B2 (en) | 2004-12-22 | 2009-04-07 | 4Sc Ag | Benzazole analogues and uses thereof |
JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
TW200804345A (en) * | 2005-08-30 | 2008-01-16 | Novartis Ag | Substituted benzimidazoles and methods of preparation |
PL2010528T3 (pl) | 2006-04-19 | 2018-03-30 | Novartis Ag | 6-0-podstawione związki benzoksazolowe i benzotiazolowe i sposoby hamowania sygnalizacji csf-1r |
US7931838B2 (en) * | 2006-08-31 | 2011-04-26 | Virginia Tech Intellectual Properties, Inc. | Method for making oriented single-walled carbon nanotube/polymer nano-composite membranes |
EP2220078B1 (en) * | 2007-10-29 | 2013-05-22 | Amgen, Inc | Benzomorpholine derivatives and methods of use |
UY32138A (es) * | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
UY32470A (es) * | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
US8674113B2 (en) | 2010-12-10 | 2014-03-18 | Boehringer Ingelheim International Gmbh | Compounds |
US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
LT2968443T (lt) | 2013-03-15 | 2021-12-10 | Protagonist Therapeutics, Inc. | Hepcidino analogai ir jų naudojimas |
EP3960754A3 (en) * | 2014-05-16 | 2022-07-06 | Protagonist Therapeutics, Inc. | Alpha4beta7 integrin thioether peptide antagonists |
RU2736637C9 (ru) | 2014-07-17 | 2021-02-08 | Протагонист Терепьютикс, Инк. | Пептидные ингибиторы рецептора интерлейкина-23 для перорального приема и их применение для лечения воспалительных заболеваний кишечника |
EP3200812B8 (en) | 2014-10-01 | 2021-04-28 | Protagonist Therapeutics, Inc. | Novel alpha4beta7 peptide monomer and dimer antagonists |
US10301371B2 (en) | 2014-10-01 | 2019-05-28 | Protagonist Therapeutics, Inc. | Cyclic monomer and dimer peptides having integrin antagonist activity |
US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
CA3009834A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
US10407468B2 (en) | 2016-03-23 | 2019-09-10 | Protagonist Therapeutics, Inc. | Methods for synthesizing α4β7 peptide antagonists |
TW201920234A (zh) | 2017-09-11 | 2019-06-01 | 美商領導醫療有限公司 | 類鴉片促效劑肽及其用途 |
CA3089868A1 (en) | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
EP3997105A4 (en) | 2019-07-10 | 2023-09-13 | Protagonist Therapeutics, Inc. | PEPTIDE INHIBITORS OF THE INTERLEUKIN-23 RECEPTOR AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES |
WO2021146441A1 (en) | 2020-01-15 | 2021-07-22 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
CN115279782A (zh) | 2020-01-15 | 2022-11-01 | 詹森生物科技公司 | 白介素-23受体的肽抑制剂及其用于治疗炎性疾病的用途 |
WO2021226261A1 (en) | 2020-05-06 | 2021-11-11 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
US11939361B2 (en) | 2020-11-20 | 2024-03-26 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of Interleukin-23 receptor |
TW202241889A (zh) | 2020-12-23 | 2022-11-01 | 美商雅捷可斯治療公司 | 作為jak2抑制劑之6-雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11510814A (ja) * | 1995-08-30 | 1999-09-21 | ジー.ディー.サール アンド カンパニー | インテグリンアンタゴニストとしてのメタ−グアニジン、尿素、チオ尿素またはアザ環状アミノ安息香酸誘導体 |
IL138677A0 (en) * | 1998-04-10 | 2001-10-31 | Searle & Co | Heterocyclic glycyl beta-alanine derivatives as vitronectin antagonists |
ATE325105T1 (de) * | 1999-02-16 | 2006-06-15 | Aventis Pharma Ltd | Bicyclische verbindungen und ihre verwendung als integrinrezeptorliganden |
-
2000
- 2000-04-12 TR TR2001/02959T patent/TR200102959T2/xx unknown
- 2000-04-12 MX MXPA01010231A patent/MXPA01010231A/es unknown
- 2000-04-12 EP EP00919064A patent/EP1183254B1/en not_active Expired - Lifetime
- 2000-04-12 PL PL00351433A patent/PL351433A1/xx not_active Application Discontinuation
- 2000-04-12 ES ES00919064T patent/ES2231179T3/es not_active Expired - Lifetime
- 2000-04-12 IL IL14574800A patent/IL145748A0/xx active IP Right Grant
- 2000-04-12 AU AU39816/00A patent/AU769554B2/en not_active Expired
- 2000-04-12 HU HU0200803A patent/HUP0200803A3/hu unknown
- 2000-04-12 EE EEP200100528A patent/EE200100528A/xx unknown
- 2000-04-12 WO PCT/GB2000/001393 patent/WO2000061580A1/en not_active Application Discontinuation
- 2000-04-12 CN CN00807512A patent/CN1350534A/zh active Pending
- 2000-04-12 BR BR0010599-6A patent/BR0010599A/pt not_active Application Discontinuation
- 2000-04-12 KR KR1020017013055A patent/KR20010110750A/ko not_active Application Discontinuation
- 2000-04-12 CZ CZ20013661A patent/CZ20013661A3/cs unknown
- 2000-04-12 SK SK1437-2001A patent/SK14372001A3/sk unknown
- 2000-04-12 CA CA002369728A patent/CA2369728A1/en not_active Abandoned
- 2000-04-12 DE DE60017389T patent/DE60017389T2/de not_active Expired - Lifetime
- 2000-04-12 NZ NZ514602A patent/NZ514602A/xx unknown
- 2000-04-12 AT AT00919064T patent/ATE286896T1/de not_active IP Right Cessation
-
2001
- 2001-10-04 IL IL145748A patent/IL145748A/en not_active IP Right Cessation
- 2001-10-10 HR HR20010732A patent/HRP20010732A2/hr not_active Application Discontinuation
- 2001-10-11 NO NO20014951A patent/NO20014951L/no not_active Application Discontinuation
- 2001-10-11 US US09/975,721 patent/US6706738B2/en not_active Expired - Lifetime
- 2001-11-05 BG BG106083A patent/BG106083A/xx unknown
-
2002
- 2002-07-30 HK HK02105579.6A patent/HK1044937A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
SK14372001A3 (sk) | 2002-06-04 |
CA2369728A1 (en) | 2000-10-19 |
BG106083A (en) | 2002-05-31 |
PL351433A1 (en) | 2003-04-22 |
NO20014951D0 (no) | 2001-10-11 |
AU3981600A (en) | 2000-11-14 |
AU769554B2 (en) | 2004-01-29 |
TR200102959T2 (tr) | 2002-04-22 |
HK1044937A1 (zh) | 2002-11-08 |
US20020173506A1 (en) | 2002-11-21 |
NZ514602A (en) | 2003-06-30 |
HUP0200803A2 (hu) | 2002-07-29 |
DE60017389T2 (de) | 2006-03-02 |
EE200100528A (et) | 2003-02-17 |
WO2000061580A1 (en) | 2000-10-19 |
CZ20013661A3 (cs) | 2002-01-16 |
BR0010599A (pt) | 2002-02-13 |
ES2231179T3 (es) | 2005-05-16 |
HRP20010732A2 (en) | 2002-12-31 |
DE60017389D1 (de) | 2005-02-17 |
CN1350534A (zh) | 2002-05-22 |
NO20014951L (no) | 2001-12-11 |
EP1183254A1 (en) | 2002-03-06 |
IL145748A (en) | 2007-02-11 |
EP1183254B1 (en) | 2005-01-12 |
US6706738B2 (en) | 2004-03-16 |
ATE286896T1 (de) | 2005-01-15 |
MXPA01010231A (es) | 2003-07-21 |
KR20010110750A (ko) | 2001-12-13 |
HUP0200803A3 (en) | 2002-12-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL145748A0 (en) | Substituted bicyclic heteroaryl compounds as integrin antagonists | |
ATE51621T1 (de) | Bicyclische kondensierte n-(4-piperidinyl)-2imidazolamin-derivate. | |
NL300006I1 (nl) | Imidazolylalkeenzuurderivaten. | |
MY135686A (en) | Indole derivatives useful as histamine h3 antagonists | |
NO986055D0 (no) | Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat | |
DE69803750D1 (de) | Thiazolidinedione- und oxazolidinedione-derivate mit antidiabetischen, hypolipidämischen und anti hypertensiven eigenschaften | |
DK1392306T3 (da) | Substituerede tetrahydroisoquinoliner til anvendelse i behandlingen af inflammatoriske sygdomme | |
DK1153017T3 (da) | Bicykliske forbindelser og deres anvendelse som integrinreceptorligander | |
ATE421958T1 (de) | Substituierte bizyclische verbindungen | |
DE69017593D1 (de) | Substituierte N-(Imidazolyl)alkyl-alanin-Derivate. | |
RS50109B (sr) | Derivati 4-heterociklilsulfonamidil-6-metoksi-5-(2-metoksi- fenoksi)-2-piridil-piridimina, njihovo dobivanje i primena kao antagonisti endotelinskih receptora | |
DE69221634D1 (de) | 5-Piperazinylalkyl)-1,5-Benzothiazepinone verwendbar als Calciumantagonisten | |
AR002715A1 (es) | Derivados de piperazina y piperazinona heterociclos substituidos particularmente utiles como antagonistas de los receptores de taquikinina,composicion farmaceutica que incluye uno de dichos derivados, uso de dichos compuestos en la preparacion de las composiciones y procedimiento para la preparacion de los derivados | |
YU71501A (sh) | Supstituisana biciklična heteroaril jedinjenja kao antagonisti integrina | |
WO1993004059A1 (en) | 4-acylaminoimidazole derivative | |
HUP0100540A2 (hu) | Szubsztituált oximok mint neurokinin antagonisták |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |