IL144299A - N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists - Google Patents
N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonistsInfo
- Publication number
- IL144299A IL144299A IL14429901A IL14429901A IL144299A IL 144299 A IL144299 A IL 144299A IL 14429901 A IL14429901 A IL 14429901A IL 14429901 A IL14429901 A IL 14429901A IL 144299 A IL144299 A IL 144299A
- Authority
- IL
- Israel
- Prior art keywords
- lower alkyl
- alkyl
- hetero
- phenyl
- twice
- Prior art date
Links
- 108050000302 Neurokinin receptors Proteins 0.000 title description 6
- 102000009493 Neurokinin receptors Human genes 0.000 title description 6
- FQXWSUOMZGXWNB-UHFFFAOYSA-N 1-(2h-triazol-4-ylmethyl)piperazine Chemical class C=1NN=NC=1CN1CCNCC1 FQXWSUOMZGXWNB-UHFFFAOYSA-N 0.000 title description 5
- 239000002464 receptor antagonist Substances 0.000 title description 3
- 229940044551 receptor antagonist Drugs 0.000 title description 3
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 171
- 150000001875 compounds Chemical class 0.000 claims abstract description 120
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 64
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 56
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 30
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 30
- 125000006413 ring segment Chemical group 0.000 claims abstract description 29
- 239000001257 hydrogen Substances 0.000 claims abstract description 23
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 23
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 22
- 150000002367 halogens Chemical class 0.000 claims abstract description 22
- 150000003839 salts Chemical class 0.000 claims abstract description 22
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 20
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 19
- 239000002253 acid Substances 0.000 claims abstract description 16
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 13
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims abstract description 12
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims abstract description 11
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims abstract description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000001301 oxygen Substances 0.000 claims abstract description 7
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 7
- 125000004429 atom Chemical group 0.000 claims abstract description 6
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 32
- -1 alkyl radical Chemical class 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 23
- 238000002360 preparation method Methods 0.000 claims description 21
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 18
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 17
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 17
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
- 125000006239 protecting group Chemical group 0.000 claims description 15
- 230000008569 process Effects 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 3
- 125000004193 piperazinyl group Chemical group 0.000 claims description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 3
- JVQIKJMSUIMUDI-UHFFFAOYSA-N 3-pyrroline Chemical compound C1NCC=C1 JVQIKJMSUIMUDI-UHFFFAOYSA-N 0.000 claims description 2
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 2
- 125000001064 morpholinomethyl group Chemical group [H]C([H])(*)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 claims 2
- CVVIJWRCGSYCMB-UHFFFAOYSA-N hydron;piperazine;dichloride Chemical compound Cl.Cl.C1CNCCN1 CVVIJWRCGSYCMB-UHFFFAOYSA-N 0.000 claims 1
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
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- 239000013543 active substance Substances 0.000 description 8
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10036818A DE10036818A1 (de) | 2000-07-28 | 2000-07-28 | Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL144299A0 IL144299A0 (en) | 2002-05-23 |
| IL144299A true IL144299A (en) | 2004-08-31 |
Family
ID=7650544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14429901A IL144299A (en) | 2000-07-28 | 2001-07-12 | N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6407106B1 (cs) |
| EP (1) | EP1176144B1 (cs) |
| JP (1) | JP2002053577A (cs) |
| KR (1) | KR100924405B1 (cs) |
| CN (1) | CN1167698C (cs) |
| AR (1) | AR028743A1 (cs) |
| AT (1) | ATE244716T1 (cs) |
| AU (1) | AU779318B2 (cs) |
| BR (1) | BR0103048A (cs) |
| CA (1) | CA2354213C (cs) |
| CZ (1) | CZ301695B6 (cs) |
| DE (2) | DE10036818A1 (cs) |
| DK (1) | DK1176144T3 (cs) |
| DZ (1) | DZ3119A1 (cs) |
| ES (1) | ES2201007T3 (cs) |
| HU (1) | HU226687B1 (cs) |
| IL (1) | IL144299A (cs) |
| IN (1) | IN191021B (cs) |
| NO (1) | NO323233B1 (cs) |
| NZ (1) | NZ513041A (cs) |
| PL (1) | PL210436B1 (cs) |
| PT (1) | PT1176144E (cs) |
| RU (1) | RU2288918C2 (cs) |
| SK (1) | SK284802B6 (cs) |
| TW (1) | TWI304403B (cs) |
| UA (1) | UA73728C2 (cs) |
| ZA (1) | ZA200105737B (cs) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA77515C2 (en) | 2002-04-04 | 2006-12-15 | Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity | |
| DE60321907D1 (de) * | 2002-04-26 | 2008-08-14 | Lilly Co Eli | Tachykininrezeptorantagonisten |
| DK1501809T3 (da) * | 2002-04-26 | 2008-05-13 | Lilly Co Eli | Trizolderivater som tachykininreceptorantagonister |
| WO2005000821A1 (en) * | 2003-06-12 | 2005-01-06 | Eli Lilly And Company | Tachykinin receptor antagonists |
| US20070082905A1 (en) * | 2005-05-27 | 2007-04-12 | De Vries Michiel H | Pharmaceutical compositions comprising n-triazolymethyl-piperazine compounds and methods of using same |
| DE602006018149D1 (de) * | 2005-07-25 | 2010-12-23 | Hoffmann La Roche | Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptors |
| PE20081229A1 (es) * | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| JP2010516731A (ja) | 2007-01-24 | 2010-05-20 | グラクソ グループ リミテッド | ２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物 |
| US20120258093A1 (en) | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
| EP2729147B1 (en) | 2011-07-04 | 2017-09-06 | IRBM - Science Park S.p.A. | Nk-1 receptor antagonists for treating corneal neovascularisation |
| JP2021514976A (ja) | 2018-02-26 | 2021-06-17 | オスペダーレ・サン・ラッファエーレ・エッセエッレエッレ | 眼痛の治療における使用のためのｎｋ−１拮抗薬 |
| EP4117673A1 (en) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Treatment of stem cell deficiency |
| CN115184498B (zh) * | 2022-07-15 | 2023-02-21 | 山东京卫制药有限公司 | N-Boc-哌嗪中有关物质哌嗪的检测方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5883098A (en) | 1993-11-29 | 1999-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
| IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5637592A (en) * | 1994-07-12 | 1997-06-10 | Janssen Pharmaceutica N.V. | Acyl derivatives of azolones |
| WO1996037489A1 (en) * | 1995-05-25 | 1996-11-28 | Fujisawa Pharmaceutical Co., Ltd. | 1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists |
| GB9513118D0 (en) * | 1995-06-28 | 1995-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| KR20000064415A (ko) * | 1995-12-18 | 2000-11-06 | 후지야마 아키라 | 타키키닌길항제로서의피페라진유도체 |
| KR100458346B1 (ko) * | 1996-03-29 | 2005-06-21 | 듀파 인터내셔날 리서치 베 파우 | 피페라진및피페리딘화합물 |
| AUPO735997A0 (en) * | 1997-06-17 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
| EP0899270B1 (de) * | 1997-08-27 | 2008-05-21 | Solvay Pharmaceuticals GmbH | Indolmethyl-N,N'-bisacylpiperazine als Neurokininrezeptorantagonisten |
| DE19824865A1 (de) | 1997-08-27 | 1999-03-04 | Solvay Pharm Gmbh | Neue Harnstoffderivate |
| ES2162731B1 (es) * | 1999-06-04 | 2003-02-16 | Faes Fabrica Espanola De Produ | Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas. |
-
2000
- 2000-07-28 DE DE10036818A patent/DE10036818A1/de not_active Withdrawn
-
2001
- 2001-05-23 CZ CZ20011813A patent/CZ301695B6/cs not_active IP Right Cessation
- 2001-06-01 SK SK757-2001A patent/SK284802B6/sk not_active IP Right Cessation
- 2001-06-21 AR ARP010102959A patent/AR028743A1/es active IP Right Grant
- 2001-07-10 CN CNB011228261A patent/CN1167698C/zh not_active Expired - Fee Related
- 2001-07-11 HU HU0102931A patent/HU226687B1/hu not_active IP Right Cessation
- 2001-07-12 IL IL14429901A patent/IL144299A/en not_active IP Right Cessation
- 2001-07-12 ZA ZA200105737A patent/ZA200105737B/xx unknown
- 2001-07-12 TW TW090117136A patent/TWI304403B/zh not_active IP Right Cessation
- 2001-07-16 IN IN672MU2001 patent/IN191021B/en unknown
- 2001-07-18 KR KR1020010043215A patent/KR100924405B1/ko not_active Expired - Fee Related
- 2001-07-18 NZ NZ513041A patent/NZ513041A/xx not_active IP Right Cessation
- 2001-07-19 ES ES01117433T patent/ES2201007T3/es not_active Expired - Lifetime
- 2001-07-19 AT AT01117433T patent/ATE244716T1/de active
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- 2001-07-19 PT PT01117433T patent/PT1176144E/pt unknown
- 2001-07-19 DK DK01117433T patent/DK1176144T3/da active
- 2001-07-25 JP JP2001224792A patent/JP2002053577A/ja active Pending
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- 2001-07-26 CA CA2354213A patent/CA2354213C/en not_active Expired - Fee Related
- 2001-07-26 AU AU57675/01A patent/AU779318B2/en not_active Ceased
- 2001-07-27 NO NO20013709A patent/NO323233B1/no not_active IP Right Cessation
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- 2001-07-27 UA UA2001075403A patent/UA73728C2/uk unknown
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