IL144227A0 - METHOD FOR PREPARING BICYCLIC COMPOUNDS AND USE OF SAID METHOD FOR PREPARING AN INTERLEUKIN-1$g (B) CONVERSION ENZYME (ICE) INHIBITOR - Google Patents
METHOD FOR PREPARING BICYCLIC COMPOUNDS AND USE OF SAID METHOD FOR PREPARING AN INTERLEUKIN-1$g (B) CONVERSION ENZYME (ICE) INHIBITORInfo
- Publication number
- IL144227A0 IL144227A0 IL14422700A IL14422700A IL144227A0 IL 144227 A0 IL144227 A0 IL 144227A0 IL 14422700 A IL14422700 A IL 14422700A IL 14422700 A IL14422700 A IL 14422700A IL 144227 A0 IL144227 A0 IL 144227A0
- Authority
- IL
- Israel
- Prior art keywords
- preparing
- interleukin
- inhibitor
- ice
- conversion enzyme
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 102000004190 Enzymes Human genes 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 title abstract 2
- 102000000589 Interleukin-1 Human genes 0.000 title 1
- 108010002352 Interleukin-1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 abstract 1
- 102000003777 Interleukin-1 beta Human genes 0.000 abstract 1
- 108090000193 Interleukin-1 beta Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003007 phosphonic acid derivatives Chemical class 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9900227A FR2788276B1 (fr) | 1999-01-12 | 1999-01-12 | NOUVEAU PROCEDE DE PREPARATION DE COMPOSES BICYCLIQUES ET L'APPLICATION DE CE PROCEDE COMME ETAPE INTERMEDIAIRE POUR LA PREPARATION D'UN COMPOSE INHIBITEUR DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1-BETA (ice) |
| PCT/FR2000/000041 WO2000042061A1 (fr) | 1999-01-12 | 2000-01-11 | Procede de preparation de composes bicycliques et l'application de ce procede pour la preparation d'un compose inhibiteur de ice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL144227A0 true IL144227A0 (en) | 2002-05-23 |
Family
ID=9540778
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14422700A IL144227A0 (en) | 1999-01-12 | 2000-01-11 | METHOD FOR PREPARING BICYCLIC COMPOUNDS AND USE OF SAID METHOD FOR PREPARING AN INTERLEUKIN-1$g (B) CONVERSION ENZYME (ICE) INHIBITOR |
| IL144227A IL144227A (en) | 1999-01-12 | 2001-07-10 | METHOD FOR PREPARING 9-AMINO-1,2,3,4,7,8,9,10-OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO-[1,2a][1,2]DIAZEPINE-1-CARBOXYLIC ACID DERIVATIVES AND USE OF SAID METHOD FOR PREPARING AN INTERLEUKIN - 1?? CONVERSION ENZYME (ICE) INHIBITOR AND THE NOVEL 1-(4-AMINO-5-CARBOXY-1-OXO)HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACID DERIVATIVES |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL144227A IL144227A (en) | 1999-01-12 | 2001-07-10 | METHOD FOR PREPARING 9-AMINO-1,2,3,4,7,8,9,10-OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO-[1,2a][1,2]DIAZEPINE-1-CARBOXYLIC ACID DERIVATIVES AND USE OF SAID METHOD FOR PREPARING AN INTERLEUKIN - 1?? CONVERSION ENZYME (ICE) INHIBITOR AND THE NOVEL 1-(4-AMINO-5-CARBOXY-1-OXO)HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACID DERIVATIVES |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6512111B1 (da) |
| EP (1) | EP1144436B1 (da) |
| JP (1) | JP4601826B2 (da) |
| KR (1) | KR100797349B1 (da) |
| CN (1) | CN1240710C (da) |
| AT (1) | ATE263780T1 (da) |
| AU (1) | AU774752B2 (da) |
| BR (1) | BR0007810B1 (da) |
| CA (1) | CA2359964C (da) |
| DE (1) | DE60009658T2 (da) |
| DK (1) | DK1144436T3 (da) |
| ES (1) | ES2215020T3 (da) |
| FR (1) | FR2788276B1 (da) |
| HK (1) | HK1045316B (da) |
| HU (1) | HU230062B1 (da) |
| IL (2) | IL144227A0 (da) |
| NO (1) | NO328110B1 (da) |
| NZ (1) | NZ512908A (da) |
| PL (1) | PL196993B1 (da) |
| PT (1) | PT1144436E (da) |
| SI (1) | SI1144436T1 (da) |
| TW (1) | TWI222443B (da) |
| WO (1) | WO2000042061A1 (da) |
| ZA (1) | ZA200105550B (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6703500B2 (en) | 1998-08-19 | 2004-03-09 | Vertex Pharmaceuticals, Incorporated | Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors |
| US6559304B1 (en) | 1998-08-19 | 2003-05-06 | Vertex Pharmaceuticals Incorporated | Method for synthesizing caspase inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ204130A (en) * | 1982-05-12 | 1986-03-14 | Hoffmann La Roche | Bicyclic heterocyclic compounds and pharmaceutical compositions |
| GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
-
1999
- 1999-01-12 FR FR9900227A patent/FR2788276B1/fr not_active Expired - Fee Related
- 1999-12-10 TW TW088121699A patent/TWI222443B/zh not_active IP Right Cessation
-
2000
- 2000-01-11 BR BRPI0007810-7A patent/BR0007810B1/pt not_active IP Right Cessation
- 2000-01-11 AT AT00900552T patent/ATE263780T1/de active
- 2000-01-11 IL IL14422700A patent/IL144227A0/xx active IP Right Grant
- 2000-01-11 ES ES00900552T patent/ES2215020T3/es not_active Expired - Lifetime
- 2000-01-11 AU AU30524/00A patent/AU774752B2/en not_active Ceased
- 2000-01-11 JP JP2000593628A patent/JP4601826B2/ja not_active Expired - Fee Related
- 2000-01-11 CA CA2359964A patent/CA2359964C/fr not_active Expired - Fee Related
- 2000-01-11 WO PCT/FR2000/000041 patent/WO2000042061A1/fr not_active Ceased
- 2000-01-11 NZ NZ512908A patent/NZ512908A/en not_active IP Right Cessation
- 2000-01-11 US US09/869,950 patent/US6512111B1/en not_active Expired - Lifetime
- 2000-01-11 DE DE60009658T patent/DE60009658T2/de not_active Expired - Lifetime
- 2000-01-11 HU HU0202665A patent/HU230062B1/hu not_active IP Right Cessation
- 2000-01-11 SI SI200030348T patent/SI1144436T1/xx unknown
- 2000-01-11 PL PL348919A patent/PL196993B1/pl unknown
- 2000-01-11 PT PT00900552T patent/PT1144436E/pt unknown
- 2000-01-11 CN CNB008048320A patent/CN1240710C/zh not_active Expired - Fee Related
- 2000-01-11 KR KR1020017008755A patent/KR100797349B1/ko not_active Expired - Fee Related
- 2000-01-11 EP EP00900552A patent/EP1144436B1/fr not_active Expired - Lifetime
- 2000-01-11 HK HK02106828.3A patent/HK1045316B/zh not_active IP Right Cessation
- 2000-01-11 DK DK00900552T patent/DK1144436T3/da active
-
2001
- 2001-07-05 ZA ZA200105550A patent/ZA200105550B/en unknown
- 2001-07-10 IL IL144227A patent/IL144227A/en not_active IP Right Cessation
- 2001-07-11 NO NO20013435A patent/NO328110B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |